scholarly journals High sensitivity C-reactive protein: Potential biomarker of inflammation in acute mTBI

Neurology ◽  
2018 ◽  
Vol 91 (23 Supplement 1) ◽  
pp. S18.1-S18
Author(s):  
Teena Shetty ◽  
Cogsil Taylor ◽  
Aashka Dalal ◽  
Kristin Halvorsen ◽  
Kelianne Cummings ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Binary Logistic Regression ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Reactive Protein ◽  
Blood Biomarker ◽  
Diagnosis And Prognosis ◽  
Potential Factors ◽  
Delayed Time

ObjectiveThis study investigated the utility of high-sensitivity C-Reactive Protein (hsCRP) as a blood biomarker for mild traumatic brain injury (mTBI).BackgroundValidation of a blood biomarker panel will greatly improve mTBI diagnosis and prognosis. hsCRP has been validated as a sensitive biomarker for inflammation. Previous studies have established relationships between CRP levels and TBI, but the utilization of hsCRP levels in assessing mTBI requires further exploration.MethodsRetrospective chart review collected hsCRP values in acute mTBI patients seen within 30 days of injury. Patients with any comorbid diagnosis known to cause elevation of inflammatory proteins were excluded. Continuous hsCRP levels were transformed into quartiles: <0.200 mg/L for Quartile 1 (Q1); 0.200–0.415 mg/L for Quartile 2 (Q2); 0.415–1.100 mg/L for Quartile 3 (Q3); and ≥1.100 mg/L for Quartile 4 (Q4). Multivariable binary logistic regression modeling identified potential factors for elevated hsCRP at first visit. Cox regression analysis identified potential factors for delayed time to recovery.ResultsThree hundred twelve injuries in 311 patients were reviewed (mean age 21 ± 12 years, 53% female). Mean hsCRP was elevated patients who presented within 2 days of injury and was found to significantly decrease between first visit and 4 weeks post-injury (p = 0.016). Initial hsCRP level was positively correlated with age (r = 0.163, p = 0.004) and negatively associated with previous concussion history (p = 0.031). When analyzed as quartiles, patients in Q4 were more likely to have endorsed headache (p = 0.036) or fatigue (p = 0.030). Age significantly increased between quartiles (p = 0.013). Multivariable binary logistic regression showed that increased age (OR: 3.48) and patients presenting with headache (OR: 3.48) or fatigue (OR: 2.16) were significantly associated with increased risk of having an hsCRP level in Q4. Females (HR: 0.32) and increased age (HR: 0.95) were associated delayed time to recovery.ConclusionshsCRP may be a viable addition to acute and longitudinal biomarker panels for diagnosis and prognosis of mTBI.

Higher level of high sensitivity C-reactive protein is associated with more fibrocalcific plaque and longer lesion in patients with acute coronary syndrome

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Katamine ◽  
Y Minami ◽  
K Asakura ◽  
A Kato ◽  
A Katsura ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Morphological Characteristics ◽  
High Sensitivity ◽  
Current Smoker ◽  
Lesion Length ◽  
Culprit Lesion ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Reactive Protein ◽  
Coronary Syndrome

Abstract Background The association between the level of high sensitivity C-reactive protein (hsCRP) and coronary plaque characteristics in patients with acute coronary syndrome (ACS) remains to be elucidated. Purpose To clarify the morphological characteristics of culprit lesion in patients with ACS according to the hsCRP levels using optical coherence tomography (OCT). Methods A total of 215 consecutive patients with ACS, who underwent OCT imaging of culprit lesions were included. The patients were classified into either the higher hsCRP group (hsCRP ≥0.14 mg/dL, n=108) or the lower hsCRP group (hsCRP &lt;0.14 mg/dL, n=107) according to the median preprocedural hsCRP level. The morphological characteristics of culprit lesion assessed by OCT were compared between the two groups. Results The higher hsCRP group had higher prevalence of insulin therapy (14 vs. 6%, p=0.037) and current smoker than the lower hsCRP group (37 vs. 18%, p=0.002). The prevalence of long lesion (≥25 mm, 67 vs. 53%, p=0.041) and fibrocalcific plaque (53 vs. 33%, p=0.003) was significantly higher in the higher hsCRP group than in the lower hsCRP group (Figure). On the other hand, the prevalence of plaque rupture (36 vs. 46%, p=0.174) and lipid-rich plaque (47 vs. 64%, p=0.011) was rather lower in the higher hsCRP group than in the lower hsCRP group (Figure). In a multivariate analysis, fibrocalcific plaque (odds ratio [OR]: 2.098, 95% confidence interval [CI]: 1.125–3.913, p=0.019), lesion length (mm, OR: 1.036, 95% CI: 1.010–1.061, p=0.004) and current smoker (OR: 2.757, 95% CI: 1.388–5.476, p=0.003) was independently associated with higher hsCRP level. Conclusions ACS patients with high hsCRP levels had more fibrocalcific plaque and longer lesion than those with low hsCRP levels. The association between high hsCRP levels and vulnerable characteristics of culprit plaque was not demonstrated. Funding Acknowledgement Type of funding source: None

scholarly journals Association between weekend catch-up sleep and high-sensitivity C-reactive protein levels in adults: a population-based study

SLEEP ◽  
2020 ◽  
Vol 43 (8) ◽  
Author(s):  
Kyu-Man Han ◽  
Heon-Jeong Lee ◽  
Leen Kim ◽  
Ho-Kyoung Yoon
Keyword(s):  
Sleep Duration ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Obese People ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Catch Up

Abstract Study Objectives To investigate the association between weekend catch-up sleep (WCS) and the levels of high-sensitivity C-reactive protein (hsCRP)—a serum inflammatory maker—in adults Methods Data of 5,506 adults aged 19 years or older were obtained from the nationwide cross-sectional Korea National Health and Nutrition Examination Surveys conducted in 2016. Serum hsCRP level, weekday and weekend sleep durations, and sociodemographic and health-related characteristics were assessed. Participants whose weekend sleep duration was more than 1 h longer than their weekday sleep duration were included in the WCS group. hsCRP level was categorized into quartiles (i.e. highest, middle-high, middle-low, and lowest). Obesity was defined by body mass index ≥ 25.0 kg/m2. Results The WCS group included 1,901 participants (34.5%). In the logistic regression analysis controlling for all variables, adults in the WCS group were significantly less likely to show the highest hsCRP level (versus the lowest level) compared with those without WCS in the complete sample (adjusted odds ratio = 0.795, 95% confidence interval [CI] = 0.662 to 0.955). In a subgroup analysis, this association was significant only for those with weekday sleep duration of 6 h or lower. Longer WCS (≥3 h) was not associated with hsCRP levels. Non-obese people with WCS demonstrated a lower risk for high hsCRP levels, while there was no significant difference in obese people with WCS. Conclusions Our findings indicate that WCS may be beneficial for low-grade systemic inflammation in adults, particularly among those with shorter weekday sleep durations. WCS may also interact with obesity.

scholarly journals MON-099 The Association Between C-Reactive Protein, Metabolic Syndrome, and Pre-Diabetes in Korean Children and Adolescents

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Jihyun Kim ◽  
Jong Bin Lee ◽  
Jung Sub Lim
Keyword(s):  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Geometric Mean ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Cross Sectional ◽  
Korean Children ◽  
Reactive Protein

Abstract Objective: Cardiovascular disease (CVD) is a leading cause of death worldwide, including in Korea. In adults, the risk for CVD is increased approximately three-fold in subjects with metabolic syndrome (MetS), and the hazard ratio for subjects with MetS has been reported as 1.37 for mortality from CVD after adjustment for other confounders. Furthermore, MetS in childhood predicts adult MetS and T2DM 25 to 30 years later. Because MetS is a state of chronic low-grade inflammation, measurements of the circulating levels of the inflammatory molecules might provide diagnostic and therapeutic approaches to modulate or alter disease progression. High sensitivity C-reactive protein (hsCRP), a biomarker of inflammation, has emerged as an independent predictor of CVD and T2DM development. The aim of this paper is to evaluate the association between hsCRP and MetS and its components in Korean children and adolescents. Methods: We performed a cross-sectional analysis using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2017. We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the KNHANES 2016–2017. MetS were defined by the modified NCEP-ATP III criteria. Results: Among the 1,247 subjects (mean age: 14.2 ± 2.7 years), the prevalence of MetS was 5.8% (7.0% in male subjects and 4.6% in female subjects; p = 0.070). The mean hsCRP level was 0.861 ± 1.567 mg/l (median and interquartile range: 0.370 and 0.430mg/l). Subjects with MetS had higher hsCRP levels than subjects without MetS (geometric mean: 1.08 vs. 0.46 mg/l, p &lt; 0.001). The prevalence of MetS in the lowest, second, third, and highest hsCRP quartiles were 1.8%, 2.4%, 3.5%, and 15.2%, respectively. Compared to the lowest quartile, the odds ratio (OR) for having MetS in the highest quartile was 8.414 (3.272–21.638), adjusting for age and sex. The OR for having abdominal obesity and low HDL-C in the highest quartile were 9.657 (4.818–19.355) and 2.408 (1.286–4.510), adjusting for age, sex, and other components of the MetS. Additionally, the OR for having pre-diabetes (HbA1c ≥ 5.7%) in the highest quartile was 2.061 (1.097–3.870). Conclusion: Serum hsCRP level is positively associated with MetS and pre-diabetes in Korean children and adolescents.

Surgeon specific effects on the postoperative systemic inflammatory response and complications following surgery for colorectal cancer.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 799-799
Author(s):  
Stephen Thomas McSorley ◽  
Campbell SD Roxburgh ◽  
Donald C McMillan ◽  
Paul G. Horgan
Keyword(s):  
Colorectal Cancer ◽  
Logistic Regression ◽  
Inflammatory Response ◽  
Regression Model ◽  
Logistic Regression Model ◽  
Binary Logistic Regression ◽  
Systemic Inflammatory Response ◽  
C Reactive Protein ◽  
Binary Logistic Regression Model ◽  
Reactive Protein

799 Background: The present study examined the impact of surgeon specific differences on the postoperative systemic inflammatory response (SIR) as measured by postoperative C-reactive protein (CRP), and complications, following elective surgery for colorectal cancer. Methods: 684 patients who underwent elective colorectal cancer resection performed by 10 consultant surgeons at single centre between 2008 and 2016 were included. Exceeding the established C-reactive protein (CRP) threshold of 150mg/L on postoperative days (POD) 3 and 4 was used to identify outliers by funnel plot analysis. Surgeons with significant differences in the proportion of patients exceeding POD 3 CRP 150mg/L were compared. Significantly different perioperative variables amongst surgeons, and the surgeons themselves, were then entered into a multivariate binary logistic regression model to asses association with POD 3 CRP. Results: Perioperative factors were compared between 3 surgeons with the highest volumes and greatest difference in the proportion of patients exceeding POD 3 CRP 150mg/L (Figure 1); (35% of 137, 50% of 117, 60% of 92, p < 0.001). Amongst the 3 surgeons there were significant differences in comorbid state (p = 0.042), the proportion of patients undergoing minimally invasive surgery (p < 0.001), or surgery lasting over 4 hours (p < 0.001), requiring blood transfusion (p = 0.038), epidural anaesthesia (p < 0.001), and receiving perioperative steroids (p < 0.001). When those factors which were significantly different between surgeons were entered into a multivariate binary logistic regression model to predict exceeding the POD 3 CRP threshold of 150mg/L, only perioperative dexamethasone (OR 0.40, 95% CI 0.19-0.82, p = 0.012), and postoperative complications (OR 2.22, 95% CI 1.14-4.32, p = 0.018), remained independently associated whilst the surgeons themselves were not significantly associated (OR 1.16, 95% CI 0.59-2.30, p = 0.663). Conclusions: This study suggests that surgeon specific difference in the magnitude of the postoperative systemic inflammatory response are related to differences in surgical approach, anaesthetic technique and complications.

scholarly journals The association between high-sensitivity C-reactive protein at admission and progressive motor deficits in patients with penetrating artery infarctions

BMC Neurology ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Pengyu Gong ◽  
Yukai Liu ◽  
Ting Huang ◽  
Wenxiu Chen ◽  
Teng Jiang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Characteristic Curve ◽  
Multivariate Logistic Regression Analysis ◽  
High Sensitivity ◽  
Motor Deficit ◽  
Motor Deficits ◽  
C Reactive Protein ◽  
Discriminative Ability ◽  
Reactive Protein ◽  
Hs Crp

Abstract Background A fraction of patients with penetrating artery infarction (PAI) experience progressive motor deficit deterioration (PMD). We sought to investigate the role of high-sensitivity C-reactive protein (hs-CRP) at admission in predicting PMD. Methods From January 2015 to September 2018, consecutive patients with PAI from three centers were prospectively enrolled in this study. PMD was defined as worsening of motor function score by ≥1 point on the National Institutes of Health Stroke Scale during the first 5 days after admission. Multivariable logistic regression analyses were performed to explore the relationship between hs-CRP and PMD in patients with PAI. We also performed receiver operating characteristic curve analysis and constructed a nomogram to assess the overall discriminative ability of hs-CRP in predicting PMD. Results We ultimately included 544 patients (mean age, 65.4 ± 11.8 years). A total of 85 (15.6%) patients were identified to have PMD. Multivariate logistic regression analysis showed that hs-CRP was independently associated with PMD (P = 0.001). The optimal cutoff value for hs-CRP as a predictor for PMD was 3.48 mg/L, with a sensitivity of 73.64% and a specificity of 82.35% (area under curve, 0.792). Moreover, the nomogram we constructed indicated that higher level of hs-CRP was an indicator of PMD (c-index = 0.780, P < 0.001). Conclusions Our study suggested that hs-CRP might be a useful biomarker for predicting the risk of PMD in patients with PAI.

scholarly journals HUBUNGAN INDEKS MASSA TUBUH DENGAN KADAR HIGH SENSITIVITY C-REACTIVE PROTEIN SERUM PADA MAHASISWA OBES DAN TIDAK OBES DI FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI MANADO

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Christy Rattu ◽  
Alexander S. L. Bolang ◽  
Shirley E. S. Kawengian
Keyword(s):  
High Sensitivity ◽  
Medical Faculty ◽  
Obesity Prevalence ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Meaningful Relationship ◽  
The Difference ◽  
Age Range

Abstract: The increasing of Metabolic syndrome become a problem nowadays. The prevalence of metabolic symbol can be confirmed tend to increase with the increasing of obesity prevalence. The indicator to measure body’s fat is Body Mass Index (BMI). For obesity patient, their adiposity system produce duce protein messenger that cause inflamation. The level of High Sensitivity C-Reactive Protein (hsCRP) is one of the parameter that used to detect inflamation process. This research is conducted with the purpose to know the difference of hsCRP level between Obese students and Non-Obese students in Medical Faculty, to know the relation between BMI and hsCRP level between Obese and Non-Obese students in Medical Faculty. This is an analitic research with cross sectional approach that used 59 sample that consists of 30 Man and 29 woman, with the age range between 18-22 years old. The result of this research shown that there is a big difference of hsCRP level between obese and non-obese students. Cobclusion: There is a meaningful positif relationship between BMI with hsCRP level for obese students, and there is no meaningful relationship between BMI with hsCRP level for the non-obese students in Medical Faculty. Keywords: BMI, hsCRP, obesity     Abstrak: Meningkatnya sindroma metabolik menjadi masalah sekarang ini. Prevalensi sindroma metabolik dapat dipastikan cenderung meningkat dengan meningkatnya prevalensi obesitas. Indikator untuk mengukur lemak tubuh adalah indeks massa tubuh (IMT). Pada penderita obesitas, jaringan adiposity menghasilkan protein-protein duta yang menyebabkan adanya inflamasi. Kadar High Sensitivity C-Reactive Protein (hsCRP) merupakan salah satu parameter uji yang dipakai untuk mendeteksi proses inflamasi. Penelitian ini telah dilakukan dengan tujuan untuk mengetahui perbedaan kadar hsCRP pada mahasiswa obes dan non-obes di Fakultas Kedokteran, untuk mengetahui hubungan antara IMT dengan kadar hsCRP pada mahasiswa obes dan non-obes di Fakultas Kedokteran. Penelitian ini bersifat analitik dengan pendekatan cross sectional menggunakan 59 sampel yang terdiri 30 laki-laki dan 29 wanita, berusia 18-22 tahun. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang bermakna kadar hsCRP pada mahasiswa obes dan non-obes. Simpulan: Ada hubungan positif yang bermakna antara IMT dengan kadar hsCRP pada mahasiswa obes, dan tidak terdapat hubungan yang bermakna antara IMT dengan kadar hsCRP pada mahasiswa non-obes di Fakultas Kedokteran. Kata kunci: IMT, hsCRP, obesitas.

Associations of Serum Pepsinogens and Helicobacter Pylori Infection with High-Sensitivity C-Reactive Protein in Medical Examination Population

2020 ◽  
Vol 52 (1) ◽  
pp. 57-63
Author(s):  
Huixing Liu ◽  
Chunrong Fei ◽  
Jun Zhang
Keyword(s):  
Helicobacter Pylori ◽  
High Sensitivity ◽  
Medical Examination ◽  
Infection Status ◽  
Serum Pepsinogen ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Infection Group ◽  
Reactive Protein ◽  
H Pylori

Abstract Objective This study aimed to clarify the distribution characteristics of serum pepsinogen (PG) and Helicobacter pylori in the medical examination population and to explore the relationships of PG level and H. pylori infection status with the high-sensitivity C-reactive protein (hsCRP) level and their significance in health examination. Methods We detected H. pylori infection by C13 urea breath test, the serum pepsinogen I (PGI) and pepsinogen II (PGII) contents were measured by chemiluminescence microparticle immunoassay, and the PGI/PGII ratio was calculated. In addition, the serum hsCRP level was determined by the Abbott C16000 automatic biochemical analyzer. Results The PGI and hsCRP levels were significantly higher in men than in women, and the PGII level was slightly higher in men than in women (both P &lt;.05). The PGI, PGII, and hsCRP levels were positively correlated with age (r = 0.210, 0.287, and 0.133, respectively; P &lt;.05), whereas the PGI/PGII ratio was negatively correlated with age (r = –0.190; P &lt;.05). The positive H. pylori infection rate was 30.2% among the patients in this study; H. pylori infection was not related to sex (P &gt;.05), and the difference in age stratification was not statistically significant (P &gt;.05). The abnormal PGI/PGII ratio in the medical examination population was not correlated with sex (P &gt;.05). In the H. pylori positive infection group, the proportion of PGI/PGII ratio &lt;3, the PGI and PGII levels were significantly higher than those in the H. pylori negative infection group, and the PGI/PGII ratio was significantly lower than that in the negative group (both P &lt;.05). The hsCRP level was not associated with H. pylori infection (P &gt;.05), and it was significantly higher in the PGI/PGII ratio &lt;3 group than in the PGI/PGII ratio ≥3 group (P &lt;.05). Conclusion The PGI and PGII levels and the PGI/PGII ratio are correlated with H. pylori infection. The abnormal PGI/PGII ratio is closely related to H. pylori infection and hsCRP level. Therefore, H. pylori infection status and hsCRP level should be considered when determining atrophic gastritis by the PGI/PGII ratio.

scholarly journals E-cigarette Smoking (Vaping) and Markers of Vascular Wall Damage in Young Subjects without Cardiovascular Disease

2021 ◽  
Vol 17 (4) ◽  
pp. 521-527
Author(s):  
V. I. Podzolkov ◽  
A. E. Bragina ◽  
N. A. Druzhinina ◽  
L. N. Mohammadi
Keyword(s):  
Multivariate Regression ◽  
Ankle Brachial Index ◽  
High Sensitivity ◽  
Vascular Wall ◽  
Multivariate Regression Analysis ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Reactive Protein ◽  
Daily Urine ◽  
Young Subjects

Aim: to investigate the effect of nicotine-containing vapes in comparison with traditional tobacco smoking on markers of vascular wall damage: high sensitivity C-reactive protein (hsCRP), albuminuria (AU), and ankle-brachial index (ABI).Material and Methods: We examined 369 young subjects without cardiovascular diseases (age median 21 [20;21] years) (159 men and 210 women). The hsCRP levels in the serum were assessed by immunochromatographic express method. AU was investigated in daily urine by a quantitative reflex photometry. ABI was determined by plethysmography.Results: All subjects were divided into groups: non-smokers (n=196, 53.1%), smokers of traditional cigarettes (n=83, 22.5%) and smokers of nicotine-containing vapes (n=90, 24.4%). The groups did not differ in main anthropometric data. Median hsCRP levels in smokers (14.30 [11; 16.5] mg/l in tobacco-smokers and 13.15 [9.65; 17.5] mg/l in vapers) were significantly higher vs nonsmokers (3.0 [2; 5.6] mg/l). In tobacco-smokers (33.0  [21.5;  60]  mg)  and  vape  smokers  (45.0  [20;  115]  mg),  the  median  AU  was  statistically  significantly  higher  than  in  non-smokers  (12.0 [10; 20] mg). ABI levels were significantly lower in the groups of tobacco smokers (0.98 [0.91; 0.99]) and vapers (0.85 [0.79; 0.93]) when compared with nonsmokers (1.125 [1.01; 1.18]), and the median ABI in vapers was lower than in tobacco smokers (p<0.001). In the group of tobacco smokers, the hsCRP level correlated with the smoker's index (rs=0.31, p<0.05), and AU (rs=0.54, p<0.05) and ABI (rs=-0.28, p<0.05) with a daily inhaled nicotine dose. In the group of vapers, CRP was associated with smoking experience (rs=0.338, p<0.05), AU with a daily inhaled nicotine dose (rs=0.79,  p<0.05), and  ABI with  BMI (rs=-0.33,  p<0.05), heart  rate (rs=-0.24,  p<0.05) and  smoking experience  (rs=-0.235, p<0.05). According to the results of multivariate regression analysis the hsCRP level was related with only the smoking experience (B=0.91±0.19, p=0.000005), AU level with the daily inhaled nicotine dose (B=1.59±0.7, p=0.0121) and smoking experience (B=3.07±1.23, p=0.0179), and ABI level with only smoking experience (B=-0.09±0.004, p=0.0419).Conclusion: In smokers, both traditional and vapers, the levels of hsCRP, AU are significantly higher, and the ABI is lower than in healthy young nonsmokers. The most significant influence on the level of hsCRP is exerted by the experience of  tobacco  and  vape  smoking;  to  the  AU  level  – the experience of tobacco and vaping and the daily inhaled nicotine dose, and by the value of the ABI – the experience of vaping.

scholarly journals Prognostic Value of Baseline High-Sensitivity C–Reactive Protein in Patients Undergoing Replacement Arthroplasty

2009 ◽  
Vol 48 (174) ◽  
pp. 144-8 ◽  
Author(s):  
S Ghosh ◽  
Suhrita Paul ◽  
D P Bhattacharjee ◽  
P Ghosh ◽  
N Chatterjee
Keyword(s):  
Postoperative Complication ◽  
Operative Time ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
College Hospital ◽  
Medical College ◽  
Reactive Protein ◽  
Replacement Arthroplasty ◽  
The Difference

Introduction:A prospective hospital based blinded study was carried out in an orthopedics department in a medical college hospital of Kolkata, West Bengal, India, with the objective of assessing the role of pre-operative high-sensitivity C-reactive protein (hsCRP) level in predicting postoperative complications in replacement arthroplasty. Methods:One hundred and twenty one study subjects were selected. The blood collected in pre-operative, perioperative and postoperative states were stored and fi nally analyzed after the data collection was over after the stipulated follow-up time of post operative Day-14. The patients were divided into two groups according to baseline hsCRP level <3mg/dl and >3mg/dl. The other preoperative parameters measured were found to be statistically comparable.Results: Among important fi ndings, operative time was signifi cantly higher in the group with hsCRP>3mg/dl, postoperative complication rate was also signifi cantly more in that group. Postoperative complication in Day-7 though quite high among both the groups (45% and 50.9%), the difference was not statistically signifi cant. Comparison of hsCRP levels at baseline, perioperative, postoperative D7 and D14 also showed no significant changes.Conclusions:We concluded that high hsCRP level(>3mg/dl), in patients with apparently no other risk factors may be at higher risk of developing complications after post operative D14 of replacement arthroplasty and operative time also signifi cantly increases with high baseline hsCRP level. Key Words: postoperative morbidity, reactive protein, replacement arthroplasty

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