scholarly journals Proliferative Myositis: A Comprehensive Review of 33 Case Reports

2019 ◽  
Vol 42 (4) ◽  
pp. 60-70
Author(s):  
Pannawat Trerattanavong ◽  
Chinnawut Suriyonplengsaeng ◽  
Jariya Waisayarat

Proliferative myositis, a rare reactive intramuscular myofibroblastic proliferation, is not well recognized in clinical practice. It overgrows within a few weeks and expands the space between the muscle causing infiltrative-like border mimicking sarcoma. Knowledge of the natural history and pathology of proliferative myositis is essential in order to prevent misdiagnosis and unnecessary surgical resection. Thirty-three reported cases of proliferative myositis in PubMed and Web of Science databases from 2000 to 2018 had been reviewed with the main emphasis in clinical presentation, radiological and pathological findings, treatment, and prognosis. Both males (19 cases) and females (14 cases), predominantly the middle-aged and senior adults, were affected. Upper extremity and shoulder girdle were commonly involved. The chief complaint varied from either painful or painless mass. The traumatic injury was reported as a significant predisposing factor. The lesion typically proliferated and separated muscle bundle. Ultrasonography of the lesion revealed a characteristic “checkerboard pattern” on transverse view. The definite diagnosis was based on the demonstration of spindle-shaped fibroblast/myofibroblast admixed with giant ganglion-like cells in the biopsy. Immunohistochemistry may be useful diagnostic tool when the histopathology was inconclusive. Misdiagnosis of sarcoma occurred due to its rapid growth and infiltrative-like border. Watchful management without surgery was sufficient because of the potential for spontaneous regression. Thoroughly clinical examination and appropriate investigations, including imaging and histopathology, are crucial.  

Author(s):  
Ioneide De Oliveira Campos ◽  
Rafael Moraes Reis

A Economia Solidária é uma alternativa para inserção laboral de pessoas com transtornos mentais. Realizou-se uma revisão da literatura, com o propósito de conhecer o que tem sido publicado sobre Economia Solidária, inclusão e Saúde Mental, quais os objetivos e métodos de pesquisa, quem são os profissionais e populações-alvo e quais os resultados obtidos nos estudos. Foram considerados os seguintes critérios para a realização desse estudo: a importância da temática para o contexto da Saúde Mental e a identificação de pesquisas e relatos de experiência que informassem práticas em Saúde Mental e Economia Solidária. A revisão foi realizada nas bases: Web of Science, DOAJ, PubMed, SciElo e LILACS, sem restrições de ano. Os descritores utilizados foram “economia solidária”, “saúde mental” e “inclusão”. Vinte e nove (n=29) artigos foram encontrados e, após a aplicação dos critérios de inclusão, dez foram analisados na íntegra. Trinta e quatro (n=34) profissionais estiveram envolvidos nas pesquisas, sendo a Terapia Ocupacional, Enfermagem e Psicologia, as profissões que apareceram mais frequentemente.  Todos os estudos encontrados eram qualitativos e foram conduzidos no Brasil. A entrevista foi o método mais adotado. Os resultados dos estudos sinalizaram ganhos para aspectos intrínsecos dos usuários no que se refere a autogestão, expressão, empoderamento, e também extrínsecos, como a questão familiar e do trabalho coletivo. A revisão agregou conhecimento que permitem refletir sobre a importância da interdisciplinaridade, do trabalho colaborativo em rede, e sobre a necessidade de documentação das experiências em Economia Solidária no país. AbstractThe Solidarity Economy is an alternative for the labour inclusion of people with mental health. A review of the literature was conducted in order to know what has been published on the issue of Solidarity Economy, Inclusion and Mental Health, what are the objectives and research methods, who are the professionals and populations’ target, and the results identified in the research. We considered the following criteria: the importance of the issue in the mental health context and identification of studies and case reports which informed practice in Mental Health and Solidarity Economy. The search was done at the databases: Web of Science, DOAJ, PubMed, Scielo and LILACS, with no year restrictions. The descriptors used were "solidarity economy", "mental health" and "inclusion". Twenty-nine (n=29) were found and after the inclusion criteria filter, ten articles were analysed. Thirty-four (n=34) professionals were involved in the studies and the most were Occupational Therapy, Nursing and Psychology. All the studies found used qualitative approaches and were conducted in Brazil. The interview was the most adopted method for data collection. The results indicate outcomes for users' intrinsic aspects such as self-management, expression, empowerment, and also extrinsic, such as family and collective work. The review added knowledge to reflect about the interdisciplinary and collaborative network, and also on the documentation of experiences in Solidarity Economy in the country.Keywords: Mental health; Solidarity economy; Public policies; Inclusion; Research.ResumenLa Economía Solidaria es una alternativa para la inserción laboral de personas con trastornos mentales. Se realizó una revisión de la literatura, con el fin de conocer qué se ha publicado sobre Economía Solidaria, inclusión y Salud Mental, cuáles son los objetivos y métodos de investigación, quiénes son los profesionales y las poblaciones objetivo y cuáles son los resultados obtenidos. Se consideraron los siguientes criterios para realizar este estudio: la importancia del tema para el contexto de la salud mental y la identificación de informes de investigación y experiencia que informarían las prácticas con la Salud Mental y la Economía Solidaria. La revisión se realizó en las bases de datos: Web of Science, DOAJ, PubMed, Scielo y LILACS, sin restricciones de año. Los descriptores utilizados fueron "economía solidaria", "salud mental" e "inclusión". Veintinueve (n = 29) artículos fueron encontrados y, después de aplicar los criterios de inclusión, diez fueron analizados en su totalidad. Treinta y cuatro (n = 34) profesionales participaron en las investigaciones, siendo la Terapia Ocupacional, Enfermería y Psicología las profesiones que aparecieron con más frecuencia. Todos los estudios encontrados fueron cualitativos y se realizaron en Brasil. La entrevista fue el método más adoptado. Los resultados de los estudios señalaron ganancias para los aspectos intrínsecos de los usuarios, como la autogestión, la expresión, el empoderamiento y también los aspectos extrínsecos, como el tema del trabajo familiar y colectivo. La revisión agregó conocimiento que nos permite reflexionar sobre la importancia de la interdisciplinariedad, así como el trabajo en red colaborativo, y sobre la necesidad de documentar experiencias en Economía Solidaria en el país.Palabras clave: Salud mental; Economía solidaria; Políticas públicas; Inclusión; Investigación.      


2021 ◽  
Vol 12 ◽  
Author(s):  
Allison Ducharme-Smith ◽  
Stefan Nicolau ◽  
C. Anwar A. Chahal ◽  
Kirstie Ducharme-Smith ◽  
Shujah Rehman ◽  
...  

Background: Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common muscular dystrophies and predominantly affects facial and shoulder girdle muscles. Previous case reports and cohort studies identified minor cardiac abnormalities in FSHD patients, but their nature and frequency remain incompletely characterized.Methods: We reviewed cardiac, neurological and genetic findings of 104 patients with genetically confirmed FSHD.Results: The most common conduction abnormality was complete (7%) or incomplete (5%) right bundle branch block (RBBB). Bifascicular block, left anterior fascicular block, complete atrioventricular block, and 2:1 atrioventricular block each occurred in 1% of patients. Atrial fibrillation or flutter were seen in 5% of patients. Eight percent of patients had heart failure with reduced ejection fraction and 25% had valvular disease. The latter included aortic stenosis in 6% (severe in 4% and moderate in 2%) and moderate aortic regurgitation in 8%. Mitral valve prolapse (MVP) was present in 9% of patients without significant mitral regurgitation. There were no significant associations between structural or conduction abnormalities and age, degree of muscle weakness, or size of the 4q deletion.Conclusions: Both structural and conduction abnormalities can occur in FSHD. The most common abnormalities are benign (RBBB and MVP), but more significant cardiac involvement was also observed. The presence of cardiac abnormalities cannot be predicted from the severity of the neurological phenotype, nor from the genotype.


2013 ◽  
Vol 20 (3) ◽  
pp. 139-143
Author(s):  
Jodi B. Wojcik ◽  
Matthew V. Benns ◽  
Glen A. Franklin ◽  
Brian G. Harbrecht ◽  
Kimberly D. Broughton-Miller ◽  
...  

2019 ◽  
pp. 1-21 ◽  
Author(s):  
Tina Karnatz ◽  
Jessica Monsees ◽  
Diana Wucherer ◽  
Bernhard Michalowsky ◽  
Ina Zwingmann ◽  
...  

ABSTRACT Background: Frontotemporal lobar degeneration (FTLD) is the second-most common cause of young-onset dementia. Personality and behavior changes lead to high caregiver stress and burden, but little support is available. Our aim is to present the evidence on the characteristics, challenges and unmet needs of caregivers as well as on possible interventions. Methods: We conducted a scoping review on caregiver burden using PubMed, Web of Science and ScienceDirect. A total of 69 articles were considered eligible and were analyzed in the present study. Results: Through the analysis of 69 empirical articles, our results show that caregivers of patients with FTLD are often younger in age, have children and find behavioral disturbances to be the most burdensome. Nine studies assessed the needs of and support for caregivers. Ten studies compared the burden in different forms of FTLD, 19 compared FTLD to other types of dementia, and one compared the caregiver burden between two countries. Eight studies reported on interventions for caregivers or interventions taking burden into account. One study assessed the support structure for caregivers of FTLD patients. Five case reports, eight research overviews and three reviews addressed specific needs and challenges. Conclusions: Further research should reproduce and validate efficacious interventions and focus on underage children of FTLD patients and findings from non-Western countries. Additionally, support structures for FTLD caregivers should be assessed and extended. Awareness both in the wider population and among healthcare professionals is an urgent need for the future.


2018 ◽  
Vol 53 (5) ◽  
pp. 523-536 ◽  
Author(s):  
Quyen T. Vo ◽  
Dennis F. Thompson

Objectives: The purpose of this article is to review the current literature on drug-induced thrombocytosis with the goal of critically assessing causality and providing a comprehensive review of the topic. Thrombopoietic growth factors, such as thrombopoietin-receptor agonists (romiplostim and eltrombopag) and erythropoietin are not included in our review. Data Sources: The literature search included published articles limited to the English language and humans in MEDLINE, EMBASE, and Web of Science databases. MEDLINE/PubMed (1966 to September 2018) was searched using the MeSH terms thrombocytosis/chemically-induced and thrombocytosis/etiology. EMBASE (1980 to September 2018) was searched using the EMTAGS thrombocytosis/side effect. Web of Science (1970 to September 2018) was searched using the search term thrombocytosis. References of all relevant articles were reviewed for additional citations and information. Study Selection and Data Extraction: Review articles, clinical trials, background data, case series, and case reports of drug-induced thrombocytosis were collected, and case reports were assessed for causality using a modified Naranjo nomogram. Data Synthesis: Drug-induced thrombocytosis, a form of reactive thrombocytosis cannot be easily differentiated from more common etiologies of reactive thrombocytosis. In all, 43 case reports of drug-induced thrombocytosis from a wide variety of drugs and drug classes were reviewed using a modified Naranjo probability scale that included criteria specific for thrombocytosis. Conclusions: Drug-induced thrombocytosis is a relatively rare adverse drug reaction. The strongest evidence of causality supports low-molecular-weight heparins and neonatal drug withdrawal. Weaker evidence exists for all-trans retinoic acid, antibiotics, clozapine, epinephrine, gemcitabine, and vinca alkaloids.


2020 ◽  
Vol 2 (12) ◽  
pp. 2647-2657
Author(s):  
Zoya Morani ◽  
Saumil Patel ◽  
Sudeshna Ghosh ◽  
Falah Abu Hassan ◽  
Shriya Doreswamy ◽  
...  

AbstractPatients with COVID-19 present with a myriad of comorbidities. An immunocompromised state like HIV in patients with COVID-19 can be life-threatening. We searched PubMed/Medline, Scopus, and Web of Science for case reports and case series about COVID-19 in HIV patients. We finally reviewed 20 case reports including cases of 43 patients with HIV and COVID-19. The mean age of 43 adult patients was 51.56 ± 27.56 years (range 24–76 years). Of these, 30 were male (69.77%), 11 were female (25.58%), and 2 were transgender (4.65%). A total of 25 patients (58.14%) were above 50 years of age. The most common cardiovascular comorbidities were hypertension and hyperlipidemia (48.8%), diabetes (20.93%), and morbid obesity (11.63%). Out of 43 HIV patients with COVID-19, 6 resulted in death (13.95%). All the patients who died were elderly above 50 years and required mechanical ventilation. HIV patients infected with COVID-19 had a high mortality rate. A high burden of pre-existing comorbidities and an advanced age in these patients make them prone to disease progression and worse outcomes.


2019 ◽  
Vol 22 (9) ◽  
pp. 987-991
Author(s):  
Laura M. Schwab ◽  
Tim McGrath ◽  
Melinda M. Franettovich Smith ◽  
M. Dilani Mendis ◽  
Deirdre McGhee ◽  
...  

Author(s):  
Shashi Kant Dhir ◽  
Jogender Kumar ◽  
Jitendra Meena ◽  
Praveen Kumar

Abstract Objective The objective of this study is to systematically synthesize the currently available literature on various modes of transmission (congenital, intrapartum, and postpartum), clinical features and outcomes of SARS-CoV-2 infection in neonates. Methods We conducted a comprehensive literature search using PubMed, EMBASE, and Web of Science until 9 June 2020. A combination of keywords and MeSH terms, such as COVID-19, coronavirus, SARS-CoV-2, 2019-nCoV, severe acute respiratory syndrome coronavirus 2, neonates, newborn, infant, pregnancy, obstetrics, vertical transmission, maternal–foetal transmission and intrauterine transmission, were used in the search strategy. We included studies reporting neonatal outcomes of SARS-CoV-2 proven pregnancies or neonatal cases diagnosed with SARS-CoV-2 infection. Results Eighty-six publications (45 case series and 41 case reports) were included in this review. Forty-five case series reported 1992 pregnant women, of which 1125 (56.5%) gave birth to 1141 neonates. A total of 281 (25%) neonates were preterm, and caesarean section (66%) was the preferred mode of delivery. Forty-one case reports describe 43 mother-baby dyads of which 16 were preterm, 9 were low birth weight and 27 were born by caesarean section. Overall, 58 neonates were reported with SARS-CoV-2 infection (4 had a congenital infection), of which 29 (50%) were symptomatic (23 required ICU) with respiratory symptoms being the predominant manifestation (70%). No mortality was reported in SARS-CoV-2-positive neonates. Conclusion The limited low-quality evidence suggests that the risk of SARS-CoV-2 infections in neonates is extremely low. Unlike children, most COVID-positive neonates were symptomatic and required intensive care. Postpartum acquisition was the commonest mode of infection in neonates, although a few cases of congenital infection have also been reported.


2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Giuseppe Lippi ◽  
Gianfranco Cervellin ◽  
Camilla Mattiuzzi

Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the keywords “migraine” and “vitamin D,” “25OH-D” “cholecalciferol,” “ergocalciferol,” with no language or date restriction. The electronic search allowed identifying seven studies (3 observational, 2 cross-sectional, and 2 case reports). The two case reports, including four women, showed favourable effects of vitamin D supplementation on migraine severity, but these studies were small and not placebo controlled. As regards the three observational studies, vitamin D deficiency was observed in 13.2 to 14.8% of migraine patients, and these rates do not differ from those reported in the general population (i.e., vitamin D deficiency between 22 and 42%). The results of the two cross-sectional studies are even more controversial, since no association was found between vitamin D status and migraine in both trials. In conclusion, the current evidence suggests that the association between migraine and vitamin D lacks reliable scientific support.


Author(s):  
Talal Khalid Abdullah Alanazi ◽  
Nasser Faris Ali Alahmari ◽  
Faris Essa Ibrahim Qubays ◽  
Solaiman Hosaian ibraheem Alenezi ◽  
Meshal Faleh Mofadhe Alenezi

Introduction: Several observational studies have found parallels between COVID-19 pneumonia and organizing pneumonia (OP). This study aims to investigate the published literature of OP related to COVID-19, estimates the prevalence of OP among COVID-19 patients, and assesses the risk or COVID-19 severity associated with OP. Methodology: This was a systematic review and meta-analysis. A systematic electronic search through PubMed, Web of Science, Science Direct, EBSCO, and Google Scholar was conducted to include relevant and eligible literature. The authors used Review Manager 5.4 to perform quantitative data synthesis for the condition of interest analyses. Results: A total of 9 eligible study articles and 12 case reports were included in this study. The estimated pooled organizing pneumonia prevalence among COVID-19 patients was 45.6% [23.1%-68.2%]. The association between OP and severe COVID-19 infection revealed a pooled OR [95% CI] of 5.22 [-0.96-11.41]. Conclusion: COVID-19 patients had a rather high OP prevalence (43%). Surprisingly, cancer patients with COVID-19 infection had the lowest OP prevalence. OP was identified as a possible risk factor for the severity of COVID-19 infection.


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