Background:
A Lewis acid promoted efficient and facile procedure for one-pot synthesis
of a novel series of fluoroquinolone clubbed with thiadiazoles motifs under microwave irradiation is
described here. This technique has more advantages such as high yield, a clean procedure, low reaction
time, simple work-up and use of Lewis acid catalyst.
Objective:
Our aim is to generate a biologically active 1,3,4- thiadiazole ring system by using a onepot
synthesis method and microwave-assisted heating. High yield and low reaction time were the
main purposes to synthesize bioactive fluoroquinolone clubbed 1,3,4- thiadiazole moiety.
Methods:
Fluoroquinolone Clubbed 1,3,4-Thiadiazole Motifs was prepared by Lewis acid promoted,
one-pot synthesis, under microwave irradiation. All the synthesized molecules were determined by
IR, 1H NMR, 13C NMR, and Mass spectra. The antimicrobial activity of synthesized compounds was
examined against two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), two
Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), and three fungi (Candida
albicans, Aspergillus niger, Aspergillus clavatus) using the MIC (Minimal Inhibitory Concentration)
method and antitubercular activity H37Rv using L. J. Slope Method.
Results:
Lewis acid promoted, one-pot synthesis of Fluoroquinolone clubbed 1,3,4-Thiadiazole motifs
under microwave irradiation is an extremely beneficial method because of its low reaction time
and good yield. Some of these novel derivatives showed moderate to good in vitro antibacterial, antifungal,
and antitubercular activity.
Conclusion:
One-pot synthesis of 1,3,4-Thiadiazole by using Lewis acid catalyst gives a good result
for saving time and also getting more production of novel heterocyclic compounds with good antimicrobial
properties via microwave heating method.
Microwave-assisted intramolecular FriedelCrafts acylation of some aryl aliphatic acids using Gd(OTf)3/ [BMI]BF4 catalytic system
