scholarly journals FEATURES OF THE STRUCTURE OF NATURAL POPULATIONS HUMULUS LUPULUS L. (REVIEW)

2020 ◽  
Vol 1 (337) ◽  
pp. 33-40
Author(s):  
Yedilova A.K. ◽  
Inelova Z.A.

The article provides an overview of the structural features of the natural populations of Humulus lupulus L. in the world and in Kazakhstan. Currently, the use in medicine of natural products, medicines and biologically active substances of plant origin is increasing. Significant parts of the medicinal raw materials are wild plants. The need for medicinal plant raw materials (medicinal plants) is not decreasing; the technology of its procurement and reproduction in natural conditions wants significant perfection. It is known that they have a milder, more complex effect on the human body and are used in the treatment of many chronic diseases. The growing anthropogenic impact on populations of valuable medicinal plants is decreasing their stocks of raw materials. In this regard, the study of biological characteristics and the development of scientifically based agricultural techniques for the cultivation of many medicinal plants are becoming relevant. Humulus lupulus L. (common hop) is a valuable medicinal plant. They are used as painkillers, sedatives, hypnotics for increased nervous irritability, sleep distur-bances, neuralgia, vegetovascular dystonia, mild coronary spasms, tachycardia, and in the early stages of hyper-tension. According to the classification of medicinal plant resources, Humulus lupulus L. is a plant with a wide range, but with a limited supply of raw materials. In places of growth of Humulus lupulus L. does not form large thickets [1]. Recently, a comprehensive approach has been applied in the study of natural plant populations, including ontomorphological and population-ecological studies. This makes it possible to objectively assess the state of the species in the cenosis and predict its future behavior. In this regard, a comprehensive study of the natural populations of Humulus lupulus L. is of great relevance. Hops (Humulus lupulus L.) is an important crop worldwide, known as the main flavor ingredient in beer. A diversified brewing industry requires a variety of flavors, superior technological properties and sustainable agro-nomy, which are the center of advanced molecular breeding efforts in hops. Hop breeders have been limited in their ability to create strains with desirable traits, however, due to unusual and unpredictable inheritance patterns and the associated non-Mendelian segregation of genetic markers [2]. The use of hops has recently been undergoing a new change, driven by a growing international preference for more intensely flavored beer, supported by the craft-brewing sector. This movement led to the introduction of much more hops at various stages of beer production and to an ever-growing search for new flavors. Some hop varieties have thus received particular attention, including several older typical hops mostly used to date, although an intensive search for new varieties dubbed "Green Gold" has also taken place. A large number of new exquisite varieties have been described and are increasingly appreciated in the market. Global hop growing areas have increased over the past 5 years, although total world beer production has declined over the same period, confirming the trend of using more hops per liter of beer. In addition, a wide range of pharmacological properties have been described for hops and its derivatives, namely antioxidant, anti-inflammatory and antitumor properties, which are of great importance for the pharmaceutical industry. The bioactivity of beer can depend on the use of hops, which can become an important tool for brewers aiming to develop functional products. Taken together, the compounds isolated from Humulus lupulus L. have a wide range of biological activity, such as anti-inflammatory action, antimicrobial action, antioxidant action, antiproliferative effects, cytochrome P450 effects, glucose metabolism effects, hormonal effects, lipid effects and sedative / hypnotic effects. Therefore, the purpose of this Chapter is to describe the importance of hops in this new direction of beer production, market overview of hops, varieties, forms and methods of use, composition, value in bioactivity of beer and new discoveries in research hops [3].

2020 ◽  
pp. 128-136
Author(s):  
T. Padalko

The purpose of the research was to study the essence of ensuring high germination of seeds and survival of chamomile plants depending on the variety, seeding rate and sowing time in the Right-bank Forest Steppe. Chamomile plants have been found to be signifi cantly responsive to the soil and climatic conditions of the region, which has led to uneven seedlings, so it is important to investigate agrotechnological techniques aimed at increasing of seed germination energy and simultaneity of sprouts. The agrobiological features of medicinal plants cultivation in the conditions of the RightBank Forest Steppe, in particular, of chamomile (Matricaria recutita), which is most used in offi cial and folk medicine among medicinal plants due to the presence of various biologically active substances in it, were investigated. The study was conducted with samples of chamomile plants in the area of the Right-bank Forest-Steppe of Ukraine (field of study (IE Prudyvus), a branch of the department of Podilsky State Agrarian and Technical University), taking into account all the requirements of the methodology of the research case. The following results were obtained: the period of vegetation of chamomile was mainly dependent on the sowing time, the duration ranged from 83 to 240 days; fi eld germination of chamomile plants in the average for 2017‒2019 was in the range of 71‒89 %; the maximum rate of plant survival at the end of the growing season was 93 %, which was obtained on the variant of autumn sowing with a sowing rate of 6 kg/ha in the Perlyna of the Forest-steppe, the minimum indicator was noted 72 % for the summer sowing with a sowing rate of 8 kg/ha in the Bodegold variety; the germination and survival rate exceeded the control by 10‒13 %. Today, this crop is quite widespread and is cultivated independently of the fi rst established cultivation areas and existing research stations of medicinal plants, and in particular, as a culture of a wide range of use of raw materials both in Ukraine and abroad. Key words: chamomile, variety, seeding rate, sowing period, fi eld germination, plant survival, vegetation factors.


Author(s):  
Э.Ю. МИШКЕВИЧ ◽  
Г.И. КАСЬЯНОВ

Усовершенствована технология безалкогольных напитков на основе СО2-шротов плодово-ягодных культур и густых экстрактов лекарственных растений для целевого потребления их в северных районах России. Для производства напитков выбраны СО2-шроты, полученные из плодово-ягодного сырья, выращенного на территории Краснодарского края: СО2-шроты шиповника, смородины черной, облепихи, малины обыкновенной. Плодово-ягодное сырье было однократно обработано жидким диоксидом углерода в докритическом состоянии (параметры экстракции: давление 6,0 МПа, температура 22°С). Для приготовления густых экстрактов использовали лекарственное растительное сырье: эхинацею пурпурную, душицу обыкновенную и ромашку аптечную. Полученные очищенные вытяжки растений подвергали сгущению до получения вязкой массы с содержанием влаги 20–25%. Разработанные безалкогольные напитки являются источником широкого спектра биологически активных веществ, в том числе витамина С. Основные нормируемые физико-химические показатели разработанных безалкогольных напитков соответствуют требованиям нормативной документации: содержание сухих веществ составляет 9–10%, массовая доля витамина С – 12,9–17,6 мг/100 мл, энергетическая ценность – 246–253 ккал, кислотность – 6,3 –11,2 см3. Биотест на определение жизнеспособности культуры Paramecia caudatum подтвердил безвредность разработанных напитков. Микробиологические и токсикологические показатели напитков не превышают допустимых уровней. The technology of soft drinks based on CO2-meal of fruit and berry crops and thick extracts of medicinal plants for their intended consumption in the Northern regions of Russia has been improved. CO2-meal obtained from fruit and berry raw materials grown on the territory of the Krasnodar region – such as rosehip, black currant, sea buckthorn, and raspberry, are selected for the production of beverages. Fruit and berry raw materials were once treated with liquid carbon dioxide in a subcritical state (extraction parameters: pressure 6,0 MPa, temperature 22°C). Echinacea purpurea, oregano, and chamomile are used for the preparation of thick extracts. The resulting purified extracts of plants were subjected to thickening to obtain a viscous mass with a moisture content of 20–25%. Developed soft drinks are a source of a wide range of biologically active substances, including vitamin C. The main normalized physical and chemical parameters of the developed soft drinks meet the requirements of regulatory documentation: the dry matter content is 9–10%, the mass fraction of vitamin C is 12,9–17,6 mg/100 ml, the energy value is 246–253 kcal, the acidity is 6,3–11,2 cm3. A biotest to determine the viability of Paramecium caudatum culture confirmed the harmlessness of the developed beverages. Microbiological and toxicological indicators of beverages do not exceed acceptable levels.


Author(s):  
Zamakhaeva E.A. ◽  
Oleshko O.A. ◽  
Yaborova O.V. ◽  
Smirnova M.M. ◽  
Kuritsyn A.V.

Herbal sedatives have been popular for several centuries, and the accumulated knowledge that has been passed down from generation to generation laid the foundation for the development of traditional medicine, and over time for such a science as herbal medicine. Herbal sedatives have a wide range of therapeutic effects, are well tolerated and have no serious adverse reactions, and are not addictive. According to statistical data on the incidence of the population by main classes and individual diseases for 2010-2018, the number of patients with diseases of the nervous system is growing annually, along with this, the need for sedative drugs is increasing. In this regard, the search and development of effective and safe medicines based on medicinal plant raw materials is an urgent area [1, 2]. Pharmaceutical infusions and decoctions, according to the order of the Ministry of Health of the Russian Federation No. 751n dated October 26, 2015, have a shelf life of 2 days, which significantly limits the possibility of their use. The production of films based on aqueous extracts from medicinal plant raw materials will make it possible to obtain more stable drugs, in addition, films have a number of advantages over other dosage forms. Films containing biologically active substances of plant origin have received the unofficial name phytofilms, which are a type of transdermal therapeutic systems. Phytofilms are hydrophilic systems that swell when in contact with water (or biological fluid), absorbing it in a certain amount, which leads to the dissolution of biologically active substances. They differ from synthetic polymeric therapeutic systems in that phytofilms are made in the form of matrix transdermal therapeutic systems on carriers of natural origin (gelatin, collagen, sodium alginate, agar-agar, etc.), which makes them safer [3, 4].


Author(s):  
Savenkova A.B. ◽  
Nesterova N.V.

given the need to expand the range of medicinal plant raw materials presented in the pharmaceutical market of the Russian Federation, many authors are exploring new types of medicinal plants, including among crops traditionally considered food. In recent years, researchers have been interested in common peach leaves, which have a wide range of pharmacological effects. On the basis of peach extract, domestic scientists have proposed a number of biologically active additives, but due to the lack of modern regulatory documentation, raw peach leaves are not official today. The authors of the article conducted a comprehensive morphological and anatomical analysis aimed at developing the sections of normative documentation "External signs" and "Microscopy". The research was conducted in accordance with the requirements of the General Pharmacopoeia articles. Specific external features were identified, as well as microscopic features were identified.


Author(s):  
Yaborova O.V. ◽  
Sosnina S.A. ◽  
Turyshev A.Yu.

The search for new sources of medicinal plant raw materials for the production of drugs is one of the urgent tasks of modern pharmacy. The expansion of the range of medicinal plant raw materials is possible, first of all, due to the types systematically close to the official ones. In medical practice, wild strawberry leaves are used. Wild strawberry leaves are used in medicine as a diuretic, anti-inflammatory, antispasmodic, choleretic, hypoglycemic, antipyretic, hypolipidemic, antimicrobial and appetite-enhancing agent. Earlier studies of strawberry leaves have shown that they have a rich chemical composition and are widely cultivated in Russia, being an affordable source for mass procurement of raw materials, and are not used in scientific medicine. At the same time, in folk medicine, strawberry garden leaves are used similarly, and sometimes instead of wild strawberries. The proximity of the composition of biologically active substances of wild strawberries and garden strawberries. To expand the modern nomenclature of medicines, studies on the comparative study of the toxicity and pharmacological activity of infusions and extraction forms from medicinal plant raw materials of strawberry leaves are relevant. In this regard, the study of the toxicity, diuretic and anti-inflammatory activity of the infusion of garden strawberry leaves and the extract of dry strawberry leaves is of practical interest for the formation of a scientific justification for their use in medical practice.


Author(s):  
A.N. TSITSILIN ◽  
◽  
N.I. KOVALEV

The cultivation of medicinal plants is currently the main way of providing the pharmaceutical industry with raw materials for obtaining biologically active substances for the production of drugs. The use of natural resources of wild species is decreasing every year for a number of reasons, the biotechnological method has not been properly expanded yet, and in some cases it is possible to reproduce only a part of the complex of target biologically active substances contained in an intact plant. In recent years, a positive growth trend has been outlined in the domestic production of medicinal starting materials of herbal origin. However, there are a number of problematic issues that inhibit the development of medicinal plant growing and lead to a certain stagnation. These are general legislative and organizational problems, as well as deterioration or deficiency of material resources – basic production assets, lack of comprehensive mechanization, shortage of qualified specialists and a number of other obstacles. Nevertheless, the actively growing demand for high-quality raw materials from medicinal plant both in our country and abroad opens up great prospects for the development of medicinal plant production. It should be noted that the analysis of the current state of collection and cultivation of medicinal plants in Russia is poorly developed or is practically absent. The paper examines the current state of medicinal plant production; attempts are made to identify the main problems and possible growth points. Finding solutions to the problems and using the growth points show promise for the transformation of medicinal plant production into an industry with a large import substituting and export potential.


2020 ◽  
pp. 3-14
Author(s):  
Aleksandr Luferov

The article provides brief information about cardiotonic, sedative, cytostatic, diuretic, and antibacterial effects of biologically active compounds of Adonis L. (Ranunculaceae) species. Chemical studies allowed to identify the cardiac glycosides, or cardenolides: or cardenolides: adontoxin, adonitol, adonitoxigenin, acetyldigitoxin and others. In scientific medicine, it is currently allowed to use Adonis vernalis L. Other types of Adonis have a similar chemical composition and are offered as substitutes for this official species, for example, Adonis apennina L. Many Adonis species have limited natural resources, and in some regions are rare, requiring conservation of their natural populations. The search for alternative sources of medicinal plant raw materials, based on this, is relevant. The experimental part of our research was carried out using the morphological and geographical method with the involvement of information on ecology and phenology. For the first time summarizes the diagnostic features of Adonis flora of Russian flora. Previously unknown structural features (shape and size of anthers) were identified that characterize the subgenera Adonanthe and Adonis. Taxonomic study of the genus Adonis of the Russian flora allowed us to determine its species composition, clarify its systematic affiliation, and nomenclature synonyms. 9 species were identified. Of these, 6 are perennials belonging to the subgenus Adonanthe, section Consiligo, which includes 2 subsections: Amurenses (2 species) and Vernales, which is differentiated into 2 rows: Apenninae (2 species) and Vernales (2 species). Subgenus Adonis is represented by 2 sections: Adonis (1 species) and Lophocarpa with sections Aestivales (1 species) and Dentatae (1 species). For all the considered species and varieties, the main distribution areas are given. A key has been compiled to determine the wild Adonis species distributed in Russia.


2021 ◽  
Vol 15 (1) ◽  
Author(s):  
L. Osipova ◽  
O. Radionova ◽  
L. Tkachenko ◽  
T. Abramova

The analysis of the current state of processing of secondary raw materials of wine-making in Ukraine is given. It is proved that the latter is a rich source of biologically active compounds, including phenolic ones, which makes it possible to use it for the production of a wide range of products (raccoon, polyphenol extracts, tartaric acid, beverages, fertilizers, grape oil, cake, vitamin D, animal feed, food powder, abrasives) with high consumer value for various industries: food, pharmaceutical, perfume and cosmetics, chemical, feed, etc. In the light of modern research, the role of phenolic compounds as essential nutrition factors that cannot remain out of the field of view of physiologists, pharmacologists, and food hygiene specialists is shown. However, currently in Ukraine there are no specialized enterprises for complex processing of secondary raw materials of winemaking; traditional technologies are not effective from a technological, economic and environmental point of view, which indicates not rational use of resources and loss of material resources; there are no systematic studies on physical and chemical, microbiological, Toxicological composition in order to determine the optimal direction of its use. A limiting factor is also the lack of comparative analysis of innovative domestic and foreign technologies for processing secondary raw materials of winemaking. In the vast majority of cases, in particular, combs and pomace are taken out of control to agricultural land without special treatment, which leads to acid soil erosion and pollution of the environment with metabolites of micromycetes, increasing one of the global problems of mankind-environmental. At the present stage of technological development, there are a number of innovative developments in the field of processing secondary raw materials, in particular grape pomace, in order to obtain biologically active additives, the limiting factor for the introduction of which is the lack of domestic and expensive imported equipment. A promising way to solve the existing problems is to create a mechanism that will unite the interests of wineries (producers of secondary raw materials of winemaking), processing enterprises (producers of products from secondary raw materials of winemaking), scientists and potential consumers of innovative products. Consolidation of the above-mentioned institutions and enterprises is possible by creating clusters for the development and implementation of innovative technologies and equipment


2018 ◽  
pp. 30-36
Author(s):  
V. M. Minarchenko ◽  
A. Yu. Butko

The popularity of herbal remedies and medicines, with the participation of biologically active substances from plants is traditionally high. The annual increase of the domestic market for herbal remedies is due to the preservation and modernization of production capacities for processing of medicinal vegetative raw materials in Ukraine, introduction of modern scientific developments, a large natural resource base of medicinal plants and attracting investments in the development of this industry. The aim of our work was the study of the domestic market of medicines of plant origin, which includes herbal remedies, substances and preparations with the participation of biologically active substances from plants. The object of the study was domestic medicines of plant origin that are registered in Ukraine for 2012–2017. The study used the analytical, statistical methods, and the results of its own resource studies of medicinal plants. Phytopharmaceutical market of Ukraine is actively developing due to the attraction of new types of medicinal plants and expanding the range of medicines. The number of domestic drugs with the participation of biologically active substances from plants has increased by 17.4% compared with 2014. It is established that as of 1 January 2017 in Ukraine was 1 141 the form of medicinal drugs of plant origin. Of them: 645 – domestic products, 496 – foreign. Most of the herbal drugs in the pharmaceutical market of Ukraine are made from wild and cultivated domestic raw materials.


2020 ◽  
Vol 14 (2) ◽  
Author(s):  
N. Pritulska ◽  
I. Motuzka ◽  
A. Koshelnyk ◽  
M. Jarossová ◽  
A. Lacková

A recent tendency in Ukraine is the changes in the structure of food consumption, which are caused by the reduced consumption of some product groups and by their decreasing quality. A persisting problem is that affordable and easy-to-consume food products made with due consideration of the needs of patients with certain categories of diseases can hardly be found on the domestic market. The products present on the domestic market are all imported, available in a limited assortment, very expensive, and not customised to suit all the specific needs of human metabolism. Approaches to the nutrition of patients with certain types of nutrition-dependent and non-infectious diseases have been analysed. It has been established that аn effective component in the diet of patients with non-infectious diseases can be plant-based milk analogues. It has been determined how important it is to use domestic raw materials: it will contribute to expanding domestic production, will help the gross domestic product growth, and will reduce the product’s costs, thus reducing the costs of diagnostic and treatment procedures. It has been established that the assortment of plant-based milk analogues is constantly expanding. The vegetable raw material conventionally used to make this product group has been analysed. It has been shown that fenugreek seeds can be most effectively used to make special food products (in particular, plant-based milk analogues) for the nutritional support of patients with non-infectious diseases. This is feasible due to the availability of the raw material, simple cultivating conditions, the chemical composition of the product (e. g. a wide range of biologically active substances), low costs of the product when it is made from domestic raw materials, and the simple production technology. It is expected that manufacture of milk analogues from fenugreek seeds will widen the assortment of this product group, and satisfy the target consumers’ needs of safe and high quality products that offer an alternative to imports.


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