Synthesis, Characterization and Biological Activity Of 1, 4-Dihydropyrimido [1,2-A] Benzimidazole
Keyword(s):
An effectual direct synthesis of 1,4-dihydropyrimido[1,2-a]benzimidazole (C-01 to C-10) was developed from 1H-benzo[d]imidazol-2-amine, 4-(benzyloxy)-3-methoxybenzaldehyde, N-(substituted phenyl)-3-oxobutanamide by adding few drop of DMF and in presence of conc.HCL. The product was obtained after about 5 hours of heating in refluxing condition. The synthesized compounds were characterized by different spectral and elemental analysis. Some of the obtained compounds showed a promising antimicrobial activity on screening against Gram-positive and Gram-negative bacterial strains.
2013 ◽
Vol 2013
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pp. 1-5
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Keyword(s):
2020 ◽
2015 ◽
Vol 56
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pp. 82-90
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Keyword(s):