scholarly journals Prevalence of Congenital Cytomegalovirus Infection Among Hospitalized Neonates in Tehran, Iran

2020 ◽  
Keyword(s):  
Late Onset ◽  
Congenital Infection ◽  
Cross Sectional Study ◽  
Limited Data ◽  
Cmv Infection ◽  
Cross Sectional ◽  
Congenital Cytomegalovirus ◽  
Diagnostic Values ◽  
Guthrie Cards ◽  
Urine Specimens

Background: Cytomegalovirus (CMV) can vertically transmit from infected mothers to fetuses and causes congenital infection in newborns. Unfortunately, there have been limited data available on the prevalence of congenital CMV (cCMV) infection among Iranian neonates at higher risk of infection. Objectives: The current study aimed to assess the prevalence of cCMV infection among hospitalized neonates in Tehran, Iran, and investigate the diagnostic values of CMV polymerase chain reaction (PCR) on Guthrie cards in comparison to those reported for urine specimens. Methods: This cross-sectional study was carried out on the hospitalized neonates with 3 weeks of age. The urine specimens and Guthrie cards were taken from each eligible newborn. Total nucleic acid was extracted from the samples and tested by PCR for the presence of CMV deoxyribonucleic acid. The cCMV infection was confirmed in the newborns, and the infected neonates underwent further evaluation. Results: Out of 224 newborns, CMV infection was identified in 11 neonates (4.9%). There were no factors in association with cCMV infection. The sensitivity and specificity of dried blood spot (DBS) samples for the identification of newborns with cCMV infection were 90% and 99%, respectively. Conclusions: A significant number of hospitalized neonates in the present study were infected with cCMV infection. The results of the current study revealed that Guthrie cards had adequate sensitivity for the identification of CMV infection in the hospitalized newborns. Since symptomatic newborns with cCMV infection have a higher chance for the development of early- or late-onset sequelae of infection, it is recommended to diagnose and treat this group of newborns.

Neonatal screening for congenital cytomegalovirus infection in Tehran, Iran, using Guthrie cards

2020 ◽  
Author(s):  
Samileh Noorbakhsh ◽  
Mohammad Farhadi ◽  
Faezeh Haghighi ◽  
Sara Minaeian ◽  
Morteza Haghighi Hasanabad
Keyword(s):  
Early Stage ◽  
Limited Data ◽  
Cmv Infection ◽  
Congenital Cytomegalovirus ◽  
Congenital Cmv Infection ◽  
Effective Counseling ◽  
Total Dna ◽  
Guthrie Cards ◽  
Congenital Cmv

Background and Objectives: Cytomegalovirus (CMV) constitutes the most common viral cause of congenital infections in newborns worldwide. There are a significant number of asymptomatic newborns with congenital CMV infection in Iran, which may develop long-term sequelae of infection. Unfortunately, limited data exsists from Iran on the rate of congenital CMV infection among neonates. The current study was aimed to investigate the prevalence of congenital CMV infection among Iranian neonates by testing Guthrie cards. Materials and Methods: Guthrie cards were collected from infants within 2 weeks of life, and total DNA was extracted from samples by thermal shock and evaluated for CMV DNA using nested-PCR assay. CMV infection in newborns was confirmed through a commercial CMV PCR kit. Infected infants underwent further evaluation at the hospital. Results: CMV infection was identified in four of 1174 infants (0.34%) which is approximately 3 cases per 1000 live births. Infected infants were asymptomatic at birth and had a normal hearing status similar to other children. There were no factors in relation with CMV infection among newborns. Conclusion: According to the results of this study, infected infants with congenital CMV infection could identify at early stage by testing Guthrie cards (within 21 days of life). Furthermore, since there is a lack of CMV knowledge in our popula- tion, educating and effective counseling by obstetricians/ gynecologists to the pregnant women are recommended.  

scholarly journals High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland

2016 ◽  
Vol 65 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Joanna Siennicka ◽  
Milena Dunal-Szczepaniak ◽  
Agnieszka Trzcińska ◽  
Paulina Godzik ◽  
Magdalena Rosińska
Keyword(s):  
Secondary Infection ◽  
Demographic Data ◽  
Congenital Infection ◽  
Cross Sectional Study ◽  
High Seroprevalence ◽  
Childbearing Age ◽  
Congenital Cytomegalovirus Infection ◽  
Cross Sectional ◽  
Congenital Cytomegalovirus ◽  
Age Dependent

Cytomegaloviruses are common worldwide, with variable frequency of infections. The infection in pregnancy may lead to pregnancy loss or serious sequelae for the child. To understand the risk posed by CMV in Poland we conducted cross-sectional study on women aged 15–49 basing on existing serum bank. Age dependent CMV incidence, the rates of congenital infection and sequelae were modelled from sero-prevalence, literature and demographic data. The overall anti-CMV IgG prevalence was 81.9% increasing from 74.3% in < 30 years old to 94.3% in subjects 45+ years old. The lowest incidence was estimated at the age of 15 and the highest at the age 34 (3.8 and 8.95 respectively/100 women/year). The estimated rate of cCMV varies from 22.4 to 37.2 per 1000 live birth depending on the assumptions made. The proportion of cases due to secondary infection ranged from 34.8% to 49.9% accordingly.

Knowledge and Hygiene Practices of Pregnant Women Regarding CMV Infection

2021 ◽  
Vol 6 (11) ◽  
pp. 39-42
Author(s):  
Sena Ceren Tatar ◽  
Ayse Filiz Gokmen Karasu ◽  
Sebnem Alanya Tosun
Keyword(s):  
Young Children ◽  
Pregnant Women ◽  
Employment Status ◽  
Health Workers ◽  
Congenital Infection ◽  
Cross Sectional Study ◽  
Cmv Infection ◽  
Cross Sectional ◽  
Number Of Children ◽  
Behavioral Score

Aim: Cytomegalovirus (CMV) is a herpes virus and a common pathogen responsible for congenital infection in 4-23% of all newborns. The objective of this study was to assess the pregnant women’s knowledge of CMV infection and to investigate their hygienic practices when attending to their young children. Material and Method: This study was carried out at Bezmialem Vakif University Medical Faculty obstetric outpatient clinic. Inclusion criteria were pregnant women 1) who were able to communicate in Turkish, 2) who had at least one child < 5 years of age. We excluded pregnant participants who were health workers. Participants were approached by a medical college student and informed about the study. After giving consent they were asked to fill out a questionnaire which included demographic questions, knowledge questions regarding CMV infection and questions regarding hygienic practices when giving care to their young children. The questionnaires were collected and a total behavioral score was calculated taking into account positive and negative hygienic practices. Results: A total of two hundred and twenty five participants were involved in the survey. Only 86 (38.2%) of the participants in our study had heard of congenital CMV infection. CMV awareness was correlated with having higher education (p:0.02) and employment status (p=0.03). The behavioral score was not correlated with age (p=0.98), educational attainment ( p=0.11), employment status (p=0.9) or number of children, (p=0.87). Conclusion: In this cross sectional study we have shown that CMV infection knowledge of mothers is low and that they do not adhere to adequate sanitation measures. Strategies to raise awareness and initiating education programs are necessary as further action.

Prevalence of COVID-19-like Symptoms among People Living with HIV, and Using Antiretroviral Therapy for Prevention and Treatment

2020 ◽  
Vol 18 (5) ◽  
pp. 373-380 ◽  
Author(s):  
SeyedAhmad SeyedAlinaghi ◽  
Maryam Ghadimi ◽  
Mahboubeh Hajiabdolbaghi ◽  
Mehrnaz Rasoolinejad ◽  
Ladan Abbasian ◽  
...  
Keyword(s):  
Respiratory Symptoms ◽  
Antiretroviral Treatment ◽  
Clinical Symptoms ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Shortness Of Breath ◽  
Sectional Study ◽  
Limited Data ◽  
Cross Sectional ◽  
Living With Hiv

Background: COVID-19 has spread globally with remarkable speed, and currently, there is limited data available exploring any aspect of the intersection between HIV and SARSCoV- 2 co-infection. Objective: To estimate the prevalence of clinical symptoms associated with COVID-19 among people living with HIV (PLWH) in Tehran, Iran. Design: Cross-sectional study. Methods: A total of 200 PLWH were recruited through the positive club via sampling, and completed the symptom-based questionnaire for COVID-19, which was delivered by trained peers. Results: Of 200 participants, respiratory symptoms, including cough, sputum, and shortness of breath, were the most prevalent among participants, but only one person developed symptoms collectively suggested COVID-19 and sought treatments. Conclusions: It appears that existing infection with HIV or receiving antiretroviral treatment (ART) might reduce the susceptibility to the infection with SARS-CoV-2 or decrease the severity of the infection acquired. Further research is needed to understand causal mechanisms.

scholarly journals PARE0006 WORK PRODUCTIVITY LOSS IN PATIENTS WITH INFLAMMATORY ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1289.2-1289
Author(s):  
T. Pilgaard ◽  
B. A. Esbensen ◽  
S. E. Stallknecht
Keyword(s):  
Inflammatory Arthritis ◽  
Productivity Loss ◽  
Work Productivity ◽  
Cross Sectional Study ◽  
Work Hours ◽  
Limited Data ◽  
Cross Sectional ◽  
Lower Productivity ◽  
Patient Reported ◽  
Hours Of Work

Background:Limited data exist of work productivity loss in patients with Rheumatoid Arthritis (RA), Psoreatic Arthritis (PsA) and Spondyloarthritis (axSpA).Objectives:The objective of this research was to assess productivity loss and absenteeism in patients with RA, PsA and axSpA.Methods:The study was designed as a cross-sectional study aimed to collect patient-reported outcomes from patients with RA, PsA and axSpA in Denmark via a nurse administered questionnaires and patient journals. Patients ≥18 years with RA, PsA or axSpA were consecutively recruited for the study over a 6-month period via routine visits to outpatient rheumatology clinics. Descriptive statistics were analyzed using SAS.Results:Of 488 respondents, 62% were women and mean age was 53.5 years (RA:57.4; PsA:52.6; axSpA:43.6). Average time since diagnosis was 11-15 years, however, for PsA and axSpA most patients answered 6-10 and 0-5 years, respectively. 280 (57%) answered that they had a job and completed the WPAI questionnaire (RA: 149 (51%); PsA: 48 (56%); axSpA: 83 (75%)). Average work hours was 31.9 in the last week (RA:31.2; PsA:33; axSpA:32.4). Average missed work hours were 4.3 in the last 7 days ((RA:4.0; PsA:4.2; axSpA:4.8), of which 32% was missed due to their inflammatory arthritis (RA:30%; PsA:38%; axSpA:32%). Mean absenteeism was highest for patients with PsA (mean=6.8; SD=17.7) followed by patients with axSpA (mean=5.4; SD=15.1) and with RA (mean=3.4; SD=12.2). Mean productivity loss was 20.5 (SD=23.8) for patients with RA, 27.6 (SD=25.8) for PsA and 26.3 (SD=25.8) for axSpAConclusion:We found that patients with PsA or axSpA miss more hours of work compared with patients with RA and when they are at work they have a higher absenteeism/lower productivity. This even though that both the group of patients with PsA and the axSpA were younger and had lived less time with their diagnosed disease compared with the group with RA.Disclosure of Interests:Trine Pilgaard Shareholder of: Pfizer, Employee of: Pfizer, Bente Appel Esbensen: None declared, Sandra Elkjær Stallknecht Consultant of: Pfizer

scholarly journals The pattern of thyroiditis in multiple sclerosis: a cross-sectional study in a tertiary care hospital in Egypt

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Nearmeen M. Rashad ◽  
Marwa G. Amer ◽  
Waleed M. Reda Ashour ◽  
Hassan M. Hassanin
Keyword(s):  
Multiple Sclerosis ◽  
Interferon Beta ◽  
Demyelinating Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Sectional Study ◽  
Cmv Infection ◽  
Cross Sectional ◽  
Disease Modifying Drugs

Abstract Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with varied clinical features. Disease-modifying drugs (DMDs) of MS associated with different types of thyroiditis. In this cross-sectional study, we aimed to assess the prevalence of thyroid dysfunction in MS and to investigate the association between DMDs and the risk of thyroiditis in MS. A cross-sectional study included 100 patients with relapsing-remitting multiple sclerosis (RRMS) in relapse, and the diagnosed was according to revised McDonald’s criteria 2010. Results Our results revealed that the prevalence of thyroiditis was 40%; autoimmune (34%) and infective (6%) among patients with RRMS in relapse and cerebellar symptoms were significantly higher in patients with thyroiditis compared to patients without thyroiditis. Regarding the association between DMDs and thyroiditis, the prevalence of patients treated with interferon-beta-1b was higher in MS patients with thyroiditis compared to MS patients without thyroiditis. However, the prevalence of patients treated with interferon-beta-1a was lower in MS patients with thyroiditis compared to MS patients without thyroiditis. In addition, we found CMV infection was more common in patients treated by interferon beta-1b and candida infection was common in patients treated by fingolimod. Conclusions Thyroiditis is commonly observed in patients with RRMS in relapse and higher prevalence of patients treated with interferon-beta-1b which is commonly associated with thyroiditis and CMV infection; however, candida thyroid infection was common in MS patients treated by fingolimod.

Omentin-1 and diabetic foot

2022 ◽  
pp. 153473462110698
Author(s):  
Tsvetan Gatev ◽  
Viktoriya Byalkova ◽  
Ivan Poromanski ◽  
Tsvetelina Velikova ◽  
Dobrin Vassilev ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Metabolic Disorders ◽  
Bioelectrical Impedance ◽  
Cross Sectional Study ◽  
Limited Data ◽  
Elisa Method ◽  
Cross Sectional ◽  
Diabetic Foot Disease ◽  
Foot Disease

Introduction: Diabetic foot disease is an advanced complication of diabetes mellitus, which is associated with severe invalidization and high mortality rate among affected people. Many factors are involved in its pathogenesis but not all of them are fully elucidated. Objectives: Adipose tissue and its hormones – adipokines, are related to diabetic complications and metabolic disorders. Until now, there are limited data on their role in diabetic foot. The aim of this cross-sectional study is to determine the levels of the adipokine omentin-1 in people with and without diabetic foot disease and to look for its potential involvement in this complication. Methods: Eighty patients with type 2 diabetes and mean age of 60.8±10.5 years were included in this study. They were divided into two groups: with (n=36) and without (n=44) diabetic foot disease. Standard antrometric, clinical and laboratory tests were made. Body composition was analyzed by bioelectrical impedance based device. Serum omentin-1 was measured using ELISA method. Results: Levels of omentin-1 were significantly higher among people with diabetic foot disease (700.2±345.1 ng/ml), compared to the other group (560.2±176.7 ng/ml). This difference remained significant even after adjusting for potential confounders. In a regression model omentin-1 proved its predictive value for development of diabetic foot. Conclusion: Adipokines, and particularly omentin-1, might be included in the pathogenesis of diabetic foot disease.

Echocardiography and Laboratory Factors Associated With Prolonged Postoperative Pericardial Effusion

2022 ◽  
pp. 875647932110702
Author(s):  
Rrezarta Alihajdaraj ◽  
Adem Grbolar ◽  
Xhevdet Krasniqi ◽  
Tefik Bekteshi ◽  
Aurora Bakalli
Keyword(s):  
Pericardial Effusion ◽  
Statistical Significance ◽  
Artery Bypass ◽  
Global Longitudinal Strain ◽  
Cross Sectional Study ◽  
Left Ventricular ◽  
Limited Data ◽  
Cross Sectional ◽  
Frequent Finding

Objective: Pericardial effusion is a frequent finding in patients who undergo cardiac surgery. There are currently limited data providing information regarding the factors that may contribute to postoperative pericarditis. The aim was to evaluate laboratory and echocardiographic features that may influence the presence of pericardial effusion 6 to 8 weeks following coronary artery bypass grafting (CABG). Materials and Methods: This was a prospective cross-sectional study that included 90 patients after CABG operation who were divided into two groups. A total of 32 (35.56%) patients with pericardial effusion on follow-up echocardiography formed the first group and 58 patients without pericardial effusion the second group, which were compared in respect to components that were taken prior to the operation. Results: The groups did not differ regarding sex (males 65.62% vs 63.79%, P = .86) or age (59.59 ± 9.29 vs 61.69 ± 10.71, P = .35). Platelet count (184.74 ± 58.79 vs 222.62 ± 88.97, P = .03) and left ventricular (LV) global longitudinal strain (GLS) (−14.64 ± 6.86 vs −16.96 ± 4.1, P = .04) demonstrated statistical significance. Conclusion: Prolonged postoperative pericardial effusion in small amounts may be found in patients, with preoperative lower thrombocyte count and LV GLS, which could be possible predisposing factors.

Admixture analysis of age at onset in older patients with schizophrenia spectrum disorders

2020 ◽  
Vol 32 (6) ◽  
pp. 781-785
Author(s):  
Maureen M. J. Smeets-Janssen ◽  
Idan M. Aderka ◽  
Paul D. Meesters ◽  
Sjors Lange ◽  
Sigfried Schouws ◽  
...  
Keyword(s):  
Late Onset ◽  
Age At Onset ◽  
Cross Sectional Study ◽  
Data Driven ◽  
Admixture Analysis ◽  
Schizophrenia Spectrum Disorders ◽  
Sectional Study ◽  
Cross Sectional ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders

ABSTRACTThe nature of schizophrenia spectrum disorders with an onset in middle or late adulthood remains controversial. The aim of our study was to determine in patients aged 60 and older if clinically relevant subtypes based on age at onset can be distinguished, using admixture analysis, a data-driven technique. We conducted a cross-sectional study in 94 patients aged 60 and older with a diagnosis of schizophrenia or schizoaffective disorder. Admixture analysis was used to determine if the distribution of age at onset in this cohort was consistent with one or more populations of origin and to determine cut-offs for age at onset groups, if more than one population could be identified. Results showed that admixture analysis based on age at onset demonstrated only one normally distributed population. Our results suggest that in older schizophrenia patients, early- and late-onset ages form a continuum.

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