The Association Between Serum Estradiol and Progesterone On the Same Day of FET and The Pregnancy Outcome; A Cross Sectional Study

Research Question Precise timed synchronization between endometrium and the embryo is essential for high implantation and pregnancy rate, it is worthy to mention that endometrial thickness is not the only factor, E2 and P levels are also regularly monitored for endometrial receptivity. So, we decided to go for this study, to investigate the impact of serum E2 and P levels on the same day of embryo transfer on pregnancy outcomes for FET cycles. Design This was a retrospective cross sectional study for 402 FET cycles which conducted between April 2018 and May 2019. All participants started endometrial preparation for FET with 6 mg/day oral estradiol for 13 days. When endometrium reached 8 mm or greater, patients were initiated on both micronized vaginal and oral P treatment. On FET day, serum level of E2 and P were assessed. Then, transfer of PGT euploid embryos was performed. 12 days’ later pregnancy test was assessed, and then 4 weeks after FET date ultrasound was scheduled to check the viability and the clinical pregnancy. Results The mean E2 value was 931.41 ± 438.65 pg/ml, while mean P value was 8.47 ± 9.4 ng/ml. 240 out of 402 cases got pregnant (59.7%) while the clinical pregnancy rate was 53.9% with no correlation between serum (E2, P & E/P ratio) and the outcome. Conclusion Our results revealed that the association between E2 and P on FET day and the pregnancy outcome is still not proven and those markers can’t serve as predictors for the outcome.

Download Full-text

Survey of Relation between Midcycle Progesterone Level with IUI Cycles Success Rate

Advances in Bioscience and Clinical Medicine ◽

10.7575/aiac.abcmed.v.7n.4p.9 ◽

2020 ◽

Vol 7 (4) ◽

pp. 9

Author(s):

Alieh Ghasemzadeh ◽

Gilda Mostafavi ◽

Mohammad Nouri ◽

Parastoo Chaichi ◽

Laya Farzadi ◽

...

Keyword(s):

Success Rate ◽

Pregnancy Rate ◽

Assisted Reproductive Technology ◽

Endometrial Thickness ◽

Cross Sectional Study ◽

Reproductive Technology ◽

Clinical Pregnancy ◽

Progesterone Level ◽

Sectional Study ◽

Cross Sectional

Introduction: Assisted reproductive technology is used routinely for treatment of infertile spouses. Previous studies reported conflicting results regarding effect of progesterone rise at the HCG injection day. The aim of current study is to evaluate the effects of mid cycle progesterone levels in IUI cycles. Methods: In this analytical cross-sectional study, the outcome of treatment in 200 IUI cycles were evaluated. Patients’ demographic findings, progesterone level at the day of HCG injection, number of follicles >16 mm, endometrial thickness and clinical pregnancy rate were recorded. For better evaluation, progesterone levels were divided to <0.5, 0.5-1.5 and >1.5 ng/dl. Results: Patients’ mean age was 29.70±4.38 years. The progesterone levels of <0.5, 0.5-1.5 and >1.5 ng/dl was detected in 24.5%, 56% and 19.5% of patients, respectively. The rate of clinical pregnancy was 27.5%. Cases with positive pregnancy had significantly lower progesterone levels (0.88±0.31 vs.1.11±0.80, p=0.04). The highest pregnancy rate was in progesterone levels 0.5-1.5 compared to levels <0.5 and >1.5 ng/dl (42% vs. 12.2% vs. 5.2%, p<0.001). There was no significant correlation between progesterone levels with endometrial thickness (r=-0.130, p=0.06) and number of follicles >16 mm(r=0.02, p=0.77). Conclusion: The results of current study showed that the increase in progesterone levels at the day of HCG injection accompanies with lower pregnancy rate. However, this increase has no correlation with number of mature follicles and endometrial thickness.

Download Full-text

Pattern analysis of S. haematobium infection and elimination in the area of Alsuki, Sudan

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20210782 ◽

2021 ◽

Vol 8 (3) ◽

pp. 1059

Author(s):

Rawia A. Abdelshafie ◽

Abdalla I. Abdalla Mohamed

Keyword(s):

Risk Factors ◽

Statistical Analysis ◽

Health Program ◽

Pattern Analysis ◽

Cross Sectional Study ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

The People ◽

The Impact

Background: The aim of this study was to determine the current conditions of children of the selected area, for the purpose of measuring the new effective health program for schistosomiasis disease eliminations and obtain the prevalence intensity and risk factors of S. haematobium among school children in the study area.Methods: A descriptive cross-sectional study was used to screen school going children of all the ages from five randomly selected schools from Alsuki region. A statistical analysis derived from data formulated based on 1062 samples aged between 6 and 15 years attending the selected schools during the period testing within 6 months were enrolled.Results: The impact of health awareness program was measured usefully and the responded factor for reducing the Schistosomiasis diseases was significantly became less than (0.05). Therefore, the actual qualified fitting degree and applicability was significantly becoming (p value=0.001).Conclusions: This research concluded that the prediction of Schistosomiasis diseases due to the risk Ratio of the collected data for those who did not attended awareness over the people who attended program became (0.248).

Download Full-text

Survey of the Impact of Myocardial Infarction on Patients’ Quality of Life: A Single-Centre Cross-Sectional Study

Evidence Based Health Policy Management and Economics ◽

10.18502/jebhpme.v4i4.4889 ◽

2020 ◽

Author(s):

Habib Jalilian ◽

Ali Imani ◽

Habibeh Mir ◽

Elnaz Javanshir ◽

Mehdi Mamene ◽

...

Keyword(s):

Quality Of Life ◽

Myocardial Infarction ◽

Heart Attack ◽

Cross Sectional Study ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

The Mean ◽

The Impact

Background: A heart attack is one of the most common cardiovascular diseases, affecting different dimensions of the patients’ quality of life due to the disease’s disabling and limiting nature. Therefore, this study aimed to examine the impact of myocardial infarction on patients’ quality of life referring to the Shahid Madani Medical & Training Hospital, in East Azerbaijan Province in 2017, in Iran. Methods: This was a cross-sectional study. A total of 220 patients with a heart attack were selected in this study. Sampling was conducted using the systematic random method. Data were collected using the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Descriptive statistics (frequency, mean) and statistical analyses (Mann-Whitney test, Spearman correlation, and Generalized Linear Models Regression) were performed at a significance level of P-value < 0.05 using SPSS22. Results: In this study, the mean score of the total effect of a heart attack on the patients’ quality of life was 30.09 ± 17.73. The mean score of the effect of a heart attack on the patient’s quality of life in the physical, emotional, and general subscales was 34.85 ± 24.24, 26.63 ± 27.73, and 27.51 ± 17.83, respectively. There was a statistically significant association between education status (P-value = 0.006), income status (P- value = 0.000), and the mean score of the effect of a heart attack on the patient’s quality of life; also a positive and significant correlation was found between age (CC = 0.135, P-value = 0.046), the number of hospitalization (CC = 0.187, P-value = 0.006) and the mean score of the effect of a heart attack on the patient’s quality of life. Conclusion: A heart attack has a considerable impact on the patients’ quality of life, particularly on the physical dimension. Hence, health professionals should pay more attention to these vulnerable groups and offer rehabilitation services suitable to these groups to reduce the impact of the disease.

Download Full-text

An intronic polymorphism of the gene Plakophilin-3 is associated with IVF failure

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193517 ◽

2019 ◽

Vol 8 (8) ◽

pp. 3092

Author(s):

Mohamad Sami Joha ◽

Chadi Soukkarieh ◽

Marwan Alhalabi

Keyword(s):

Pregnancy Outcome ◽

Cross Sectional Study ◽

Clinical Pregnancy ◽

P Value ◽

Implantation Failure ◽

Male Factor ◽

Cross Sectional ◽

Vitro Fertilization ◽

Intronic Polymorphism

Background: Implantation failure is determined when transferred embryos fail to implant following in vitro fertilization (IVF). In recent years, many studies suggest that implantation failure could be related to several genetic factors. In the current study, authors aimed to investigate the association of PKP3 rs10902158 (G>A) polymorphisms with the risk of implantation failure after ICSI treatment.Methods: 97 women, who underwent ICSI treatment owing to male factor infertility, were prospectively recruited in this cross-sectional study. Genomic DNA was prepared from peripheral blood samples in order to analyze the polymorphism (rs10902158) at the PKP3 gene by PCR-RFLP. The Results were presented as a genotype (GG, GA, and AA), and their relationship to IVF outcome was analyzed.Results: The patients were divided into two groups according to clinical pregnancy: the pregnant group included 51 patients (53%) and the non-pregnant group included 46 patients (47%). The clinical pregnancy outcome was significantly different between genotypes, which was 0%, 45.8% and 58.8% in the patients having the genotype AA, GA and GG respectively (p-value = 0.03).Conclusions: The presence of the allele A of the PKP3 SNP rs10902158 is associated with a reduced clinical pregnancy outcome in the patients undergoing ICSI treatment and may be helpful predictor for implantation failure.

Download Full-text

Endometrial thickness is a limiting factor in achieving a successful pregnancy in infertile women undergoing IVF/ICSI cycle.

10.21203/rs.3.rs-785729/v1 ◽

2021 ◽

Author(s):

Haroon Latif Khan ◽

Shahzad Bhatti ◽

Samina ◽

Humaira Hamayun ◽

Farah Enver ◽

...

Keyword(s):

Pregnancy Rate ◽

Embryo Transfer ◽

Endometrial Thickness ◽

Embryo Implantation ◽

Implantation Rate ◽

Cross Sectional Study ◽

Limiting Factor ◽

Successful Pregnancy ◽

Cross Sectional ◽

The Impact

Abstract Introduction: Embryo transfer into the uterus during IVF/ICSI treatment is followed by embryo implantation, which depends on the receptivity of endometrium and is a pre-requisite for the initiation of a successful pregnancy. The endometrium proliferates under the hormonal influence (estrogen and progesterone), which is reflected by its thickness which is measurable by transvaginal ultrasonic scanning (TVS). The thickness of the endometrium less than 8 mm has been linked with implantation failure.11 Endometrial thickness of 9-14 mm on the day of progesterone supplementation has been shown to have a higher implantation rate. Thus, the implantation potential of a good embryo remains low during IVF treatment despite ovarian stimulation methods of assisted fertilization and improved culture condition.Objectives: This study was planned to determine the impact of endometrial thickness on ET and pregnancy rate in Pakistani patients undergoing IVF/ ICSI.Methods: This was a prospective, cross-sectional study conducted at a private fertility clinic (Lahore institute of fertility and endocrinology, LIFE) in Lahore, Pakistan, from January 2015 to December 2015. In this study, all those cases were included that reached oocytes pickup and embryo transfer (ET). Two protocols, agonist and antagonist, were used. In all cases, human menopausal gonadotrophin (hMG) and follicle-stimulating hormone (FSH) were used for stimulation. Follicles development was monitored; at least 3 follicles were reached at the diameter of ≥16mm.Results: Thickness of endometrium on decision day was calculated at various ranges concerning both groups and find pregnancy rates. When endometrial thickness was ≤ 6mm, PR was 2.22%, 7mm pregnancy rate (PR) was 1.11%, 8 mm PR was 3.33%, 9mm PR was 17.78%, 10mm PR was 33.33%, 11mm PR was 32.22%, and more than 11 mm PR was 10%. So, PR was higher from 2.22% to 10%. The overall pregnancy rate was 45.45%.Conclusion: The study concluded that endometrial thickness has significant effects on embryo transfer and outcomes.

Download Full-text

Assessing the usage of screen based media and screen time among adolescents in Mysuru: a cross-sectional study

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20202477 ◽

2020 ◽

Vol 7 (6) ◽

pp. 2233

Author(s):

G. Shwetha ◽

Sunil Kumar Doddaiah ◽

Anil S. Bilimale ◽

M. R. Narayana Murthy

Keyword(s):

School Children ◽

Screen Time ◽

Statistical Significance ◽

Structured Interview ◽

Cross Sectional Study ◽

P Value ◽

Sectional Study ◽

Cross Sectional ◽

Total Study Population ◽

The Impact

Background: Media is one of the important parts of the life of school children, especially those aged between 13 to 17 years. It has both positive and negative impacts on children. It affects both physical and mental health; there will be a prominent impact on their studies also. Nowadays everyone has the accessibility of television, mobile, etc in India. This study mainly aims to assess the impact of screen-based media (SBM) and screen time among middle adolescents and the association of socio-demographic status with the usage of SBM.Methods: A cross-sectional study was conducted in Government and Private schools of Mysuru district from November to December 2019. The study included 180 school children between the age group of 13 to 17 years through simple random sampling. A semi-structured interview questionnaire was used.Results: Mobile formed the maximum used SBM. Out of the total screen time, time contributed by television 90.5%, mobile 95.6%, and both television and mobile 91.7% will be more followed by other SBM. The proportion of children having the screen time of maybe 3 hrs was found to be 25.6% and more than 3 hrs was 5.9% among the total study population. There is an association between SBM usage and the socio-demographic status i.e. age, type of family, father's education, and father occupation with the statistical significance of p value <0.05.Conclusions: According to the current study, there is a high proportion of school children using SBM. So, there is a need to create awareness regarding the use of SBM and its impact on children among parents, teachers, and children.

Download Full-text

Initial Psychological Response of Various Population Groups to COVID-19 Pandemic: A Cross Sectional Study

Proceedings of Shaikh Zayed Medical Complex Lahore - October to December ◽

10.47489/pszmc-815354-13-17 ◽

2021 ◽

Vol 35 (4) ◽

pp. 13-17

Author(s):

Shahzaib Ahmad

Keyword(s):

Cross Sectional Study ◽

Categorical Variables ◽

Economic Losses ◽

P Value ◽

Sectional Study ◽

Online Questionnaire ◽

Cross Sectional ◽

Psychological Response ◽

Lower Socioeconomic ◽

The Impact

Introduction: The corona virus pandemic has brought with it psychological problems like anxiety, stress, and depression. Research studies are urgently required to generate data that would help formulate strategies to manage the ensuing psychiatric and psychological maladies at societal level. Aims & Objectives: The aim of our study is to better comprehend the initial psychological response of society to COVID-19 outbreak though a survey. Place and duration of study: This cross-sectional study was conducted in King Edward Medical University, Lahore from April 2020 to October 2020. Material & Methods: An online questionnaire comprising of 20 items including the Zung self-rating Anxiety Scale (SAS) was disseminated to three fifty (350) participants. Two hundred and seventy-one (n=271) responses were received. Collected data was entered and analyzed using the SPSS software version 20. Categorical variables were presented as frequencies and percentages. Relationships between categorical variables were tested by Chi square test. Regression analysis was conducted to investigate the effect of various variables on total stress score. A p-value of <0.05 was considered significant. Results: It was revealed that 85.2% of the respondents reported minimal psychological impact, 14.8% had mild to moderate anxiety levels and 0.4% reported marked to severe anxiety. The impact was 2.5 times greater in subjects belonging to lower socioeconomic status (p=0.02). Conclusion: Population belonging to lower socioeconomic class is more vulnerable to be impacted by psychological disturbances due to the pandemic owing to economic losses that are magnified in the population with fragile earning sources.

Download Full-text

The impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst

Reproductive Biology and Endocrinology ◽

10.1186/s12958-019-0545-0 ◽

2019 ◽

Vol 17 (1) ◽

Cited By ~ 7

Author(s):

Zhiqin Bu ◽

Xinhong Yang ◽

Lin Song ◽

Beijia Kang ◽

Yingpu Sun

Keyword(s):

Pregnancy Rate ◽

Pregnancy Outcome ◽

Embryo Transfer ◽

Endometrial Thickness ◽

Clinical Pregnancy ◽

Clinical Pregnancy Rate ◽

Natural Cycle ◽

Thickness Change ◽

The Impact ◽

Day Of Embryo Transfer

Abstract Background The aim of this study was to explore the impact of endometrial thickness change after progesterone administration on pregnancy outcome in patients transferred with single frozen-thawed blastocyst. Methods This observational cohort study included a total of 3091 patients undergoing their first frozen-thawed embryo transfer (FET) cycles between April 2015 to March 2019. Endometrial thickness was measured by trans-vaginal ultrasound twice for each patient: on day of progesterone administration, and on day of embryo transfer. The change of endometrial thickness was recorded. Results Regardless of endometrial preparation protocol (estrogen-progesterone/natural cycle), female age, body mass index (BMI), and infertility diagnosis were comparable between patients with an increasing endometrium on day of embryo transfer and those without. However, clinical pregnancy rate increases with increasing ratio of endometrial thickness. Compared with patients with Non-increase endometrium, those with an increasing endometrium on day of embryo transfer resulted in significantly higher clinical pregnancy rate (56.21% vs 47.13%, P = 0.00 in estrogen-progesterone cycle; 55.15% vs 49.55%, P = 0.00 in natural cycle). Conclusions In most patients, endometrial thickness on day of embryo transfer (after progesterone administration) increased or kept being stable compared with that on day of progesterone administration. An increased endometrium after progesterone administration was associated with better pregnancy outcome.

Download Full-text

Is there any correlation between Estradiol supplementation, as luteal phase support, and clinical pregnancy in ART cycles? A cross-sectional study

International Journal of Reproductive BioMedicine ◽

10.18502/ijrm.v13i11.7964 ◽

2020 ◽

Author(s):

Maryam Eftekhar ◽

Banafsheh Mohammadi ◽

Esmat Mangoli ◽

Maryam Mortazavi

Keyword(s):

Pregnancy Rate ◽

Embryo Transfer ◽

Intracytoplasmic Sperm Injection ◽

Luteal Phase ◽

Cross Sectional Study ◽

Clinical Pregnancy ◽

Control Group ◽

Sectional Study ◽

Cross Sectional ◽

Luteal Phase Support

Background: Endometrial receptivity is one of the important factors in assisted reproductive technology (ART) success. In the luteal phase of an ART cycle, serum estradiol (E2) and progesterone are often placed in low levels. Supporting the luteal phase with progesterone is a usual method. Objective: To evaluate the effects of E2 supplementation plus progesterone on the luteal phase support in the antagonist protocol who have undergone intracytoplasmic sperm injection-embryo transfer cycles. Materials and Methods: In this cross-sectional study, 200 patients with antagonist stimulation protocol, who had undergone intracytoplasmic sperm injection treatment, were divided into two groups based on the use of E2 supplementation. In both groups, 400 mg progesterone suppositories (Cyclogest®), twice a day/vaginally, was administered starting from the day of oocyte collection until the fetal heart activity. However, in the E2 group, in addition to progesterone, 4 mg tablet of E2 was received daily. Beta hCG was checked 14 days after the embryo transfer, and the clinical pregnancy rate was the main endpoint. Results: The patients’ characteristics were matched, and insignificant differences were observed, except for endometrial thickness. The clinical outcomes showed the rate of pregnancy was higher in the E2 group compared to the control group; nonetheless, statistically, there was no noticeable difference. Conclusion: E2 supplementation had no beneficial effect in the luteal phase support of IVF cycles. Nevertheless, more studies are required to confirm the supportive role of E2 supplementation for embryo implantation and to improve the outcomes in ART cycles. Key words: Luteal phase, Estradiol, Progesterone, ICSI, Pregnancy rate.

Download Full-text