Toxic Effects of Oral Administration Doses of Hydroxylated C60 Fullerene on Liver in Swiss Albino Mice

2016 ◽  
Vol 8 (12) ◽  
pp. 1040-1046
Author(s):  
Doaa M. El-Nagar ◽  
Hanaa M. Ahmed ◽  
Badr Abdullah Aldahmash ◽  
Khalid Elfakki Ibrahim
Keyword(s):  
Oral Administration ◽  
Toxic Effects ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Evaluation of acute oral toxicity of herbal rumenotoric and stomachic

2021 ◽  
Vol 10 (5) ◽  
pp. 282-285
Author(s):  
Sunil Hajare ◽  
◽  
Ranjit Suresh Ingole ◽  
Maheshkumar Vitthal Ingawale ◽  
Vivek Borekar ◽  
...  
Keyword(s):  
Body Weight ◽  
Oral Administration ◽  
Adult Female ◽  
Blood Biochemistry ◽  
Toxic Effects ◽  
Test Substance ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Swiss Albino Mice ◽  
Common Problems

Maintaining optimum digestive functions is crucial for achieving health and profitability in livestock enterprises. However, the efficiency of these functions is upset by common problems such as indigestion, anorexia, flatulence, ruminal stasis and impaction. Pachoplus™ (M/s Ayurvet Limited, India) is a polyherbal rumenotoric, carminative and stomachic that helps to achieve and restore optimum digestive functions in livestock. A study was undertaken to evaluate the potential of Pachoplus™ to elicit acute oral toxicity as per OECD 423 guidelines. Nine non-pregnant, nulliparous, adult female Swiss albino mice were used for the study. The animals were observed for the manifestation of toxic effects and mortality after the oral administration of the test substance. Toxicity was evaluated on the basis of changes in body weight, overt signs of toxicity, gross and histological appearances of vital organs, and blood biochemistry. Pachoplus™ was found safe for oral use as no toxic effects or mortalities were observed till day 14

scholarly journals Gross and histomorphological effects of formaldehyde on brain and lungs of Swiss albino mice

2016 ◽  
Vol 2 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Marya Afrin ◽  
Tanjina Amin ◽  
Md Rabiul Karim ◽  
M Rafiqul Islam
Keyword(s):  
Medical Students ◽  
Adverse Effects ◽  
Brain Tissue ◽  
Morphological Study ◽  
Diarrheal Disease ◽  
Toxic Effects ◽  
Systemic Effects ◽  
Swiss Albino Mice ◽  
Disease Research ◽  
Albino Mice

Formaldehyde (FA) is toxic over a range of doses and of particular concern to anatomists and medical students on laboratory use. FA induces several characteristics of neurotoxicity in addition to systemic effects. Therefore, to know the toxic effects of FA on brain and lungs, mice were collected from international center for diarrheal disease research. They were divided into four groups i.e. control, inhalation, oral and intraperitoneal. The inhalation, oral and intraperitoneal exposure groups further divided into three subgroups which were subjected to exposure of FA daily for 30 days in case of inhalation and oral groups and 10 days in intraperitoneal group for acute toxic effects. Morphological study showed gross abnormalities i.e. congestion on lungs. But no gross abnormal features observed on brain. In 5 ppm treated inhaled group, lungs tissue revealed hemorrhages. In the inhaled groups, brain tissue showed degenerating neurons with either pyknotic or karyorrhectic nuclei are gradually increased in highest concentration group. These data supports the view that FA has adverse effects on the morphology of brain and lungs.Asian J. Med. Biol. Res. June 2016, 2(2): 229-235

scholarly journals Combined toxic effects of aflatoxin B2 and the protective role of resveratrol in Swiss albino mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alperen Gündüz ◽  
Emine Yalçın ◽  
Kültiğin Çavuşoğlu
Keyword(s):  
Tap Water ◽  
Radical Scavenging ◽  
Treated Group ◽  
Protective Role ◽  
Toxic Effects ◽  
Control Group ◽  
Buccal Epithelium ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Cytogenetic Parameters

AbstractIn this study, the toxic effects of aflatoxin B2 (AFB2) on Swiss albino mice and the protective effects of resveratrol were investigated. Physiological (body weight, liver and kidney weight), biochemical (aspartate aminotransferase-AST, alanine transaminase-ALT, blood urea nitrogen-BUN, creatinine, malondialdehyde-MDA and glutathione-GSH) and cytogenetic parameters (micronucleus-MN in buccal epithelium, erythrocyte and leukocyte cells and chromosomal aberrations-CAs) were used to determine the toxic effects. Additionally, scavenging effects of resveratrol against superoxide, hydrogen peroxide (H2O2) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals were also investigated. In experimental period, mice were divided into six groups and the groups were treated with tap water, 10 mg/kg b.w resveratrol, 20 mg/kg b.w resveratrol, 20 µg/kg b.w. AFB2, 10 mg/kg b.w resveratrol + 20 µg/kg b.w AFB2, 20 mg/kg b.w resveratrol + 20 µg/kg b.w AFB2, respectively. As a result, the scavenging effects of resveratrol increased with increasing dose and the superoxide, H2O2 and DPPH radical scavenging activity of resveratrol were 74.9%, 79.1% and 49.2%, respectively. AFB2 administration caused a significant decrease in physiological parameters, and these decreases regressed in AFB2 + resveratrol treated groups. Serum ALT and AST activities, BUN and creatinine levels were higher in the AFB2 treated group compared to the control group and serious abnormalities were found in MDA and GSH levels in the kidney and liver. In the group treated with AFB2 + 20 mg/kg resveratrol, ALT, AST, BUN and creatinine levels decreased significantly and GSH levels increased compared to only-AFB2 treated group. AFB2 triggered MN formation in buccal epithelium, erythrocyte and leukocyte cells and CAs in bone marrow cells. The application of 20 mg/kg resveratrol together with AFB2 was decreased the MN and CAs frequency. Resveratrol exhibited a recovery effect in the range of 40.9–80.5% against AFB2 toxicity in all tested parameters. In this study, it was determined that AFB2 caused serious changes in selected physiological, biochemical and cytogenetic parameters while resveratrol displayed a protective role against these toxic effects.

scholarly journals In vivo immunomodulatory effects of the methanolic leaf extract of Gymnema sylvestre in Swiss albino mice

2015 ◽  
Vol 67 (2) ◽  
pp. 561-570 ◽  
Author(s):  
Laxmi Ahirwal ◽  
Siddhartha Singh ◽  
Manish Dubey ◽  
Vandana Bharti ◽  
Archana Mehta ◽  
...  
Keyword(s):  
Oral Administration ◽  
Leaf Extract ◽  
Delayed Type Hypersensitivity ◽  
Phytochemical Analysis ◽  
Gymnema Sylvestre ◽  
Secondary Antibody ◽  
Swiss Albino Mice ◽  
Flow Cytometric ◽  
Albino Mice

In the present study we performed a comparative phytochemical analysis of the immunomodulating activities of the methanol leaf extract of Gymnema sylvestre (MLEGS) in Swiss albino mice. The phytochemical screening conducted on MLEGS revealed the presence of several phytoconstituents, including saponins, alkaloids, glycosides, phenols, tannins, and flavonoids. Immunomodulatory activities were determined by hemagglutination antibody (HA) titer and delayed-type hypersensitivity (DTH) tests for determining specific and non-specific immune responses. Flow cytometric techniques were performed for the estimation of B lymphocytes (CD3 and CD19) and Th2 cytokines (IL-2, IFN-? and IL-4). The response produced by oral administration of MLEGS elicited a significant reduction in a dose-related manner in the primary and secondary antibody response and DTH response. The response produced by oral administration of MLEGS elicited significant reduction in a dose-related manner in the primary and secondary antibody and DTH responses, with maximum reduction observed at 200 mg/kg-body wt. The maximal reductions in the production of CD3, CD19, IL-2, IFN-? and IL-4 were 31.59, 32.12, 29.51, 32.45 and 33.53%, respectively, at 200 mg/kg body weight. This study demonstrates that G. sylvestre exerts immunosuppressive effects on the components of the immune system of mice, and points to its significant immunomodulatory potential.

scholarly journals Effect of Manganese Chloride in Histological of Ovaries in Albino mice

2011 ◽  
Vol 8 (1) ◽  
pp. 235-243
Author(s):  
Baghdad Science Journal
Keyword(s):  
Heavy Metals ◽  
Blood Vessels ◽  
Manganese Chloride ◽  
Toxic Effects ◽  
Histopathological Changes ◽  
High Toxicity ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Different Tissues ◽  
Acute Toxic

Manganese is considered as one of heavy metals with high toxicity .This element has been used widely in various industries and it is spread with huge quantities in polluted industries areas. As a result the concentrations of this element in the environment have increased and consequently producing acute toxic effects in different tissues and organs of all organisms. A study has been conducted on (30) female of Swiss albino mice, to find out the effect of manganese chloride in histopathological changes of ovaries. The study includes, giving the manganese chloride with concentrations (150, 200 and 250 mg/kg) for (15, 30 and 45 day) for each concentration. The study has reported the existence of histopathological changes in the ovaries including congestion, reddening with emergence of blood vessels. In addition to that there is decrease in their weights and their sizes get smaller. Also there is degeneration in cells of the corpus lutum, and decrease in number of these bodies in the ovaries, with increase in atretic follicles, especially within the concentration (250 mgkg) for (45 day).

scholarly journals Acute Oral Toxicity of a Herbal Gut Function Modulator

2020 ◽  
pp. 58-61
Author(s):  
Sunil Hajare ◽  
Ranjit Suresh Ingole ◽  
Sunidhi . ◽  
Ravikanth Kotagiri ◽  
Bhaskar Ganguly
Keyword(s):  
Oral Administration ◽  
Biochemical Parameters ◽  
Toxic Effects ◽  
Test Substance ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Swiss Albino Mice ◽  
Toxicity Potential ◽  
Gut Function ◽  
Histopathological Studies

The current study was designed to evaluate the acute oral toxicity potential of AV/AGP/30 (M/s Ayurvet Limited, Baddi, India) according to OECD 423 guidelines. AV/AGP/30 is a polyherbal gut function modulator in swine and poultry. Nine female Swiss albino mice were used for the study. Each animal served as its own control. Following the oral administration of the test substance, the animals were observed for manifestation of toxic effects and deaths. No toxic effects or mortalities were observed. The estimation of biochemical parameters (AST, ALT, ALP and creatinine) and histopathological studies also did not reveal any significant findings. Hence, AV/AGP/30 was found to be safe for use.

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