scholarly journals COMPARATIVE STUDY OF SERUM CALCIUM, MAGNESIUM, URIC ACID AND GLUCOSE IN PREECLAMPSIA AND NORMAL PREGNANT WOMEN OF MALWA REGION OF MADHYA PRADESH

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Darshna Jain ◽  
Mohit Kulmi ◽  
Prachi Paliwal ◽  
Manoj Narayan Paliwal
Keyword(s):  
Uric Acid ◽  
Comparative Study ◽  
Pregnant Women ◽  
Serum Calcium ◽  
Gestational Age ◽  
Serum Levels ◽  
Madhya Pradesh ◽  
Control Group ◽  
Case Group ◽  
Calcium Magnesium

Background: Comparative study of serum calcium, magnesium, uric acid and glucose in preeclampsia and normal pregnant women of malwa region of Madhya pradesh Methods: For the Study, a total of 100 women ranging in age from 18-35 years were recruited. They were divided in two groups. 50 were pre-eclamptic women with gestational age of ?20 weeks (Case group) and rest 50 were normal pregnant women of same gestational age (Control group).The levels of magnesium, calcium, glucose, and uric acid in the blood were measured. Result: Serum calcium and magnesium levels were significantly lower (p<0.001) in the pre-eclamptic group, whereas serum uric acid levels were significantly higher (p0<001) in preeclamptic group. The level of serum glucose was raised in preeclampsia. Conclusion: serum levels of calcium, magnesium, uric acid and glucose are altered in pre-eclampsia, implying that these factors may play a role in the aetiology and severity of pre-eclampsia.so assessing the serum level of this parameters will aid in the early detection of pre-eclampsia. Keywords: Calcium, Magnesium, Uric acid, Glucose, Pre-eclampsia, Pregnancy

scholarly journals Hypo-magnesium and Hyperlipidemia Responsible for Hypertensive Status of Pregnant Women in Pakistani Population

2020 ◽  
pp. 61-66
Author(s):  
Asia Parveen ◽  
Khan Farooq ◽  
Fatima Arshad ◽  
Modasrah Mazhar ◽  
Nureen Zahra ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Serum Magnesium ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Case Group ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Group A

Background/ Aim: Pregnancy induced hypertension (PIH) has been a leading cause of maternal mortality worldwide. It could be responsible for several complications like hemodilution, altered lipid metabolism and deficiencies of different minerals in body. Although the causes of Pregnancy induced hypertension (PIH) remains indistinct. The aim of our present study was to evaluate the changes in magnesium serum levels and lipid profile in hypertensive and normotensive pregnant women. Materials and Methods: An analytical case control study comprising 60 individuals was designed. From which 30 normotensive pregnant women served as control group (A) and 30 pregnancy induced hypertensive women served as case group (B). Patients with pre-existing hypertension were excluded. Results: The independent t-test was used for comparison of various parameters between group A and B. Triacylglycerol (TAG) and low density lipoprotein cholesterol (LDL-C) levels were significantly high in PIH (B) as compare to normotensive group (A). Mean serum values of TG were measured as (195.73 ± 70.28 vs 156.27 ± 55.60 mg dL-1) and LDL-C vs control (87.33 ± 37.74 vs 69.45 ± 28.58 mg dL-1) in PIH and normotensive groups respectively. HDL-C in PIH vs Control (47.40±1.12 vs 54.43 ±1.27 mg dL-1) and Mg+2 PIH vs control (1.36±0.07 vs 1.94±0.35 mg dL-1) were measured respectively. High density lipoprotein cholesterol (HDL-C) and magnesium Mg+2 levels were significantly reduced in PIH. Conclusion: The lower serum magnesium levels and abnormal lipids profile may indicate their possible role as risk factors in the development of PIH in pregnant women. Hence initial diagnosis of hypomagnesemia in PIH cases may help in minimizing the complications and development of new cure strategies.

Study on comparison of serum levels of calcium, magnesium, and uric acid in mild preeclamptics, severe preeclamptics, and normal pregnant women in Ilorin, Nigeria

2015 ◽  
Vol 3 (2) ◽  
pp. 71
Author(s):  
OmokanyeLukman Omotayo ◽  
Abdulkareem Nura ◽  
OlatinwoAbdul Waheed Olajide ◽  
AbdulIsiak Funsho ◽  
DurowadeKabir Adekunlae ◽  
...  
Keyword(s):  
Uric Acid ◽  
Pregnant Women ◽  
Serum Levels ◽  
Calcium Magnesium

scholarly journals Serum NF-κBp65, TLR4 as biomarker for diagnosis of preeclampsia

Open Medicine ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 399-402 ◽  
Author(s):  
Zhao Litang ◽  
Wang Hong ◽  
Zhang Weimin ◽  
Tian Xiaohui ◽  
Sun Qian
Keyword(s):  
Pregnant Women ◽  
Patient Group ◽  
Roc Curve ◽  
Pearson Correlation ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Diagnostic Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Case Group

AbstractThe aim of this study was to evaluate the serum NF-κBp65, TLR4 (Toll-like receptor 4) expression in patients of preeclampsia and its diagnostic value as biomarkers.MethodsThirty patients with preeclampsia (case group) and 30 normal pregnant women (control group) were included in this study. The serum level of NF-κBp65 and TLR4 were examined by enzyme linked immunosorbent assay (ELISA), and compared between the two groups. The diagnostic sensitivity, specificity and area under the receiver operating characteristic (ROC) curve were calculated by STATA11.0 statistical software.ResultsThe expression level of TLR4 and NF-κBp65 in serum of preeclampsia patient group was 3.76±1.07ng/ ml and 183.20±49.19ng/ml, whereas that in the serum of the normal pregnant group was 2.43±0.69ng/ml and 98.68±29.80ng/ml. The expression of TLR4 and NF-κBp65 in serum of preeclampsia patient group was significantly higher than that of the normal pregnant group (P<0.05); The Pearson correlation test showed that the TLR4 expression in the serum of preeclampsia patients and normal pregnant women was positively correlated with their NF-κBp65 expression [rpreeclampsia=0.46, (P<0.05), rnormal=0.48, (P<0.05)]. When TLR4 and NF-κBp65 were selected as the reference indexes, the diagnostic sensitivity of preeclampsia was 86.67% (95%CI:69.28%-96.24%) and 90.33% (95%CI:73.47%-97.89%), and the specific ity was 70.00% (95%CI:50.60%-85.27%) and 83.33% (95%CI:65.28%-94.36%). The area under the ROC curve was 0.84 and 0.89.ConclusionSerum levels of TLR4 and NF-κBp65 was significantly higher in patients with preeclampsia which may involve in the pathogenesis of preeclampsia, and can be used as biomarker for predicting preeclampsia.

scholarly journals Association between Serum C-reactive Protein and Pre-eclampsia

2021 ◽  
Vol 15 (2) ◽  
pp. 58-61
Author(s):  
Sanjoy Kumar Das ◽  
Shafeya Khanam ◽  
Rajib Kumar Roy ◽  
Samiya Alam ◽  
Tapan Kumar Roy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Blood Pressures ◽  
Serum Crp

Among the common disorders of pregnancy, Pre-eclampsia is important one which causes significant maternal and perinatal morbidity and mortality. Its incidence is still high in the developing countries. The triad of high blood pressure, edema and albuminuria is neither specific nor sensitive enough; therefore, a reliable biochemical marker is needed to solve the problem. C-reactive protein(CRP), a marker of tissue damage and inflammation, is elevated in serum in overt preeclampsia. The present study is aimed to explore the association of high maternal serum C-reactive protein (CRP) level with preeclampsia and correlation with the severity of pre-eclamptic process. A total of 60 pregnant women constituting 30 pre-eclamptic (case) and 30 normal (control) pregnant women in the third trimester were enrolled in this study. Both the groups were matched for their age, parity and other baseline characteristics. More than three quarters (76.70%) of the case group exhibited raised serum CRP, which was 20% in control group (p=0.001). CRP was elevated about 13 fold higher than that in the normal pregnant women. The mean systolic and diastolic blood pressure were significantly higher in case group (154±12 mm of Hg) vs (107±7 mm of Hg) in control group (p<_0.001) and serum level of CRP bears linear relationship with both systolic and diastolic blood pressures. Preeclamptic women with higher serum CRP level were at a significantly (p<0.001) lower gestational age than control. Twenty two (73.30%) cases had gestational age <37 weeks (p=0.302) and 66.70% control group had gestational age > 37 weeks. The hypothesis of the study was supported by the study findings that maternal CRP concentration was higher in women with preeclampsia and was correlated with disease progression as evidenced by the investigative analysis. Faridpur Med. Coll. J. Jan 2020;15(2): 58-61

scholarly journals Low Serum Calcium Levels in Pre-eclampsia

2015 ◽  
Vol 7 (3) ◽  
pp. 126-129
Author(s):  
Bushra Rashid ◽  
Mariam Malik Richard ◽  
Gul-E-Rana LNU
Keyword(s):  
Pregnant Women ◽  
Serum Calcium ◽  
Calcium Supplementation ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Cross Sectional ◽  
Low Serum

ABSTRACT Background Pre-eclampsia remains the most threatening obstetric complication in Pakistan, resulting in high fetomaternal morbidity and mortality. Etiology of pre-eclampsia is not still clearly established. Association of low serum calcium levels with pre-eclampsia may be a factor in poorly nourished women, and some preventive measures may help to reduce the burden of disease. Objective To compare mean serum calcium levels in preeclamptic and normotensive pregnant women at third trimester of gestation. Study design Cross-sectional study. Place and duration of study The Department of Obstetrics and Gynecology, Unit-1, Sir Ganga Ram Hospital, Lahore, from July 2012 to July 2013. Methodology Two hundred patients were enrolled in the study. One hundred each in case and control group. History and examination performed. Proteinuria was checked by dip stick methods. Peripheral venous blood samples were taken to determine mean serum calcium levels of both the groups. Oral calcium supplementation was analyzed through stratification. Data was analyzed through SPSS by applying student's t test and calculating p-value. Results The mean serum calcium levels of the case group were 8.313 ± 0.377 while that of control group were 9.40 ± 0.427 with p-value 0.016. With increasing proteinuria (determined by dipstick method) and so the severity of pre-eclampsia, a gradual fall in serum calcium levels was observed. Conclusion Serum calcium levels in pre-eclamptic pregnant women are lower than in normal pregnant women and so hypocalcemia is associated with pre-eclampsia. How to cite this article Rashid B, Richard MM, Gul-E-Rana. Low Serum Calcium Levels in Pre-eclampsia. J South Asian Feder Obst Gynae 2015;7(3):126-129.

scholarly journals Evaluation Serum Copper Levels in Preeclampsia and Healthy Pregnant Women

2019 ◽  
Vol 9 (1) ◽  
pp. 18-22
Author(s):  
Nilima Baral ◽  
Rezwana Haque ◽  
Farzana Akonjee Mishu
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Case Group ◽  
Second Trimester ◽  
Serum Copper Level ◽  
Third Trimester

Background: Preeclampsia is a fatal medical disorder of pregnancy. It has been associated with adverse course and outcome of the pregnancy resulting in increased maternal and infant mortality and morbidity. As the pathogenesis of preeclampsia is not completely understood, prevention remains a complex issue. In recent times, there has been an increasing prevalence in the incidence of preeclampsia globally. The aim of this study is to determine the states of the copper in pregnant women with preeclampsia. Methods: This case-control study was carried out in the Department of Biochemistry, Mymensingh Medical College, Mymensingh, from July 2013 to June 2014. The subjects were selected on the basis of inclusion and exclusion criteria by purposive method. This study included 73 patients with preeclampsia as case (Gr.I) classified into two subgroups according to the gestational age: Gr.I(a); preeclampsia in the second trimester (n = 35), and Gr.I(b); preeclampsia in the third trimester (n = 38). Copper levels were analyzed and results were compared with 73 apparently healthy pregnant control (Gr.II), and the corresponding gestational age subgroups [Gr.II(a); normal pregnancy of second trimester (n = 35) and Gr.II(b), normal pregnancy of third trimester (n = 38)]. Results: The mean serum copper level was significantly (p<0.001) lower in case group than that of control group. Similar extent of reduction was observed in serum copper level at different gestational age groups of preeclamptic women when compared with corresponding control groups. Conclusion: Estimation of serum copper level should be incorporated in pre eclamptic patients for prevention of complications. Birdem Med J 2019; 9(1): 18-22

scholarly journals Serum Homocystine Level in Women with Severe Preeclampsia

2017 ◽  
Vol 5 (1-2) ◽  
pp. 54-60
Author(s):  
Shahnaz Akter Jahan ◽  
Nahid Reaz ◽  
Shafeya Khanam ◽  
Mirza Md Asaduzzaman ◽  
Zebunnessa Parvin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Roc Curve ◽  
Predictor Variable ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Case Group ◽  
History Of ◽  
And Control

Objective: Though preeclampsia (PE) is an age-old disease, its pathology still remains obscure. Available epidemiological evidences suggest that PE is a disease of multiple theories. Recently serum homocystine level is considered as factor to be associated with preecampsia and the higher the level the greater is the severity of preeclampsia. The present study is aimed at investigating this hypothesized association. Methodology: This case-control study was conducted over a period of 24 months from January 2012 to December 2013 in the Department of Obstetrics & Gynaecology, Dhaka Medical College, Dhaka. Pregnant women admitted with severe preeclampsia were the case, while pregnant women attending at the antenatal clinic without preeclampsia were the controls. Severe preeclampsia was diagnosed by blood pressure > 160/110 mm of Hg with proteinuria 3+ or more in dipstick test. The control group comprised of women of 24 - 40 weeks gestation, with blood pressure (both diastolic and systolic) remaining within normal limits without having any medical or obstetric complications. Data were analysed using software SPSS (Statistical Package for Social Sciences) version 16.0. The test statistics used to analyse the data were descriptive statistics, Chi-square (χ2) Test, Student’s t-Test and Receiver-operating characteristic (ROC) curve analysis. Result: Around two-thirds of the patients in both groups were in the age range of 21-30 years with mean age of the cases and control being 25.8 ± 5.2 and 24.1 ± 3.7 years respectively (p = 0.108). Over three-quarters (77.5%) of the patients in case group and 60.0% in control group belonged to middle class (p = 0.091). Majorities of the cases (85.0%) and controls (90.0%) were preterm (gestational age < 37 weeks) with mean gestational age being 33.2 ± 3.3 and 32.3 ± 3.5 weeks in case and control groups respectively (p > 0.05). The patients in either group were predominantly primigravida. Seven (17.5%) patients in the case group gave the history of past preeclampsia as opposed to none in the control group (p = 0.005). Family history of preeclampsia was reported by the case group alone (p = 0.027). Majority (95.0%) of the cases had 3+ proteinuria. Serum homocystine concentration was significantly raised (15.7 ± 8.3 μmol/L) in case group than that in the control group (6.7 ± 1.3 μmol/L) (p < 0.001). Based on the receiver-operator characteristic (ROC) curve, serum homocysteine levels in pregnant women had the best area under the curve (0.975 or 97.5%) with sensitivity and specificity of the predictor variable being 92.5 and 77.5% respectively. Conclusion: The study concluded that homocysteine levels are significantly elevated in patients with preeclampsia compared to the pregnant women without preeclampsia. Homocysteine may be of value in the monitoring of pregnancies to be complicated by preeclampsia. Ibrahim Card Med J 2015; 5 (1&2): 54-60

scholarly journals The Predictive Value of the Mother’s Risk Factors in Formation of Fetal Developmental Delay

2021 ◽  
Vol 8 ◽  
pp. 2333794X2199914
Author(s):  
Maka Chigladze
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Predictive Value ◽  
Negative Impact ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Retrospective Case ◽  
Standards Of Living ◽  
Poor Nutrition

The research aimed at studying the mother’s social-hygienic and medical biological risk factors and determining their predictive value. The retrospective case-control study was conducted with 142 pregnant women participating in it. In the case group there were involved 92 mothers whose pregnancy was completed by the birth of a newborn baby suffering from the intrauterine growth restriction. The control group was made of 50 pregnant women, whose pregnancy was completed by the birth of a healthy neonate. The research resulted in specifying the risk factors of high priority: the low standards of living (OR 3.61), chronic stress (OR-3.06), sleeping disorder (OR-3.33) and poor nutrition (OR-3.81). As regards the coexisting pathology the following was revealed: endocrine pathology (OR-3.27), ischemic heart disease (OR-4.35), arterial hypertension (OR-6.47), iron deficiency anemia (OR-4.11), pathology of respiratory system (OR-3.42), chronic genital inflammatory and infectious processes. The preeclampsia (92%) and low amniotic fluid (89%) were detected to have the high predictive value. The awareness of risk factors allows us to employ the timely measures for the reduction of negative impact on the fetus and neonate.

scholarly journals Analysis of Circulating microRNA Signatures and Preeclampsia Development

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1003
Author(s):  
Margarita L. Martinez-Fierro ◽  
Idalia Garza-Veloz
Keyword(s):  
Pregnant Women ◽  
Expression Profiling ◽  
Gene Prediction ◽  
Microrna Expression ◽  
Differentially Expressed ◽  
Control Group ◽  
Case Group ◽  
Circulating Microrna ◽  
Activated T Cells ◽  
Serum Microrna

microRNAs are important regulators of cell processes and have been proposed as potential preeclampsia biomarkers. We evaluated serum microRNA expression profiling to identify microRNAs involved in preeclampsia development. Serum microRNA expression profiling was evaluated at 12, 16, and 20 weeks of gestation (WG), and at the time of preeclampsia diagnosis. Two groups were evaluated using TaqMan low-density array plates: a control group with 18 normotensive pregnant women and a case group with 16 patients who developed preeclampsia during the follow-up period. Fifty-three circulating microRNAs were differentially expressed between groups (p < 0.05). Compared with controls, hsa-miR-628-3p showed the highest relative quantity values (at 12 WG = 7.7 and at 20 WG = 3.45) and the hsa-miRs -151a-3p and -573 remained differentially expressed from 16 to 20 WG (p < 0.05). Signaling pathways including cancer-related, axon guidance, Neurotrophin, GnRH, VEGF, and B/T cell receptor, were most commonly altered. Further target gene prediction revealed that nuclear factor of activated T-cells 5 gene was included among the transcriptional targets of preeclampsia-modulated microRNAs. Specific microRNAs including hsa-miRs -628-3p, -151a-3p, and -573 were differentially expressed in serum of pregnant women before they developed preeclampsia compared with controls and their participation in the preeclampsia development should be considered.

Serum kallistatin level is decreased in women with preeclampsia

2021 ◽  
Vol 49 (1) ◽  
pp. 60-66
Author(s):  
Onur Güralp ◽  
Nevin Tüten ◽  
Koray Gök ◽  
Kübra Hamzaoglu ◽  
Huri Bulut ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Gestational Age ◽  
Late Onset ◽  
Serine Proteinase ◽  
Serum Levels ◽  
Control Group ◽  
Positive Correlation ◽  
Uncomplicated Pregnancy ◽  
Appropriate For Gestational Age

AbstractObjectivesTo evaluate the serum levels of the serine proteinase inhibitor kallistatin in women with preeclampsia (PE).MethodsThe clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and 55 consecutive women with late-onset PE (LOPE) were compared with 110 consecutive gestational age (GA)-matched (±1 week) pregnant women with an uncomplicated pregnancy and an appropriate for gestational age fetus.ResultsMean serum kallistatin was significantly lower in women with PE compared to the GA-matched-controls (27.74±8.29 ng/mL vs. 37.86±20.64 ng/mL, p<0.001); in women with EOPE compared to that of women in the control group GA-matched for EOPE (24.85±6.65 ng/mL vs. 33.37±17.46 ng/mL, p=0.002); and in women with LOPE compared to that of women in the control group GA-matched for LOPE (30.87±8.81 ng/mL vs. 42.25±22.67 ng/mL, p=0.002). Mean serum kallistatin was significantly lower in women with EOPE compared to LOPE (24.85±6.65 ng/mL vs. 30.87±8.81 ng/mL, p<0.001). Serum kallistatin had negative correlations with systolic and diastolic blood pressure, creatinine, and positive correlation with GA at sampling and GA at birth.ConclusionsSerum kallistatin levels are decreased in preeclamptic pregnancies compared to the GA-matched-controls. This decrease was also significant in women with EOPE compared to LOPE. Serum kallistatin had negative correlation with systolic and diastolic blood pressure, creatinine and positive correlation with GA at sampling and GA at birth.

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