scholarly journals Measurement of the lower canine pulp chamber through periapical radiography for age estimation

2021 ◽  
Vol 5 (2) ◽  
pp. 48
Author(s):  
Otty Ratna Wahyuni ◽  
Deny Saputra ◽  
Nastiti Faradilla Ramadhani ◽  
Dennaya Listya Dias
Keyword(s):  
Biological Age ◽  
Chronological Age ◽  
Pulp Chamber ◽  
Index Method ◽  
Chamber Height ◽  
Lower Canine ◽  
The Mean ◽  
The Difference ◽  
Parallel Technique ◽  
Periapical Radiography

Objectives: The principle of measurement using the TCI (Tooth Coronal Index) method is to compare the pulp chamber height with a person's chronological age based on the formation of secondary dentin. The purpose of this study is to estimate age based on pulp chamber height in lower canines using periapical radiographs with TCI measurement. Materials and Methods: This study is an observational analytic study using 42 samples of periapical radiographs with the parallel technique of the lower canines. Samples were measured for CH and CPCH heights to determine TCI values and then linear regression was made to determine their biological age. Finally, the difference between biological and chronological age is calculated to determine the approximate age. Results: The mean difference between chronological age and biological age was ± 5.05 years and an average biological age of 29.38 years. Conclusion: TCI method based on pulp chamber height in lower canines using periapical radiographs can be used to estimate age with the difference between chronological age and biological age of ±5.05 years.

scholarly journals Healthy Aging Guided by Circadian Rhythm Monitoring Using a Smartwatch-Like Device

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
Adriano Barreto Nogueira ◽  
Manoel Teixeira
Keyword(s):  
Circadian Rhythm ◽  
Healthy Aging ◽  
Biological Age ◽  
Chronological Age ◽  
Healthy Individuals ◽  
Temperature Changes ◽  
Non Invasive ◽  
Invasive Method ◽  
The Mean ◽  
Main Factor

: Aging is the main factor for onset of disease. Nonetheless, chronological age does not necessarily correspond to biological age. The regulation of aging, circadian rhythms, and temperature involves the same brain structure: the hypothalamus. We previously showed that the analysis of the circadian rhythm of temperature may predict neurologic signs with 24 hours of antecedence. Our hypothesis is that the circadian rhythm of temperature changes gradually with aging and correlates with biological age. This study aims to assess whether the circadian rhythm of temperature correlates with the chronological age of healthy individuals aged between 18 and 72 years and changes more intensely in individuals with obesity, which is a disease associated with unhealthy aging. To achieve the study goals, 60 individuals will be enrolled and separated into four groups according to age (< or ≥ 45 years) and health status (healthy or obese). The participants will wear a wristband with vital sign sensors and an accelerometer for three days to detect movement during wake period and lack of movement during sleep period. The ratio between the mean skin temperature during the sleep and preceding wake period will be the main parameter to be analyzed in the study. The possible result is that this ratio is higher in healthy young individuals, as well as healthy age-matched individuals. This could imply the discovery of a simple and non-invasive method related to the biological age that could guide the prevention and treatment of aging-related diseases.

scholarly journals RACE, BIOLOGICAL AGE, AND COGNITION: THE SYSTEMATIC ASSESSMENT OF GERIATRIC ELEMENTS IN ATRIAL FIBRILLATION STUDY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S322-S322
Author(s):  
Sarah N Forrester ◽  
David D McManus ◽  
Jane S Saczynski ◽  
Catarina I Kiefe
Keyword(s):  
Atrial Fibrillation ◽  
Cognitive Decline ◽  
Racial Differences ◽  
Biological Age ◽  
Chronological Age ◽  
Systematic Assessment ◽  
Race Ethnicity ◽  
The Difference ◽  
Using Data ◽  
Moca Score

Abstract Atrial Fibrillation (AF) is associated with dementia and cognitive decline. AF is less prevalent among Blacks than Whites, although AF-related complications are more common in Blacks. In the general population, all-cause cognitive decline and dementia are more prevalent among Blacks than Whites. Thus, studying diverse populations with AF may advance our understanding of racial disparities in cognitive functioning. We created a measure of multisystem dysregulation (weathering), which includes but is more encompassing than aging, and examined its association with racial differences in cognition using data from the SAGE-AF study, a prospective cohort of &gt;65-year olds with AF, at high stroke risk, and eligible for anticoagulation. Biological (as opposed to chronological) age among 974 participants was calculated using the Klemera and Doubal method using biomarkers representing physiological functioning, metabolism, and blood pressure. We defined weathering as the difference between biological and chronological age (weathering &gt;0 indicates that biological age is higher than chronological age). We measured the association between weathering and the Montreal Cognitive Assessment (MoCA) score. Mean weathering (SD) was -0.7 (11.5) and 4.3 (12.6) for whites and non-whites, respectively. There was an interaction between race/ethnicity and weathering on cognition (P=0.004). In stratified analyses, higher weathering was associated with a lower MoCA score among both Whites and non-Whites but more so among non-whites (B = -0.09, 95% CI: -0.17, -0.02) for Whites (B = -0.03, 95% CI: -0.06, -0.01) for non-whites. Aging-related multisystem dysregulation is more strongly associated with worse cognition in non-whites than in whites.

scholarly journals Gambaran Estimasi Usia Biologis dengan Menggunakan Metode Blenkin-Taylor (Modifikasi Sistem Demirjian) di Kota Semarang

e-GIGI ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Niluh R. Woroprobosari ◽  
Devina V. Wisaputri ◽  
Muhammad H. Ni'am
Keyword(s):  
Data File ◽  
Biological Age ◽  
Chronological Age ◽  
Taylor Formula ◽  
Cross Sectional ◽  
Digital Radiograph ◽  
Application Data ◽  
Taylor Method ◽  
The Difference ◽  
Cross Sectional Design

Abstract: Unexpected incident such as natural disaster and accident often occur in many countries including Indonesia which causes many victims with unknown identity. Tooth is one of the indicators to assess and determine a person's identity. Blenkin-Taylor method is used for age estimation of an individual by using teeth. This study was aimed to obtain the estimation of biological age by using Blenkin-Taylor method in Semarang. This was a descriptive study with a cross sectional design. Samples were panoramic digital radiograph data of patients aged 5-15 years, copied in the form of a soft file. The observation and measurement were performed on seven teeth of right lower jaw by using the DICOM RadiAnt application. Data of observations and measurements of maturation scores were calculated and converted into the Blenkin-Taylor formula to determine the biological age. The results showed that the difference between biological and chronological age was ±0.32 years. This value was lower than the Blenkin-Taylor previous study result which was ±0,6 years. In conclusion, by using the Blenkin-Taylor method, there was a difference between biological age and chronological age as many as ±0,32 years in individuals aged 5-15 years old in Semarang.Keywords: biological age, the Blenkin-Taylor method, panoramic radiography Abstrak: Kejadian tidak terduga seperti bencana alam dan kecelakaan sering terjadi di berbagai negara, salah satunya di Indonesia yang menimbulkan banyak korban jiwa yang tidak diketahui identitasnya. Gigi merupakan salah satu indikator untuk menilai dan menentukan identitas seseorang. Salah satu metode dalam menentukan estimasi usia dengan menggunakan gigi ialah metode Blenkin-Taylor. Penelitian ini bertujuan untuk mendapatkan gambaran estimasi usia biologis dengan menggunakan metode Blenkin-Taylor di Kota Semarang. Jenis penelitian ialah deskriptif dengan desain potong lintang. Sampel penelitian ialah data file digital radiograf panoramik pasien berusia 5-15 tahun yang disalin ke dalam bentuk soft file, kemudian dilakukan pengamatan dan pengukuran pada 7 gigi  regio  kanan  rahang  bawah  dengan  menggunakan  aplikasi  RadiAnt DICOM. Hasil pengamatan dan pengukuran skor maturasi dihitung dan dikonversikan ke dalam rumus metode Blenkin-Taylor untuk menentukan usia biologis. Hasil penelitian menunjukkan bahwa selisih usia biologis dan usia kronologis sebesar 0,32 tahun. Hal ini lebih kecil dibandingkan penelitian Blenkin-Taylor terdahulu sebesar 0,6 tahun. Simpulan penelitian ini ialah dengan mengggunakan metode Blenkin-Taylor terdapat selisih rerata usia kronologis dan usia biologis sebesar ± 0,32 tahun pada individu usia 5-15 tahun di Kota Semarang.Kata kunci: usia biologis, metode Blenkin-Taylor, radiograf panoramik

scholarly journals Extracting biological age from biomedical data via deep learning: too much of a good thing?

2017 ◽  
Author(s):  
Tim Pyrkov ◽  
Konstantin Slipensky ◽  
Mikhail Barg ◽  
Alexey Kondrashin ◽  
Boris Zhurov ◽  
...  
Keyword(s):  
Deep Learning ◽  
Proportional Hazards ◽  
Wearable Sensors ◽  
Learning Technologies ◽  
Biological Age ◽  
Chronological Age ◽  
Biomedical Data ◽  
Care Providers ◽  
Proportional Hazards Models ◽  
The Difference

Aging-related physiological changes are systemic and, at least in humans, are linearly associated with age. Therefore, linear combinations of physiological measures trained to estimate chronological age have recently emerged as a practical way to quantify aging in the form of biological age. Aging acceleration, defined as the difference between the predicted and chronological age was found to be elevated in patients with major diseases and is predictive of mortality. In this work, we compare three increasingly accurate biological age models: metrics derived from unsupervised Principal Components Analysis (PCA), alongside two supervised biological age models; a multivariate linear regression and a state-of-the-art deep convolution neural network (CNN). All predictions were made using one-week long locomotor activity records from a 2003-2006 National Health and Nutrition Examination Survey (NHANES) dataset. We found that application of the supervised approaches improves the accuracy of the chronological age estimation at the expense of a loss of the association between the aging acceleration predicted by the model and all-cause mortality. Instead, we turned to the NHANES death register and introduced a novel way to train parametric proportional hazards models in a form suitable for out-of-the-box implementation with any modern machine learning software. Finally, we characterized a proof-of-concept example, a separate deep CNN trained to predict mortality risks that outperformed any of the biological age or simple linear proportional hazards models. Our findings demonstrate the emerging potential of combined wearable sensors and deep learning technologies for applications involving continuous health risk monitoring and real-time feedback to patients and care providers.

The Effect of Vocabulary Intervention on Text Comprehension: Who Benefits?

2019 ◽  
Vol 50 (4) ◽  
pp. 562-578 ◽  
Author(s):  
Dawna Duff
Keyword(s):  
Middle School ◽  
Reading Comprehension ◽  
Text Comprehension ◽  
Classroom Instruction ◽  
Vocabulary Instruction ◽  
Clinical Intervention ◽  
Vocabulary Knowledge ◽  
Vocabulary Intervention ◽  
The Mean ◽  
The Difference

Purpose Vocabulary intervention can improve comprehension of texts containing taught words, but it is unclear if all middle school readers get this benefit. This study tests 2 hypotheses about variables that predict response to vocabulary treatment on text comprehension: gains in vocabulary knowledge due to treatment and pretreatment reading comprehension scores. Method Students in Grade 6 ( N = 23) completed a 5-session intervention based on robust vocabulary instruction (RVI). Knowledge of the semantics of taught words was measured pre- and posttreatment. Participants then read 2 matched texts, 1 containing taught words (treated) and 1 not (untreated). Treated texts and taught word lists were counterbalanced across participants. The difference between text comprehension scores in treated and untreated conditions was taken as a measure of the effect of RVI on text comprehension. Results RVI resulted in significant gains in knowledge of taught words ( d RM = 2.26) and text comprehension ( d RM = 0.31). The extent of gains in vocabulary knowledge after vocabulary treatment did not predict the effect of RVI on comprehension of texts. However, untreated reading comprehension scores moderated the effect of the vocabulary treatment on text comprehension: Lower reading comprehension was associated with greater gains in text comprehension. Readers with comprehension scores below the mean experienced large gains in comprehension, but those with average/above average reading comprehension scores did not. Conclusion Vocabulary instruction had a larger effect on text comprehension for readers in Grade 6 who had lower untreated reading comprehension scores. In contrast, the amount that children learned about taught vocabulary did not predict the effect of vocabulary instruction on text comprehension. This has implications for the identification of 6th-grade students who would benefit from classroom instruction or clinical intervention targeting vocabulary knowledge.

Efficacy and Safety of Oral Ivermectin and Topical Permethrin in the Treatment of Scabies

2020 ◽  
Vol 33 (1) ◽  
pp. 41-47
Author(s):  
Mohsena Akhter ◽  
Ishrat Bhuiyan ◽  
Zulfiqer Hossain Khan ◽  
Mahfuza Akhter ◽  
Gulam Kazem Ali Ahmad ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Close Contact ◽  
Randomized Study ◽  
Sarcoptes Scabiei ◽  
Efficacy And Safety ◽  
Common Skin ◽  
Group A ◽  
The Mean ◽  
The Difference ◽  
Group B

Background: Scabies is one of the most common skin diseases in our country. It is caused by the mite Sarcoptes scabiei var hominis, which is an ecto-parasite infesting the epidermis. Scabies is highly contagious. Prevalence is high in congested or densely populated areas. Individuals with close contact with an affected person should be treated with scabicidal which is available in both oral and topical formulations. The only oral but highly effective scabicidal known to date is Ivermectin. Amongst topical preparations, Permethrin 5 % cream is the treatment of choice. Objective: To evaluate the efficacy & safety of oral Ivermectin compared to topical Permethrin in the treatment of scabies. Methodology: This prospective, non-randomized study was conducted at the out-patient department of Dermatology and Venereology of Shaheed Suhrawardy Medical College & Hospital over a period of 6 months, from August 2016 to January 2017. The study population consisted of one hundred patients having scabies, enrolled according to inclusion criteria. They were divided into two groups. group A was subjected to oral Ivermectin and the group B to Permethrin 5% cream. Patients were followed up on day 7 and 14 for assessment of efficacy and safety. Result: The mean scoring with SD in group A (Ivermectin) and group B (Permethrin) were 8.26 ± 2.22 and 7.59 ± 2.01 respectively at the time of observation. The difference between the mean score of the two group is not significant (p=0.117) the mean scoring with SD in group A and group B were 4.54 ± 2.05 and 1.64 ± 1.84 respectively at 7thdays. The difference between the mean score of the two group is significant (p<0.001). The mean scoring with SD in group A and group B were 2.68± 2.35 and .36± 1.10 respectively at 14th day difference between the mean score of the group is significant (p<0.001). Conclusion: Topical application of permethrin 5% cream is more effective and safer than oral Ivermectin in the treatment of scabies. TAJ 2020; 33(1): 41-47

EFFECTS OF SYNTHETIC LH/FSH-RELEASING HORMONE (LRH) ON PLASMA LH AND FSH IN AMENORRHOEIC WOMEN

1974 ◽  
Vol 75 (4) ◽  
pp. 647-652 ◽  
Author(s):  
G. Rannevik ◽  
J. Thorell
Keyword(s):  
Urinary Excretion ◽  
Initial Response ◽  
Releasing Hormone ◽  
The Mean ◽  
The Difference ◽  
Serial Measurements

ABSTRACT Eight amenorrhoeic women were given 100 μg synthetic LRH (Hoechst) iv and im, respectively, at an interval of 2 weeks. Four of the women received the iv injection first and four the im injection. The urinary excretion of oestrogens and pregnanediol was low and unaltered throughout the test weeks. The effects of LRH were compared by serial measurements of the plasma LH and FSH during 8 h. The initial response of LH for up to 25 min and that of FSH for up to 60 min were equal whether LRH was given iv or im. The difference appeared later. Four hours after the injection the mean increase of LH to iv injection was 0.5 ng/ml (N. S.), while that to im injection was 1.9 ng/ml (P < 0.01). The corresponding values for FSH were 1.3 (P < 0.05) and 3.2 (P < 0.001). The effect of LRH administration im was thus found to be larger and more prolonged.

Development of Prolonged Delivery of Tramadol and Dissolution Translation by Statistical Data Treatment

2011 ◽  
Vol 4 (1) ◽  
pp. 1331-1337
Author(s):  
P B Parejiya ◽  
B S Barot ◽  
P K Shelat
Keyword(s):  
Drug Release ◽  
Study Data ◽  
Stability Study ◽  
Dissolution Time ◽  
Matrix Tablet ◽  
Burst Effect ◽  
The Matrix ◽  
The Mean ◽  
The Difference ◽  
Dissolution Efficiency

The present study was carried out to fabricate a prolonged design for tramadol using Kollidon SR (Polyvinyl acetate and povidone based matrix retarding polymer). Matrix tablet formulations were prepared by direct compression of Kollidon SR of a varying proportion with a fixed percentage of tramadol. Tablets containing a 1:0.5 (Drug: Kollidon SR) ratio exhibited a rapid rate of drug release with an initial burst effect. Incorporation of more Kollidon SR in the matrix tablet extended the release of drug with subsequent minimization of the burst effect as confirmed by the mean dissolution time, dissolution efficiency and f2 value. Among the formulation batches, a direct relationship was obtained between release rate and the percentage of Kollidon SR used. The formulation showed close resemblance to the commercial product Contramal and compliance with USP specification. The results were explored and explained by the difference of micromeritic characteristics of the polymers and blend of drug with excipients. Insignificant effects of various factors, e.g. pH of dissolution media, ionic strength, speed of paddle were found on the drug release from Kollidon-SR matrix. The formulation followed the Higuchi kinetic model of drug release. Stability study data indicated stable character of Batch T6 after short-term stability study.

Seasonal trends in the stable isotopic composition of snow and meltwater runoff in a subarctic catchment at Okstindan, Norway

2004 ◽  
Vol 35 (2) ◽  
pp. 119-137 ◽  
Author(s):  
S.D. Gurney ◽  
D.S.L. Lawrence
Keyword(s):  
Isotopic Composition ◽  
Mean Value ◽  
Mean Values ◽  
Stable Isotopic Composition ◽  
Meltwater Runoff ◽  
Stable Isotopic ◽  
The Mean ◽  
The Difference ◽  
Δ18o And Δd

Seasonal variations in the stable isotopic composition of snow and meltwater were investigated in a sub-arctic, mountainous, but non-glacial, catchment at Okstindan in northern Norway based on analyses of δ18O and δD. Samples were collected during four field periods (August 1998; April 1999; June 1999 and August 1999) at three sites lying on an altitudinal transect (740–970 m a.s.l.). Snowpack data display an increase in the mean values of δ18O (increasing from a mean value of −13.51 to −11.49‰ between April and August), as well as a decrease in variability through the melt period. Comparison with a regional meteoric water line indicates that the slope of the δ18O–δD line for the snowpacks decreases over the same period, dropping from 7.49 to approximately 6.2.This change points to the role of evaporation in snowpack ablation and is confirmed by the vertical profile of deuterium excess. Snowpack seepage data, although limited, also suggest reduced values of δD, as might be associated with local evaporation during meltwater generation. In general, meltwaters were depleted in δ18O relative to the source snowpack at the peak of the melt (June), but later in the year (August) the difference between the two was not statistically significant. The diurnal pattern of isotopic composition indicates that the most depleted meltwaters coincide with the peak in temperature and, hence, meltwater production.

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