scholarly journals Serum Homocystine Level in Women with Severe Preeclampsia

2017 ◽  
Vol 5 (1-2) ◽  
pp. 54-60
Author(s):  
Shahnaz Akter Jahan ◽  
Nahid Reaz ◽  
Shafeya Khanam ◽  
Mirza Md Asaduzzaman ◽  
Zebunnessa Parvin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Roc Curve ◽  
Predictor Variable ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Case Group ◽  
History Of ◽  
And Control

Objective: Though preeclampsia (PE) is an age-old disease, its pathology still remains obscure. Available epidemiological evidences suggest that PE is a disease of multiple theories. Recently serum homocystine level is considered as factor to be associated with preecampsia and the higher the level the greater is the severity of preeclampsia. The present study is aimed at investigating this hypothesized association. Methodology: This case-control study was conducted over a period of 24 months from January 2012 to December 2013 in the Department of Obstetrics & Gynaecology, Dhaka Medical College, Dhaka. Pregnant women admitted with severe preeclampsia were the case, while pregnant women attending at the antenatal clinic without preeclampsia were the controls. Severe preeclampsia was diagnosed by blood pressure > 160/110 mm of Hg with proteinuria 3+ or more in dipstick test. The control group comprised of women of 24 - 40 weeks gestation, with blood pressure (both diastolic and systolic) remaining within normal limits without having any medical or obstetric complications. Data were analysed using software SPSS (Statistical Package for Social Sciences) version 16.0. The test statistics used to analyse the data were descriptive statistics, Chi-square (χ2) Test, Student’s t-Test and Receiver-operating characteristic (ROC) curve analysis. Result: Around two-thirds of the patients in both groups were in the age range of 21-30 years with mean age of the cases and control being 25.8 ± 5.2 and 24.1 ± 3.7 years respectively (p = 0.108). Over three-quarters (77.5%) of the patients in case group and 60.0% in control group belonged to middle class (p = 0.091). Majorities of the cases (85.0%) and controls (90.0%) were preterm (gestational age < 37 weeks) with mean gestational age being 33.2 ± 3.3 and 32.3 ± 3.5 weeks in case and control groups respectively (p > 0.05). The patients in either group were predominantly primigravida. Seven (17.5%) patients in the case group gave the history of past preeclampsia as opposed to none in the control group (p = 0.005). Family history of preeclampsia was reported by the case group alone (p = 0.027). Majority (95.0%) of the cases had 3+ proteinuria. Serum homocystine concentration was significantly raised (15.7 ± 8.3 μmol/L) in case group than that in the control group (6.7 ± 1.3 μmol/L) (p < 0.001). Based on the receiver-operator characteristic (ROC) curve, serum homocysteine levels in pregnant women had the best area under the curve (0.975 or 97.5%) with sensitivity and specificity of the predictor variable being 92.5 and 77.5% respectively. Conclusion: The study concluded that homocysteine levels are significantly elevated in patients with preeclampsia compared to the pregnant women without preeclampsia. Homocysteine may be of value in the monitoring of pregnancies to be complicated by preeclampsia. Ibrahim Card Med J 2015; 5 (1&2): 54-60

scholarly journals Association between Serum C-reactive Protein and Pre-eclampsia

2021 ◽  
Vol 15 (2) ◽  
pp. 58-61
Author(s):  
Sanjoy Kumar Das ◽  
Shafeya Khanam ◽  
Rajib Kumar Roy ◽  
Samiya Alam ◽  
Tapan Kumar Roy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Blood Pressures ◽  
Serum Crp

Among the common disorders of pregnancy, Pre-eclampsia is important one which causes significant maternal and perinatal morbidity and mortality. Its incidence is still high in the developing countries. The triad of high blood pressure, edema and albuminuria is neither specific nor sensitive enough; therefore, a reliable biochemical marker is needed to solve the problem. C-reactive protein(CRP), a marker of tissue damage and inflammation, is elevated in serum in overt preeclampsia. The present study is aimed to explore the association of high maternal serum C-reactive protein (CRP) level with preeclampsia and correlation with the severity of pre-eclamptic process. A total of 60 pregnant women constituting 30 pre-eclamptic (case) and 30 normal (control) pregnant women in the third trimester were enrolled in this study. Both the groups were matched for their age, parity and other baseline characteristics. More than three quarters (76.70%) of the case group exhibited raised serum CRP, which was 20% in control group (p=0.001). CRP was elevated about 13 fold higher than that in the normal pregnant women. The mean systolic and diastolic blood pressure were significantly higher in case group (154±12 mm of Hg) vs (107±7 mm of Hg) in control group (p<_0.001) and serum level of CRP bears linear relationship with both systolic and diastolic blood pressures. Preeclamptic women with higher serum CRP level were at a significantly (p<0.001) lower gestational age than control. Twenty two (73.30%) cases had gestational age <37 weeks (p=0.302) and 66.70% control group had gestational age > 37 weeks. The hypothesis of the study was supported by the study findings that maternal CRP concentration was higher in women with preeclampsia and was correlated with disease progression as evidenced by the investigative analysis. Faridpur Med. Coll. J. Jan 2020;15(2): 58-61

scholarly journals The association between serum betahuman Chorionic gonadotropin and Preeclampsia

2015 ◽  
Vol 23 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Zinat Begum ◽  
Iffat Ara ◽  
Shaorin Tanira ◽  
Kashfia Ahmed Keya
Keyword(s):  
Pregnant Women ◽  
Severe Preeclampsia ◽  
Control Group ◽  
Case Group ◽  
Control Groups ◽  
Medical College ◽  
Significant Difference ◽  
Blood Pressures ◽  
The Mean ◽  
And Control

Background: Exact aetiology of this potentially fatal disorder remains poorly understood. A number of theories have been put forward where different biochemical markers have been implicated in the causal association of preeclampsia. This study was intended to find the association between serum b-hCG level and preclampsia Methods: This cross-sectional, case-control study was conducted on 74 pregnant women with preeclampsia (cases) who were admitted in the Eclampsia ward of Dhaka Medical College Hospital, Dhaka between January and July of 2013. A total of 76 normotensive pregnant women were also taken from the Obstetrics & Gynaecology Out-patient Department of the same hospital as control. The study subjects were selected on the basis of predefined eligibility criteria. The serum levels of b-hCG were compared between case and control groups as well as between mild and severe preeclampsia. Result: The case and control groups were almost similar in terms of all the baseline demographic and obstetric characteristics except past history of PET which was significantly higher in the former group than that in the latter group. Majority (97.1%) of the cases had severe hypertension (74.3%) with mean systolic and diastolic blood pressures being 162.6 and 110.8 mmHg respectively. The mean serum ?-hCG was much higher in the case group than that in the control group (p<0.001). The mean serum ?-hCG was the highest in severe preeclampsia and the lowest in the control group, while that in mild preeclampsia lie in between the two (p<0.001). The serum ?-hCG exhibits a significantly linear correlation with systolic and diastolic blood pressures (p<0.001 respectively). Conclusion: There was a significant difference between the ?-hCG level in the preeclamptic women compared to the normotensive pregnant women and the severity of preeclamsia increases with further rise of ?-hCG level. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22701 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 89-93

scholarly journals EFFECTIVENESS OF LAVENDER AROMATHERAPY AND CLASSICAL MUSIC THERAPY IN LOWERING BLOOD PRESSURE IN PREGNANT WOMEN WITH HYPERTENSION

2017 ◽  
Vol 3 (6) ◽  
pp. 750-756
Author(s):  
Sri Maisi ◽  
Suryono Suryono ◽  
Melyana Nurul Widyawati ◽  
Ari Suwondo ◽  
Suryati Kusworowulan
Keyword(s):  
Blood Pressure ◽  
Music Therapy ◽  
Systolic Blood Pressure ◽  
Pregnant Women ◽  
Classical Music ◽  
Combination Group ◽  
Control Group ◽  
P Value ◽  
The Mean ◽  
And Control

Background: Hypertension during pregnancy remains high in Indonesia. It is a major cause of maternal death. Aromatherapy lavender and classical music therapy are considered effective in lowering blood pressure in hypertension.Objective: To examine the effect of lavender aromatherapy and classical music therapy in lowering blood pressure in pregnant women with hypertension.Methods: A quasy experimental study with pretest-posttest control group design. There were 52 pregnant women with the inclusion criteria selected as samples using simple random sampling, divided into lavender aromatherapy group, classical music group, combination of aromatherapy and music group, and control group. Sphygmomanometer was used to measure blood pressure. Mann Whitney and Post Hoc test were used for data analysis.Results: Results showed that four groups have a significant decrease in systolic blood pressure after given intervention with p-value <0.05. The mean decrease of systolic blood pressure among four groups was: lavender group (5.77 mmHg), music group (7.23 mmHg), combination group (9.54 mmHg), and control group (3.67 mmHg); and the mean decrease of diastolic blood pressure was: the lavender group (2.77 mmHg), music group (0.61 mmHg), combination group (8.23 mmHg), and control group (3.42 mmHg).Conclusion: there was a significant effect of lavender aromatherapy and classical music therapy in lowering blood pressure in pregnant women with hypertension. However, the combination of both interventions was more effective than lavender aromatherapy or music therapy alone.

scholarly journals Association of serum neutrophil gelatinase associated lipocalin (NGAL) levels with preeclampsia

2019 ◽  
Vol 8 (2) ◽  
pp. 513
Author(s):  
M. Dhivya ◽  
Chippy Tess Mathew ◽  
G. Jeyachandran
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Correlation Coefficients ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Multiple Organs ◽  
Systemic Disorder ◽  
Neutrophil Gelatinase ◽  
And Control ◽  
Control Study

Background: Preeclampsia is a systemic disorder that affects multiple organs and is characterized by the new onset of hypertension and proteinuria or end-organ dysfunction or both in the second half of pregnancy. NGAL is a 25-KDa protein of the lipocalin family and is considered to be a novel biomarker for ischemic injury. The objective of this study is to compare the levels of serum NGAL in preeclamptic patients and gestational age matched normotensive controls.Methods: The study design is case control study in which pregnant women with preeclampsia (n=40) are selected as cases. Cases were selected from pregnant women attending OG-OPD and IP satisfying the inclusion criteria and not coming under exclusion criteria. 0.5ml of blood was collected in vacutainers and was centrifuged at 3500rpm for 10 minutes. The serum thus separated was aliquoted into smaller plain containers and stored at -20 degree Celsius for analysis. The urine sample was also collected. Controls were also selected from the OP patients.Results: In present study, the serum NGAL ranged from 40-900ng/ml in cases and from 110-795ng/ml in controls. There is no difference in NGAL between cases and control. The correlation coefficients between the NGAL levels and other parameters like maternal age, gestational age, systolic Blood pressure, diastolic Blood pressure, uric acid levels, urine PCR are also not statistically significant.Conclusions: Serum NGAL levels are not significantly elevated in patients with preeclampsia when compared with the normotensive controls and also there is no significant correlation between serum NGAL levels and other assessed parameters.

scholarly journals A Comparative Study of Relationship between Micronutrients and Gestational Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Farideh Akhlaghi ◽  
Seyyed Majid Bagheri ◽  
Omid Rajabi
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Gestational Age ◽  
Control Group ◽  
Study Group ◽  
Inclusion Criteria ◽  
Control Groups ◽  
Significant Difference ◽  
Micronutrient Concentration ◽  
And Control

In this paper, we studied the relation between the micronutrient and gestational diabetes. Therefore, we measured micronutrient concentration including Ni, Al, Cr, Mg, Fe, Zn, Cu, and Se in serum of women with gestational diabetes between 24 and 28 weeks of gestational age (study group) who had inclusion criteria and comparison with micronutrient levels in normal pregnant women with same gestational age (control group). Results showed that there was no significant difference between the serum micronutrient level (Ni, Al, Cr, Mg, Zn, Cu, Se) in study and control groups except serum level of iron which in serum of gestational diabetic women was lower than normal pregnant women and difference was significant.

scholarly journals Risk Factors for premature birth in a hospital

2016 ◽  
Vol 24 (0) ◽  
Author(s):  
Margarita E. Ahumada-Barrios ◽  
German F. Alvarado
Keyword(s):  
Risk Factors ◽  
Prenatal Care ◽  
Pregnant Women ◽  
Premature Birth ◽  
Bivariate Analysis ◽  
Control Group ◽  
Case Group ◽  
Retrospective Case ◽  
History Of ◽  
Inadequate Prenatal Care

Abstract Objective: to determine the risk factors for premature birth. Methods: retrospective case-control study of 600 pregnant women assisted in a hospital, with 298 pregnant women in the case group (who gave birth prematurely <37 weeks) and 302 pregnant women who gave birth to a full-term newborn in the control group. Stata software version 12.2 was used. The Chi-square test was used in bivariate analysis and logistic regression was used in multivariate analysis, from which Odds Ratios (OR) and Confidence Intervals (CI) of 95% were derived. Results: risk factors associated with premature birth were current twin pregnancy (adjusted OR= 2.4; p= 0.02), inadequate prenatal care (< 6 controls) (adjusted OR= 3.2; p <0.001), absent prenatal care (adjusted OR= 3.0; p <0.001), history of premature birth (adjusted OR= 3.7; p <0.001) and preeclampsia (adjusted OR= 1.9; p= 0.005). Conclusion: history of premature birth, preeclampsia, not receiving prenatal care and receiving inadequate prenatal care were risk factors for premature birth.

scholarly journals Lipoprotein (a) level in pre-eclampsia patients

1970 ◽  
Vol 36 (3) ◽  
pp. 97-99 ◽  
Author(s):  
Saila Parvin ◽  
Latifa Samsuddin ◽  
Ahammed Ali ◽  
Safiqul Alam Chowdhury ◽  
Ibrahim Siddique
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
High Serum ◽  
Serum Lipoprotein ◽  
Control Group ◽  
High Serum Level ◽  
Lipoprotein A ◽  
Control Serum ◽  
The Mean ◽  
And Control

This study was carried in BSMMU from July 2001 to June 2003. During the study period, 60 pregnant women were studied. Thirty patients were preeclamptic and thirty were normal healthy pregnant women served as control. Serum lipoprotein(a) was found significantly higher in preeclamptic women 56.63±22.6 mg/dl and found within limit in normal healthy pregnant women, 12.89±4.59mg/dl. Result is statistically highly significant (P<0.001). Mean Systolic Blood Pressure was 163.33±29.63 mmHg and 117.00±11.19mmHg in case and control and Diastolic Blood Pressure was 108.53±14.54 mmHg and 76.00±6.87mmHg respectively in case and control group. Result was highly significant as P <0.001. The mean (±SD) serum lipoprotein(a) concentration in normal pregnancies and preeclampsia were found to be 12.91±4.94 and 56.65±22.62. Moderate Proteinuria was found in 77.5% and severe proteinuria in 22.2% cases of preeclampsia respectively. Regardless of mechanism and pathophysiology of preeclampsia, we found high serum level of lipoprotein (a) in preeclampsia patients. These high levels of lipoprotein (a) significantly correlated with blood pressure and proteinuria. DOI: 10.3329/bmrcb.v36i3.7289Bangladesh Med Res Counc Bull 2010; 36: 97-99

Salivary miRNA-210 involvement in medication-related osteonecrosis of the jaws.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e23052-e23052
Author(s):  
Antonio Picone ◽  
Antonia Marcianó ◽  
Rosanna Dimarco ◽  
Eleonora Miano ◽  
Alessandra Zacchia ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Saliva Sample ◽  
Methylation Status ◽  
Previous History ◽  
Predictor Variable ◽  
Control Group ◽  
Case Group ◽  
Osteonecrosis Of The Jaws ◽  
Health Related ◽  
And Control

e23052 Background: Improved survival rates from cancer have increased the need to understand the health related problems of cancer treatment. Persistent oral health related problems significantly affect patient's quality of life. Medication-related osteonecrosis of the jaws (MR-ONJ) is an oral complication of antiresorptive medications, denosumab and other medications that target angiogenesis for the management of metastatic bone cancer. The purpose of this pilot study, is to investigate, for the first time, microRNAs expression in MR-ONJ. Recent studies reported the miRNA-210 (a specific angiogenic-related miRNA) demethylation in the Osteonecrosis of the Femoral Head. We hypothesized that MiRNA-210 could also be involved in MR-ONJ development. Primary objective of the study is to investigate the role of miRNA-210 in MR-ONJ pathogenesis. Secondary objective is to investigate the feasibility of salivary miRNAs detection as potential non invasive biomarkers for MR-ONJ. Methods: A case-and-control study has been designed. Inclusion criteria are malignant tumors with ongoing treatment or previous history of anti-resorptive or anti-angiogenic medications. The predictor variable is the presence or absence of MR-ONJ. Oral examination and dental x-ray examinations suggestive of MR-ONJ will be performed. Saliva sample will be collected according to the protocol by Navazesh. The methylation status of miRNA-210 will be investigated using quantitative PCR (Q-PCR). Values will be compared between case and control group. Results: The main expected results are to enroll approximatively twenty patients in case group and sixty patients in control group within a one year recruitment period, validate that saliva is a medium for the identification of biomarkers associated with MR-ONJ and confirm the hypothesis that miRNA-210 is involved in MR-ONJ development. Conclusions: Results acquired within this project would represent a contribute to the understanding of the molecular mechanisms driving to the development of MR-ONJ lesions. MiRNA-210 demethylation could serve as a potential therapeutic target for the treatment of MR-ONJ through stimulation of angiogenesis.

scholarly journals Relationship between small for gestational age and aortic intima-media thickness in newborns

2014 ◽  
Vol 54 (1) ◽  
pp. 57 ◽  
Author(s):  
Ahmad Bayu Alfarizi ◽  
Ria Nova ◽  
Julniar Mawardi Tasli ◽  
Theodorus Theodorus
Keyword(s):  
Gestational Age ◽  
Small For Gestational Age ◽  
Intima Media Thickness ◽  
Control Group ◽  
Case Group ◽  
Media Thickness ◽  
And Control ◽  
Aortic Intima ◽  
The Relationship ◽  
Control Study

Background Small for gestational age (SGA) has been associatedwith adult cardiovascular disease. Small for gestational agenewborns may undergo early aortic wall intima-media thickening(aIMT) in utero.Objective To determine the relationship between SGA as a riskfactor for increased aIMT, as a sign of atherosclerosis onset.Methods We conducted a case-control study in the Neonatal Wardand Rooming-in Nursery at Dr. Mohammad Hoesin Hospital,Palembang, between April to June 2012. Subjects were allocatedto either the case group (aIMT 2: 0.9 mm) or to the controlgroup (aIMT <0.9 mm). Newborns were classified as SGA iftheir birthweight (BW) was < l O'h percentile, and appropriatefor gestational age (AGA) if their BW was between lQth - 90'hpercentile, according to the Lubchenco curve. Abdominal aorticintima-media thickness was measured by echocardiographyexamination.Results The case and control groups consisted of 30 n ewbornseach. The proportion of SGA newborns was higher in the casegroup than the control group. The likelihood of infants in the casegroup being SGA was significantly higher compared to the controlgroup, with odds ratio of 10.8 (95%CI 3,26 to 35, 72) . The meanaIMT was significantly higher in SGA than in AGA infants, 0.9(SD 0.16) mm vs. 0.8 (SD 0.13) mm, respectively, with a meandifference of 0, 13 (9 5% CI 0, 050 to 0,209 mm; P"" 0,02).Conclusion Increased aIMT is more likely found in SGA newborns.

scholarly journals Factors of Incidence of Hypertension in Southwest Sumba

2020 ◽  
Vol 2 (2) ◽  
pp. 86-96
Author(s):  
Apliana Lupu Kaka ◽  
Johny A.R Salmun ◽  
Agus Setyo Budi
Keyword(s):  
Blood Pressure ◽  
Case Control ◽  
Smoking Habits ◽  
Observational Research ◽  
Control Group ◽  
Case Group ◽  
A Value ◽  
Control Research ◽  
And Control ◽  
The Relationship

Hypertension in conditions when blood pressure is at a value of 130/80 mmHg or more with the number of cases experiencing an increase from 2016-2018, Tana Mete Village, Kodi Balaghar District. in 2016 there were 880 (8.8%), cases in 2017 were 2,580 (25.8%) cases and in 2018 there were 3. 410 (34.1%) cases. Hypertension in influenced by factors of age, smoking habits, stress, and alcohol consumption. This study aims to analyze the relationship between age, smoking habits, stress, and alcohol comsuption. This research is an analytic observational research with a case control research design. The number of cases in Tana Mete Village, Kodi Balaghar District, Southwest Sumba Regency was 220 (22%) and the sample was 80 respondents and divided into two groups, namely the case and control group, the case group was 40 respondents and the control group was 40 respondents. These variables have been analyzed univariately and bivariately, the results of this study incidate that there are three risk factor variables for the incidence of hypertentsion. Namely age with a value p= 0.003, OR=4.059 (95% CI: 1.568-10.510), smoking habits with a value p=0.001, OR: 6.378 (95%CI:2.280-17.842), stress with a value of p=0.014, OR: 3.095 (95%CI: 3.095-7.706) while the variable alcohol comsumption has no relationship with the value of p=0.133. To prevent the occurrence of hypertension, the activities undertaken include avoiding smoking, stress and taking time for recreation.

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