scholarly journals The chemical composition of polyphenolic compounds Achillea micranthoides Klok. herbs

2020 ◽  
pp. 80-87
Author(s):  
I. F. Duyun ◽  
O. V. Mazulin ◽  
G. V. Мazulin ◽  
Т. V. Oproshanska
Keyword(s):  
Trifluoroacetic Acid ◽  
Practical Interest ◽  
Polyphenolic Compounds ◽  
Hydroxycinnamic Acids ◽  
Biologically Active ◽  
Herbal Remedies ◽  
Actual Problem ◽  
Mediterranean Countries ◽  
Wide Range ◽  
Anti Inflammatory

For obtain modern herbal remedies, medicinal plants containing flavonoids and hydroxycinnamic acids are promising. These polyphenolic compounds are characterized by structural diversity, non-toxicity, a wide range of pharmacological activity. An actual problem is the development of new modern instrumental research methods. In scientific and folk medicine the genus Achillea L. of the Asteraceae L. family are widely used to accelerate wound healing, stop bleeding of various etiologies, as anti-inflammatory and anthelmintic agents. The herb of Achillea micranthoides Klok. has theoretical and practical interest. The plant is distributed in the southern regions of the Black Sea and Mediterranean countries, Europe, Ukraine. A long growing season contributes to the accumulation of biologically active polyphenolic compounds from groups of flavonoids and hydroxycinnamic acids. The aim of the work was to study the composition of polyphenolic compounds (flavonoids and the hydroxycinnamic acids) in the herbs of the Achillea micranthoides Klok. during flowering (june-september). The object of research was herb of Achillea micranthoides Klok. Harvesting was carried out in south and oust regions of Ukraine during flowering (June–September, 2017). The investigation of polyphenolic compounds were performed by TLC and HPLC methods. HPLC analyzes were performed using an Agilent Technogies (Model 1100) (Japan). The chromatographic column ZORBAX-SB C-18 measuring 2.1×150 mm, filled with octadecylsilyl sorbent, with a grain diameter of 3.5 microns were used. The systems as the mobile phase: trifluoroacetic acid 0,2%, methanol anhydrous and a mixture of trifluoroacetic acid 0,2% with methanol 70% were used; wave length 313 nm, 350 nm.             During the flowering period, the presence and quantitative content were established 8 flavonoids (up to 1,176 ± 0,122%) and 6 hydroxycinnamic acids (up to 0,807 ± 0,071%). The identified flavonoids are dominated by compounds: apigenin-7,4'-di-O-glucoside, quercetin-3-O-rutinoside, luteolin-6-C-glucoside, luteolin-7-O-β-D-glucopyranoside, apigenin-7-O-β-D-glucopyranoside. The highest content in the composition of hydroxycinnamic acids was found for chlorogenic and caffeic acids. The obtained results to be used for perspective modern herbal remedies from Achillea micranthoides Klok. herb with anti-inflammatory, antioxidative, haemostatic and hepatoprotective activities. The qualitative and quantitative determination methods of polyphenolic compounds in Achillea micranthoides Klok. herb may be used to the State Ukraine Pharmacopoeia monographs.

scholarly journals Phytochemical screening and HPLC- UV method quantiϐication of Flavonoids in Coffee Arabica green seeds

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1895-1904
Author(s):  
Bothiraj K V ◽  
Kalaivani P ◽  
Murugan K ◽  
Vanitha V
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Biologically Active ◽  
Coffee Bean ◽  
Green Coffee ◽  
High Concentration ◽  
Antimitotic Activity ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Green Coffee Bean

The green coffee bean is the most commonly used beverages in India and it is one of the most commercialised food products. They have a rich source of biologically active compounds that are important for human health. The coffee tree or a shrub belongs to the family Rubiaceae. Commercially available, two species of green coffee bean are Coffea Arabica and Coffea canephora. Cancer is the most important cause of death. Apart from cancer, quercetin can also prevent Osteoporosis. The phytochemicals present in the green coffee bean can be used as an alternate therapy for cancer due to its antimitotic activity and free radical scavenging activity. Total antioxidant shows IC50 value 45.81. Kaempferol is a potent antioxidant that can defence against free radicals and cure chronic diseases. Flavonoids are phenolic substances that act as an antioxidant, anti-inflammatory, anti-allergenic, antiviral and also have vasodilating actions. Green coffee bean shows a high concentration of Flavonoids in hydroethanolic extraction. The aim of this study is used to analyse the presence of Flavonoids in green coffee bean by using High-performance Liquid Chromatography (HPLC). Flavonoids are potent antioxidant that can bind to a protein. Flavonoids show a wide range of biological and pharmacological activities like anti-allergic, anti-inflammatory, anti-cancer and anti-microbial activity.

Application of Plant-Based Preparations in a Comprehensive Treatment of Inflammatory Periodontal Diseases

2021 ◽  
Vol 6 (5) ◽  
pp. 38-44
Author(s):  
O. D. Saliuk ◽  
◽  
P. H. Gerasimchuk ◽  
L. O. Zaitsev ◽  
I. I. Samoilenko ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
The Body ◽  
Comprehensive Treatment ◽  
Complex Treatment ◽  
Medicinal Products ◽  
Actual Problem ◽  
Periodontal Tissues ◽  
Wide Range ◽  
Anti Inflammatory

In this article the review of foreign and domestic literary sources, which are devoted to the actual problem of modern dentistry – the treatment of inflammatory diseases of periodontal tissues: gingivitis and periodontitis are presented. The complex approach to their treatment involves the appointment of a significant amount of pharmacotherapeutic drugs. Therapeutic failures and iatrogenic complications have led to the fact that today the interests of doctors and population to medicinal products significantly increased. The purpose of the study is to analyze the data of scientific literature on the use of plant-based medicinal products for the treatment of periodontal inflammatory diseases over the past 10 years. Materials and methods. Comprehensive and systematic analysis of literature. Review and discussion. The analysis of information sources on the use of plant-based medicinal products in dentistry both independently and in the composition of medical and prophylactic means has established that the modern assortment of plant-based preparations in the pharmaceutical market of Ukraine to a certain extent is limited. The emergence of new plant-based species that have been tested in conditions of experimental pathology and require an evidence-based clinical base is noted. The composition of plant-based preparations used for the treatment of inflammatory periodontal diseases include vitamins, biologically active substances, glycosides, alkaloids, in connection with a wide range of action: antiseptic, anti-inflammatory, regenerating, hemostatic, antioxidative. The data on plant-based preparations that are most often used such as chamomile extracts, calendula, hypericum, plantain, kalanchoe, aloe, eucalyptus, milfoil, nettle, calamus and plant-based species are summarized. The medicinal agents considered are mainly recommended for local treatment of periodontal diseases in the form of dental care means, mouth rinse, gel, chewing gum, herbal liquer. It is known that the complex treatment of periodontal diseases includes a general influence on the body. The properties of green tea with its wide range of actions are investigated. With antioxidant properties, it can be a healthy alternative for controlling destructive changes in periodontal diseases. Attention is drawn to the proposed unique natural complex “Resverazin” due to a wide range of pharmacological action, low toxicity and relative safety. The drug produces antioxidant, anti-inflammatory, immune stimulating, vasodilative, neuroprotective action. Conclusion. Based on the literature analysis, it can be concluded that the accumulated experimental and clinical data on the therapeutic properties of plants prove perspective of their use in the complex treatment of inflammatory periodontal diseases. Future studies are mandatory for further confirmation of the effectiveness of these medicinal plants

scholarly journals FEATURES OF THE STRUCTURE OF NATURAL POPULATIONS HUMULUS LUPULUS L. (REVIEW)

2020 ◽  
Vol 1 (337) ◽  
pp. 33-40
Author(s):  
Yedilova A.K. ◽  
Inelova Z.A.
Keyword(s):  
Medicinal Plants ◽  
Medicinal Plant ◽  
Raw Materials ◽  
Natural Populations ◽  
Humulus Lupulus ◽  
Biologically Active ◽  
Humulus Lupulus L ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Beer Production

The article provides an overview of the structural features of the natural populations of Humulus lupulus L. in the world and in Kazakhstan. Currently, the use in medicine of natural products, medicines and biologically active substances of plant origin is increasing. Significant parts of the medicinal raw materials are wild plants. The need for medicinal plant raw materials (medicinal plants) is not decreasing; the technology of its procurement and reproduction in natural conditions wants significant perfection. It is known that they have a milder, more complex effect on the human body and are used in the treatment of many chronic diseases. The growing anthropogenic impact on populations of valuable medicinal plants is decreasing their stocks of raw materials. In this regard, the study of biological characteristics and the development of scientifically based agricultural techniques for the cultivation of many medicinal plants are becoming relevant. Humulus lupulus L. (common hop) is a valuable medicinal plant. They are used as painkillers, sedatives, hypnotics for increased nervous irritability, sleep distur-bances, neuralgia, vegetovascular dystonia, mild coronary spasms, tachycardia, and in the early stages of hyper-tension. According to the classification of medicinal plant resources, Humulus lupulus L. is a plant with a wide range, but with a limited supply of raw materials. In places of growth of Humulus lupulus L. does not form large thickets [1]. Recently, a comprehensive approach has been applied in the study of natural plant populations, including ontomorphological and population-ecological studies. This makes it possible to objectively assess the state of the species in the cenosis and predict its future behavior. In this regard, a comprehensive study of the natural populations of Humulus lupulus L. is of great relevance. Hops (Humulus lupulus L.) is an important crop worldwide, known as the main flavor ingredient in beer. A diversified brewing industry requires a variety of flavors, superior technological properties and sustainable agro-nomy, which are the center of advanced molecular breeding efforts in hops. Hop breeders have been limited in their ability to create strains with desirable traits, however, due to unusual and unpredictable inheritance patterns and the associated non-Mendelian segregation of genetic markers [2]. The use of hops has recently been undergoing a new change, driven by a growing international preference for more intensely flavored beer, supported by the craft-brewing sector. This movement led to the introduction of much more hops at various stages of beer production and to an ever-growing search for new flavors. Some hop varieties have thus received particular attention, including several older typical hops mostly used to date, although an intensive search for new varieties dubbed "Green Gold" has also taken place. A large number of new exquisite varieties have been described and are increasingly appreciated in the market. Global hop growing areas have increased over the past 5 years, although total world beer production has declined over the same period, confirming the trend of using more hops per liter of beer. In addition, a wide range of pharmacological properties have been described for hops and its derivatives, namely antioxidant, anti-inflammatory and antitumor properties, which are of great importance for the pharmaceutical industry. The bioactivity of beer can depend on the use of hops, which can become an important tool for brewers aiming to develop functional products. Taken together, the compounds isolated from Humulus lupulus L. have a wide range of biological activity, such as anti-inflammatory action, antimicrobial action, antioxidant action, antiproliferative effects, cytochrome P450 effects, glucose metabolism effects, hormonal effects, lipid effects and sedative / hypnotic effects. Therefore, the purpose of this Chapter is to describe the importance of hops in this new direction of beer production, market overview of hops, varieties, forms and methods of use, composition, value in bioactivity of beer and new discoveries in research hops [3].

scholarly journals Therapeutic Potential of Iridoid Derivatives: Patent Review

Inventions ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 29 ◽  
Author(s):  
Hidayat Hussain ◽  
Ivan R. Green ◽  
Muhammad Saleem ◽  
Muhammad Liaquat Raza ◽  
Mamona Nazir
Keyword(s):  
Therapeutic Potential ◽  
Biological Effects ◽  
Antimalarial Drugs ◽  
Biologically Active ◽  
Future Research ◽  
Patent Review ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Plant Families

Iridoids belong to a family of monoterpenoids comprising the cyclopentan[c]-pyran system; this class of compounds offers a wide range of biological effects, namely antileishmanial, anticancer, antiplasmodial, and anti-inflammatory potency. To date, a large number of biologically active iridoid derivatives have been reported from various plant families, including Rubiaceae, Plantaginaceae, Scrophulariaceae, and Verbenaceae. Furthermore, iridoids have the potential to form conjugates with other anticancer, antidiabetic, antileishmanial, and antimalarial drugs which synergistically have the potential to increase their effects. Additionally, future research should focus on the synthesis of halo analogs as well as preparing homo dimers or heterodimers of iridoids, since these might quite conceivably possess an increased bioactivity.

Prunella vulgaris L: Critical Pharmacological, Expository Traditional uses and Extensive Phytochemistry: A Review

2021 ◽  
Vol 18 ◽  
Author(s):  
Reyaz Hassan Mir ◽  
Mohammad Faizan Bhat ◽  
Gifty Sawhney ◽  
Parveen Kumar ◽  
Nusrit Iqbal Andrabi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Phenolic Acid ◽  
Research Literature ◽  
Biologically Active ◽  
Bibliographic Databases ◽  
Prunella Vulgaris ◽  
Volatile Oils ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anti Inflammatory

Background: Prunella vulgaris, family Lamiaceae also known as self-heal, has been traditionally used as an expectorant, anti-inflammatory, anti-pyretic, and anti-rheumatic. Due to widespread distribution of the plant, Vulgaris is also called ‘vulgar’ in Latin adjective meaning common. Objective: The objective of this review was to describe the relevant aspects of phytochemistry and therapeutic uses of different fractions as well as isolated compounds from Prunella vulgaris. An attempt was also made to enumerate the possible leads e.g. betulinic acid, oleanolic acid, ursolic acid, umbelliferone, scopoletin, esculetin, luteolin, homoorientin, Rosmarinic acid and cinaroside for further development. Method: For peer-reviewed research literature, we undertook a structured search of bibliographic databases using a focused review question. Scientific databases such as PubMed, Scopus, Science Direct, and Google Scholar were used Results: Phytochemistry of Prunella vulgaris (PV) after a thorough literature survey revealed varied and copious metabolites, such as triterpenoids, phenolic acid, sterols, carbohydrates, coumarins, fatty acids, and volatile oils. Many of these compounds have been found to possess wide range of biological activity per se, including anti-microbial, immunosuppressive, anti-cancer, cardio-protective, anti-allergic and anti-inflammatory. Conclusion: Prunella vulgaris is a medicinal plant of immense medicinal importance having a variety of compounds such as such as triterpenoids, phenolic acid, sterols, carbohydrates, coumarins, fatty acids, and volatile oils and diversity in pharmacological spectrum. The plant could be further exploited, to isolate the various biologically active constituents responsible for its activity.

scholarly journals Comparative study of phenolic compounds of the herb of Betonica L. genus species of flora of Ukraine

2021 ◽  
pp. 66-75
Author(s):  
Iryna Sas ◽  
Andrii Hrytsyk ◽  
Taras Koliadzhyn ◽  
Oleh Koshovyi
Keyword(s):  
Phenolic Compounds ◽  
Comparative Study ◽  
Hydroxycinnamic Acids ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
New Drugs ◽  
Raw Material ◽  
Wide Range ◽  
Nitrogen Containing Compounds ◽  
Active Substances

Species of Betonica L. genus are widespread in Ukraine and contain different groups of biologically active substances: hydroxycinnamic acids, flavonoids, tannins, iridoids, terpenoids, steroids, essential oil, organic acids, vitamin K, nitrogen-containing compounds, phenylethanoid glycosides. Species of Betonica L. genus show a wide range of pharmacological activity (anti-inflammatory, antioxidant, choleretic, diuretic, sedative, antitumor, antihypertensive, etc.) and phenolic compounds are one of the most important and promising groups of biologically active substances of these plants. The aim. The aim of the work was to conduct a comparative study of the phenolic compounds of the herb of Betonica L. genus species of flora of Ukraine. Materials and methods. The object of the study was the herb of Betonica peraucta and Betonica brachydonta harvested in the phase of mass flowering of the plant in Ivano-Frankivsk region. The study of phenolic compounds was carried out by paper chromatography, HPLC and spectrophotometry. Results. 7 components of tannins, 4 flavonoids, 5 hydroxycinnamic acids, 2 coumarins were identified and quantified by HPLC in the studied raw material. The quantitative content of the main groups of phenolic compounds in the herb of Betonica peraucta and Betonica brachydonta was determined by the method of absorption spectrophotometry: polyphenols – 5.96 % and 4.82 %, tannins – 1.62 % and 0.68 %, flavonoids – 2.07 % and 1.13 %, hydroxycinnamic acids – 7.01 % and 3.58 %, respectively. Conclusions. As a result of the conducted studies it was found that the content of phenolic compounds in the herb of Betonica peraucta is significantly higher than in the herb of Betonica brachydonta. Therefore, this species is promising for further research and creation of new drugs

Coumarin: A Promising Scaffold for Design and Development of Bioactive Agents

2020 ◽  
Vol 16 (6) ◽  
pp. 837-852 ◽  
Author(s):  
Hanan M. Alshibl ◽  
Ebtehal S. Al-Abdullah ◽  
Hamad M. Alkahtani
Keyword(s):  
Biological Activities ◽  
Biologically Active ◽  
Present Review ◽  
Coumarin Derivatives ◽  
Design And Development ◽  
Strong Potential ◽  
Starting Point ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Bioactive Agents

Background: As coumarin derivatives are known to prevent and treat various diseases, they have attracted the attention of medicinal chemists. They have strong potential as drugs because their benzopyrone structure can interact noncovalently with numerous enzymes and receptors. Methods: The aim of this review was to summarize the most recently published literature on coumarin derivatives in terms of their antioxidant, antimicrobial, anti-inflammatory, anticancer, and other miscellaneous properties. Results: Coumarin derivatives have a wide range of biological activities. They exhibit antioxidant, antimicrobial, anti-inflammatory, anticancer, anti-coagulant, and anti-Alzheimer effects. Conclusion: The coumarin nucleus is an interesting starting point for the design and development of novel bioactive agents. The present review may help medicinal chemists design biologically active molecules based on the coumarin nucleus.

scholarly journals Research Advances in the Intervention of Inflammation and Cancer by Active Ingredients of Traditional Chinese Medicine

2016 ◽  
Vol 19 (1) ◽  
pp. 114 ◽  
Author(s):  
Yinghong Huang ◽  
Tiange Cai ◽  
Xi Xia ◽  
Y Cai ◽  
Xiao Yu Wu
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Current Knowledge ◽  
Large Body ◽  
Treatment Strategies ◽  
Biologically Active ◽  
Active Ingredients ◽  
Wide Range ◽  
Anti Inflammatory ◽  
Underlying Mechanisms

A large body of evidence has shown that inflammation and cancer are strongly related. Thus anti-inflammatory agents have been investigated for cancer prevention and treatment in preclinical and clinical studies, including the nonsteroidal anti-inflammatory drugs (NSAIDs) and traditional Chinese medicine (TCM). In TCM, there exist a wide range of biologically active substances, such as saponins, flavonoids, alkaloids, polysaccharides, polyphenols, phenylpropanoids, and quinones. Many of these active ingredients have been reported to inhibit inflammation, activate inflammatory immune response, and/or inhibit cancer cell proliferation and tumor growth. Given the potential role of inflammation in cancer initiation and progression, the inflammatory tumor microenvironment, the cross-talks between inflammatory and cancer cells, and multitargeting activities of some TCM compounds, we summarize the current knowledge on the anti-inflammatory and anti-cancer properties of ingredients of TCM together with their underlying mechanisms in an integrated way. We hope to provide a reliable basis and useful information for the development of new treatment strategies of inflammation and cancer comprehensively using TCM and their active ingredients. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

STUDY OF DIURETIC AND ANTI-INFLAMMATORY ACTIVITY OF INFUSION AND EXTRACT OF DRIED STRAWBERRY LEAVES

2021 ◽  
pp. 136-142
Author(s):  
Yaborova O.V. ◽  
Sosnina S.A. ◽  
Turyshev A.Yu.
Keyword(s):  
Medicinal Plant ◽  
Medical Practice ◽  
Raw Materials ◽  
Practical Interest ◽  
Biologically Active ◽  
Inflammatory Activity ◽  
Plant Raw Materials ◽  
Wild Strawberry ◽  
Anti Inflammatory ◽  
Wild Strawberries

The search for new sources of medicinal plant raw materials for the production of drugs is one of the urgent tasks of modern pharmacy. The expansion of the range of medicinal plant raw materials is possible, first of all, due to the types systematically close to the official ones. In medical practice, wild strawberry leaves are used. Wild strawberry leaves are used in medicine as a diuretic, anti-inflammatory, antispasmodic, choleretic, hypoglycemic, antipyretic, hypolipidemic, antimicrobial and appetite-enhancing agent. Earlier studies of strawberry leaves have shown that they have a rich chemical composition and are widely cultivated in Russia, being an affordable source for mass procurement of raw materials, and are not used in scientific medicine. At the same time, in folk medicine, strawberry garden leaves are used similarly, and sometimes instead of wild strawberries. The proximity of the composition of biologically active substances of wild strawberries and garden strawberries. To expand the modern nomenclature of medicines, studies on the comparative study of the toxicity and pharmacological activity of infusions and extraction forms from medicinal plant raw materials of strawberry leaves are relevant. In this regard, the study of the toxicity, diuretic and anti-inflammatory activity of the infusion of garden strawberry leaves and the extract of dry strawberry leaves is of practical interest for the formation of a scientific justification for their use in medical practice.

scholarly journals PRELIMINARY SCREENING OF PHYTOCHEMICALS AND ANTIPROLIFERATIVE AND ANTI-INFLAMMATORY PROPERTIES OF THESPESIA POPULNEA (L.) SOLAND LEAF EXTRACTS

2018 ◽  
Vol 11 (5) ◽  
pp. 382
Author(s):  
Megha Kb ◽  
Sanith Cheriyamundath ◽  
Joseph Madassery ◽  
Elyas Kk
Keyword(s):  
Leaf Extract ◽  
Chemical Constituents ◽  
Biologically Active ◽  
Bioactive Molecules ◽  
Phytochemical Analysis ◽  
Leaf Extracts ◽  
Thespesia Populnea ◽  
Wide Range ◽  
Anti Inflammatory

Objective: Plant-derived bioactive molecules are providing infinite opportunities for new drug development as they possess a wide range of actions against diseases with lesser side effects. The present study is made to analyze the qualitative phytochemicals and to evaluate in vitro antiproliferative and anti-inflammatory potentials of leaf extracts of Thespesia populnea. Methods: T. populnea leaf extracts were prepared sequentially according to the increasing polarity of the solvents, i.e., petroleum ether, chloroform, ethyl acetate, and methanol. Qualitative phytochemical analysis was performed to identify the chemical constituents of the extracts, and antiproliferative properties were evaluated against different cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide assay. Bovine serum albumin anti-denaturation assay was done to identify the anti-inflammatory activity.Results: Phytochemical analysis of the extracts revealed the presence of alkaloids, terpenoids, glycosides, tannins, flavonoids, and phenolics. The chloroform extract (CHFE) of T. populnea has a dose-dependent antiproliferative effect against acute T-cell leukemia (Jurkat E6-1), prostate Grade IV adenocarcinoma (PC-3), mouse fibroblast (L-929), and monkey kidney normal (Vero) cells. Their inhibitory concentration 50% (IC50) values were found to be 35.73±0.94 μg/ml for Jurkat E6-1, 60.79±1.84 μg/ml for PC-3, 60.88±1.45 μg/ml for L-929, and 83.482±2.05 μg/ml for Vero, respectively. CHFE also displayed the anti-inflammatory potential.Conclusion: The chloroform leaf extract of T. populnea possesses potent antiproliferative and anti-inflammatory activity. These properties present in leaf extract may be explained by the presence of biologically active constituents.

Sign in / Sign up

Export Citation Format

Share Document