On the territory of the Republic of Buryatia, the epizootological profile is formed by 8 nosological forms of infectious pathology of farm animals. The dominant epizootic significance is rabies, leptospirosis, brucellosis. Rabies was registered in 8 (38.1 %) rural administrative districts of the republic and in the urban district of Ulan-Ude. In the total number of cases of rabies, the disease of farm animals occupies 48.3%, domestic carnivores-3.9, and in 47.6% of cases, epizootic foci began among wild animals. The main reservoir of the rabies virus is the wild fox: 46.2 % in the total number of cases and 97.1 % - in autochthonous epizootic foci. Leptospirosis in the conditions of Buryatia is an indigenous natural focal infection with a pronounced indicator of epizootic manifestation in the form of infection of animals without clinical signs. It is registered in 11 (52.4 %) rural administrative districts of the republic in 1.5 % of cattle and 0.6% of horses. The unfavorable situation with bovine brucellosis persisted from 2009 to 2018, 26 unfavorable points were registered. In the Jida district, 5 km from the state border with Mongolia, brucellosis was first registered in a dog. In this area, the corridor of migration of wild animals across the border passes, which confirms the assumption of the existence of natural foci of brucellosis in the transboundary territories of Russia and Mongolia and the introduction of the pathogen from the natural focus to the territory of the buffer zone farms.