scholarly journals EFFECT OF AQUEOUS EXTRACT PLANT MIXTURE ON LIPID PROFILE AND HEPATOTOXICITY OF BROILER CHICKS

2019 ◽  
pp. 131-136
Author(s):  
MUHAMMAD JAVED ◽  
AAMIR IQBAL ◽  
MIAN NAZIR SHAH ◽  
SAMIULLAH KHAN ◽  
ABDUR RAHMAN SIAL ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Broiler Chicks ◽  
Internal Organs ◽  
Improve Liver Function ◽  
Plant Mixture ◽  
Group A ◽  
Group B ◽  
Group D

A research study was conducted to find the effect aqueous extract mixture of Zingiberofficinale, Carumcapticum, Withania somnifera, Trigonella foenum graecum, Silybummarianum, Allium sativum and Berberis lyceum on the growth performance of internal organs, lipid profile and hepatotoxicity of broiler chicks. A total of 240 day old chicks were purchased and were reared for 35 days in summer month. The birds were raised on conventional deep litter system, in open shed and all the pens/cages were placed in the same shed to ensure the same environment for all of the groups. Each pen was provided with a feeder and drinker. This aqueous extract mixture of plant was then mixed in drinking water of chicks at the rate of @ 0.0, 5.0, 10.0 and 15.0 ml/L for group A, B, C and D, respectively while group A served as a control. Feed and water were provided on calculated basis. Total numbers of chicks were divided into four groups (A, B, C and D) each having 60 chicks. Each group was further subdivided into three groups (replicates) each having 20 chicks. The data were recorded to explore the effect of infusion based plant mixture on the lipid profile and hepatotoxicity. AST and ALP had significantly (P<0.05) decreasing trend in groups B, C & D. ALT was significantly (P<0.05) lower in Group B. Group D had significantly (P<0.05) lower cholesterol, Triglyceride and LDL and higher HDL values. Serum protein were significantly (P<0.05) higher in group A. Group B @ 5.0 ml/L of Aqueous Extract water to improve liver function. Lipid profile could be well controlled, while using plant mixture extract @ 15.0 ml/L of water. Therefore the use of these medicinal plants is of great concern especially for broiler hepatic-toxicity and lipid profile. Keywords: Broilers, lipid profile, hepatotoxicity, higher density lipoprotein.

scholarly journals Effect of Supplementation With Chitosan on Weight, Cardiometabolic, and Other Risk Indices in Wistar Rats Fed Normal and High-Fat/High-Cholesterol Diets Ad Libitum

2017 ◽  
Vol 10 ◽  
pp. 117863881771066 ◽  
Author(s):  
Suhad M Bahijri ◽  
Lubna Alsheikh ◽  
Ghada Ajabnoor ◽  
Anwar Borai
Keyword(s):  
Food Intake ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
High Cholesterol ◽  
High Fat ◽  
Mean Values ◽  
Group A ◽  
Group B ◽  
Glutamyl Transferase ◽  
Group D

The aim was to investigate effect of chitosan on markers of obesity and cardiometabolic risk in rats fed normal chow (NC) or high-fat/high-cholesterol diet (HF/HCD). Forty male rats were fed NC or HF/HCD for 3 months, then divided into 4 groups: group A fed NC, group B: NC + chitosan, group C: HF/HCD, and group D: HF/HCD + chitosan. Food intake and weight were recorded, and serum glucose, lipid profile, insulin, leptin, gamma glutamyl transferase (GGT), and tumor necrosis factor α were measured at beginning and after 12 weeks. Atherogenic index (AI), low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C), and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. At the end of study, food intake was significantly increased in group B; mean values of triglycerides, total cholesterol, LDL-C, LDL-C:HDL-C, and AI were decreased in group B and group D; mean leptin was increased in group A and decreased in group B; and mean values of insulin, HOMA-IR, and GGT were increased in group C. The results from this study suggest that chitosan improved lipid profile, insulin sensitivity, and oxidative stress caused by HF/HCD.

scholarly journals Effect of dietary fatty acid on blood lipid profile and induced bacterial infection in rat

2015 ◽  
Vol 1 (2) ◽  
pp. 235-243
Author(s):  
Most Sumona Akter ◽  
Md Abu Yousuf ◽  
Md Yousuf Ali ◽  
Most Mahfuja Khatun ◽  
Sukumar Saha ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Blood Cholesterol ◽  
Control Group ◽  
Blood Lipid Profile ◽  
Bacterial Colony ◽  
Group A ◽  
Group B

Ground nut is one of the commonly used decorative nutritious relish seed around the world. Ground nut have hypocholesterolamic, hypoglycemic, hypolipidemic, anti-atherosclerotic, immune-modulatory and bacterial counting effects. In Bangladesh, limited research has so far been performed on the action of ground nut in biological system and its comparative efficacy with commercialized drugs that reduce blood cholesterol. The aim of this study was carried on the effects of PUFA on blood total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) and against artificial inoculation (I/N) Staphylococcus aureus infection of experimental rat by feeding of ground nut. A total of fifteen long Evans rats (Rattus norvegicus) were used for this study. The rats were randomly divided into three equal groups (n=5) and numbered as A, B and C. Group A (control), Group B (50gm ground nut/ day/group), group C (100 gm ground nut/day/group). All groups were supplied with standard broiler pellet and fresh drinking water throughout the experimental period (January to June /2012). The blood samples were collected directly from the heart at the 1st and 60th day for biochemical test (TC, LDL, HDL and TG) and test was performed as per Memorial Diagnostic Centre, Charpara, Mymensingh. Staphylococcus aureus was cultured in nutrient broth and 100 µl of their culture was inoculated into the rats through intranasal route. Among all the treated groups, the rats of group C exhibited the lowest TC value, TG and LDL and reduced blood cholesterol significantly than (control group A) followed by group B. In bacteriological examinations, it was found that the number of bacterial colony lowest in group C in comparison with the group of A and B. From the present experiment, it can be assumed that PUFA has significant effect on blood lipid profile and against bacterial infection.Asian J. Med. Biol. Res. June 2015, 1(2): 235-243

scholarly journals Effect of Spirulina platensis on Lipid Profile of Long Evans Rats

1970 ◽  
Vol 45 (3) ◽  
pp. 249-254 ◽  
Author(s):  
M Omar Faruq Mridha ◽  
Parvin Noor ◽  
Rahima Khaton ◽  
Dipa Islam ◽  
Motaher Hossain
Keyword(s):  
Lipid Profile ◽  
Spirulina Platensis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Other ◽  
High Fat ◽  
High Sugar ◽  
Group B ◽  
Group D ◽  
Effective Result

To study the Effect of Spirulina platensis on lipid profile of Long Evan rats, an experiment was conducted by feeding the rats with diets supplemented with Spirulina platensis dry powder. Five different types of diets were included in the feeding. Group A containing high fat and high sugar considered as control-01. Group B with high fat, high sugar and 0.5% Spirulina. Group C with high fat, high sugar and 2.5% Spirulina. These three groups were included in Diet-1. Group D with laboratory diets considered as control-02 and Group E i.e., laboratory diet with Spirulina 150mg/kg/body weight. These two groups were included in Diet-2. This study describes the useful effect of Spirulina powder after administration in high fat and high sugar diet and in normal laboratory diet. Spirulina platensis powder showed an effective result in the lipid profile of Long Evan rats. Total cholesterol (TC) serum lipid significantly reduced in Group B than that of 2.5% of Spirulina powder in Group C rats. 0.5% and 2.5% Spirulina powder had the same effect in dropping low density lipoprotein (LDL) in both B and C Groups of rats. Conversely 2.5% Spirulina powder was found more effective in increasing high density lipoprotein (HDL) in Group C (50.54%) rats than the group B (24.18%) rats. On the other hand, the dose 150mg/kg b.w Spirulina powder mixed in laboratory diet showed an effective result in decreasing total cholesterol (TC) and low density lipoprotein (LDL) 19.21% and 46.06%, respectively. The findings clearly indicated that 150mg/kg b.w Spirulina powder had positive effect to increase the value of high density lipoprotein (HDL) in Group E (24.98%) rats compare to control group D rats. There were no significant differences in diet-1 groups' TC, TG and LDL-C of the groups of A (control- 01), B and C (p<0.05), although they varies statistically for HDL among these groups (p>0.05). On the other hand in diet-2 groups' TG, LDL and HDL of E groups of rats were significantly varies than control-2 groups of rats D ( p>0.05), although TC was not significant statistically (p<0.05). Keywords: High fat diet; Body weight (b.w); Hypercholesterolemia; Hypolipidaemic; Spirulina platensis. DOI: 10.3329/bjsir.v45i3.6533Bangladesh J. Sci. Ind. Res. 45(3), 249-254, 2010

scholarly journals Effects of Aqueous Extract of Basella alba L. leaves on Blood Cell Count in Rats

2019 ◽  
Vol 22 (1) ◽  
pp. 73-78
Author(s):  
Farhana Sabrin ◽  
AF Mohammed Shafiqul Alam ◽  
Muhammad Rashedul Islam ◽  
Md Elias Al Mamun ◽  
Jakir Ahmed Chowdhury
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Aqueous Extract ◽  
Control Group ◽  
P Value ◽  
Blood Cell Count ◽  
Basella Alba ◽  
Group A ◽  
Group B ◽  
Group D

The effect of aqueous extract of Basella alba (puishak) leaves on blood cell count of rats was studied. Forty rats of both sexes weighing between 100-150 gm were used. The rats were divided into four groups (7 rats in each group), with group A as the control group and experimental groups were denoted as B, C and D. With all aseptic precautions, aqueous extract of Basella alba (Puishak) leaves was administered into the three different doses (For group B: 60 mg/kg bw, group C: 80 mg/kg bw and group D: 100 mg/kg bw). Control group A also received distilled water as a placebo at the dose of 10 mg/kg bw for 14 days. At day 15, blood samples were collected and sent for haematological analysis. Data analysis of blood count profile of 28 rats revealed that there is an increased number of RBC, WBC and platelet count in experimental groups than in control group. ANOVA test revealed that increased blood cell counts following administration of aqueous leaves extract of keeves of B. alba were statistically significant (p value for each case was .0001<.05) than control group. Paired samples t test was performed to compare between baseline hematological parameters and parameters after 14 days of intervention. Then comparison between Group A & Group B, between Group A & Group C and between Group A & Group D were done. In all cases, probability (p) value < 0.05 was considered as statistically significant.This it is clearly evident that aqueous extract of B.alba has positive stimulant effect on blood cells count of rats. Moreover, it was found that increment of doses also increases the cell count that is positively correlated with the hypothesis. Bangladesh Pharmaceutical Journal 22(1): 73-78, 2019

scholarly journals Study of serum lipid profile and magnesium in preeclampsia

2019 ◽  
Vol 8 (4) ◽  
pp. 1445
Author(s):  
Hymavathi K. Reddy ◽  
Vineela P. ◽  
Bhargavi M. Chowdary
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Magnesium ◽  
Low Density Lipoprotein ◽  
Tertiary Care ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Low Density ◽  
Group A ◽  
Group B

Background: A comparative study of serum lipid profile and magnesium levels in normal pregnancy versus preeclampsia (PE).Methods: A prospective study done for 2 years (October 2014 to October 2016) in the Department of Obstetrics and Gynecology, Narayana medical college and hospital, a tertiary care centre, Nellore, Andhra Pradesh, India. A sample size of 200 pregnant women, recruited and divided into group A and B. group A being women with PE and group B is normal pregnant women.A10ml of venous blood was collected in the fasting state and serum collected from clotted blood to measure lipid profile, magnesium, Apo lipoprotein A-I and Apo lipoprotein B 100.Serum Lipid profile  measured by enzymatic method using commercially available kit Human (GmbH Germany) using humastar 600 chemistry analyzer (Human GmbH Germany). Serum magnesium measured by dye binding method using commercially available kit Human (GmbH Germany) using Humastar 600 chemistry analyzer (Human GmbH Germany). Serum ApoA-I and ApoB were measured by immune-turbidometry using commercial kits from Spinreact Spain. Urine albumin done by dipstick method.Results: Serum total cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), Apo lipoprotein B 100 (Apo B100) were high and serum Magnesium, high density lipoprotein (HDL) and Apo lipoprotein A1(Apo A1) were low in the study group (group A) compared to controls (group B).Conclusions: Abnormal lipid profile (low HDL and increased TG concentration) and serum hypomagnesaemia may be contributing etiologies of preeclampsia, having good predictive value as a screening procedure for PE in high risk pregnant population.

Residual Renal Function Affects Lipid Profile in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

1997 ◽  
Vol 17 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Alexander Kagan ◽  
Eti Elimalech ◽  
Zvi Lerner ◽  
Aaron Fink ◽  
Yaacov Bar-Khayim
Keyword(s):  
Renal Function ◽  
Peritoneal Dialysis ◽  
Lipid Profile ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Residual Renal Function ◽  
Lipoprotein Cholesterol ◽  
Group A ◽  
Group B

Objective To determine whether lipoprotein abnormalities associated with continuous ambulatory peritoneal dialysis (CAPD) are influenced by residual renal function (RRF). Design Open, non randomized prospective and com -parative study. Setting Single university teaching hospital dialysis unit and outpatient clinic. Patients Twenty adult patients on standard CAPD (1 -38 months) were divided into two groups: group A (RRF ≤ 0.8 mL/min, n = 10) and group B (RRF ≥ 1.1 mL/ min, n = 10). Patients in the two groups were matched for age, time on dialysis, body weight, body mass index, serum urea and albumin levels, peritoneal and urinary albumin losses, and peritoneal transport characteristics such as overnight 8hour peritoneal creatinine and β2-microglobulin clearances and overnight 8-hour effluent glucose concentrations. Results The degree of uremia in patients with preserved RRF (group B) was obviously lower than in patients with negligible RRF (group A), that is, patients in group B had significantly lower serum creatinine and β2-microglobulin levels and significantly higher weekly KTN than group A patients. Despite the prevalence of allele 4 of apolipoprotein E genotype in group A patients, their levels of serum total cholesterol, low-density lipoprotein cholesterol, lipoprotein (a) [Lp(a)], apolipoprotein B (ApoB), and apolipoprotein A1 (ApoA1) were significantly lower than those of patients with preserved RRF (group B). The two groups did not differ significantly in the serum levels of triglyceride or high-density lipoprotein cholesterol. Serum concentrations of Lp(a) and ApoA1, as well as ratios of ApoA1 to ApoB, were correlated significantly with RRF (r = 0.63, r = 0.51, and r = 0.61, respectively). Conclusions The findings suggest that RRF affects the lipid profile of CAPD patients, especially serum levels of cholesterol-rich lipoproteins.

scholarly journals Role of lipid profile and uterine artery doppler in predicting risk of preeclampsia in early second trimester

2020 ◽  
Vol 9 (5) ◽  
pp. 1806
Author(s):  
Sheena Chopra ◽  
Sangeeta Pahwa
Keyword(s):  
Lipid Profile ◽  
Uterine Artery ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Uterine Artery Doppler ◽  
Group A ◽  
Group B ◽  
Risk Of Preeclampsia

Background: Preeclampsia is associated with adverse pregnancy outcome and is a major cause of the fetomaternal morbidity and mortality. This study aimed at finding the role of lipid profile and uterine artery Doppler as a reliable predictor of risk of preeclampsia in early second trimester.Methods: This study is conducted in the obstetrics and gynecology department of a tertiary care teaching hospital, Amritsar. Lipid profile and Uterine artery doppler is estimated in 100 antenatal women from 14-20 weeks of period of gestation who met the inclusion criteria and are followed up till delivery or till preeclampsia sets in.Results: Out of 100 subjects 74 remained normotensive (Group A) and 26 developed preeclampsia (Group B). The mean serum level of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL) and very low-density lipoprotein cholesterol (VLDL) was significantly higher in Group B as compared to group A women. The Preeclamptic women showed significant fall in high density lipoprotein cholesterol (HDL) level as compared to normal pregnant women. The mean S/D ratio, PI and RI values of uterine artery Doppler were higher for group B and were statistically significant.Conclusions: The combined predictive value of lipid profile and uterine artery Doppler for estimating risk of preeclampsia was more reliable than of any of the test individually.

scholarly journals Effect of vitamins, minerals and probiotics on production of antibody and live weight gain following vaccination with BCRDV in broiler birds

1970 ◽  
Vol 6 (1) ◽  
pp. 31-36 ◽  
Author(s):  
P Monoura ◽  
M Rahman ◽  
MFR Khan ◽  
MB Rahman ◽  
MM Rahman
Keyword(s):  
Antibody Titre ◽  
Serum Antibody ◽  
Live Weight ◽  
Poultry Feed ◽  
Control Group ◽  
Broiler Chicks ◽  
Antibody Titres ◽  
Group A ◽  
Group B ◽  
Group D

The effect of vitamins, minerals and probiotics supplementation to the balanced ration of the broiler chicks on the immune response and growth performance after vaccination with BCRDV was evaluated. For this 50 broiler birds were divided into five equal groups such as A, B, C, D and E, and five types of separate treatments with normal poultry feed were provided to the indivisual experimental groups. All the birds were vaccinated with BCRDV primarily at 3 days of age and boostered at 17 days of age. The birds of group A, B, C and D were supplemented with only probiotics, mixture of probiotics and minerals, mixture of probiotics, minerals and vitamins, respectively. The birds of group E were kept as vaccinated control. Blood samples were collected at the age of 9, 12, 16, 23, 26 and 30 days sequencially. The serum antibody titres were measured by HI test and ELISA. The highest value of HI antibody titre was 384±242.65 (Mean ±SD) in group B at 23 days of age. The lowest value of HI at 23 days was 56±32.86 (Mean ±SD) obtained in group C. The ELISA antibody titre was also highest (4675.12±485.72) at 23 days in group B and obviously the lowest (2169.38±724.45) in control group E. In case of group C, the ELISA antibody titre was 3105.73±877.57 at 23 days but then the titre decreased gradually compared to control group. The highest body weight (1420±90.82) was recorded at 30 days of age in group D and the lowest value (1188±44.38) was in group B. Key words: Probiotics, BCRDV, broiler birds DOI = 10.3329/bjvm.v6i1.1336 Bangl. J. Vet. Med. (2008). 6 (1): 31-36

scholarly journals Impact of anti-inflammatory agent like Bryophyllum pinnatum aqueous extract and diclofenac on blood pressure and creatinine clearance.

2020 ◽  
Vol 27 (10) ◽  
pp. 2110-2116
Author(s):  
Farwa Naqvi ◽  
Iram Imran ◽  
Bilal Habib ◽  
Summyia Sadia ◽  
Zaib ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Creatinine Clearance ◽  
Aqueous Extract ◽  
Control Group ◽  
Inflammatory Agent ◽  
Group A ◽  
Anti Inflammatory ◽  
Group B ◽  
Group D ◽  
Bryophyllum Pinnatum

Objectives: To study the impact of anti-inflammatory agent like Bryophyllum pinnatum aqueous extract and diclofenac on blood pressure and creatinine clearance. Study Design: Experimental study. Setting: Sargodha Medical College, Sargodha, Department of Pharmacy, University of Sargodha. Period: 1st January 2019 to 30th June 2019. Material & Methods: 24 Sprague Dawley rats were obtained and were then divided into four groups. Negative control group (A) contained animals received normal diet while Group B, C and D received diet containing sucrose (20% w/w) to induce hypertension. After that group B (positive control group) received distilled water 0.5 ml was by oral route, group C (Bryophyllum pinnatum group) received Bryophyllum pinnatum aqueous extract 300 mg/ml intraperitoneally and group D received diclofenac 12 mg/kg intraperitoneally as a single morning dose for two weeks. Blood pressure of animals was recorded at baseline and then weekly throughout the study using tail cuff using non-invasive blood pressure controller (ML125R). Animals were anesthetised with chloroform and two ml blood was drawn through cardiac puncture at 0, 4and 6 weeks. Blood was tested for haematocrit. Serum sodium and potassium levels were estimated by flame photometer. Urinary creatinine levels were estimated by kinetic Jaffé method. The data collected was processed by using Statistical Package for Social Sciences (SPSS 20). Results: Mean and standard deviation of systolic blood pressure (BP) of group A rats did not change with time, while that of group B, C and D increased till 4th week. Creatinine clearance of group A, B and C did not change much with time but that of group D decreased towards end of study period. Conclusion: Bryophyllum pinnatum leaf aqueous extract is an effective anti-hypertensive agent with minimal renal effects.

scholarly journals Study of thyroid dysfunction and dyslipidemia in chronic kidney diseases

2017 ◽  
Vol 6 (1) ◽  
pp. 110
Author(s):  
S. K. Tripathy ◽  
N. Dhal ◽  
M. Kanungo ◽  
S. Das ◽  
S. K. Mishra ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Lipid Profile ◽  
Thyroid Function ◽  
Conservative Management ◽  
Thyroid Dysfunction ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Group A ◽  
Group B

Background: Though there are many studies on thyroid dysfunction and dyslipidemia in Chronic Kidney Disease (CKD), no study is conclusive. Aim of this study was to correlate abnormalities in thyroid function and lipid profile with the severity of renal failure and also to observe the difference of these abnormalities between patients on conservative management verses hemodialysis.Methods: Hundred consecutive CKD cases admitted to Medicine Department were taken up for the study. They were divided into two groups as Group-A [on conservative management] and Group-B [on regular Hemodialysis (HD)]. Hundred healthy persons were taken as control in Group-C. After evaluation of thyroid function and lipid profile statistical analysis was done by students t-test, chi-square and regression analysis.Results: Hundred CKD cases with 74% male (n=74) and 26% female (n=26) in a M: F ratio of 2.9:1 were found to be in different stages CKD (0, 2, 20, 28 and 50 in stage-1 to stage-5 respectively). In 50 cases of stage-5 CKD, 30 were on HD and 20 on conservative management. Diabetes Mellitus (DM) (40%) was the commonest etiology of CKD followed by Hypertension (HTN), obstructive uropathy, chronic glomerulonephritis (CGN) and polycystic kidney disease (PKD). Thyromegaly was not found in a single case. In all CKD cases (Group-A+B) TT3 (TT3) was significantly low (P =0.0011) when compared with control (Group-C) and no difference was found between Group-A and Group-B. Fall in TT3 worsened with increasing severity of CKD. Lipid profile study revealed Decreased High-Density Lipoprotein Cholesterol (HDLc) and increased Triglyceride (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDLc), TC/HDLc and LDLc/HDLc in Group-A than Group-B but only TG and TC increase was statistically significant. The levels of TG and TC and TC/HDLc increased as the stage of CKD progressed and was statistically significant (P= 0.035).Conclusions: There occurs a state of biochemical hypothyroidism without overt clinical hypothyroid state in CKD, the extent of which correlates with the severity of CKD. Increased cardiovascular complications occur due to accelerated atherosclerosis in CKD. This study confirmed that atherogenic lipid profile and thyroid dysfunction worsen with the progression of disease. Difference between patients on conservative management and HD was not found.

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