scholarly journals An Unsual Site about Small Cells Osteosarcoma Parietal Region and Classique Osteosarcoma Occipital Region Mimicking Meningioma with Literature Review Management and Outcome

2019 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Correct Diagnosis ◽  
Small Cell ◽  
Small Cells ◽  
Long Bones ◽  
Unusual Site ◽  
First Case ◽  
Review Management ◽  
Similar Materials ◽  
One Year ◽  
Age Range

Introduction: Primary osteosarcoma (OS) is the second most common primary bone malignancy, the first being multiple myeloma. OS occurs in the second decade, with a predilection for ends of long bones. Head and neck involvement is seen in 2-9% with extragnathic craniofacial bones in 1–2% of cases. Small Cell OS (SCO) constitutes 1.3-4% of all OS, skeletal distribution and age range being similar. Materials and Methods: We report two rare osteosarcoma and we done the review of the literature about the management and the outcome about intracranial osteosarcoma in our department of neurosurgery. Results: It is two osteosarcoma cases about a 72-year-old man and one 49-year-old man who both mimiking first meningioma. The first case is an unusual site parietal and the second case is occipital. The both benefited surgery with excision and exam of histology confirm diagnosis. But the first case died 15 days after surgery in intensive unit care and the second cases died after one year, he benefited surgery and chemotherapy. Conclusion: Small cell osteosarcoma (SCO) is an extremely uncommon entity that mainly involves the metaphysics of long bones and, rarely, the skull. Histopathology is the key to establishing the correct diagnosis, including sub typing for appropriate management and prognostication, as radiological features are not specific.

scholarly journals An Unsual Site about Small Cells Osteosarcoma Parietal Region and Classique Osteosarcoma Occipital Region Mimicking Meningioma with Literature Review Management and Outcome

2019 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Correct Diagnosis ◽  
Small Cell ◽  
Small Cells ◽  
Long Bones ◽  
Unusual Site ◽  
First Case ◽  
Review Management ◽  
Similar Materials ◽  
One Year ◽  
Age Range

Introduction: Primary osteosarcoma (OS) is the second most common primary bone malignancy, the first being multiple myeloma. OS occurs in the second decade, with a predilection for ends of long bones. Head and neck involvement is seen in 2-9% with extragnathic craniofacial bones in 1–2% of cases. Small Cell OS (SCO) constitutes 1.3-4% of all OS, skeletal distribution and age range being similar. Materials and Methods: We report two rare osteosarcoma and we done the review of the literature about the management and the outcome about intracranial osteosarcoma in our department of neurosurgery. Results: It is two osteosarcoma cases about a 72-year-old man and one 49-year-old man who both mimiking first meningioma. The first case is an unusual site parietal and the second case is occipital. The both benefited surgery with excision and exam of histology confirm diagnosis. But the first case died 15 days after surgery in intensive unit care and the second cases died after one year, he benefited surgery and chemotherapy. Conclusion: Small cell osteosarcoma (SCO) is an extremely uncommon entity that mainly involves the metaphysics of long bones and, rarely, the skull. Histopathology is the key to establishing the correct diagnosis, including sub typing for appropriate management and prognostication, as radiological features are not specific.

scholarly journals Primary Small-Cell Carcinoma of the Palate with Cushing’s Syndrome: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Yingqiu Song ◽  
Zhenyu Lin ◽  
Lingjuan Chen ◽  
Gang Wu
Keyword(s):  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Cushing’S Syndrome ◽  
Neck Region ◽  
Cushing's Syndrome ◽  
Small Cell ◽  
First Case ◽  
Tender Mass ◽  
One Year

We report a 24-year-old woman presenting with a relapsed soy-bean-size tender mass at the junction of the soft and hard palate and a history of palatine tumor of small cell carcinoma. Reexcision surgery was performed and histopathological features were consistent. The patient was treated with six cycles of chemotherapy consisting of etoposide and cisplatin. After one year, the patient developed bone metastases and Cushing's syndrome, and successfully recovered with subsequent chemotherapy with irinotecan and cisplatin plus radiotherapy. There was no evidence of recurrence or metastasis for more than three years. Small cell carcinoma originating in the head and neck region has been reported to be highly aggressive and has a poor prognosis. This is the first case report of a patient with relapsed primary small cell carcinoma of the palate and successfully treated with second-line chemotherapy and local radiotherapy.

Cytomorphologic and Immunophenotypic Profile of a Cohort of Small Cell Carcinoma of the Urinary Bladder

2016 ◽  
Vol 60 (5) ◽  
pp. 475-480 ◽  
Author(s):  
Anurag Sharma ◽  
Shivani Sharma ◽  
Niharika Patnaik ◽  
Dinesh Pradhan ◽  
Kaliprasad Satapathy ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Correct Diagnosis ◽  
Small Cell ◽  
Ki 67 ◽  
Cytologic Examination ◽  
Cytology Specimen ◽  
Age Range ◽  
Urine Specimens

Background: The incidence of primary small cell carcinoma (SCC) of the urinary bladder is extremely rare. We sought to analyze the cytologic and immunophenotypic features of SCC of the urinary bladder in urine and reassert the importance of cytologic examination of urine specimens for diagnosis of this tumor. Methods: We studied the clinical and cytomorphologic features in the presurgical urine specimens (4 voided urine and 2 bladder-washing specimens) of histopathologically and immunohistochemically proven cases of SCC of the urinary bladder. Results: There were 6 cases, all males, with an age range of 61-81 years. On cytologic and histopathologic examination, typical SCC morphology was present in all cases. On immunohistochemistry, synaptophysin and CD56 were positive in all 6 cases, while chromogranin was positive in only 3. The Ki-67 labeling index ranged from 30 to 100%. Conclusions: SCC should be kept in the differential diagnosis, when high-grade urothelial carcinoma is suspected in a urine cytology specimen, as this distinction has important therapeutic and prognostic implications. Therefore, a careful observation and, if required, the use of an appropriate immunocytochemical panel on the presurgical urine specimens can lead to a correct diagnosis.

Intramedullary Well-Differentiated Osteosarcoma: Imaging and Pathologic Findings in 17 Patients

2021 ◽  
Vol 18 ◽  
Author(s):  
Shu-Man Han ◽  
Yuan Wu ◽  
Jin-Xu Wen ◽  
Tian-Hao Wu ◽  
Tao Sun ◽  
...  
Keyword(s):  
Distal Femur ◽  
Correct Diagnosis ◽  
Long Bones ◽  
Endoprosthetic Replacement ◽  
Post Operation ◽  
Soft Tissue Masses ◽  
Bone Cortex ◽  
Well Differentiated ◽  
Age Range

Background: Intramedullary well-differentiated osteosarcoma (IMWDOS) is rare and may easily be misdiagnosed. Objective: This study was to investigate the clinical, imaging and pathological features of IMWDOS for correct diagnosis. Results: There were 13 males and 4 females with an age range of 19-55 years (mean 32). The lesion was located at long bones in 16 patients and at the second region of acetabulum in one patient. Except for three patients with limited areas of lesions, all the other patients had wide areas of disease, and the lesion in long bones all involved the metaphysis area with possible extension towards the diaphysis. In imaging, the lesion usually had an unclear boundary with destruction of bone cortex, uneven thickness of the bone cortex, thick and coarse trabecula in the lesion, but few periosteal reaction and soft tissue masses. The lesion was histologically composed of spindle cells with slight atypia. Follow-up was performed 2-101 months (mean 37.7) in 14 cases, 10 years in one case and 26 years in the remaining two. At follow-up, 12 patients (12/17 or 70.6%) who had complete resection including amputation (n=2), wide excision (n=8) and endoprosthetic replacement (n=2) had no recurrence or metastasis. Among five patients with curettage, three (3/17 or 17.6%) were recurrent with two deaths, and the third one died during post-operation chemotherapy. Conclusion: Intramedullary well-differentiated osteosarcoma tends to occur at the metaphysis of long bones, especially at the distal femur. Histological, clinical and imaging findings lack characteristics and should be closely combined to reach a correct diagnosis. The prognosis of patients with complete lesion resection is good while incomplete lesion curettage or resection will lead to recurrence and transformation into a highly malignant tumor.

scholarly journals Intramedullary Well-Differentiated Osteosarcoma: Imaging and Pathologic Findings in a Group of 17 Patients

2021 ◽  
Author(s):  
Shu-Man Han ◽  
Yuan Wu ◽  
Jin-Xu Wen ◽  
Tian-Hao Wu ◽  
Tao Sun ◽  
...  
Keyword(s):  
Correct Diagnosis ◽  
Long Bones ◽  
Imaging Data ◽  
Large Area ◽  
Clinical Imaging ◽  
Post Operation ◽  
Bone Cortex ◽  
Well Differentiated ◽  
Age Range

Abstract Background: Intramedullary well-differentiated osteosarcoma (IMWDOS) is rare and may easily be misdiagnosed. Objective: This study was to investigate the clinical, imaging and pathological features of IMWDOS for correct diagnosis. Materials and methods: Seventeen patients with IMWDOS were enrolled and the clinical, imaging and pathological data were analyzed. Results: There were 13 males and 4 females with an age range of 19-55 years (mean 32). The lesion was located at long bones in 16 patients and at the second region of acetabulum in one patient. Except for three patients with limited areas of lesions, all the other patients had wide areas of disease, and the lesion in long bones all involved the metaphysis area with possible extension towards the diaphysis. In imaging, the lesion usually had an unclear boundary with destruction of bone cortex, uneven thickness of the bone cortex, thick and coarse trabecula in the lesion, but few periosteal reaction and soft tissue masses. The lesion was histologically composed of spindle cells with slight atypia. Follow-up was performed 2-101 months (mean 37.7) in 14 cases, 10 years in one case and 26 years in the remaining two. At follow-up, 12 patients (12/17 or 70.6%) who had complete resection including amputation (n=2), wide excision (n=8) and endoprosthetic replacement (n=2) had no recurrence or metastasis. Among five patients with curettage, three (3/17 or 17.6%) were recurrent with two deaths, and the third one died during post-operation chemotherapy. Conclusion: Intramedullary well-differentiated osteosarcoma tends to occur at the metaphysis of long bones especially at the distal femur involving a large area. Histological, clinical and imaging data have to be closely combined to reach the correct diagnosis.

scholarly journals Alveolar Echinococcosis of the Parotid Gland—An Ultra Rare Location Reported from Western Europe

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 426
Author(s):  
Tim Koppen ◽  
Thomas F. E. Barth ◽  
Klaus W. Eichhorn ◽  
Jennis Gabrielpillai ◽  
Ralph Kader ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Larval Stage ◽  
Western Europe ◽  
Alveolar Echinococcosis ◽  
Correct Diagnosis ◽  
Western China ◽  
First Case ◽  
Immunohistological Staining ◽  
One Year ◽  
The Right

(1) Background: Alveolar echinococcosis (AE) is restricted to the northern hemisphere with high endemic regions in Central Europe, North and Central Asia as well as Western China. The larval stage of Echinococcus multilocularis (E. multilocularis) causes AE with tumor-like growth. Humans are accidental hosts. This report is on the first case of AE becoming clinically manifested in the parotic gland. (2) Case presentation: A 52-year-old male patient presented with progressive and painful swelling of the right parotid gland persisting for one year. We performed a partial parotidectomy. The histological examination and immunohistological staining revealed larval stage of E. multilocularis. (3) Conclusion: E. multilocularis is known to infect animals and humans coincidentally, and leads to AE. It is one of the most life-threatening zoonoses in Europe. It typically manifests in the liver (50–77%), with further spreading to other organs being a rare phenomenon. Echinococcosis should be considered in the differential diagnosis of lesions of the parotid gland in endemic areas, but AE has not been described so far in the parotid gland as the sole manifestation and, therefore, impedes the correct diagnosis. A complete resection should be the aim, however, preservation of the facial nerve and adjuvant albendazole therapy is mandatory.

Major Surgery in a Subject with Factor V Deficiency

1971 ◽  
Vol 25 (03) ◽  
pp. 438-446 ◽  
Author(s):  
E. J Melliger ◽  
F Duckert
Keyword(s):  
Intercellular Space ◽  
Correct Diagnosis ◽  
Postoperative Bleeding ◽  
Major Surgery ◽  
Factor V ◽  
Factor V Deficiency ◽  
Disappearance Time ◽  
Fresh Plasma ◽  
One Year

SummaryA further case of parahaemophilia is reported. One year after the correct diagnosis had been made the patient had to undergo cholecystectomy which was performed under prophylactic substitutive treatment with fresh plasma at a factor V level of 31 %. A minimal factor V level of 11 to 12% was maintained throughout the first week after operation. There was no abnormal postoperative bleeding. The half disappearance time of factor V was found to be about 12 h. Infusion of equivalent amounts of fresh plasma supplied a higher yield of factor V in the patient’s plasma before operation than postoperatively what may be explained by an increased diffusion of factor V into the intercellular space resulting from a postoperatively increased capillar permeability. The results are compared with those of other authors.

Outcome of Patch Test on Crack Sole among Bangladeshi Population

2020 ◽  
Vol 7 (2) ◽  
pp. 64-67
Author(s):  
Abu Sayeed Mohammad ◽  
Shahadat Hossain ◽  
Zulfiqur Hossain Khan
Keyword(s):  
Patch Test ◽  
Clinical History ◽  
Significant Morbidity ◽  
Exclusion Criteria ◽  
Study Population ◽  
Bangladeshi Population ◽  
One Year ◽  
Medical University ◽  
Age Range ◽  
Test Result

Background: Crack sole may produce significant morbidity among the physical labourer. Objective: The purpose of this study was to find out the patch test result in crack sole which was due to allergic contactants. Methodology: This test was conducted in the Department at Dermatology and Venereology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from July 2001 to June 2002 for a period of one year. Patients with crack sole were selected as study population. All patients were asked about the details clinical history. Patch test was done by individually prepared alminium Finn Chamber mounted on scanpore tape. Result: A total number of 15 patients were recruited for this study after fulfilling the inclusion and exclusion criteria. The age range was 8 years to 70 years. Among 15 patients 3 patients were patch test positive remaining 12 patients were patch test negative. Two patient were female and one was male. Conclusion: In conclusion patch test is positive among the crack sole patients. Journal of Current and Advance Medical Research 2020;7(2): 64-67

scholarly journals A Comparative Analysis of Wi-Fi Offloading and Cooperation in Small-Cell Network

Electronics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1493
Author(s):  
Ayesha Ayub ◽  
Sobia Jangsher ◽  
M. Majid Butt ◽  
Abdur Rahman Maud ◽  
Farrukh A. Bhatti
Keyword(s):  
Small Cell ◽  
Base Stations ◽  
Small Cells ◽  
Effective Capacity ◽  
Rate Enhancement ◽  
Cell Network ◽  
Small Cell Network ◽  
User Throughput ◽  
Average User ◽  
Cell Cooperation

Small cells deliver cost-effective capacity and coverage enhancement in a cellular network. In this work, we present the interplay of two technologies, namely Wi-Fi offloading and small-cell cooperation that help in achieving this goal. Both these technologies are also being considered for 5G and B5G (Beyond 5G). We simultaneously consider Wi-Fi offloading and small-cell cooperation to maximize average user throughput in the small-cell network. We propose two heuristic methods, namely Sequential Cooperative Rate Enhancement (SCRE) and Sequential Offloading Rate Enhancement (SORE) to demonstrate cooperation and Wi-Fi offloading, respectively. SCRE is based on cooperative communication in which a user data rate requirement is satisfied through association with multiple small-cell base stations (SBSs). However, SORE is based on Wi-Fi offloading, in which users are offloaded to the nearest Wi-Fi Access Point and use its leftover capacity when they are unable to satisfy their rate constraint from a single SBS. Moreover, we propose an algorithm to switch between the two schemes (cooperation and Wi-Fi offloading) to ensure maximum average user throughput in the network. This is called the Switching between Cooperation and Offloading (SCO) algorithm and it switches depending upon the network conditions. We analyze these algorithms under varying requirements of rate threshold, number of resource blocks and user density in the network. The results indicate that SCRE is more beneficial for a sparse network where it also delivers relatively higher average data rates to cell-edge users. On the other hand, SORE is more advantageous in a dense network provided sufficient leftover Wi-Fi capacity is available and more users are present in the Wi-Fi coverage area.

Meningitis Due to Haemophilus influenzae Other Than Type b: Case Report and Review

PEDIATRICS ◽  
1978 ◽  
Vol 62 (6) ◽  
pp. 1021-1025
Author(s):  
Gerald R. Greene
Keyword(s):  
Clinical Trial ◽  
Age Distribution ◽  
Effective Vaccine ◽  
Type B ◽  
Review Of The Literature ◽  
Large Clinical Trial ◽  
Serious Infections ◽  
One Year ◽  
Age Range ◽  
Observation Period

A 4-month-old female infant with meningitis caused by Haeinophilus influenzae type f had a hospital course complicated by sterile subclural effusions and persistent neurologic normalities. One year later she was normal in all respects. The infant's mother had serum bactericidal antibodies to H. influenzae type b but not to type f. During recovery the patient had no bactericidal antibodies to type b, and the type f organism could not be maintained in her serum. Review of the literature identified 40 cases of meningitis reported as caused by H. influenzae other than type b. An evaluation of the ten cases described as due to encapsulated strains (a, e, and f) shows that the age distribution and clinical features are similar to those of meningitis caused by type b. Only five cases of meningitis caused by unencapsulated H. influenzae have been described. Four of the patients were older than the usual age range for type b meningitis and two had prior head trauma. A large clinical trial in Finland with a two-year observation period has denionstrated no untoward increase in non-b H. influenzae meningitis in recipients of a type b vaccine. Serious infections caused by other H. influenzae types will continue to occur sporadically and may increase in frequency when an effective vaccine against type b is widely used in infants.

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