scholarly journals Maxillary Sinus Pneumatization and Its Relationship with Vitamin D Deficiency; A Cross Sectional Study

2019 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Vitamin D ◽  
Maxillary Sinus ◽  
Significant Relationship ◽  
Serum Vitamin ◽  
P Value ◽  
Cross Sectional Survey ◽  
Chi Square ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Objectives: To identify any correlation and its severity with the levels of serum vitamin D with the level of maxillary sinus pneumatization. Study Design: Descriptive cross-sectional survey. Setting: Oral and Maxillofacial Department, Fatima Memorial Hospital, Lahore. Materials and Methods: A sample size of 100 subjects met the inclusion criteria. Serum Vitamin D levels of the patients was done using liquid chromatography tandem mass spectrometry, also known as LC/MS/MS. While level of sinus pneumatization was recorded according to Sharan and Majdar classification of maxillary sinus pneumatization. Data was collected and entered into the Statistical Package for Social Science (SPSS) version 25.0 for analysis. Parametric analysis was performed that included the Pearson’s Chi- Square test to determine an association between excessive maxillary sinus pneumatization and hypovitaminosis. A p-value of <0.05 was defined as the level of significance. Results: A statistically significant relationship was found between levels of hypovitaminosis and levels of pneumatization with a chi square value to be 0.002 (p<0.05) While there was no statistically significant relationship of age or gender with levels of maxillary sinus pneumatization and hypovitaminosis D (p>0.05). Conclusion: There is a significant relationship between levels of hypovitaminosis and levels of pneumatisation.

scholarly journals Vitamin D Levels among Hospitalized and Non-Hospitalized COVID-19 Patients in Dr. M. Djamil General Hospital Padang

2021 ◽  
Vol 3 (6) ◽  
pp. 78-81
Author(s):  
Harika Putra ◽  
Efrida ◽  
Rismawati Yaswir
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Study Groups ◽  
P Value ◽  
Chi Square ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Chemiluminescent Microparticle Immunoassay

Coronavirus Disease 2019 (COVID-19) causes immune system dysregulation and an exaggerated systemic inflammatory response. Vitamin D acts as an immunomodulator that enhances the immunity defense. Low levels of vitamin D affect the severity of COVID-19 infection. This study aims to determine vitamin D levels in hospitalized and non-hospitalized COVID-19 patients. A case-control study was conducted involving 62 COVID-19 patients, equally divided into hospitalized and non-hospitalized groups at RSUP dr. M. Djamil, Padang from February to September 2020. Serum vitamin D levels were measured using the Chemiluminescent Microparticle Immunoassay. Vitamin D deficiency was defined as a level less than 20 ng/mL. The hospitalized group consisted of moderate to critical COVID-19 patients, whereas the non-hospitalized group consisted of the asymptomatic and mild COVID-19 patients according to the Indonesian Ministry of Health Guidelines. All data were analyzed using a T-test and Chi-square with a significant p-value of 0.05. The results showed that most subjects were women between 21–60 years. The mean level of vitamin D (ng/mL) in the hospitalized group was lower than in the non-hospitalized group (15.5 ± 7.72 vs. 19.2 ± 14.30; 95% CI -9.509–2.167; p=0.213). Vitamin D deficiency affected hospitalized group more than the non-hospitalized group, but not statistically significant (71% vs. 64.5%, p=0.566). It indicated the role of vitamin D in preventing immune system hyperactivation causing COVID-19 cytokine storm. This study concluded no difference in vitamin D levels among the study groups. Nevertheless, further research on vitamin D is needed to determine its role and benefits against COVID-19 infection.

To Compare Serum Vitamin D Levels with Severity of Liver Cirrhosis According to Child-Pugh Score in Amritsar, Punjab

2021 ◽  
Vol 8 (33) ◽  
pp. 3090-3096
Author(s):  
Jaskiran Kaur ◽  
Gurinder Mohan ◽  
Manish Chandey
Keyword(s):  
Vitamin D ◽  
Liver Cirrhosis ◽  
Serum Vitamin ◽  
Alcoholic Cirrhosis ◽  
P Value ◽  
Chi Square ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Study Population ◽  
Sufficient Vitamin

BACKGROUND Cirrhosis of liver and its extrahepatic manifestations like hepatic osteodystrophy has been linked to vitamin D deficiency, and has been proposed as a potential therapeutic target. Its metabolism to 25-hydroxylation, makes liver necessary for its activation. In this study sources of vitamin D, functions and its metabolism with a focus on its variation with severity of liver cirrhosis is discussed. METHODS This is an observational study conducted on 60 patients with liver cirrhosis. The severity of liver cirrhosis was assessed according to the Modified CPS. By technique of enhanced chemiluminscence values of vitamin D were obtained. The results were statistically analyzed using SPSS Statistics-20.0 version. Association among different variables were calculated using Chi-Square Test and One Way ANOVA. Results were considered significant if p value obtained was below 0.05 and highly significant if it was below 0.001. RESULTS Mean age group of study population was 54.83 ± 13.56 years. 27 patients had Alcoholic cirrhosis, 11 patients were HCV positive, 2 patients were HBsAg positive and 20 patients had cirrhosis due to other etiologies. Mean vitamin D level of the study population was 35.34 ± 22.4. 27 patients (45 %) had sufficient vitamin D, 18 patients (30 %) were deficient and 14 patients had insufficient vitamin D levels. 1 patient had vitamin D toxicity. There was no significant correlation between mean vitamin D and etiology of liver cirrhosis (P value = 0.457; Not Significant). There was significant correlation between vitamin D levels with severity of liver disease (p value < 0.001). CONCLUSIONS In conclusion, low concentrations of 25 (OH) D are correlated with severity of liver dysfunction irrespective of the etiology. KEYWORDS Child-Pugh Score, Liver cirrhosis, Serum Vitamin D

Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

2020 ◽  
Vol 90 (3-4) ◽  
pp. 346-352
Author(s):  
Vincenzo Pilone ◽  
Salvatore Tramontano ◽  
Carmen Cutolo ◽  
Federica Marchese ◽  
Antonio Maria Pagano ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Inverse Correlation ◽  
Model Assessment ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Female Sex ◽  
Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

Association of Vitamin D Levels and Other Risk Factors with Asthma Exacerbations in Children

2020 ◽  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Serum Vitamin ◽  
Persistent Asthma ◽  
Food Allergies ◽  
P Value ◽  
Serum Vitamin D ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Animal Dander

Background: The risk factors for asthma exacerbations are well understood. However, the effect of vitamin D levels on number of asthma exacerbations per year is not clearly studied. The objective of the study was to find out the association of serum vitamin D levels and asthma risk factors on asthma exacerbations. Methods: In this study, ninety-nine subjects from 5 to 15 years of age were recruited at an episode of acute exacerbation. It was a cross sectional study and carried out from 2012 to 2015. Pulmonary function test was done by spirometry. Asthma exacerbation was labeled when forced expiratory volume/ forced vital capacity (FEV1/FVC) ratio was less than 80% (American Thoracic Society). Global Initiative for Asthma (GINA) guidelines were used to classify asthma into mild, moderate and severe persistent asthma. Serum vitamin D levels were measured by chemiluminescence method. Pearson Chi-square test was applied and p value (p<0.05) was considered as statistically significant. Results: Children who had exposure to animal dander had significantly lower asthma exacerbations per year (p-value <0.046). There was no significant association between vitamin D levels and number of exacerbations per years (p-value <0.099). Asthma was prevalent in girls of low socioeconomic status (SES) compared to males. However, there was no significant association between smoke, exercise, home environment, food allergies, weather, pollen and dust with asthma exacerbations. Conclusion: Low levels of vitamin D were not associated with increased number of asthma exacerbations per year. However, children exposed to animal dander had lesser number of exacerbations per year (p-value <0.046). Keywords: Asthma; Vitamin D; Children; Exacerbations, Risk factors.

Association between vitamin D deficiency and prostate cancer: Prospective case-control study

2021 ◽  
pp. 205141582199360
Author(s):  
Ghanshyam Kumawat ◽  
Vijay Chaudhary ◽  
Anurag Garg ◽  
Nishkarsh Mehta ◽  
Gagan Talwar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Case Control Study ◽  
Serum Vitamin ◽  
P Value ◽  
Serum Vitamin D ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
Control Study

Objective: We aimed to find out the association of low serum vitamin D levels with the incidence of prostate cancer through a prospective case-control study. Material and methods: This study was carried out in the tertiary care hospital (India). All newly diagnosed patients of prostate cancer and age-matched controls were included. Serum vitamin D levels were measured in all of them. Vitamin D status (ng/mL) was classified as severe deficiency <10, moderate deficiency 10–<30, normal 30–100, and toxicity >100. Normality of the data was tested by the Kolmogorov–Smirnov test, statistical analysis was done with Statistical Package for the Social Sciences version 26.0, p-value of <0.05 was considered significant. Results: In our study, 320 cases and 320 controls were included. The mean vitamin D levels in cases and controls were 15.71 ± 6.5 (ng/mL) and 17.63 ± 4.54 (ng/mL), respectively, ( p-Value <0.01). Patients with severe vitamin D deficiency (73.58%) had a Gleason score ⩾8 on biopsy and 79.24% of them had a serum prostate specific antigen (PSA) level >20 ng/mL. Conclusion: We had concluded that there was no significant association between vitamin D deficiency and increased risk of prostate cancer, although patients with higher-grade prostate cancer and with higher PSA level had severe vitamin D deficiency. Level of evidence: Not applicable for this multicentre audit.

scholarly journals Correlation of psoriasis and serum vitamin D

2021 ◽  
Vol 7 (4) ◽  
pp. 320-323
Author(s):  
Ritika Gujrati ◽  
Krishnendra Varma ◽  
Ujjwal Kumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Psoriasis Vulgaris ◽  
Systemic Disease ◽  
Serum Vitamin ◽  
Psoriatic Skin ◽  
Control Group ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Psoriasis is an immuno-mediated chronic systemic disease involving cytokines of helper Th1 pathway. Vitamin D has an effect on keratinocyte proliferation, differentiation and immune modulation of immune system especially Th1 pathway, which is altered in psoriatic skin suggesting that Vitamin D may have a role in pathogenesis of psoriasis. To study correlation between psoriasis vulgaris and serum vitamin D. To evaluate serum vitamin D level in psoriasis cases and in control group and correlating vitamin D level with severity and duration of the psoriasis. 57 cases (&#62;15years of age) with psoriasis and 57 healthy subjects were recruited. Psoriasis was clinically diagnosed and severity evaluated by PASI scale. Vitamin D was analysed by enhanced chemilumine scence on vitrus Eci autoanalyzer of Orth clinical diagnostic. Vitamin D deficiency defined as &#60;20ng/ml, insufficiency 20-30ng/ml and sufficient 30-100ng/ml. Vitamin D deficiency in the study was 22.8% in patients and 14% in control group. Vitamin D insufficiency was found in 42.1% of cases and 19.3% of control. According to chi-square the p-value is 0.003 showing significant association. There was a tendency towards decrease in vitamin D level with increase in disease duration. There was negative correlation between vitamin D and PASI score. The study found a significant relationship between vitamin D and psoriasis. Further metanalysis involving larger study population will be required to establish whether vitamin D levels benefits patient with psoriasis vulgaris.

scholarly journals A clinical study to determine the relationship between serum vitamin D levels and severity of asthma

2017 ◽  
Vol 4 (4) ◽  
pp. 1397
Author(s):  
Pragalatha Kumar ◽  
Aruna Gowdra ◽  
Arathi Arathi ◽  
Ananya Sampath
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Asthma Severity ◽  
Severe Form ◽  
P Value ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Children With Asthma ◽  
Age And Sex

Background: Vitamin D deficiency has been rediscovered as a public health problem worldwide. Few studies have shown that vitamin D deficiency is associated with asthma severity. The objective of present work was to study the serum vitamin D levels and its relationship with asthma severity in children.Methods: A prospective cohort study of 100 children with asthma between the age group of 5 to 15 years and age and sex matched 40 healthy controls who had come to Indira Gandhi Institute of Child Health, Bengaluru was done. These children’s serum vitamin D levels were estimated and correlated with asthma severity.Results: A total of 100 children with asthma and 40 healthy age and sex matched controls were evaluated. The study group had lower vitamin D (34.95 ng/ml) levels as compared to the control group (57.94 ng/ml) which was statistically significant (p<0.05). 68.4% children had significantly low vitamin D levels and severe form of asthma (p value <0.001). There was also a marked rise in absolute eosinophil count in those who had low vitamin D levels (56.6%) (p-value <0.0001).Conclusions: Vitamin D deficiency is an important risk factor for asthma severity. It modifies the immune system and reduces the inflammation. In the present study, low serum vitamin D levels were significantly correlated with severe form of asthma. There was a significant rise in the absolute eosinophil count in those who exhibited deficiency of vitamin D.  

scholarly journals Correlation of Serum Vitamin D and Metabolic Disturbances in Polycystic Ovarian Syndrome

2021 ◽  
Vol 4 (1) ◽  
pp. 64-71
Author(s):  
Shasya Aniza Santoso ◽  
◽  
Tita Husnitawati Madjid ◽  
Anita Rachmawati
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Fasting Blood Glucose ◽  
Serum Vitamin ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Objective: This study was aimed to determine the correlation between vitamin D and insulin resistance in women with PCOS. Method: This study was correlational analytic with cross-sectional approach to 34 women diagnosed with PCOS based on ultrasonography. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. Women with hormonal therapy and vitamin D supplementation were not included to this study. This study used consecutive sampling method. Result: The average of age was 25.6±6.1 years old. Waist circumference and fasting blood glucose (FBG) represented insulin resistance. The average of waist circumference and FBG were 87.6±12.4 cm and 86.2±27.9 mg/dl, respectively. The mean of vitamin D levels was 11,5±3,6 ng/ml. According to Spearman’s correlation, vitamin D levels were weak negative correlated with waist circumference (r=-0.2; p>0.05) and FBG (r= -0,1; p>0,05), it statistically was not significant. Conclusion: There is weak negative correlation between vitamin D and metabolic syndrome in PCOS patients.

scholarly journals Comparison of Vitamin D Levels, Bone Metabolic Marker Levels, and Bone Mineral Density among Patients with Thyroid Disease: A Cross-Sectional Study

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1075
Author(s):  
Masliza Hanuni Mat Ali ◽  
Tuan Salwani Tuan Ismail ◽  
Wan Norlina Wan Azman ◽  
Najib Majdi Yaacob ◽  
Norhayati Yahaya ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Thyroid Diseases ◽  
Z Score ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Thyroid hormones have a catabolic effect on bone homeostasis. Hence, this study aimed to evaluate serum vitamin D, calcium, and phosphate and bone marker levels and bone mineral density (BMD) among patients with different thyroid diseases. This cross-sectional study included patients with underlying thyroid diseases (n = 64, hyperthyroid; n = 53 euthyroid; n = 18, hypothyroid) and healthy controls (n = 64). BMD was assessed using z-score and left hip and lumbar bone density (g/cm2). The results showed that the mean serum vitamin D Levels of all groups was low (<50 nmol/L). Thyroid patients had higher serum vitamin D levels than healthy controls. All groups had normal serum calcium and phosphate levels. The carboxy terminal collagen crosslink and procollagen type I N-terminal propeptide levels were high in hyperthyroid patients and low in hypothyroid patients. The z-score for hip and spine did not significantly differ between thyroid patients and control groups. The hip bone density was remarkably low in the hyperthyroid group. In conclusion, this study showed no correlation between serum 25(OH)D levels and thyroid diseases. The bone markers showed a difference between thyroid groups with no significant difference in BMD.

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