scholarly journals CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF A NEW CORONAVIRUS INFECTION IN THE PRESENT CONDITIONS

2021 ◽  
Vol 17 (2) ◽  
pp. 90-95
Author(s):  
V.D. Moskalyuk ◽  
Y.O. Randiuk ◽  
I.V. Balanyuk ◽  
T.R. Kolotylo
Keyword(s):  
Health Professionals ◽  
The Elderly ◽  
Lung Damage ◽  
Epidemiological Features ◽  
Gastrointestinal Lesions ◽  
Patients At Risk ◽  
Coronavirus Infection ◽  
Medical Histories ◽  
Bilateral Lung ◽  
Epidemiological Characteristics

Relevance. In today's world, the attention of health professionals in each country is focused on the outbreak of acute respiratory disease, called coronavirus disease in 2019 - COVID-19. Today there is an increase in the incidence of this disease both in Ukraine and abroad, the disease is more severe, mortality has increased and the percentage of diseases among children has increased. Objective іs to analyze the clinical and epidemiological features of COVID-19 in Bukovina. Materials and methods. A retrospective analysis of medical histories of patients with confirmed diagnosis of COVID-19, who were hospitalized in the infectious department of OKNP "Chernivtsi Regional Clinical Hospital". Results. The age of patients ranged from 22 to 79 years; the average age is 53.6 years. There were 35 men and 30 women (53.8 and 46.2%, respectively). In most patients the course of the disease was moderate, and only 6% of patients had a severe course of the disease. Each hospitalized patient had bronchial and pulmonary lesions, which were confirmed radiologically and by computed tomography (CT). The structure of diagnosed pneumonia was dominated by bilateral lung damage (98.3%). Symptoms of gastrointestinal lesions were noted in 11 patients (16.9%). Conclusions. According to our observations, we can conclude that susceptibility to a new coronavirus infection is common. However, the elderly, as well as patients with comorbidities, are more likely to develop severe symptoms and higher mortality. Patients at risk with severe course (6%) required special attention. In the early stages of the disease, the use of minimal respiratory support through oxygen therapy is justified.

scholarly journals Can Melatonin Reduce the Severity of COVID-19 Pandemic?

2020 ◽  
Author(s):  
Alex Shneider ◽  
Aleksandr Kudriavtsev ◽  
Anna Vakhrusheva
Keyword(s):  
Severe Disease ◽  
Active Phase ◽  
The Elderly ◽  
Lung Damage ◽  
Melatonin Level ◽  
Sleep Habits ◽  
Over The Counter ◽  
Disease Symptoms ◽  
Life Threatening ◽  
Coronavirus Infection

The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children don’t suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats are nocturnal animals possessing high levels of melatonin, which may contribute to their high anti-viral resistance. Viruses induce an explosion of inflammatory cytokines and reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. The programmed cell death coronaviruses cause, which can result in significant lung damage, is also inhibited by melatonin. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients’ health after the active phase of the infection is over.

scholarly journals Clinical and epidemiological characteristics of measles in adults residents of the Altai territory

2019 ◽  
Vol 11 (3) ◽  
pp. 77-82
Author(s):  
I. P. Saldan ◽  
N. V. Karbysheva ◽  
E. A. Bobrovsky ◽  
M. A. Nikonorova ◽  
I. G. Pashchenko ◽  
...  
Keyword(s):  
Morbidity Rate ◽  
Present Stage ◽  
Post Vaccination ◽  
Epidemiological Features ◽  
Erroneous Diagnosis ◽  
Timely Immunization ◽  
The Republic ◽  
Medical Histories ◽  
Cytolysis Syndrome ◽  
Epidemiological Characteristics

The aim of the study is to determine the clinical and epidemiological features of measles in the Altai territory. Materials and methods: a retrospective analysis of 92 medical histories of inpatient patients with a confirmed diagnosis of «Measles» at the age of 17 to 54 years, who were treated in the Infectious Departments of City Hospitals № 5 and №11 in Barnaul in 2015–2018, was made. Results: the epidemic situation of measles in the Altai territory is characterized by an increase of morbidity rate in 2015, as well as isolated cases in 2017–2018. The peculiarity of the outbreak of the disease was in-hospital infection of patients upon admission to medical hospitals and late diagnosis of measles, as well as the importation of infection from adjacent territories (regions of Russia and the Republic of Kazakhstan), which is confirmed by genotyping of the virus in patients. The development of the disease in 23,9% of those,who were vaccinated, was routinely observed in the age group older than 30 years. In the clinical picture of measles at the present stage, along with the classical manifestations, in 15.2% of patients in the first days of the disease gastroenteritis was marked, in 40,2% of patients the signs of hepatitis (cytolysis syndrome) were observed. Conclusion: the prevalence among the patientspersons, older than 30 years, may indicate the extinction of post-vaccination immunity. Timely immunization against measles in adulthood (after 30 years), will increase the effectiveness of measures to implement the program of elimination of measles in the Altai territory. The development of gastroenteritis up to the 5 days of the disease (on average 2,5±0.9 days), hepatitis in the period of height of the disease (in 15,2% and 40,2% of patients, respectively), determined the erroneous diagnosis of «Enterovirus infection», pseudotuberculosis, etc. and deserved the attention of practitioners.

scholarly journals Can Melatonin Reduce the Severity of COVID-19 Pandemic?

2020 ◽  
Author(s):  
Alexander Shneider1 ◽  
Aleksandr Kudriavtsev ◽  
Anna Vakhrusheva
Keyword(s):  
Severe Disease ◽  
Active Phase ◽  
The Elderly ◽  
Lung Damage ◽  
Melatonin Level ◽  
Negative Effects ◽  
Sleep Habits ◽  
Over The Counter ◽  
Life Threatening ◽  
Coronavirus Infection

The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. So, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children do not suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats also do not suffer from the virus they transmit, and bats too have a much higher level of melatonin. Viruses generate an explosion of reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. Melatonin inhibits the programmed cell death which coronaviruses induce, causing significant lung damage. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks the inflammasome. The immune response is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the negative effects of coronavirus infection on patients’ health after the active phase of the infection is over.

scholarly journals Course of severe coronavirus (COVID-19) in a patient at risk

2020 ◽  
Vol 24 (3) ◽  
pp. 21-26
Author(s):  
Nikolai I. Kuznetsov ◽  
Valery V. Vasiliev ◽  
Elena S. Romanova ◽  
Galina Yu. Startseva
Keyword(s):  
At Risk ◽  
Patient Management ◽  
Severe Form ◽  
Lung Damage ◽  
Patients At Risk ◽  
Risk Patients ◽  
Coronavirus Infection ◽  
Patient At Risk ◽  
Tomography Data ◽  
Severe Lung

The article is devoted to the peculiarities of the clinical course of severe coronavirus infection in a 59-year-old woman at risk for comorbidities. Data on the pathogenesis of the severe form of COVID-19 are presented. Prognostic laboratory signs of an unfavorable outcome of coronavirus infection in people at risk are considered. The patient management tactics are described in accordance with the protocol for the treatment of new coronavirus infection. The assessment of patient management at the outpatient stage is given. A new coronavirus infection in at-risk patients can quickly lead to a worsening of the condition, which is manifested by severe lung damage not only according to computed tomography data, but also by the clinical symptom of ARDS. The severity of the condition in this category of patients is due to severe viral aggression, the development of a cytokine storm. The use of the recommended protocol for the treatment of new coronavirus infection in patients at risk does not always give the expected positive result.

Epidemiological Characteristics of Meningococcal Infection in Moscow

2020 ◽  
Vol 19 (2) ◽  
pp. 56-62
Author(s):  
M. I. Gritsay ◽  
M. A. Koroleva ◽  
N. N. Fomkina ◽  
I. S. Koroleva
Keyword(s):  
Young Adults ◽  
Mortality Rate ◽  
Incidence Rate ◽  
Meningococcal Disease ◽  
Invasive Meningococcal Disease ◽  
Meningococcal Infection ◽  
Epidemic Process ◽  
Epidemiological Features ◽  
Teenagers And Young Adults ◽  
Epidemiological Characteristics

Aims. The purpose of this study was to identify current epidemiological features of meningococcal infection in Moscow.Materials and methods. Cases of invasive meningococcal disease in Moscow from 2014 to 2018 and the biomaterial from patients with an invasive meningococcal disease were analyzed.Results. The features of the epidemic process of meningococcal disease in Moscow were revealed: increasing in the incidence rate involving teenagers and young adults into the epidemic process; meningococcal strains of serogroups W and A increased in the etiology of the invasive meningococcal disease; high mortality rate.Conclusions. It seems reasonable to recommend vaccination against meningococcal disease by including adolescents, young adults and persons over 65 years old.

SIGNIFICANCE OF PLATELETS IN INFLAMMATORY AND THROMBOTIC REACTIONS IN THE ELDERLY

2021 ◽  
pp. 76-83
Author(s):  
А. М. Осадчук ◽  
И. Л. Давыдкин ◽  
И. А. Золотовская
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular System ◽  
Antiplatelet Therapy ◽  
Plasma Levels ◽  
The Elderly ◽  
Wide Audience ◽  
Hemostatic System ◽  
Clinical Consequences ◽  
Coronavirus Infection ◽  
System Today

Развитие тромботических реакций, приводящих к нежелательным клиническим последствиям у лиц пожилого возраста, известно при многих заболеваниях, включая патологию сердечно-сосудистой системы. Сегодня идет накопление данных о степени выраженности изменений системы гемостаза у пациентов с новой коронавирусной инфекцией (COVID-19) и изучение тромбоцитарного и плазменного звена. Для понимания некоторых механизмов, связанных с патологией тромбоцитов, нами представлен обзор, в котором обобщены сведения о патофизиологических реакциях тромбоцитов в условиях их старения и возможных механизмах их патологической агрегации. Возможно, представленные фундаментальные и клинические данные будут интересны широкой аудитории специалистов для обсуждения ранней антитромбоцитарной терапии и ее обоснования не только у пациентов с сердечно-сосудистыми заболеваниями, но и с COVID-19. The development of thrombotic reactions that lead to undesirable clinical consequences in the elderly is known in many diseases, including pathology of the cardiovascular system. Today, data on the severity of changes in the hemostatic system in patients with a new coronavirus infection (COVID-19) and the study of platelet and plasma levels are being accumulated. In order to understand some of the mechanisms associated with platelet pathology, we present a review that summarizes information about the pathophysiological reactions of platelets in the conditions of their aging and possible mechanisms of their pathological aggregation. Perhaps the presented fundamental and clinical data will be of interest to a wide audience of specialists to discuss early antiplatelet therapy and its justification not only in patients with cardiovascular diseases, but also with COVID-19.

‘Nucleated red blood cells’ as hypoxia marker in clinical analysis of blood in patients with coronavirus infection

2021 ◽  
pp. 23-24
Author(s):  
O. Yu. Dorn ◽  
F. M. Orifova ◽  
E. G. Stepanova
Keyword(s):  
Clinical Practice ◽  
Blood Cells ◽  
Blood Test ◽  
Clinical Analysis ◽  
Lung Damage ◽  
Hypoxic Stress ◽  
Urgent Problem ◽  
Nucleated Red Blood Cells ◽  
Hypoxia Marker ◽  
Coronavirus Infection

Assessment of the condition of a patient with coronavirus infection is an urgent problem in clinical practice. The parameter ’nucleated erythrocytes’ in a clinical blood test can be used in clinical practice as a marker of hypoxia in case of lung damage, since it objectively reflects the consequences of acute hypoxic stress in the patient’s body.

scholarly journals The First Lumpy Skin Disease Outbreak in Thailand (2021): Epidemiological Features and Spatio-Temporal Analysis

2022 ◽  
Vol 8 ◽  
Author(s):  
Orapun Arjkumpa ◽  
Minta Suwannaboon ◽  
Manoch Boonrod ◽  
Issara Punyawan ◽  
Supawadee Liangchaisiri ◽  
...  
Keyword(s):  
Skin Disease ◽  
Temporal Analysis ◽  
Space Time ◽  
Effective Control ◽  
Outbreak Response ◽  
Lumpy Skin Disease ◽  
Epidemiological Features ◽  
Spatio Temporal ◽  
Epidemiological Characteristics ◽  
Cattle Farms

The first outbreak of lumpy skin disease (LSD) in Thailand was reported in March 2021, but information on the epidemiological characteristics of the outbreak is very limited. The objectives of this study were to describe the epidemiological features of LSD outbreaks and to identify the outbreak spatio-temporal clusters. The LSD-affected farms located in Roi Et province were investigated by veterinary authorities under the outbreak response program. A designed questionnaire was used to obtain the data. Space-time permutation (STP) and Poisson space-time (Poisson ST) models were used to detect areas of high LSD incidence. The authorities identified 293 LSD outbreak farms located in four different districts during the period of March and the first week of April 2021. The overall morbidity and mortality of the affected cattle were 40.5 and 1.2%, respectively. The STP defined seven statistically significant clusters whereas only one cluster was identified by the Poisson ST model. Most of the clusters (n = 6) from the STP had a radius <7 km, and the number of LSD cases in those clusters varied in range of 3–51. On the other hand, the most likely cluster from the Poisson ST included LSD cases (n = 361) from 198 cattle farms with a radius of 17.07 km. This is the first report to provide an epidemiological overview and determine spatio-temporal clusters of the first LSD outbreak in cattle farms in Thailand. The findings from this study may serve as a baseline information for future epidemiological studies and support authorities to establish effective control programs for LSD in Thailand.

scholarly journals Bilateral Pulmonary Nodules after Surgery for Ameloblastoma: A Case of Misdiagnosis for 32 Years

2020 ◽  
Author(s):  
Jie Liu ◽  
Shudong Yang ◽  
zhen yu ◽  
Tao Bian
Keyword(s):  
Rare Case ◽  
Inflammatory Cell ◽  
Pulmonary Nodules ◽  
Radical Resection ◽  
Case Presentation ◽  
Bronchoscopic Biopsy ◽  
Medical Histories ◽  
Bilateral Lung ◽  
The Right ◽  
Systemic Condition

Abstract Background: We describe a rare case of metastatic ameloblastoma in a 68-year-old Chinese woman diagnosed with ameloblastoma of the right mandible in 1974. Case presentation: Despite radical resection, she experienced repeated local recurrences, including asymptomatic bilateral pulmonary nodules, cough, and hemoptysis diagnosed as non-malignant inflammatory cell infiltration. The patient developed an aggravated cough, palpitations, and dyspnea and was admitted to our respiratory department in September 2018. Chest computed tomography revealed multiple bilateral lung nodules, masses, and soft tissue opacities. She was diagnosed with advanced metastatic ameloblastoma in bilateral lungs via bronchoscopic biopsy, with a misdiagnosis time of 32 years. Because her systemic condition was poor, systemic chemotherapy and radiotherapy were not recommended. Dyspnea significantly improved after interventional bronchoscopic therapy and tumor electroexcision; she died of respiratory failure 1 year after diagnosis. Conclusions: Clinicians should carefully explore the medical histories of patients with surgical histories of ameloblastoma and subsequent unexplained pulmonary metastatic tumors to avoid misdiagnosis.

scholarly journals Terapia Nutricional Enteral Domiciliar em tempos de isolamento social devido à pandemia de COVID-19

2020 ◽  
Vol 35 (3) ◽  
pp. 199-203
Author(s):  
Emilaine Ferreira dos Santos ◽  
Estela Iraci Rabito ◽  
Caryna Eurich Mazur ◽  
Rubia Daniela Thieme ◽  
Maria Eliana Madalozzo Schieferdecker
Keyword(s):  
Health Services ◽  
Enteral Nutrition ◽  
Social Distance ◽  
Health Professionals ◽  
Care Service ◽  
Specific Treatment ◽  
Monitoring And Evaluation ◽  
The Social ◽  
Work Routine ◽  
Coronavirus Infection

Home enteral nutrition (HEN) provides care for the special need for food at home. Although the majority of patients in HEN is clinically stable, support from health professionals, and monitoring and evaluation for maintenance or evolution of therapy are necessary. However, the current pandemic situation of COVID-19 and the lack of specific treatment for coronavirus infection have led to changes in the health services work routine. The social distance recommendation to contain the progress of COVID-19 interferes with the home care service. Thus, in order to provide assistance effectively and safely to the patient, family members and health professionals, adaptations can be made. Therefore, the objective of this manuscript is to discuss elements and recommendations that contribute to HEN care during the COVID-19 pandemic.

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