Omentin-1 and diabetic foot

2022 ◽  
pp. 153473462110698
Author(s):  
Tsvetan Gatev ◽  
Viktoriya Byalkova ◽  
Ivan Poromanski ◽  
Tsvetelina Velikova ◽  
Dobrin Vassilev ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Metabolic Disorders ◽  
Bioelectrical Impedance ◽  
Cross Sectional Study ◽  
Limited Data ◽  
Elisa Method ◽  
Cross Sectional ◽  
Diabetic Foot Disease ◽  
Foot Disease

Introduction: Diabetic foot disease is an advanced complication of diabetes mellitus, which is associated with severe invalidization and high mortality rate among affected people. Many factors are involved in its pathogenesis but not all of them are fully elucidated. Objectives: Adipose tissue and its hormones – adipokines, are related to diabetic complications and metabolic disorders. Until now, there are limited data on their role in diabetic foot. The aim of this cross-sectional study is to determine the levels of the adipokine omentin-1 in people with and without diabetic foot disease and to look for its potential involvement in this complication. Methods: Eighty patients with type 2 diabetes and mean age of 60.8±10.5 years were included in this study. They were divided into two groups: with (n=36) and without (n=44) diabetic foot disease. Standard antrometric, clinical and laboratory tests were made. Body composition was analyzed by bioelectrical impedance based device. Serum omentin-1 was measured using ELISA method. Results: Levels of omentin-1 were significantly higher among people with diabetic foot disease (700.2±345.1 ng/ml), compared to the other group (560.2±176.7 ng/ml). This difference remained significant even after adjusting for potential confounders. In a regression model omentin-1 proved its predictive value for development of diabetic foot. Conclusion: Adipokines, and particularly omentin-1, might be included in the pathogenesis of diabetic foot disease.

scholarly journals Short screening for diabetic foot disease in an omani population at Al-Dahira, Sultanate of Oman: A cross-sectional study

2021 ◽  
Vol 9 (1) ◽  
pp. 16
Author(s):  
SabriaA L Marshoudi ◽  
Fatma Ahmed ◽  
SyedWali Peeran ◽  
Amru AlBurji ◽  
Khalid Al-Kalbani ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Cross Sectional Study ◽  
Sultanate Of Oman ◽  
Sectional Study ◽  
Cross Sectional ◽  
Diabetic Foot Disease ◽  
Foot Disease

The values of cardio-ankle vascular and ankle-brachial indices in patients with carbohydrate metabolic disorders: The ESSE-RF study in the Kemerovo Region

2016 ◽  
Vol 88 (12) ◽  
pp. 11-20 ◽  
Author(s):  
A N Sumin ◽  
N A Bezdenezhnykh ◽  
N V Fedorova ◽  
A V Shcheglova ◽  
E V Indukaeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Metabolic Disorders ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated ◽  
The Russian Federation ◽  
Peripheral Arterial

Aim. To investigate factors associated with pathological cardio-ankle vascular and ankle-brachial indices (CAVI and ABI) in patients with carbohydrate metabolic disorders (CMD). Subjects and methods. A cross-sectional study was conducted in the framework of the multicenter epidemiological study “Epidemiology of Cardiovascular Diseases and Their Risk Factors in the Russian Federation” (ESSE-RF) in March to October 2013. The standard ESSE-RF protocol was extended by an additional study of peripheral arterial stiffness, by estimating CAVI and ABI automatically. A sample of 1619 people was formed in several stages, in which 311 patients with type 2 diabetes mellitus and prediabetes were identified and divided into 3 groups: 1) 41 patients with pathological CAVI values (≥9.0); 2) 241 with normal CAVI (

scholarly journals Benefits of Hydrocolloid-Absorbent Dressings in “Diabetic Foot” Therapy

2020 ◽  
Vol 25 (2) ◽  
pp. 22-25
Author(s):  
Denisa Tănăsescu
Keyword(s):  
Diabetic Foot ◽  
Conservative Therapy ◽  
Therapeutic Option ◽  
Therapeutic Education ◽  
Varicose Ulcer ◽  
Patients With Diabetes ◽  
Diabetic Foot Disease ◽  
Foot Disease ◽  
The Right

AbstractThe incidence of diabetes is constantly increasing, so in 2014 about 8, 5% of adults over the age of 18 had diabetes worldwide. Also mortality in patients with diabetes is increased, only in 2015 being the direct cause for 1.6 million deaths worldwide. Worldwide, there are currently 425 million people living with diabetes; by 2045, 629 million people are expected to have diabetes. The authors present the case of patient I.A. 46 years old, male, from urban area, known with type 2 diabetes mellitus insulinotreated, secondary to acute pancreatitis, necrotico-haemorrhagic, operated on antecedents, which is presented in our service accusing spontaneous sensitivity and palpation of the lower limb right, premaleolar ulceration on the inner face of the lower right limb, with Celsian signs at this level, paresthesias at the level of the right leg, muscular weakness, weight loss. Alternative absorbent-hydrocolloid therapy is a feasible therapeutic option for patients with varicose ulcer wounds, especially in those with diabetic background. The combination of targeted antibiotic therapy, systemic treatment, local surgical treatment followed by local colloidal-absorbent treatment has very good results in a much shorter time than conventional, conservative therapy. Prophylaxis of any “diabetic foot” disease is extremely important. Therapeutic education is a major role in preventing the complications of diabetes. The diabetic patient should be trained and learned in order to prevent problems that may occur in the foot.

scholarly journals Diabetic Foot Care Practice and its Associated Factors among Type 2 Diabetes Mellitus Patients Attending Primary Health Clinics in Kuantan, Malaysia: A Cross Sectional Study

2020 ◽  
Vol 19 (2) ◽  
Author(s):  
Azmi NH ◽  
Abdul Hadi A ◽  
Md Aris MA ◽  
Nasreen HE ◽  
Che-Ahmad A
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Cross Sectional Study ◽  
Care Practice ◽  
Sectional Study ◽  
Foot Care ◽  
Cross Sectional ◽  
Health Clinics ◽  
Primary Health

  INTRODUCTION: One of the most important and debilitating complication of diabetes mellitus is foot problem such as ulcers, infections and amputations. However, these complications are preventable by simple intervention such as regular foot care practice. This study aims to assess the foot care practice and its associated factors among type 2 diabetes mellitus patients attending primary health clinics in Kuantan. MATERIALS AND METHODS: This was a cross-sectional study conducted at four primary health clinics in Kuantan involving 450 study participants who were selected by using universal sampling method. Level of awareness and practice toward diabetic foot care was assessed using validated self-administered questionnaire. Multiple logistic regressions were performed to identify factors associated with poor foot care practice among the respondents. RESULTS: About 59.6% of respondents had poor foot care practice and 50.9% had poor awareness level. Multivariate logistic regression analysis identified that, increasing age (OR  0.97, 95% CI: 0.955-0.993) and good awareness towards foot problem (OR  0.43, 95%CI: 0.289-0.643) were less likely to have poor foot care practice. However, Malay ethnicity (OR 1.81, 95% CI: 1.002-3.271) and obesity (OR  1.9, 95% CI: 1.225-2.976) were associated with poor foot care practice after controlling other variables. CONCLUSION: Majority of the respondents had poor foot care practice and poor awareness. Respondents who are older and have better awareness are less likely to have poor foot care practice. Diabetic patients who are Malays and/or obese are predicted to have poor diabetic foot practice and hence must be prioritized for a sustainable patient education and compliance towards foot care practice at primary care level. 

scholarly journals Awareness of diabetic foot disease among patients with diabetes mellitus in Al-Ahsa Saudi Arabia

2021 ◽  
Vol 8 (12) ◽  
pp. 3506
Author(s):  
Abdulaziz S. Aldhafar ◽  
Mohamed Abdullah ◽  
Abdulaziz K. Althafar
Keyword(s):  
Diabetes Mellitus ◽  
Saudi Arabia ◽  
Diabetic Foot ◽  
Diabetic Patients ◽  
Foot Care ◽  
Cross Sectional ◽  
Attitude And Practice ◽  
Diabetic Foot Disease ◽  
Foot Disease ◽  
Knowledge Attitude And Practice

Background: The prevalence of diabetes mellitus (DM) in Saudi Arabia is 18.3% in 2020. One of the most common complications that affects diabetic patients is diabetic foot disease (DFD). Patient education is the most effective way to reduce the complications of DFD.Methods: A cross-sectional study was conducted in the period from January to May 2021. A pretested standardized questionnaire was used to collect information upon knowledge, attitude and practice toward diabetic foot care. Data entry was performed using SPSS.Results: The responses of 480 of which 294 male and 186 female, 41.6% have high school degree, 19.3% have bachelor’s degree and 2.2% have master or Ph. D. degree. The mean age of the respondents was 47 years. The 58% of the participant agreed that they might develop reduce flow to their feet. half of the participant were not aware that smoking can reduce blood flow in their feet. There were only 2.3% of the respondents attended a class on how to care of the foot. Participants who received information about foot care from a nurse and physician were 23% and 9.2% respectively. The 97.5% of the participant would like to know how to care for their foot. 75.8% of participants walk barefoot and 42.2% use a comfortable coated shoe.  Conclusions: Participants have inadequate knowledge, attitude and practice about DFD. providing a structured educational program about diabetic foot care has significant impact on diabetic patient to improve their knowledge and practices and to motivate them to have a positive attitude toward diabetic foot care.

scholarly journals Metabolic Disorders in HIV-Infected Adolescents Receiving Protease Inhibitors

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Jeerunda Santiprabhob ◽  
Surapong Tanchaweng ◽  
Sirinoot Maturapat ◽  
Alan Maleesatharn ◽  
Watcharee Lermankul ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Metabolic Disorders ◽  
Tolerance Test ◽  
Cross Sectional Study ◽  
Oral Glucose ◽  
Cross Sectional ◽  
Abnormal Glucose Metabolism ◽  
Asian Adolescents ◽  
Abnormal Lipid Metabolism

Protease inhibitor (PI) may cause abnormal glucose metabolism, abnormal lipid metabolism, and metabolic syndrome in HIV-infected adults but less well studied in Asian adolescents. This cross-sectional study evaluated anthropometric factors, oral glucose tolerance test, and lipid profiles of perinatally HIV-infected Thai adolescents who had received PI-based antiretroviral therapy for at least 6 months. Eighty adolescents were enrolled [median (IQR) age 16.7 (14.6–18.0) years, 42 males]. Metabolic syndrome, prediabetes, and type 2 diabetes mellitus (T2DM) were found in 8 (10%), 17 (22.1%), and 3 (3.8%) adolescents, respectively. Dyslipidemia was found in 56 (70%) adolescents, with hypertriglyceridemia being the most common type. In multivariate analysis, presence of lipohypertrophy (OR: 25.7, 95% CI: 3.2–202.8;p=0.002) and longer duration of PI use (OR: 1.04, 95% CI: 1.00–1.08;p=0.023) were associated with metabolic syndrome. Obesity (OR: 7.71, 95% CI: 1.36–43.7;p=0.021), presence of lipohypertrophy (OR: 62.9, 95% CI: 4.97–795.6;p=0.001), and exposure to stavudine for ≥6 months (OR: 8.18, 95% CI: 1.37–48.7;p=0.021) were associated with prediabetes/T2DM, while exposure to tenofovir for ≥6 months reduced the risk (OR: 0.17, 95% CI: 0.04–0.78;p=0.022). Metabolic disorders were commonly found in adolescents receiving PI. Careful monitoring and early intervention to modify cardiovascular risk should be systematically implemented in this population particularly those with exposure to stavudine.

scholarly journals Comorbidities and laboratory parameters associated with SARS-CoV-2 infection severity in patients from the southeast of Mexico: a cross-sectional study

F1000Research ◽  
2022 ◽  
Vol 11 ◽  
pp. 10
Author(s):  
Eduardo De la Cruz-Cano ◽  
Cristina del C Jiménez–González ◽  
José A Díaz-Gandarilla ◽  
Carlos J López–Victorio ◽  
Adelma Escobar-Ramírez ◽  
...  
Keyword(s):  
Categorical Data ◽  
Metabolic Disorders ◽  
Invasive Mechanical Ventilation ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Laboratory Parameters ◽  
Reactive Protein

Background. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the etiological agent of the coronavirus disease 2019 (COVID-19) pandemic. Among the risk factors associated with the severity of this disease is the presence of several metabolic disorders. For this reason, the aim of this research was to identify the comorbidities and laboratory parameters among COVID-19 patients admitted to the intensive care unit (ICU), comparing the patients who required invasive mechanical ventilation (IMV) with those who did not require IMV, in order to determine the clinical characteristics associated with the COVID-19 severity. Methods. We carried out a cross-sectional study among 152 patients who were admitted to the ICU from April 1st to July 31st, 2021, in whom the comorbidities and laboratory parameters associated with the SARS-CoV-2 infection severity were identified. The data of these patients was grouped into two main groups: “patients who required IMV” and “patients who did not require IMV”. The nonparametric Mann–Whitney U test for continuous data and the χ2 test for categorical data were used to compare the variables between both groups. Results. Of the 152 COVID-19 patients who were admitted to the ICU, 66 required IMV and 86 did not require IMV. Regarding the comorbidities found in these patients, a higher prevalence of type 2 diabetes mellitus (T2DM), hypertension and obesity was observed among patients who required IMV vs. those who did not require IMV (p<0.05). Concerning laboratory parameters, only glucose, Interleukin 6 (IL-6), lactate dehydrogenase (LDH) and C-reactive protein (CRP) were significantly higher among patients who required IMV than in those who did not require IMV (p<0.05). Conclusion. This study performed in a Mexican population indicates that comorbidities such as: T2DM, hypertension and obesity, as well as elevated levels of glucose, IL-6, LDH and CRP are associated with the COVID-19 severity.

scholarly journals Associations of health literacy with risk factors for diabetic foot disease: a cross-sectional analysis of the Southern Tasmanian Health Literacy and Foot Ulcer Development in Diabetes Mellitus Study

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e025349 ◽  
Author(s):  
Pamela Chen ◽  
Michele Callisaya ◽  
Karen Wills ◽  
Tim Greenaway ◽  
Tania Winzenberg
Keyword(s):  
Risk Factors ◽  
Health Literacy ◽  
Diabetic Foot ◽  
Short Form ◽  
Functional Health ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Diabetic Foot Disease ◽  
Foot Disease ◽  
Sectional Analysis

ObjectivesPoor health literacy (HL) is associated with poorer health outcomes in diabetes but little is known about its effects on foot disease. This study was aimed to determine the associations between HL and diabetic foot disease.DesignThis is a cross-sectional analysis of baseline data from a prospective study of foot disease.SettingAttendees of the Royal Hobart Hospital’s Diabetes outpatient clinics.Participants222 people with type 1 or type 2 diabetes aged >40 years and without a history of foot disease, psychotic disorders or dementia.MeasuresOutcomes were peripheral neuropathy, peripheral arterial disease and foot deformity according to published guidelines. The exposure, HL, was measured using the short form Test of Functional Health Literacy in Adults (S-TOFHLA) and the Health Literacy Questionnaire (HLQ). Covariates included demographic characteristics, medical history, psychological measures and foot care behaviour.ResultsOf 222 participants, 204 had adequate HL. (Mean (SD) S-TOFHLA scores were 31.9 (6.7)), mean(SD) HLQ scores were 134.4 (18.4)). In univariable but not multivariable analyses, higher S-TOFHLA scores were associated with lower overall risk for foot disease (OR 0.96, 95% CI 0.93 to 0.99) and loss of protective sensation (OR 0.95, 95% CI 0.91 to 0.995).ConclusionsThese data provide little support for clinically important impacts of HL on risk factors for diabetic foot disease. However, in the absence of longitudinal data, such effects cannot be ruled out. Longitudinal studies measuring incident foot disease are needed to properly judge the potential for interventions improving HL to reduce the incidence of diabetic foot disease.

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