scholarly journals Analysis of the vitamin’s list with pharmacoeconomic rates for the treatment of long covid conditions during the pandemic COVID-19 in Ukraine

2021 ◽  
pp. 16-26
Author(s):  
Я. О. Гриньків ◽  
О. Б. Блавацька ◽  
Г. Ю. Яцкова ◽  
О. М. Заліська
Keyword(s):  
Trace Elements ◽  
Cost Minimization ◽  
Pharmacoeconomic Analysis ◽  
Daily Intake ◽  
Quantitative Composition ◽  
Vital Activity ◽  
Cost Of Treatment ◽  
Qualitative And Quantitative ◽  
The Cost ◽  
Comparative Content

To ensure adequate vital activity, especially during the COVID-19 pandemic, the human body needs, in particular vitamins, minerals (macro and micronutrients). The purpose of the study is the range, qualitative and quantitative composition of vitamin complexes (VC) in the pharmaceutical market of Ukraine; to develop a method of pharmacoeconomic analysis to determine the cost of treatment of VC. Materials of research – data DRLZ, «Compendium», prices for VC (www.tabletki.ua). Research methods: webometric, comparative, content, «cost minimization» analysis; systematization, generalization. 20 VCs were analyzed, of which 15 – group A11A (75%) and 5 – A11B (25%). The highest content of vitamins in: Elevit Pronatal, Vitrum Energy, etc. All groups of vitamins contain: Vitrum Centuri, Vitrum Energy. The least vitamins in – Metovitan, Optics. Vitrum Centuri and Vitrum Energy contain most of the trace elements. Metovitan, Optics, Quadevit contain the least amount of trace elements. In addition to trace elements, the composition of VC includes: amino acids (cysteine, methionine), papain, fish oil, etc. It is established that the recommended doses of vitamins A, C, B1, B2, B5, B6, B12 in Ukraine are higher than recommended by the WHO; D, B9, H – the recommended doses in Ukraine are lower than recommended by the WHO; recommended doses of all trace elements in Ukraine are higher than the WHO. 20 VCs are registered in Ukraine, of which 15 are group A11A and 5 are A11B. 90% of VC contain vitamins A, E, C, B1, B2, B9, B12, PP. Vitamin B6 – in 85% of VC; vitamin D3 is in the composition of 62% of VC; vitamin B5 – 58%; vitamins H and K – in the composition of almost 15% of VC. It was found that 54% of VCs contain calcium; 61.5% of VC contain iron and copper; 31% of VC contain phosphorus and manganese; up to 23% of VCs contain molybdenum, boron, nickel, vanadium, tin, etc. It is established that Zinc is a part of 62% of VCs registered in Ukraine. The results of pharmacoeconomic analysis by the method of «minimization of cost» showed that the affordability of domestic multivitamin and vitamin-mineral complexes are 1.5–4.7 times more economically affordable for treatment compared to imported, with a qualitative composition are similar. Quantitative content of vitamins and minerals in domestic VC meets the national requirements of daily intake.

scholarly journals PHARMACOECONOMIC ANALYSIS OF STATIN TABLETS - IN VITRO PERFORMANCE PERSPECTIVE

2018 ◽  
Vol 11 (7) ◽  
pp. 210
Author(s):  
Vidyavathi M ◽  
Koteswaramma L ◽  
Krishnaveni A ◽  
Madhuri T ◽  
Sarada B
Keyword(s):  
Cost Benefit Analysis ◽  
Cost Minimization ◽  
Pharmacoeconomic Analysis ◽  
Cost Benefit ◽  
Scientific Discipline ◽  
Pharmaceutical Drugs ◽  
Weight Variation ◽  
The Cost ◽  
In Vitro Performance

Objective: Pharmacoeconomics refers to the scientific discipline that compares the value of pharmaceutical drugs or drug therapies. The pharmacoeconomic analysis includes the research methods related to cost minimization, cost-effectiveness, and cost-benefit analysis. The present study concerned with the pharmacoeconomic analysis of statin tablets (simvastatin [S1-S5], atorvastatin [A1-A5], and rosuvastatin [R1-R5]) of different brands which are varying in their prices using in vitro evaluation methods of tablets.Methods: Weight variation, friability, hardness, disintegration, and dissolution tests of all selected statin tablets were performed as per official procedure for the pharmacoeconomic comparative analysis.Results: It was found the least T90% with S5 and high T90% with S1 tablets among simvastatin tablets, the least T90% was observed with A1 and A5 and high T90% with A2 tablets among atorvastatin tablets, and least T 90% was observed with R5 and high T90% with R2 was found among rosuvastatin tablets without any relation with their order of prices. Hence, the study concluded that there is no significant correlation between cost and in vitro performance as there is no excellent in vitro performance found from the costliest tablets and vice versa.Conclusion: The range of the cost of different marketed statin tablets is from Rs.17.5 to Rs.127.0 per a strip of 10 tablets. All brands of three drugs have equal strength which are assumed to produce the same outcomes. As there is no significant correlation between cost and results of some of in vitro parameters of the tablets, the cost minimization analysis can be ruled out for these brands of S1 to

scholarly journals Calculation of the cost-effectiveness of subcutaneous administration of trastuzumab

2020 ◽  
Vol 55 (1) ◽  
pp. 9-11
Author(s):  
I. M. OMAROVA ◽  
J. O. NURKETAEVA ◽  
D. D. DOROGAN
Keyword(s):  
Targeted Therapy ◽  
Cost Effectiveness ◽  
Cost Minimization ◽  
Pharmacoeconomic Analysis ◽  
Subcutaneous Administration ◽  
Comparable Efficacy ◽  
Minimization Method ◽  
Efficient Treatment ◽  
Outpatient Chemotherapy ◽  
The Cost

Rational selection of medicines with an assessment of their pharmacoeconomic effectiveness is the most effective way to ensure safe and efficient treatment and economical use of budget funds allocated for drug therapy, as well as to reduce the time of hospitalization and treatment of patients. The purpose of the research was to evaluate the pharmacoeconomic effectiveness of using the subcutaneous and intravenous forms of drug Trastuzumab. Research tasks: 1. Estimate costs when using subcutaneous trastuzumab in an outpatient chemotherapy room (OCR). 2. Estimate costs when using intravenous trastuzumab in a day patient department (DPD). 3. Estimate costs when using intravenous trastuzumab in a round-the-clock hospital. Results: The paper presents the pharmacoeconomic analysis of targeted therapy with trastuzumab in two forms for intravenous administration (IV) and trastuzumab emtansine for subcutaneous administration (SC) in breast cancer by cost minimization method. The costs of used drugs are according to the price-list of the unified national distributor SK Pharmacia as of January 1, 2018. At comparable efficacy and toxicity, the estimated cost-effectiveness of trastuzumab per 100 patients per year is KZT 16,939,600 ($ 50,972) for SC administration in OCR and IV administration in DPD vs. KZT 41,783,200 ($ 125,728) for SC administration in OCR and IV administration in a round-the-clock hospital. Conclusions: Based on the above, the subcutaneous form is economically feasible for conducting targeted therapy with trastuzumab.

METHODS OF WATER PURIFICATION AT THE STAGE OF WATER TREATMENT FOR FEEDING BOILERS AND THEIR OWN TECHNOLOGICAL NEEDS AT THE PLANT CHPP

2021 ◽  
Vol 3 (1) ◽  
pp. 099-103
Author(s):  
M. V. Vasina ◽  
◽  
A. S. GOLYSH ◽  
K. V. TROFIMENKO ◽  
◽  
...  
Keyword(s):  
Water Treatment ◽  
Water Purification ◽  
Quantitative Composition ◽  
Source Water ◽  
Initial Water ◽  
Qualitative And Quantitative ◽  
Pre Treatment ◽  
The Cost ◽  
Selection Of

This work consists of the characteristics of production, assessment of the qualitative and quantitative composition of water, consideration of the process of water purification in the chemical shop, comparison and selection of coagulants and flocculants, and demonstration of the most affordable technology used at the CHPP which increases the efficiency of source water purification. The problem of pretreatment of the source water has always been relevant. The quality of the water used depends on the operation of boilers and turbines at the CHPP. The paper presents the average annual indicators of the quality of the source water, pre-treatment methods, and considers which reagents that do not require the cost of reconstruction of clarifiers can improve their performance. The initial water after the application of the test samples of coagulants and flocculants was studied. Conclusions are drawn about the work of clarifiers after the use of the proposed reagents.

scholarly journals Pharmacoeconomic issues of antihypertensive therapy in elderly patients (older than 75 years)

2011 ◽  
Vol 17 (4) ◽  
pp. 361-365
Author(s):  
M. M. Petrova ◽  
O. P. Bobrova ◽  
D. S. Kaskaeva
Keyword(s):  
Cardiovascular Risk ◽  
Elderly Patients ◽  
Antihypertensive Therapy ◽  
Cost Efficiency ◽  
Antihypertensive Effect ◽  
Cost Minimization ◽  
Pharmacoeconomic Analysis ◽  
High Cardiovascular Risk ◽  
Drug Combination Therapy ◽  
The Cost

Objective. To carry out a pharmacoeconomic analysis of the antihypertensive therapy in elderly patients of high cardiovascular risk by the means of the method assessing «expenses - benefits», cost minimization, the increment of cost efficiency. Results. The cost of the daily efficient dose of the original (Renitec, MSD) and generic Enalapril (Hemofarm) was 6,54 and 7,25 rubles, respectively. Minimal coefficient «expenses - benefits» was defined in the group of patients receiving two drug combination therapy including original Enalapril (Renitec, MSD) compared to combination of three drugs including generic Enalapril (Hemofarm) while the antihypertensive effect was comparable. The cost efficiency increment (CER incr) was 169,12 rubles regarding original Enalapril (Renitec, MSD) benefit.

scholarly journals THE USE OF CATALYTIC NEUTRALIZATION FOR THE PURIFICATION OF EXHAUST GASES FROM MARINE POWER PLANTS IN AN AGGRESSIVE ENVIRONMENT

2020 ◽  
pp. 157-166
Author(s):  
Nina N. Gorlova
Keyword(s):  
Power Plants ◽  
Material Selection ◽  
Point Of View ◽  
Quantitative Composition ◽  
Qualitative And Quantitative ◽  
Aggressive Environment ◽  
Catalytic Material ◽  
The Cost ◽  
Selection Of

    Among the methods used, the most effective, from the point of view of the quality of cleaning from the main harmful substances, is catalytic neutralization. The effectiveness of using this method is largely determined by the properties and characteristics of the used catalytic material. Selection of the appropriate composition determines the provision of physical, physico-mechanical and corrosive properties of the used catalytic materials. In this regard, the possibilities of using steel oxide and molding clay as basic components in the charge of the material were studied. In order to reduce the cost of the treatment system, the possibility of replacing valuable expensive components with ore mills of the appropriate composition was considered.As a result of the studies, the optimal qualitative and quantitative composition of the charge of the catalytic material was determined.

scholarly journals PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUGS FOR OPTIMIZING BLOOD PRESSURE IN YOUNG ADULTS

2019 ◽  
Vol 8 (2) ◽  
pp. 30-36
Author(s):  
I. S. Kovrigin ◽  
M. M. Petrova ◽  
D. S. Kaskaeva ◽  
I. V. Romanova
Keyword(s):  
Blood Pressure ◽  
Young Adults ◽  
Side Effects ◽  
Enzyme Inhibitor ◽  
Antihypertensive Drugs ◽  
Pharmacoeconomic Analysis ◽  
Sharp Decrease ◽  
Cost Of Treatment ◽  
Group 2 ◽  
The Cost

Aim. To evaluate the pharmacoeconomic analysis of three antihypertensive drugs routinely used to optimize blood pressure in young adults.Methods. 250 patients were recruited to the study and subdivided into three groups: Group 1 patients (n = 131) received monotherapy with angiotensin-converting enzyme inhibitor, ramipril; Group 2 and 3 patients (n = 119) received combination therapy with perindopril + amlodipine and ramipril + amlodipine.Results. The group of patients receiving ramipril had the average daily dose of 10 mg, patients taking egipres received 5/10 mg daily, and patients receiving prestans took 5/5 mg daily. Thus, the cost of treatment with ramipril at the dose optimally reducing blood pressure remained the same, while the cost of treatment with prestans decreased up to 37400.00 RUB, and egipres up to 45218.00 RUB. 4.76% of patients who received these antihypertensive medicines experienced side effects, namely cough, dizziness, a sharp decrease in blood pressure, allergic dermatitis, nausea. The least rate of side effects occurred in patients who received perindopril, whereas the highest was recorded in the group of patients receiving ramipril (3.5% vs. 6.5%, respectively).Conclusion. No significant differences found in the antihypertensive effects between three groups of drugs (ramipril, prestans, egipres). All three medicines included in this study effectively reduced blood pressure. However, prestans was associated with the least rate of side effects. Most side effects were short-term and of mild to moderate severity.

scholarly journals PHARMACOECONOMIC ANALYSIS OF THE CONVENTIONAL PHARMACOTHERAPYOF dEEP VEIN THROMBOSIS

2015 ◽  
Vol 7 (1) ◽  
pp. 128-133
Author(s):  
V I Petrov ◽  
O V Shatalova ◽  
O N Smuseva ◽  
V S Gorbatenko
Keyword(s):  
Deep Vein Thrombosis ◽  
Cost Analysis ◽  
Conventional Treatment ◽  
Pharmacoeconomic Analysis ◽  
Hospital Treatment ◽  
Cost Of Treatment ◽  
Vein Thrombosis ◽  
Hospitalization Costs ◽  
The Cost ◽  
Deep Vein

The cost analysis of treatment of deep vein thrombosis was performed in conventional therapy. The estimation of the cost of treatment of DVT in conventional treatment was done, using clinical-economic analysis - the «cost of illness» (COI). The study took into account only the direct costs of state and patients during 6 month treatment course. The cost analysis of DVT in conventional treatment was held, the economic burden of DVT is 1,8 billion rubles, in structure of cost it is occupying 98%. The cost of purchase of warfarin is occupying only 2%. At the present stage DVT and its complications are the serious problem, spending resources. In the cost`s structure of DVT outgoings of hospital treatment are 83%, if we reduce hospitalization costs, we can reduce state costs of DVT treatment.

scholarly journals Pharmacoeconomic analysis by the cost-minimization method of fluconazole drugs recommended for use in candidiosis

2020 ◽  
pp. 59-68
Author(s):  
O. V. Tkachova ◽  
L. V. Iakovlieva ◽  
T. I. Sheptak
Keyword(s):  
Cost Minimization ◽  
Pharmacoeconomic Analysis ◽  
Direct Costs ◽  
Antifungal Drugs ◽  
Vaginal Candidiasis ◽  
Oropharyngeal Candidiasis ◽  
Minimization Method ◽  
Mucous Membranes ◽  
Calculation Results ◽  
The Cost

Candidiasis is a group of fungal diseases of the skin, mucous membranes and internal organs caused by fungi of the genus Candida. Candidiasis treatment is mainly carried out with antifungal agents for systemic use. Fluconazole preparations, which have proven clinical efficacy and safety, and are also most often used in Ukraine, are presented in the largest number of TN in the pharmaceutical market. The aim of the work is to analyze cost minimization when using fluconazole preparations for pharmacotherapy of three different pharmacotherapy schemes for candidiasis. The analysis of minimizing the costs of fluconazole preparations was carried out using the retail cost of medicines according to the Morion company Pharmexplorer analytical market research system (as of February 2019). In the process of calculating the cost of the course of treatment of patients with candidiasis, fluconazole preparations used for pharmacotherapy of 1) vaginal candidiasis were used; 2) dermatomycosis, atrophic candidiasis of the mucous membranes, oropharyngeal candidiasis; 3) candidiasis of the esophagus, candiduria. The study evaluated only the direct costs of treating patients with candidiasis with fluconazole preparations. Calculation of the cost of pharmacotherapy with fluconazole was carried out taking into account the price per package of drugs, the daily dose of drugs with the determination of the cost of one unit (tablets, capsules), one day of treatment and the course of treatment. Based on the results obtained, using the pharmacoeconomic method of «cost minimization», the least costly drugs were selected for the course of treatment with fluconazole. The calculation results showed that the minimum direct costs for the course of pharmacotherapy of the vaginal candidiasis are 9.88 UAH; the minimum direct costs for the treatment of dermatomycoses, atrophic candidiasis of the mucous membranes, oropharyngeal candidiasis are UAH 26.01, and for the treatment of candidiasis of the esophagus and candiduria – UAH 50.28. In a difficult socio-economic situation in Ukraine, the use of the least expensive representatives of antifungal drugs for systemic use is economically feasible. The results of this study will allow the doctor or pharmacist to choose fluconazole preparations in various doses and dosage forms for patients with low solvency.

scholarly journals Evaluation of restricted antibiotic utilization and cost-minimization analysis in a tertiary care hospital in India

2021 ◽  
Vol 7 (2) ◽  
pp. 116
Author(s):  
Dhakchinamoorthi Krishna Kumar ◽  
Mani Swapna ◽  
Srinivasan Kanmani ◽  
Varghese Varsha ◽  
Nair V. Vidya
Keyword(s):  
Infectious Diseases ◽  
Cost Minimization ◽  
Pharmacoeconomic Analysis ◽  
Statistical Significance ◽  
Unit Cost ◽  
Tertiary Care ◽  
Care Hospital ◽  
Cost Minimization Analysis ◽  
The Cost ◽  
Mean Cost

<p class="abstract"><strong>Background:</strong> Antibiotic resistance is a major menace to public health and treatment of several infectious diseases, also associated with an economic burden to society.  Pharmacoeconomic analysis of antibiotic usage and cost-minimization analysis provides better and low-cost drug selection for the patients.</p><p class="abstract"><strong>Methods:</strong> The study was conducted as a cross-sectional, observational analysis of restricted antibiotics in the prescriptions (n= 191). Cost minimization analysis was conducted for the restricted antibiotics alone. The drug costs of prescribed brands were compared with the least cost brands, and the percentage cost difference was calculated and compared by student paired ‘t’ test. P&lt;0.05 considered statistical significance.  </p><p class="abstract"><strong>Results:</strong> The average age of the patients was found to be 58.1±18.3 (Mean±SD) years, and most of the restricted antibiotics were prescribed for the treatment of hospital-acquired infections 71.7%. Meropenem was prescribed highly 29.8% followed by imipenem (28.8%) and colistin (12%). The major reason for starting restricted antibiotics was found to be infectious diseases (27.7%). The cost-minimization analysis showed that the total unit cost for caspofungin (₹1,85,000 or $2523.40) was found to be higher followed by meropenem (₹1,29,800) in the prescriptions. The mean cost of actually prescribed restricted antibiotics was found to be ₹68,338±61,332 (Mean±SD). The lowest mean cost of restricted antibiotics was found to be ₹32,223±31,082 (p&lt;0.05).</p><p class="abstract"><strong>Conclusions:</strong> Pharmacoeconomic cost-minimization analysis was a useful tool for clinical pharmacist in the selection of appropriate antibiotics and minimizing the burden of the cost of the drugs, it provides a better outcome in patients while using restricted antibiotics with infectious disease.</p>

Meat and Meat Products Consumption in Italy: Contribution to Trace Elements, Heme Iron and selected B Vitamins supply

2004 ◽  
Vol 74 (4) ◽  
pp. 247-251 ◽  
Author(s):  
Lombardi-Boccia ◽  
Lanzi ◽  
Lucarini ◽  
Di Lullo
Keyword(s):  
Trace Elements ◽  
Daily Intake ◽  
Meat Products ◽  
Heme Iron ◽  
B Vitamins ◽  
Zinc Intake ◽  
Consumption Frequency ◽  
Iron And Zinc ◽  
Iron Heme ◽  
Daily Intakes

This study was undertaken to estimate the contribution of meat and meat products consumption to the daily intakes of trace elements (Fe, Zn, Cu, Se), heme iron, and selected B vitamins (thiamine, riboflavin, niacin) in Italy. Meat and meat products were selected on the basis of their consumption frequency reported by the most recent nationwide dietary individual survey carried out in Italy (INN-CA study). The daily intakes of total iron and heme iron were 1.65 and 1.13 mg/person/day. Zinc intake was 3.65 mg/person/day. Beef made the main contribution to iron, heme iron, and zinc daily intakes. Copper daily intake was 107.3 mug/person/day, with meat products provided the highest contribution (40 mug/person/day). Daily intake of selenium (7.14 mug/person/day) was provided mainly by poultry consumption. Thiamine intake was 228 mug/person/day, and meat products were the main source (110 mug/person/day). Riboflavin intake was 136 mug/person/day, with both beef and meat products as the main contributors (40 mug/person/day). Niacin intake was 7.53 mg/person/day, and poultry was the main source (2.28 mg/person/day). Meat and meat products were a valuable source of micronutrients, supplying 47, 48, and 24% of zinc, niacin, and thiamin daily requirements, respectively, and over 10% of iron, copper, selenium, and riboflavin daily average requirement values of the italian RDAs calculated for the population involved in the survey (INN-CA study).

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