scholarly journals Utility Of Salivary CA-125 And LDH As Tumor Markers In Oral Malignancy

2018 ◽  
Vol 4 (3) ◽  
pp. 65-69
Author(s):  
Shweta Rakesh Yadav ◽  
Deherkar JA ◽  
Sangle AR ◽  
Chandorkar SS
Keyword(s):  
Tumor Markers ◽  
Early Stage ◽  
Saliva Sample ◽  
Tertiary Care ◽  
Ca 125 ◽  
Care Hospital ◽  
Healthy Individuals ◽  
Whole Saliva ◽  
Oral Malignancies ◽  
Oral Malignancy

Background: The mortality and morbidity associated with oral squamous cell carcinoma(OSCC)  can be greatly reduced if tumor markers which can detect OSCC at an early stage are available. This study attempts to use saliva as the diagnostic medium to determine the correlation of salivary CA 125 and LDH in tobacco users with and without potentially malignant disorders. Changes in CA 125 and  LDH level can be used as a marker in patients with and without premalignant disease and can be used as a deterrent in continuation of the habit. Aims: To assess the role of CA 125 & LDH as a tumour marker in Oral cancer patients. Materials and methods: Cross sectional observational study .Time period: December 2015 to August 2017.Study area: OPD of tertiary care hospital in pune. Total participants: 150 persons. Under non-stimulatory conditions whole saliva sample was collected from each individual  and was centrifuged. The resulting supernatant was used for estimation of CA 125 and LDH levels. Results: In present study, mean Salivary LDH level was found to be  lowest among cases of healthy individuals  while it was highest among individuals who were diagnosed and  underwent treatment for malignancy. However there was insignificant difference seen between levels of diagnosed case of oral malignancy and the ones who underwent treatment for oral malignancy. Also mean Salivary CA-125 was lowest in healthy individuals and highest in individuals diagnosed with oral malignancy and the levels were seen to be reduced significantly in the one who underwent treatment for oral malignancies than those who didn’t. Conclusion: Salivary CA 125 and LDH has a role in early detection of oral malignancies  and  can be used as a diagnostic marker. However LDH levels are persistently raised even after treatment for oral malignancy.

TO DETERMINE THE ROLE OF CA125 IN THE DIAGNOSIS OF ACUTE APPENDICITIS

2020 ◽  
Vol 4 (7) ◽  
Author(s):  
Vinod Kumar ◽  
Bhupen Songra ◽  
Richa Jain ◽  
Deeksha Mehta
Keyword(s):  
Acute Appendicitis ◽  
Clinical Diagnosis ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Ca 125 ◽  
Care Hospital ◽  
Serum Samples ◽  
Roc Curve Analysis ◽  
Surgery Department

Background: the present study was under taken to determine the role of CA-125 in the diagnosis of acute appendicitis (AA), to prevent its complications and also in preventing negative appendicectomies in tertiary care hospital. Methods: The study was conducted at a tertiary care and research center between 01/03/2018 to 30/06/2019. Patients admitted to the surgery department with diagnosis of AA were considered for the study. After informed consent, a, standardized history was obtained as a case Performa. Serum samples from all the cases with clinical diagnosis of AA were obtained and stored. Only the cases with histopathologically approved AA were included in the study. Cases operated for clinical diagnosis of AA, but not histopathologically proven AA was not included in the study. CA125 levels in cases with definitive diagnosis of AA were measured. Results: In present study, ROC curve analysis revealed the sensitivity of 87.27 % and specificity of 90.91 % when the CA 125 cut-off value of > 16.8 was taken to diagnose acute appendicitis. AUC was 0.911 with a standard error of 0.0292. Conclusion: In this study we have observed that CA125 showed a positive correlation with acute appendicitis, that was statistically not significant (P>0.05). We didn’t evaluate the correlation with the disease severity. We consider that CA125 can be used as a marker in acute appendicitis cases although further research is still needed. Keywords: CA125, Acute Appendicitis, Surgery.

A STUDY FOR EVALUATION OF CLINICAL, BIOCHEMICAL, TUMOR MARKERS AND RADIOLOGICALPARAMETERS IN PATIENTS OF OBSTRUCTIVE JAUNDICE

2021 ◽  
pp. 59-61
Author(s):  
Sangamesh S K ◽  
S R Ghosh ◽  
Debarshi Jana
Keyword(s):  
Obstructive Jaundice ◽  
Tumor Markers ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Final Diagnosis ◽  
Care Hospital ◽  
Malignant Obstructive Jaundice ◽  
Purposive Sampling ◽  
Radiological Parameters ◽  
Ca 19.9

Study was conducted in Command Hospital (Eastern Command) Kolkata - ATertiary Care Hospital with the following Aims and Objectives. Study and co relate clinical, biochemical, radiological parameters in obstructive jaundice. MATERIAL AND METHODS: Study was conducted in Command Hospital (Eastern Command) Kolkata - A tertiary care hospital. All adult patients who was diagnosed as case of obstructive jaundice based on clinical, radiological and pathological criteria. Study duration 3 Years. Purposive sampling, 50 in each group,100. RESULT AND ANALYSIS: BENIGN OBSTRUCTIVE JAUNDICE, 6(12.0%) patients had FEVER. In MALIGNANT OBSTRUCTIVE JAUNDICE, 2(4.0%) patients had FEVER. Association of FEVER vs FINAL DIAGNOSIS was not statistically signicant (p=0.1403). In BENIGN OBSTRUCTIVE JAUNDICE, 4(8.0%) patients had PRURITIS. In MALIGNANT OBSTRUCTIVE JAUNDICE, 37(74.0%) patients had PRURITIS. Association of PRURITIS vs FINAL DIAGNOSIS was statistically signicant (p<0.0001). CONCLUSION: AST and ALP were higher in malignant obstructive jaundice compared to benign obstructive jaundice which were statistically signicant. Mean GGT was higher in malignant obstructive jaundice compared to benign obstructive jaundice which was statistically signicant. It was found that mean CA 19.9 was higher in malignant obstructive jaundice compared to benign obstructive jaundice which was statistically signicant.

Factors Affecting Choice of Treatment for Early-Stage Breast Cancer in West Virginia: A 10-Year Experience from a Rural Tertiary Care Center

2017 ◽  
Vol 83 (7) ◽  
pp. 709-716
Author(s):  
Patrick D. Suggs ◽  
Tyler L. Holliday ◽  
Stephanie N. Thompson ◽  
Bryan K. Richmond
Keyword(s):  
Breast Cancer ◽  
West Virginia ◽  
Early Stage ◽  
Univariate Analysis ◽  
Tertiary Care ◽  
Breast Conservation ◽  
Early Stage Breast Cancer ◽  
Treatment Modalities ◽  
Insurance Status ◽  
Care Hospital

Recent literature shows changing trends in use of breast conservation surgery (BCS), mastectomy, and contralateral prophylactic mastectomy (CPM) in women with early-stage breast cancer (ESBC). We analyzed factors associated with selection of these treatment modalities in a rural West Virginia tertiary care hospital. We conducted a 10-year analysis of women treated for ESBC at our institution from the institutional cancer registry. Variables were compared between patients choosing BCS versus mastectomy. In women who chose mastectomy, predictors for choice of CPM were also examined. Variables with P < 0.05 on univariate analysis were entered into a multivariate logistic regression model to define independent predictors of treatment choice. The mastectomy rate increased from 18.0 per cent in 2006 to 40.2 per cent in 2013. On multivariate analysis, insurance status (P < 0.001), comorbidities (P = 0.001), and surgeon graduation after 1987—a surrogate for surgeon age—(P = 0.010) predicted receipt of mastectomy. Of those receiving mastectomy, 106 (25.1%) elected CPM. CPM rates increased from 8.0 per cent in 2006 to 45.0 per cent in 2013. Younger age at diagnosis (P < 0.001) and use of preoperative MRI (P = 0.012) independently predicted use of CPM versus unilateral mastectomy. Rates of mastectomy and CPM in ESBC have increased in West Virginia over time. Independent predictors of selecting mastectomy over BCS included insurance status, surgeon age, and associated comorbidities. Younger patients and patients receiving preoperative MRI were more likely to choose CPM. Awareness of these factors will aid in counseling women with ESBC and allow clinicians to address potential biases or disparities that may affect treatment choices. Further prospective study of these findings is warranted.

scholarly journals A study of thyroid profile in cases of primary infertility attending a tertiary care hospital of south India

2018 ◽  
Vol 7 (6) ◽  
pp. 2180
Author(s):  
Anitha Nirakari B.
Keyword(s):  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Early Stage ◽  
Tertiary Care ◽  
P Value ◽  
Large Sample Size ◽  
Care Hospital ◽  
Cross Sectional ◽  
Infertile Women ◽  
Primary Infertility

Background: Infertility is a rising major problem affecting more than 50 million couples globally every year. Endocrine as well as immune system abnormalities can impair the fertility. Most of the studies globally indicated association of infertility with multiple factors like stress, luteal phase defects, structural and functional reproductive disturbances. Many infertile women with thyroid dysfunction had associated hyperprolactinemia with increases TSH in ovulatory dysfunction. The aim of the present study was to determine the association of hypo and hyperthyroidism with infertility among cases of primary infertility in women.Methods: A cross sectional study was conducted among the patients attending the infertility clinic for the first time. The study was approved by the institutional ethical committee and the study was carried as per the guidelines of the ethical committee. The serum levels of T3, T4 and TSH were estimated and Prolactin in cases where necessary by Chemiluminiscence immunoassay. The data was analyzed by using the unpaired “t” test. A ‘p’ value <0.05 was considered significant.Results: 285 cases were enrolled and majority (38.6%) was in 31-34 age groups with mean age of 24.2± 1.6 years. 30.53% were found with thyroid dysfunction. Majority (16.49%) were found with subclinical hypothyroid, followed in order by primary hypothyroid (9.82%), subclinical hyperthyroid (2.11%), primary hyperthyroid (1.05%), secondary hypothyroid (0.70%) and secondary hyperthyroid (0.35%).Conclusions: To conclude, thyroid dysfunction is a common cause of infertility and can be easily managed by correcting the levels of thyroid hormones. Present study suggests that thyroid replacement therapy in subclinical hypothyroidism at an early stage is justified in infertile women. Borderline variations in TSH levels should not be ignored in infertile women who are otherwise asymptomatic for subclinical hypothyroidism. Hence for better management of cases of primary infertility studies with large sample size and long term follow up are required to validate and justify the variation in TSH and prolactin levels.

scholarly journals Study of clinical profile of cervical cancer patients: a hospital based study

2017 ◽  
Vol 6 (11) ◽  
pp. 4873
Author(s):  
Preeti Umate ◽  
Dhuldev S. Thengal ◽  
Dhundiraj Kurdukar
Keyword(s):  
Early Stage ◽  
Past History ◽  
Clinical Stage ◽  
Tertiary Care ◽  
Cost Effective ◽  
Educational Status ◽  
Clinical Staging ◽  
Common Symptom ◽  
Care Hospital ◽  
Quality Cancer Care

Background: As a consequence of growing and ageing populations, developing countries are disproportionately affected by the increasing number of cancers. Though the situation in India is gradually improving there still exists a disparity between the availability of quality cancer care. With this view, the present study was planned to undertake in this tertiary care institute to find out symptoms, clinical staging, complications and management of cases of carcinoma of cervix.Methods: This was a prospective observational study of carcinoma of cervix carried out at a tertiary care hospital catering services to the people of Maharashtra and neighbouring states. A thorough history including presenting complaints, demographic details, educational status and occupational details, details of menstrual and obstetric history along with any significant past history were recorded on a standard proforma.Results: Most common symptom was per vaginal bleeding which was found in 29 (69.04%). In the present study almost two third of cases i.e. 28 (66.6%) had advanced stage (IIB, III, IV) at the time of admission while the number of cases diagnosed at early stage were only 14 (33.3%). For Wertheim’s hysterectomy, most commonly used approach was transperitoneal 08 (61.53%) while 05 (38.46%) were operated by extraperitoneal approach. Pelvic lymph nodes were positive in 03 (23.07%).Conclusions: A high proportion of patients presented in stages III and IV. This emphasizes the need for early detection of Gynecological cancers in our population. Accordingly, the importance of detection of the pre-clinical stage of the diseases by considering the possibility of initiating cost-effective screening measures needs to be emphasized. 

scholarly journals Awareness and screening practices of cervical cancer among nursing staff working in tertiary care hospital

2017 ◽  
Vol 4 (10) ◽  
pp. 3590
Author(s):  
Swati M. Mahajan ◽  
Vijaykumar S. Jadhav ◽  
Anwaya R. Magare ◽  
Sangita A. Adchitre ◽  
Sobha B. Salve
Keyword(s):  
Cervical Cancer ◽  
Nursing Staff ◽  
Early Stage ◽  
Tertiary Care ◽  
Female Genital Tract ◽  
Hpv Infection ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Screening Process ◽  
Cross Sectional

Background: In India there are an estimated of 1,32,000 new cases and 74,000 deaths each year of cervical cancer. Out of all the female genital tract cancers, it is the only pre­ventable cancer if detected at its early stages. More than one fifth of all new cases are diagnosed in India due to a lack of screening that allows detection of precancerous and early stage cervical cancer. Staff nurses if trained properly, can make aware and screen all the women coming to detect suspicious cases. The present study was carried to assess knowledge regarding cervical cancer, screening procedures and attitude and practices regarding prevention and screening of cervical cancer among nursing staff.Methods: A cross-sectional study was carried out among the nursing staff between March to June 2016. A total of 215 nursing staff was enrolled in the study.Results: Majority 75 (34.88%) of the participants were from 41-50 years of age and 147 (67.90%) were married. The majority of the participants received information about cervical cancer and screening from hospital 135 (71.05%) and 40 (21.05%) from the newspaper. Majority of females 68 (35.78%) said HPV infection as major risk factor for cervical cancer. Majority of the females 125 (65.78%) mentioned that discharge p/v is the main symptom. Majority of the participants 66 (38.82%) replied that married Women and sexually active 54 (31.76%) women must be screened.Conclusions: It can be concluded that presently the knowledge and understanding of cervical cancer, as well as its screening process, is satisfactory, but there is a vast scope for improvement. 

Disparities in Rural Breast Cancer Care: Factors Affecting Choice of Breast Reconstruction in a West Virginia Tertiary Care Hospital

2017 ◽  
Vol 83 (7) ◽  
pp. 717-721 ◽  
Author(s):  
Tyler L. Holliday ◽  
Patrick D. Suggs ◽  
Stephanie N. Thompson ◽  
Bryan K. Richmond
Keyword(s):  
Breast Cancer ◽  
West Virginia ◽  
Breast Reconstruction ◽  
Rural Population ◽  
Early Stage ◽  
Tertiary Care ◽  
The United States ◽  
Care Hospital ◽  
Unilateral Breast Cancer ◽  
Insurance Type

The decision to pursue immediate postmastectomy breast reconstruction (IBR) is not uniform across all groups of women in the United States. We sought to investigate if the challenges of caring for a socioeconomically and geographically challenged rural population affected the incidence of IBR and to identify predictive factors of IBR in this population. Using our institution's cancer registry, we conducted a 10-year review of women with early-stage, unilateral breast cancer who received mastectomy. Demographics, insurance status, comorbidities, and surgeon graduation year were compared for patients receiving IBR versus no reconstruction. Variables with P < 0.05 on univariate analysis were included into a multivariate logistic regression model to determine independent predictors of IBR. From 2006 to 2015, 53/423 (12.5%) patients underwent IBR. On multivariate analysis, three factors independently predicted the decision to undergo IBR: age (P = 0.004), insurance type (P = 0.034), and use of contralateral prophylactic mastectomy (CPM, P < 0.001). Our data indicate that age, insurance type, and utilization of CPM influence the decision to pursue reconstruction. Additionally, the rate of IBR was found to be much lower in our West Virginia population than reported nationally, suggesting disparities in the care of women with early-stage, unilateral breast cancer in a rural population, even in a tertiary care environment.

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