Targeting Sphingolipids for Cancer Therapy

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis. Several inhibitors or activators of sphingolipid signaling, such as fenretinide, safingol, ABC294640, ceramide nanoliposomes (CNLs), SKI-II, α-galactosylceramide, fingolimod, and sonepcizumab, have been described. The objective of this review was to analyze the results from preclinical and clinical trials of these drugs for the treatment of cancer. Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo. As a consequence of treatments, the most frequent mechanism of cell death is apoptosis, followed by autophagy. Aslthough all these drugs have produced good results in preclinical studies of multiple cancers, the outcomes of clinical trials have not been similar. The most effective drugs are fenretinide and α-galactosylceramide (α-GalCer). In contrast, minor adverse effects restricted to a few subjects and hepatic toxicity have been observed in clinical trials of ABC294640 and safingol, respectively. In the case of CNLs, SKI-II, fingolimod and sonepcizumab there are some limitations and absence of enough clinical studies to demonstrate a benefit. The effectiveness or lack of a major therapeutic effect of sphingolipid modulation by some drugs as a cancer therapy and other aspects related to their mechanism of action are discussed in this review.

Ways for russian and vietnamese military terminology formation

Терминология представляет собой обширный класс специальной лексики. Термины противопоставлены общей лексике в том отношении, что они связаны с определенной научной концепцией. В связи с развитием форм общественной жизни, успехом хозяйственной, культурной деятельности, быстрым развитием военной науки появляются новые профессионально соответствующие термины. Система военной терминологии очень разнообразна и в русском, и во вьетнамском языках. На основе систематизации, обобщения, анализа русских и вьетнамских военных терминов данная статья поставляет и решает задачу рассмотреть пути формирования военной терминологии русского и вьетнамского языков, что, как нам хотелось бы, может быть предпосылкой для дальнейшего изучения и грамотного употребления терминов в обоих языках. Terminology is an extensive class of specialized vocabulary. Terms are contrasted with general vocabulary in the sense that they are associated with a specific scientific concept. As a result of the development of forms of social life, economic, cultural activities, and military science, new professionally relevant terms appear. Therefore, military terminology is very diverse in both Russian and Vietnamese languages. Based on the systematization, generalization, analysis of Russian and Vietnamese military terms, this article proposes some problems and also suggests some solutions in order to consider ways of forming Russian and Vietnamese military terminology. We hope that this article could be a prerequisite for further study and competent use of terms in both languages.

A Literature Curated Profile of miRNA IN Modulating Multi-Drug Resistance for Cancer Therapy

At present, cancer is one of the major causes of death, affecting millions of people each year. Multi Drug Resistance (MDR) remains the major clinical obstacle in cancer treatment. Till date various mechanisms of MDR has been elucidated which includes- over expression of drug transporter, defect in cell cycle and apoptotic machinery, induction of autophagy, alteration in drug metabolism and drug target. microRNAs (miRNAs) are an extensive class of 22 nucleotide long non coding RNAs which are involved in gene regulation. Recent work has underlined the involvement of miRNA in cancer development with several studies regarding their involvement in drug resistance, thereby holding much promise for developing novel and more effective therapy for cancer treatment. This review presents the mechanisms of MDR and focuses on the profile of miRNA in regulating MDR in cancer treatment. Keywords: miRNA, Cancer, Multi-drug resistance, Drug target, Drug transporter, Apoptotic machinery.

Fixed Points of Monotone Total Asymptotically Nonexpansive Mapping in Hyperbolic Space via New Algorithm

In this article, we consider an extensive class of monotone nonexpansive mappings and introduce a new iteration algorithm to approximate the fixed point for monotone total asymptotically nonexpansive mappings in the framework of hyperbolic space. Faster convergence and stability results are proved for that iteration; also, fixed point is approximated numerically in a nontrivial example by using MATLAB.

Convergence Results for Total Asymptotically Nonexpansive Monotone Mappings in Modular Function Spaces

In this article, we consider an extensive class of monotone nonexpansive mappings. We use S -iteration to approximate the fixed point for monotone total asymptotically nonexpansive mappings in the settings of modular function space.

Modeling and Exact Reliability for a Consecutive Linear (k1,k2,…,kn−r+1)-Out-of-r-from-n: F System and Consecutive Circular (k1,k2,…,kn)-Out-of-r-from-n: F System

The consecutive linear [Formula: see text]-out-of-[Formula: see text]-from-[Formula: see text]:F system consists of [Formula: see text] linear ordered components and the consecutive circular [Formula: see text]-out-of-[Formula: see text]-from-[Formula: see text]:F system consists of [Formula: see text] circular ordered components. In this paper, we suggest, for the first time, modeling and exact reliability for these models. The linear system fails if and only if there exists a [Formula: see text]-order statistic of [Formula: see text]-consecutive [Formula: see text] [Formula: see text] of components in the failed state, [Formula: see text], [Formula: see text]; and the circular system fails if and only if there exists a [Formula: see text]-order statistic of [Formula: see text]-consecutive [Formula: see text] [Formula: see text] of components in the failed state, [Formula: see text], [Formula: see text]. In this paper, we designed an innovative algorithm to obtain the exact reliability for an extensive class of consecutive linear and circular systems. In continuation, there are the MATLAB Programs of exact reliability for consecutive linear and circular systems. In the following, we applied comparative and numerical results and calculated the exact reliability of this strategic systems. Finally, we calculated the exact reliability for two real-world practical examples.

Microwave-assisted Synthesis of Benzoxazoles Derivatives

Background: Benzoxazole, containing a 1,3-oxazole system fused with a benzene ring, has a profound effect on medicinal chemistry research owing to its important pharmacological activities. On the other hand, the benzoxazole derivative has exhibited important properties in material science. Especially in recent years, microwave-assisted synthesis is a technique that can be used to increase diversity and quick research in modern chemistry. The utilization of microwave irradiation is beneficial for the synthesis of benzoxazole in recent years. In this focused review, we provide a metaanalysis of studies on benzoxazole in different reaction conditions, catalysts, and starting materials by microwave technique so far, which is different from conventional heating. Methods: Synthesis of different kind of benzoxazole derivatives have been carried out by microwave irradiation. The most used method to obtain benzoxazoles is the condensation of 2-aminophenol or its derivatives with aldehydes, carboxylic acids, nitriles, isocyanates, and aliphatic amines. Results: Benzoxazole system and its derivatives have exhibited a broad range of pharmacological properties. Thus, many scientists have remarked on the importance of the synthesis of different benzoxazole derivatives. Conventional heating is a relatively inefficient and slow method to convey energy in orientation to the reaction medium. However, the microwave-assisted heating technique is a more effective interior heating by straight coupling of microwave energy with the molecules. Conclusion: In this review, different studies were presented on the recent details accessible in the microwave- assisted techniques on the synthesis of the benzoxazole ring. It presents all examples of such compounds that have been reported from 1996 to the present. Benzoxazoles showed an extensive class of chemical substances not only in pharmaceutical chemistry but also in dyestuff, polymer industries, agrochemical, and optical brighteners. Thus the development of fast and efficient achievement of benzoxazoles with a diversity of substituents in high yield is getting more noteworthy. As shown in this review, microwave-assisted synthesis of benzoxazoles is a very effective and useful technique.

Inverse problems of structural mechanics

The paper presents a brief review of the main ideas on the extensive class of inverse problems in structural mechanics relating to the identification of design models, technical condition monitoring and finding damages. The numerical implementation of identified incorrectness of inverse problems requires regularization. References include works describing the cases of practical application of reverse problem solutions.

Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

SUMMARYDuring virus infection B cells are critical for the production of antibodies and protective immunity. Here we show that the human B cell compartment in patients with diagnostically confirmed SARS-CoV-2 and clinical COVID-19 is rapidly altered with the early recruitment of B cells expressing a limited subset of IGHV genes, progressing to a highly polyclonal response of B cells with broader IGHV gene usage and extensive class switching to IgG and IgA subclasses with limited somatic hypermutation in the initial weeks of infection. We identify extensive convergence of antibody sequences across SARS-CoV-2 patients, highlighting stereotyped naïve responses to this virus. Notably, sequence-based detection in COVID-19 patients of convergent B cell clonotypes previously reported in SARS-CoV infection predicts the presence of SARS-CoV/SARS-CoV-2 cross-reactive antibody titers specific for the receptor-binding domain. These findings offer molecular insights into shared features of human B cell responses to SARS-CoV-2 and other zoonotic spillover coronaviruses.

GenC: A Fast Tool for Applications Involving Belief Revision

The process of belief revision occurs in many applications where agents may have incorrect or incomplete information. One important theoretical model of belief revision is the well-known AGM approach. Unfortunately, there are few tools available for solving AGM revision problems quickly; this has limited the use of AGM operators for practical applications. In this demonstration paper, we describe GenC, a tool that is able to quickly calculate the result of AGM belief revision for formulas with hundreds of variables and millions of clauses. GenC uses an AllSAT solver and parallel processing to solve revision problems at a rate much faster than existing systems. The solver works for the class of parametrised difference operators, which is an extensive class of revision operators that use a weighted Hamming distance to measure the similarity between states. We demonstrate how GenC can be used as a stand-alone tool or as a component of a reasoning system for a variety of applications.