scholarly journals Gross and histomorphological effects of formaldehyde on brain and lungs of Swiss albino mice

2016 ◽  
Vol 2 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Marya Afrin ◽  
Tanjina Amin ◽  
Md Rabiul Karim ◽  
M Rafiqul Islam
Keyword(s):  
Medical Students ◽  
Adverse Effects ◽  
Brain Tissue ◽  
Morphological Study ◽  
Diarrheal Disease ◽  
Toxic Effects ◽  
Systemic Effects ◽  
Swiss Albino Mice ◽  
Disease Research ◽  
Albino Mice

Formaldehyde (FA) is toxic over a range of doses and of particular concern to anatomists and medical students on laboratory use. FA induces several characteristics of neurotoxicity in addition to systemic effects. Therefore, to know the toxic effects of FA on brain and lungs, mice were collected from international center for diarrheal disease research. They were divided into four groups i.e. control, inhalation, oral and intraperitoneal. The inhalation, oral and intraperitoneal exposure groups further divided into three subgroups which were subjected to exposure of FA daily for 30 days in case of inhalation and oral groups and 10 days in intraperitoneal group for acute toxic effects. Morphological study showed gross abnormalities i.e. congestion on lungs. But no gross abnormal features observed on brain. In 5 ppm treated inhaled group, lungs tissue revealed hemorrhages. In the inhaled groups, brain tissue showed degenerating neurons with either pyknotic or karyorrhectic nuclei are gradually increased in highest concentration group. These data supports the view that FA has adverse effects on the morphology of brain and lungs.Asian J. Med. Biol. Res. June 2016, 2(2): 229-235

scholarly journals Combined toxic effects of aflatoxin B2 and the protective role of resveratrol in Swiss albino mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alperen Gündüz ◽  
Emine Yalçın ◽  
Kültiğin Çavuşoğlu
Keyword(s):  
Tap Water ◽  
Radical Scavenging ◽  
Treated Group ◽  
Protective Role ◽  
Toxic Effects ◽  
Control Group ◽  
Buccal Epithelium ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Cytogenetic Parameters

AbstractIn this study, the toxic effects of aflatoxin B2 (AFB2) on Swiss albino mice and the protective effects of resveratrol were investigated. Physiological (body weight, liver and kidney weight), biochemical (aspartate aminotransferase-AST, alanine transaminase-ALT, blood urea nitrogen-BUN, creatinine, malondialdehyde-MDA and glutathione-GSH) and cytogenetic parameters (micronucleus-MN in buccal epithelium, erythrocyte and leukocyte cells and chromosomal aberrations-CAs) were used to determine the toxic effects. Additionally, scavenging effects of resveratrol against superoxide, hydrogen peroxide (H2O2) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals were also investigated. In experimental period, mice were divided into six groups and the groups were treated with tap water, 10 mg/kg b.w resveratrol, 20 mg/kg b.w resveratrol, 20 µg/kg b.w. AFB2, 10 mg/kg b.w resveratrol + 20 µg/kg b.w AFB2, 20 mg/kg b.w resveratrol + 20 µg/kg b.w AFB2, respectively. As a result, the scavenging effects of resveratrol increased with increasing dose and the superoxide, H2O2 and DPPH radical scavenging activity of resveratrol were 74.9%, 79.1% and 49.2%, respectively. AFB2 administration caused a significant decrease in physiological parameters, and these decreases regressed in AFB2 + resveratrol treated groups. Serum ALT and AST activities, BUN and creatinine levels were higher in the AFB2 treated group compared to the control group and serious abnormalities were found in MDA and GSH levels in the kidney and liver. In the group treated with AFB2 + 20 mg/kg resveratrol, ALT, AST, BUN and creatinine levels decreased significantly and GSH levels increased compared to only-AFB2 treated group. AFB2 triggered MN formation in buccal epithelium, erythrocyte and leukocyte cells and CAs in bone marrow cells. The application of 20 mg/kg resveratrol together with AFB2 was decreased the MN and CAs frequency. Resveratrol exhibited a recovery effect in the range of 40.9–80.5% against AFB2 toxicity in all tested parameters. In this study, it was determined that AFB2 caused serious changes in selected physiological, biochemical and cytogenetic parameters while resveratrol displayed a protective role against these toxic effects.

Toxic Effects of Oral Administration Doses of Hydroxylated C60 Fullerene on Liver in Swiss Albino Mice

2016 ◽  
Vol 8 (12) ◽  
pp. 1040-1046
Author(s):  
Doaa M. El-Nagar ◽  
Hanaa M. Ahmed ◽  
Badr Abdullah Aldahmash ◽  
Khalid Elfakki Ibrahim
Keyword(s):  
Oral Administration ◽  
Toxic Effects ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Effect of Manganese Chloride in Histological of Ovaries in Albino mice

2011 ◽  
Vol 8 (1) ◽  
pp. 235-243
Author(s):  
Baghdad Science Journal
Keyword(s):  
Heavy Metals ◽  
Blood Vessels ◽  
Manganese Chloride ◽  
Toxic Effects ◽  
Histopathological Changes ◽  
High Toxicity ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Different Tissues ◽  
Acute Toxic

Manganese is considered as one of heavy metals with high toxicity .This element has been used widely in various industries and it is spread with huge quantities in polluted industries areas. As a result the concentrations of this element in the environment have increased and consequently producing acute toxic effects in different tissues and organs of all organisms. A study has been conducted on (30) female of Swiss albino mice, to find out the effect of manganese chloride in histopathological changes of ovaries. The study includes, giving the manganese chloride with concentrations (150, 200 and 250 mg/kg) for (15, 30 and 45 day) for each concentration. The study has reported the existence of histopathological changes in the ovaries including congestion, reddening with emergence of blood vessels. In addition to that there is decrease in their weights and their sizes get smaller. Also there is degeneration in cells of the corpus lutum, and decrease in number of these bodies in the ovaries, with increase in atretic follicles, especially within the concentration (250 mgkg) for (45 day).

scholarly journals Role of newly developed novel multi herbal formulation (AKSS16-LIV01) in ameliorating carbon tetrachloride induced haemato-toxicity in Swiss albino mice

2020 ◽  
Vol 7 (10) ◽  
pp. 22-30
Author(s):  
Soumendra Darbar ◽  
Srimoyee Saha ◽  
Kausikisankar Pramanik ◽  
Atiskumar Chattopadhyay
Keyword(s):  
Carbon Tetrachloride ◽  
Adverse Effects ◽  
Cell Volume ◽  
Liver Transaminase ◽  
Swiss Albino Mice ◽  
Experimental Animals ◽  
Group Iii ◽  
Herbal Formulation ◽  
Group I ◽  
Albino Mice

Haematological disorders and related complications are very common phenomenon against hazardous chemicals. Alteration of hematologic parameters disrupts the body’s normal homeostasis. There is a worldwide need to develop a safe and symptomatic medication which controls the haematological complications. Healthy adult Swiss albino mice were assigned to four groups of six mice each according to their weights. Group-I serve as control, Group-II received multi herbal formulation (AKSS16-LIV01) 400 mg/kg/day, Group-III received carbon tetrachloride (CCl4) 1 ml/kg-bw and Group-IV received CCl4 along with AKSS16-LIV01 (400 mg/kg). Blood samples were collected from the retro orbital plexus of each animal to determine various blood parameters and liver transaminase. Administration of carbon tetrachloride (CCl4) showed decline body weight, food consumption and water intake in mice whereas treatment with multi herbal formulation (AKSS16-LIV01) normalized the same as compared with untreated animals. Treatment with CCl4 (Group-III) decline the packed cell volume (PCV), haemoglobin (Hb), means cell volume (MCV), means cell hemoglobin (MCH) and greater the white blood cell (WBC) compared with control. Pre-treatment with AKSS16-LIV01 significantly (p<0.001) increased the PCV, Hb, MCH, MCH and decreased WBC count in experimental animals as compared with CCl4 treated group. On the other hand elevated liver transaminase enzymes i.e. AST and ALP by CCl4 was restored with administration of multi herbal formulation (AKSS16-LIV01). Chronic administration of CCl4 indicated adverse effects on haematologic parameters upon experimental animals. Simultaneous administration with newly developed novel multi herbal formulation (AKSS16-LIV01) was able to ameliorate these adverse effects and may be a potent drug in future which controls the blood related medical complications against the toxicants.

Protective Effects of Prunus Avium Extract on 10 Ghz Induced Damages in the Spleen of Swiss Albino Mice

2011 ◽  
Vol 3 (8) ◽  
pp. 680-684 ◽  
Author(s):  
Faiza Rifat ◽  
◽  
Archana Sharma ◽  
Preeti Srivastava ◽  
Shikha Patni ◽  
...  
Keyword(s):  
Prunus Avium ◽  
Protective Effects ◽  
Swiss Albino Mice ◽  
Albino Mice
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