scholarly journals Effect of Spirulina platensis on Lipid Profile of Long Evans Rats

1970 ◽  
Vol 45 (3) ◽  
pp. 249-254 ◽  
Author(s):  
M Omar Faruq Mridha ◽  
Parvin Noor ◽  
Rahima Khaton ◽  
Dipa Islam ◽  
Motaher Hossain
Keyword(s):  
Lipid Profile ◽  
Spirulina Platensis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Other ◽  
High Fat ◽  
High Sugar ◽  
Group B ◽  
Group D ◽  
Effective Result

To study the Effect of Spirulina platensis on lipid profile of Long Evan rats, an experiment was conducted by feeding the rats with diets supplemented with Spirulina platensis dry powder. Five different types of diets were included in the feeding. Group A containing high fat and high sugar considered as control-01. Group B with high fat, high sugar and 0.5% Spirulina. Group C with high fat, high sugar and 2.5% Spirulina. These three groups were included in Diet-1. Group D with laboratory diets considered as control-02 and Group E i.e., laboratory diet with Spirulina 150mg/kg/body weight. These two groups were included in Diet-2. This study describes the useful effect of Spirulina powder after administration in high fat and high sugar diet and in normal laboratory diet. Spirulina platensis powder showed an effective result in the lipid profile of Long Evan rats. Total cholesterol (TC) serum lipid significantly reduced in Group B than that of 2.5% of Spirulina powder in Group C rats. 0.5% and 2.5% Spirulina powder had the same effect in dropping low density lipoprotein (LDL) in both B and C Groups of rats. Conversely 2.5% Spirulina powder was found more effective in increasing high density lipoprotein (HDL) in Group C (50.54%) rats than the group B (24.18%) rats. On the other hand, the dose 150mg/kg b.w Spirulina powder mixed in laboratory diet showed an effective result in decreasing total cholesterol (TC) and low density lipoprotein (LDL) 19.21% and 46.06%, respectively. The findings clearly indicated that 150mg/kg b.w Spirulina powder had positive effect to increase the value of high density lipoprotein (HDL) in Group E (24.98%) rats compare to control group D rats. There were no significant differences in diet-1 groups' TC, TG and LDL-C of the groups of A (control- 01), B and C (p<0.05), although they varies statistically for HDL among these groups (p>0.05). On the other hand in diet-2 groups' TG, LDL and HDL of E groups of rats were significantly varies than control-2 groups of rats D ( p>0.05), although TC was not significant statistically (p<0.05). Keywords: High fat diet; Body weight (b.w); Hypercholesterolemia; Hypolipidaemic; Spirulina platensis. DOI: 10.3329/bjsir.v45i3.6533Bangladesh J. Sci. Ind. Res. 45(3), 249-254, 2010

scholarly journals Effect of Supplementation With Chitosan on Weight, Cardiometabolic, and Other Risk Indices in Wistar Rats Fed Normal and High-Fat/High-Cholesterol Diets Ad Libitum

2017 ◽  
Vol 10 ◽  
pp. 117863881771066 ◽  
Author(s):  
Suhad M Bahijri ◽  
Lubna Alsheikh ◽  
Ghada Ajabnoor ◽  
Anwar Borai
Keyword(s):  
Food Intake ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
High Cholesterol ◽  
High Fat ◽  
Mean Values ◽  
Group A ◽  
Group B ◽  
Glutamyl Transferase ◽  
Group D

The aim was to investigate effect of chitosan on markers of obesity and cardiometabolic risk in rats fed normal chow (NC) or high-fat/high-cholesterol diet (HF/HCD). Forty male rats were fed NC or HF/HCD for 3 months, then divided into 4 groups: group A fed NC, group B: NC + chitosan, group C: HF/HCD, and group D: HF/HCD + chitosan. Food intake and weight were recorded, and serum glucose, lipid profile, insulin, leptin, gamma glutamyl transferase (GGT), and tumor necrosis factor α were measured at beginning and after 12 weeks. Atherogenic index (AI), low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C), and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. At the end of study, food intake was significantly increased in group B; mean values of triglycerides, total cholesterol, LDL-C, LDL-C:HDL-C, and AI were decreased in group B and group D; mean leptin was increased in group A and decreased in group B; and mean values of insulin, HOMA-IR, and GGT were increased in group C. The results from this study suggest that chitosan improved lipid profile, insulin sensitivity, and oxidative stress caused by HF/HCD.

scholarly journals Study of serum lipid profile and magnesium in preeclampsia

2019 ◽  
Vol 8 (4) ◽  
pp. 1445
Author(s):  
Hymavathi K. Reddy ◽  
Vineela P. ◽  
Bhargavi M. Chowdary
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Magnesium ◽  
Low Density Lipoprotein ◽  
Tertiary Care ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Low Density ◽  
Group A ◽  
Group B

Background: A comparative study of serum lipid profile and magnesium levels in normal pregnancy versus preeclampsia (PE).Methods: A prospective study done for 2 years (October 2014 to October 2016) in the Department of Obstetrics and Gynecology, Narayana medical college and hospital, a tertiary care centre, Nellore, Andhra Pradesh, India. A sample size of 200 pregnant women, recruited and divided into group A and B. group A being women with PE and group B is normal pregnant women.A10ml of venous blood was collected in the fasting state and serum collected from clotted blood to measure lipid profile, magnesium, Apo lipoprotein A-I and Apo lipoprotein B 100.Serum Lipid profile  measured by enzymatic method using commercially available kit Human (GmbH Germany) using humastar 600 chemistry analyzer (Human GmbH Germany). Serum magnesium measured by dye binding method using commercially available kit Human (GmbH Germany) using Humastar 600 chemistry analyzer (Human GmbH Germany). Serum ApoA-I and ApoB were measured by immune-turbidometry using commercial kits from Spinreact Spain. Urine albumin done by dipstick method.Results: Serum total cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), Apo lipoprotein B 100 (Apo B100) were high and serum Magnesium, high density lipoprotein (HDL) and Apo lipoprotein A1(Apo A1) were low in the study group (group A) compared to controls (group B).Conclusions: Abnormal lipid profile (low HDL and increased TG concentration) and serum hypomagnesaemia may be contributing etiologies of preeclampsia, having good predictive value as a screening procedure for PE in high risk pregnant population.

scholarly journals Role of lipid profile and uterine artery doppler in predicting risk of preeclampsia in early second trimester

2020 ◽  
Vol 9 (5) ◽  
pp. 1806
Author(s):  
Sheena Chopra ◽  
Sangeeta Pahwa
Keyword(s):  
Lipid Profile ◽  
Uterine Artery ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Uterine Artery Doppler ◽  
Group A ◽  
Group B ◽  
Risk Of Preeclampsia

Background: Preeclampsia is associated with adverse pregnancy outcome and is a major cause of the fetomaternal morbidity and mortality. This study aimed at finding the role of lipid profile and uterine artery Doppler as a reliable predictor of risk of preeclampsia in early second trimester.Methods: This study is conducted in the obstetrics and gynecology department of a tertiary care teaching hospital, Amritsar. Lipid profile and Uterine artery doppler is estimated in 100 antenatal women from 14-20 weeks of period of gestation who met the inclusion criteria and are followed up till delivery or till preeclampsia sets in.Results: Out of 100 subjects 74 remained normotensive (Group A) and 26 developed preeclampsia (Group B). The mean serum level of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL) and very low-density lipoprotein cholesterol (VLDL) was significantly higher in Group B as compared to group A women. The Preeclamptic women showed significant fall in high density lipoprotein cholesterol (HDL) level as compared to normal pregnant women. The mean S/D ratio, PI and RI values of uterine artery Doppler were higher for group B and were statistically significant.Conclusions: The combined predictive value of lipid profile and uterine artery Doppler for estimating risk of preeclampsia was more reliable than of any of the test individually.

scholarly journals EFFECT OF AQUEOUS EXTRACT PLANT MIXTURE ON LIPID PROFILE AND HEPATOTOXICITY OF BROILER CHICKS

2019 ◽  
pp. 131-136
Author(s):  
MUHAMMAD JAVED ◽  
AAMIR IQBAL ◽  
MIAN NAZIR SHAH ◽  
SAMIULLAH KHAN ◽  
ABDUR RAHMAN SIAL ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Broiler Chicks ◽  
Internal Organs ◽  
Improve Liver Function ◽  
Plant Mixture ◽  
Group A ◽  
Group B ◽  
Group D

A research study was conducted to find the effect aqueous extract mixture of Zingiberofficinale, Carumcapticum, Withania somnifera, Trigonella foenum graecum, Silybummarianum, Allium sativum and Berberis lyceum on the growth performance of internal organs, lipid profile and hepatotoxicity of broiler chicks. A total of 240 day old chicks were purchased and were reared for 35 days in summer month. The birds were raised on conventional deep litter system, in open shed and all the pens/cages were placed in the same shed to ensure the same environment for all of the groups. Each pen was provided with a feeder and drinker. This aqueous extract mixture of plant was then mixed in drinking water of chicks at the rate of @ 0.0, 5.0, 10.0 and 15.0 ml/L for group A, B, C and D, respectively while group A served as a control. Feed and water were provided on calculated basis. Total numbers of chicks were divided into four groups (A, B, C and D) each having 60 chicks. Each group was further subdivided into three groups (replicates) each having 20 chicks. The data were recorded to explore the effect of infusion based plant mixture on the lipid profile and hepatotoxicity. AST and ALP had significantly (P<0.05) decreasing trend in groups B, C & D. ALT was significantly (P<0.05) lower in Group B. Group D had significantly (P<0.05) lower cholesterol, Triglyceride and LDL and higher HDL values. Serum protein were significantly (P<0.05) higher in group A. Group B @ 5.0 ml/L of Aqueous Extract water to improve liver function. Lipid profile could be well controlled, while using plant mixture extract @ 15.0 ml/L of water. Therefore the use of these medicinal plants is of great concern especially for broiler hepatic-toxicity and lipid profile. Keywords: Broilers, lipid profile, hepatotoxicity, higher density lipoprotein.

scholarly journals Atorvastatin and carnitine combination versus atorvastatin alone impacts on the lipid profile of haemodialyzed patients: A randomised clinical trial

2018 ◽  
Vol 6 (4) ◽  
pp. 165-171
Author(s):  
Hamid Noshad ◽  
Davoud Mohammadi Nejhad ◽  
Parastou Hoseini ◽  
Majid Montazer ◽  
Behnaz Ghamari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Randomised Clinical Trial ◽  
Hemodialysis Patients ◽  
The Other ◽  
Medical Sciences ◽  
Before And After

Introduction: Dyslipidemia is one of the most common problems in hemodialysis patients and healthcare system. Some studies have suggested the use of carnitine in the treatment of dyslipidemia in hemodialysis patients. This study was carried out aiming to evaluate the effect of atorvastatin and carnitine combination versus atorvastatin alone on the lipid profile of hemodialyzed patients. Methods: In this clinical trial, 50 hemodialysis patients referred to the educational centres of Tabriz University of Medical Sciences, Tabriz, Iran, for haemodialysis were enrolled. Patients were randomly assigned into two groups. In the first group, patients were treated with carnitine (1000 mg three times daily) and atorvastatin (10-80 mg/day based on the baseline lipid profile of the patients) and in the second group, the patients were treated with atorvastatin alone for six months. The levels of triglyceride (TG), cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and haemoglobin before and after intervention were compared. The side effects of carnitine administration were also evaluated. Results: Results showed that TG, cholesterol, and LDL levels were significantly lower in the carnitine group compared to those in the other group at the end of study (P < 0.050). In addition, HDL and haemoglobin levels were significantly higher in the carnitine group in comparison to the other group (P < 0.050). No major side effects of carnitine were observed among the patients. Conclusion: The use of carnitine plus atorvastatin combination is an effective and safe method in the treatment of dyslipidemia in patients undergoing hemodialysis without imposing significant side effects.

scholarly journals A CLINICAL STUDY TO EVALUATE THE EFFICACY OF VAMANA KARMA IN THE MANAGEMENT OF DYSLIPIDEMIA

2018 ◽  
Vol 11 (12) ◽  
pp. 350
Author(s):  
Shipra Singh ◽  
Alok Kumar Srivastava
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Biochemical Parameter ◽  
Serum Lipid Profile ◽  
Standard Drug ◽  
Safe Management ◽  
Group A ◽  
Group B

Objective: The aim of the present study is to evaluate the efficacy of Vamana karma in the management of dyslipidemia.Methods: Patients were selected from the OPD and IPD at the Department of Panchakarma, Hospital of Rishikul Campus, Uttarakhand Ayurved University, Haridwar. Patients in Group A will be administered with two sittings of Vamana procedure. In Group B, 20 patients will be treated with atorvastatin for 60 days in dose of 10 mg once daily after meals with water.Results: The overall assessment of the therapy was decided on the basis of improvement in biochemical parameter (serum lipid profile) by applying statistics. Vamana karma had statistically highly significant result in all the objective parameters except high-density lipoprotein [HDL].Conclusion: Thus, it can be concluded that dyslipidemia is a form of Kaphavikara specifically may be Medodushti in the form of Abaddha meda. Vamana karma is highly effective in correcting serum lipid profile except HDL and very low-density lipoprotein but have better effect than the standard drug in both of them. Vamana karma can be used for the effective and safe management of dyslipidemia.

scholarly journals Study on Effects of Medroxyprogesterone Acetate on Serological Parameters, Ultrasonographic and Histopathological Profile of Uterine Endometrial Morphology in Female Rabbits

2022 ◽  
Author(s):  
H.A. Tahir ◽  
U.F. Durrani ◽  
A.K. Mahmood ◽  
K. Matloob ◽  
M. Imran ◽  
...  
Keyword(s):  
Single Dose ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Medroxyprogesterone Acetate ◽  
Reproductive Tract ◽  
Liver Enzymes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Group B

Background: Rabbits are small mammals from the family Leporidae. Rapid multiplication profile of the rabbits often necessitates contraceptive controls in which ovario-hysterectomy is the only recommended method worldwide but still rabbit owners avoid surgical manipulation and opt for the contraceptive injections but contraceptive injections are also known to cause undesired effects in different animal species. The present study was conducted to evaluate effects of Medroxyprogesterone acetate on liver enzymes, lipid profile, blood glucose and uterine endometrial morphology. Methods: The study was conducted on 20 breeding female rabbits at Pet Centre, University of Veterinary and Animal Sciences, Lahore, Pakistan. The study animals were divided into two groups, A and B having 10 rabbits each. Group A was treated with single dose of Medroxyprogesterone acetate (10 mg/kg IM). While group B was kept as control and was given a single dose of 0.9% normal saline placebo injection. Pre and post treatment serum sampling was performed on days 0, 7, 14, 21, 28, 35, 42 and histopathological evaluation of reproductive tract (mainly uterus) was conducted at the end of study. Result: Serological parameters i.e. liver profile, lipid profile and blood glucose level (random) were significantly increased after treatment along with congestion, engorgement of blood vessels, degeneration, hyperplasia of uterine epithelium and uterine glands in Treatment group in contrast to control group. On the basis of this study it was concluded that Medroxyprogesterone acetate poses undesirable effect on the uterine endometrium and different serological parameters of body like liver enzymes (total bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase), blood glucose, lipid profile (cholesterol, high density lipoprotein, low density lipoprotein, triglyceride).

Melatonin Improves Lipid Profile and Ameliorates Lipid Peroxidation in Patients with Chronic Kidney Disease.

2018 ◽  
pp. 38-45
Keyword(s):  
Lipid Peroxidation ◽  
Placebo Group ◽  
Lipid Profile ◽  
Kidney Diseases ◽  
Oxidized Ldl ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Before And After ◽  
Inhibit Lipid Peroxidation ◽  
Controlled Clinical Study

Dyslipidemia and oxidative modifications of lipid are frequently associated in patients with chronic kidney diseases (CKD) and considered the most important risk factors for cardiovascular events. Melatonin is a well-known potent antioxidant and has beneficial effect on lipid metabolism. the study was designed to evaluate if Melatonin could improve lipid profile and ameliorates lipid peroxidation. This single blind placebo controlled clinical study carried out on 41 patients with CKD who were randomized into two groups, control groups (n=20) those who received placebo cap and melatonin group those who received 5mg melatonin (n=21). Lipid profile [total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C)] and parameters of lipid peroxidation [oxidized LDL (oxLDL) and malondialdehyde (MDA) were measured before and after 12 weeks of the treatment. After 12 weeks of treatment, melatonin significantly increased HDL-C and decreased LDL-C compared to the initial value. The elevation in HDL-C and reduction in LDL-C were significantly different from that in placebo group. Also, both oxLDL and MDA levels significantly lowered by melatonin compared to the baseline and to the placebo group. Collectively, the results of our study showed that melatonin has advantageous effect on lipid profile and inhibit lipid peroxidation in patients with CKD.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

scholarly journals Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Efosa Godwin Ewere ◽  
Ngozi Paulinus Okolie ◽  
Erhunmwunsee Dalton Avan ◽  
Patience Edet Umoh
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Sodium Arsenite ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Stem Bark ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Irvingia Gabonensis

Abstract Background Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative effects of the ethanol leaf (ELEIG) and stem bark extracts (ESEIG) of Irvingia gabonensis on sodium arsenite (SA)-induced lipid profile disturbances in Wistar rats were investigated. Methods Fifty five Wistar rats weighing between 100 g and 179 g were distributed into eleven groups (n=5). Group 1 (control) received feed and water ad libitum. Group 2 received SA at a dose of 4.1 mg/kg body weight (kgbw) for 14 days. Groups 3–11 were treated with the extracts with or without SA. Treatment was done by oral intubation for 14 days. Serum concentrations of total cholesterol (TC), triacylglycerol (TAG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c), total lipids (TL) and atherogenic index of plasma (AIP) were used to determine the lipid profile effects of the extracts. Results Exposure to SA caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Post-treatment and simultaneous treatment with ELEIG and ESEIG mitigated the effects of SA. In addition, ELEIG alone at various doses produced results comparable with control values. However, ESEIG alone caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Conclusion These results show that ELEIG and ESEIG ameliorate SA-induced lipid profile disturbances in Wistar rats. However, long-term administration of ESEIG alone may be discouraged.

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