scholarly journals Frequency of HLA-B27 gene among patients with ankylosing spondylitis and its consequences on clinical manifestation

2019 ◽  
Vol 9 (3) ◽  
pp. 188-192
Author(s):  
Marjoa Humaira Mekhola ◽  
Mohammad Abdul Jalil Chowdhury ◽  
Mohammad Shamim Ahmed ◽  
Abed Hussain Khan ◽  
Shrebash Paul
Keyword(s):  
Back Pain ◽  
Ankylosing Spondylitis ◽  
Clinical Manifestation ◽  
Human Leukocyte ◽  
Cross Sectional Study ◽  
Hla B27 ◽  
Cross Sectional ◽  
Reactive Protein ◽  
History Of ◽  
High Level

Background: Ankylosing spondylitis is an inflammatory disease and leading case of back pain worldwide. It is thought that the gene human leukocyte antigen-B27 (HLA-B27) provides a strong tendency in people to develop ankylosing spondylitis. This study was designed to evaluate the frequency of HLA-B27 among patients with ankylosing spondylitis and clinical manifestation among the HLA-B27 positive and negative patients. Methods: A cross-sectional study was done in the Department of Medicine and Department Rheumatology of BSMMU, Shahbag, Dhaka, Bangladesh from 1st January 2016 to 30th June 2016. Results: Total 70 patients were included in this study, among those 54 were male and 16 were female and total 54 patients (77.14%) were HLA-B27 positive and 16 patients (22.86%) were HLA-B27 negative. Most HLAB27 positive patients had extra-articular manifestation, family history of low back pain and high level of BASDAI score, compared to those who were negative. Among the 54 positive patients, 9 (16.67%) had combination of tendinitis, enthesitis and uveitis and 2 (3.70%) had all four of extra-articular manifestation. Among the 16 negative patients, 2 (12.5%) had all four extra-articular manifestation. Among 16 negative patients 9 (56.25%) had raised erythrocyte sedimentation rate (ESR) and 5 (31.25%) had raised C-reactive protein (CRP). On the other hand, among 54 positive patients 48 (88.89%) had raised ESR and 44 (81.48%) had raised CRP. Conclusion: The association of HLA-B27 might be the reason of disease severity among the positive patients. Birdem Med J 2019; 9(3): 188-192

Comparison of Non-radiographic Axial Spondyloarthritis and Ankylosing Spondyltis from a Single Rheumatology Hospital in Morocco

2020 ◽  
Vol 16 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Nessrine Akasbi ◽  
Siar Nihad ◽  
Zoukal Sofia ◽  
El Kohen Khadija ◽  
Harzy Taoufik
Keyword(s):  
Disease Burden ◽  
Axial Spondyloarthritis ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Low Back ◽  
New Classification ◽  
Cross Sectional ◽  
Asas Criteria ◽  
History Of ◽  
High Level

Background: According to the new classification criteria developed by The Assessment of SpondyloArthritis International Society, patients with axial spondyloarthritis (axSpA) can be classified in 2 subgroups: Patients with radiographic axial spondyloarthritis: ankylosing spondylitis patients (AS) and those with non-radiographic axial spondyloarthritis (nr-axSpA). Objective: The aim of the present study is to describe and discuss the differences and similarities between the two subgroups. Patients and Methods: A cross-sectional study was conducted in a single rheumatology hospital in Morocco. These included patients diagnosed as having axial spondyloarthritis according to ASAS criteria 2010, during a period of 6 years. The AS and the nr-axSpA subgroups were compared for the various axSpA-related variables. Results: Of the 277 patients with a diagnosis of axial SpA who were included in this study, 160 had AS and 117 had nr-axSpA. AS and nr-ax-SpA shared a similar age at diagnosis, similar prevalence of low back pain, lumbar stiffness, extra-articular manifestations, BASDAI and BASFI. In the multivariate analysis, AS patients were mainly male with cervical stiffness, enthesitis, coxitis and high level of ESR (erythrocyte sedimentation rate). The females generally had a family history of SpA and arthritis and were associated to the nr-axSpA form in the univariate analysis. Conclusion: This was the first study to characterise patients with AS and nr-axSpA in Morocco. Consistent with other studies published, this study showed that patients with nr-axSpA and patients with AS shared a comparable degree of disease burden.

scholarly journals Prévalence De La Douleur Neuropathique Chez Des Patients Souffrant De Lomboradiculalgie Commune En Consultation Rhumatologique À Lomé (Togo)

2017 ◽  
Vol 13 (24) ◽  
pp. 267
Author(s):  
Kodjo Kakpovi ◽  
Komi Cyrille Tagbor ◽  
Eyram Fianyo ◽  
Agbeko Komlan Doleagbenou ◽  
Kokou Mensah Guinhouya ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Low Back Pain ◽  
Back Pain ◽  
Past History ◽  
Cross Sectional Study ◽  
Radicular Pain ◽  
Low Back ◽  
Cross Sectional ◽  
Study Results ◽  
History Of

Objective: To determine the prevalence and factors associated with neuropathic pain in patients with non-specific low back pain. Methods: This was a cross-sectional study conducted from May to July 2016 in the Rheumatology, Neurology and Neurosurgery departments of Lome. The DN4 questionnaire was used for the diagnosis of neuropathic pain in the 200 patients with low back pain included in this study. Results: Of the 200 patients (147 women and 53 men) included in the study, neuropathic pain was present in 92 (46%). The average age of the 92 patients (67 women vs 25 men, p = 0.04) was 55.5 ± 12.4 years (women 55.2 ± 12.8 vs. men 54.6 ± 11.4, p = 0.5). The characteristics of neuropathic pain mainly found were: burning sensation (n = 67, 72.8%); electrical discharges (n = 64, 69.6%); tingling (n = 90; 97.8%); tickling (n = 57; 62%); numbness (n = 89; 96.7%); hypoesthesia (n = 52; 56.5%). Factors significantly associated with the presence of neuropathic pain in LBP were age (p = 0.005), duration of LBP (p = 0.04), high blood pressure (p = 0.001), radicular pain (p = 0.00002) and the past history of the LBP (0.000000). Conclusion: Neuropathic pain is common in patients with LBP at Lome. The duration of LBP, past history of LBP, previous NSAID use, BMI, pain severity and radicular pain appear to be predictive of the occurrence of these neuropathic pains.

MRI Detection of Active Sacroiliitis in First Degree Relatives of Ankylosing Spondylitis Patients with Clinical and Laboratory Correlations

2021 ◽  
Author(s):  
Haron Obaid ◽  
Stephan Milosavljevic ◽  
Udoka Okpalauwaekwe ◽  
Brenna Bath ◽  
Catherine Trask ◽  
...  
Keyword(s):  
Back Pain ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Hla B27 ◽  
Physical Test ◽  
First Degree Relatives ◽  
Pain Provocation ◽  
History Of ◽  
Active Sacroiliitis

Abstract Background. Detection of ankylosing spondylitis (AS) in the preclinical stage could help prevent long term morbidity in this patients’ population. The aim of this study was to examine the prevalence of active sacroiliitis in first-degree relatives of AS patients using MRI with clinical and laboratory correlations as these patients may benefit from MRI screening and early treatment.Methods. Seventeen first-degree relatives of AS patients were recruited prospectively. AS screening questionnaires (Ankylosing Spondylitis Disease Activity Score, Bath Ankylosing Spondylitis Disease Activity Index & Visual Analogue Scale), blood tests (C-Reactive Protein, HLA-B27), and an MRI of the SIJs were taken. Two musculoskeletal radiologists interpreted the MRI scans, and two physiotherapists applied four symptom provocation tests (Gaenslen's test, posterior pelvic pain provocation test, Patrick's Faber (PF) test and palpation of the long dorsal SIJ ligament test), and two functional movement tests (active straight leg raise and Stork test). Results. Seven (41%) of the 17 participants demonstrated MRI evidence of active sacroiliitis. Of the 7 participants with active sacroiliitis, two (29%) had no history of recent low back pain (LBP), two (29%) had negative HLA-B27, and one (14%) participant had neither back pain nor positive HLA-B27. The Cohen's Kappa score for the interobserver agreement between the radiologists was 1.00 (p-value <0.0001). Despite fair to strong between therapist agreement for the physical test outcomes (Kappa 0.26 to 1.00), the physical test results per se did not have any predictive association with a positive MRI.Conclusions. MRI detected active sacroiliitis in 41% of first-degree relatives of AS patients. The lack of a history of prior LBP or positive HLA-B27 in active sacroiliitis participants might suggest that MRI screening for this high-risk population is warranted; however, further larger studies are needed to help elucidate its cost-effectiveness and long-term benefits.

What is known about Prostate Cancer? Response from Men Aged 50 Years and Above in Lindi Municipal, Tanzania

2020 ◽  
Vol 31 (2) ◽  
pp. 33-44
Author(s):  
Simon Francis ◽  
Obadia V. Nyongole
Keyword(s):  
Prostate Cancer ◽  
Family History ◽  
Positive Family History ◽  
Negative Attitude ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Adult Men ◽  
History Of ◽  
One Year ◽  
High Level

Background: The incidence of prostate cancer in Tanzania is among the highest recorded in Africa. Prostate cancer is also the most common cancer among men aged 50 years and above in Tanzania. Our study aimed to determine the awareness, knowledge, and attitudes among adult men with age 50 years and above regarding prostate cancer.Methods: This was a cross-sectional study that included 250 adult men aged 50 years and above in Lindi municipal being purposively selected and we interviewed them by using a structured questionnaire. A stratified random sampling method was used for obtaining our participants. All men who had stayed for not less than one year in Lindi and willing to participate were enrolled in the study. These men were selected at households without screening whether or not they had taken prostate screening test or had been diagnosed with prostate cancer Quantitative data were cleaned and analyzed with SPSS version 20.Results: Majority, 216(86.7%) of our study participants were aged 50–69 years and most of them, 142(56.8%) had primary education with 93.2% of them being married. Among the study subjects 7.2% had positive family history of cancer and 195(78%) were aware of prostate cancer with source of information being mass media (62.6%). Majority of them, 63.2%, did not know the risk age group. Few, 20.8% of our participants had good knowledge while majority, 95.2% had negative attitude toward prostate cancer. We found a statistically significant association between level of education, family history and level of knowledge regarding prostate cancer with p < 0.005.Conclusion: This study revealed high level of awareness, but poor knowledge regarding prostate cancer and negative attitude toward prostate cancer among men with age ≥50 years in Lindi municipal Tanzania. Key words: Awareness, knowledge, attitude, prostate cancer.

scholarly journals Comparison of Cardiometabolic Biomarkers in Two Groups of US Adults Using Multiple Dietary Supplements: A Cross-Sectional Study (P18-116-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sonhee Park ◽  
Hong Wang ◽  
Bruce Daggy ◽  
Jamie McManus ◽  
Paul Jacques
Keyword(s):  
Dietary Supplements ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Funding Sources ◽  
Informed Consent Form ◽  
Significant Difference ◽  
History Of ◽  
Blood Pressures

Abstract Objectives The aim of the present study is to compare cardiometabolic biomarker levels (MARKERS) from a cohort using multiple (2+) dietary supplements (MDS) manufactured by Shaklee Corporation for 3–5 yr (SHAKLEE) to those from the age-matched MDS users from NHANES 2007–10 (NHANES). Methods Each subject from SHAKLEE [n = 58; mean age: 48 yr (22–79 yr)], using MDS manufactured by Shaklee Corp for 3–5 yr, voluntarily signed the IRB approved informed consent form before the study participation. Body mass index (BMI), systolic and diastolic blood pressures (SBP and DSP) were measured, and approximately 30 mL of 12-h fasting blood sample was collected. Pregnant women and people with a history of cancer were excluded. MARKERS from SHAKLEE were compared to those from NHANES [n = 1952; mean age: 51 yr (22–79 yr)]. MARKERS included total cholesterol (TC), HDL-c, TC/HDL-c ratio, LDL-c, triglycerides (TG), high sensitivity C-Reactive Protein (CRP), glucose, hemoglobin A1c (HbA1c), and Insulin levels in the blood as well as BMI, SBP, and DBP. Statistical analyses were performed using independent samples t-tests, and P < 0.05 was considered significantly different between groups. Results SHAKLEE had significantly lower TC (189 vs. 201 mg/dL), TC/HDL-c ratio (3.1 vs. 4.0), LDL-c (103 vs. 118 mg/dL), TG (81 vs. 131 mg/dL), glucose (93 vs. 107 mg/dL), HbA1c (5.1 vs. 5.7%), insulin (8.3 vs. 13.4 mIU/L), BMI (26.7 vs. 29.0), and SBP (110 vs. 122 mmHg), and higher HDL-c (69 vs. 55 mg/dL) but had higher DBP (76 vs. 71 mmHg) than NHANES. There was no significant difference in CRP although CRP was slightly lower in SHAKLEE than NHANES (2.9 vs. 3.8 mg/L). Conclusions The present study showed that 3–5 yr MDS users from the Shaklee cohort had healthier pattern in cardiometabolic biomarkers than the age-matched MDS users from NHANES 2007–2010. Funding Sources Shaklee Corporation, 4747 Willow Road, Pleasanton, CA 94,588, USA.

Correlates of Axial Gout: A Cross-sectional Study

2012 ◽  
Vol 39 (7) ◽  
pp. 1445-1449 ◽  
Author(s):  
RUKMINI M. KONATALAPALLI ◽  
ELENA LUMEZANU ◽  
JAMES S. JELINEK ◽  
MARK D. MURPHEY ◽  
HONG WANG ◽  
...  
Keyword(s):  
Back Pain ◽  
Clinical Laboratory ◽  
Gouty Arthritis ◽  
Cross Sectional Study ◽  
Strongly Correlated ◽  
Sectional Study ◽  
Cross Sectional ◽  
American College Of Rheumatology ◽  
History Of ◽  
Hands And Feet

Objective.A cross-sectional study was undertaken to determine the prevalence of axial gout in patients with established gouty arthritis and to analyze clinical, laboratory, and radiological correlations.Methods.Forty-eight subjects with a history of gouty arthritis (American College of Rheumatology criteria) for ≥ 3 years under poor control were included. Subjects underwent history, physical examination, laboratory testing, and imaging studies, including radiographs of the hands and feet and computerized tomography (CT) of the cervical and lumbar spines and sacroiliac joints (SIJ). Patients with characteristic erosions and/or tophi in the spine or SIJ were considered to have axial or spinal gout.Results.Seventeen patients (35%) had CT evidence of spinal erosions and/or tophi, with tophi identified in 7 of the 48 subjects (15%). The spinal location of axial gout was cervical in 7 patients (15%), lumbar in 16 (94%), SIJ in 1 (6%), and more than 1 location in 14 (82%). Duration of gout, presence of back pain, and serum uric acid levels did not correlate with axial gout. Extremity radiographs characteristic of gouty arthropathy found in 21 patients (45%) were strongly correlated with CT evidence of axial gout (p < 0.001). All patients with tophi in the spine had abnormal hand or feet radiographs (p = 0.005).Conclusion.Axial gout may be a common feature of chronic gouty arthritis. The lack of correlation with back pain, the infrequent use of CT imaging in patients with back pain, and the lack of recognition of the problem of spinal involvement in gouty arthritis suggest that this diagnosis is often missed.

The serum concentrations of leptin and MCP-1 independently predict low back pain duration

2017 ◽  
Vol 55 (9) ◽  
Author(s):  
Giuseppe Lippi ◽  
Concetta Dagostino ◽  
Ruggero Buonocore ◽  
Rosalia Aloe ◽  
Chiara Bonaguri ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Relative Risk ◽  
Area Under The Curve ◽  
Cross Sectional Study ◽  
Low Back ◽  
Cross Sectional ◽  
Monocyte Chemoattractant Protein 1 ◽  
Reactive Protein ◽  
Pain Duration

AbstractBackground:Low back pain (LBP) is a very frequent condition, affecting most people at some point throughout their life. This cross-sectional study was aimed to investigate a selected panel of cytokines and inflammatory biomarkers in patients with or without LBP.Methods:The study population consisted of 104 patients diagnosed with LBP (52 non-persistent and 52 persistent) and 52 healthy subjects with no LBP. Blood samples were collected for assessment of adiponectin, leptin, monocyte chemoattractant protein-1 (MCP-1) and C reactive protein (CRP). The duration of LBP was categorized as “no pain”, “non-persistent LBP” and “persistent LBP”.Results:Higher values of CRP and lower concentrations of both leptin and MCP-1 were found in LBP patients compared to controls, whereas adiponectin did not differ among groups. MCP-1 was also lower in patients with non-persistent than in those with persistent LBP. Age, leptin (relative risk, 11.8; 95% CI, 3.9–35.8) and MCP-1 (relative risk, 2.7; 95% CI, 1.7–4.4) were independently associated with presence and duration of LBP. The combination of age, leptin and MCP-1 predicted 61% of the risk of LBP duration. The area under the curve of MCP-1 for distinguishing persistent from non-persistent LBP was 0.65 (95% CI, 0.54–0.76).Conclusions:Then results of our study suggest that leptin and MCP-1 may be promising biomarkers for diagnosis of acute LBP and its risk to become chronic.

scholarly journals Knowledge and Attitude Towards Shisha Smoking Among Health College Students at Princess Nourah University.

2020 ◽  
Author(s):  
Atheer Aldoss ◽  
REEM BEN JABER ◽  
NUJUD ALRUSHUD ◽  
Sarah Al-Qahtani ◽  
Randah M. AlAlweet ◽  
...  
Keyword(s):  
College Students ◽  
Saudi Arabia ◽  
Cross Sectional Study ◽  
Cluster Sampling ◽  
Negative Effects ◽  
Cross Sectional ◽  
History Of ◽  
Knowledge And Attitude ◽  
High Level ◽  
Rehabilitation Sciences

Abstract Background Despite the negative effects of tobacco use, Saudi Arabia is one of the leading causes of death globally. In Saudi Arabia, 17.1% of both sexes and 3.0% of females aged 15 or older smoke. One common way to consume tobacco is through a shisha (waterpipe). This study aims to measure the knowledge of the negative health effects and attitudes toward shisha use among health college students at Princess Nourah University (PNU) in Riyadh, Saudi Arabia. Method A descriptive, cross-sectional study was conducted at PNU’s health colleges, with the 525 student participants selected evenly from each college by using cluster sampling into five health colleges(College of Health and Rehabilitation Sciences, Nursing, Dentistry, Medicine and Pharmacy), data was collected by a pretested, structured questionnaire and was coded, entered and analyzed by Statistical Package for the Social Sciences (SPSS) v.20. Results 15.4% is the percentage for who had a history of smoked shisha. The percentage of current smokers was 4.19%. There was no association between the knowledge and shisha smoking practice ( P = .603). Conclusion In conclusion, the percentage of shisha smoking was high, in spite of having a high level of knowledge. Also, the knowledge toward shisha smoking and shisha practice was not associated. In contrast to a study conducted in USA which showed a slight association between the knowledge and smoking practice. (44)

scholarly journals Is previous azithromycin treatment associated with azithromycin resistance in Neisseria gonorrhoeae? A cross-sectional study using national surveillance data in England

2018 ◽  
Vol 94 (6) ◽  
pp. 421-426 ◽  
Author(s):  
Soazig Clifton ◽  
Katy Town ◽  
Martina Furegato ◽  
Michelle Cole ◽  
Hamish Mohammed ◽  
...  
Keyword(s):  
Neisseria Gonorrhoeae ◽  
Previous Treatment ◽  
Cross Sectional Study ◽  
Reference Laboratory ◽  
Electronic Patient Records ◽  
Cross Sectional ◽  
Susceptibility Data ◽  
History Of ◽  
High Level ◽  
Azithromycin Resistance

ObjectivesIt has been suggested that treatment of STIs with azithromycin may facilitate development of azithromycin resistance in Neisseria gonorrhoeae (NG) by exposing the organism to suboptimal doses. We investigated whether treatment history for non-rectal Chlamydia trachomatis (CT), non-gonococcal urethritis (NGU) or NG (proxies for azithromycin exposure) in sexual health (GUM) services was associated with susceptibility of NG to azithromycin.MethodsAzithromycin susceptibility data from the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP 2013–2015, n=4606) and additional high-level azithromycin-resistant isolates (HL-AziR) identified by the Public Health England reference laboratory (2013–2016, n=54) were matched to electronic patient records in the national GUMCAD STI surveillance dataset (2012–2016). Descriptive and regression analyses were conducted to examine associations between history of previous CT/NGU/NG and subsequent susceptibility of NG to azithromycin.ResultsModal azithromycin minimum inhibitory concentration (MIC) was 0.25 mg/L (one dilution below the resistance breakpoint) in those with and without history of previous CT/NGU/NG (previous 1 month/6 months). There were no differences in MIC distribution by history of CT/NGU (P=0.98) or NG (P=0.85) in the previous 1 month/6 months or in the odds of having an elevated azithromycin MIC (>0.25 mg/L) (Adjusted OR for CT/NGU 0.97 (95% CI 0.76 to 1.25); adjusted OR for NG 0.82 (95% CI: 0.65 to 1.04)) compared with those with no CT/NGU/NG in the previous 6 months. Among patients with HL-AziR NG, 3 (4%) were treated for CT/NGU and 2 (3%) for NG in the previous 6 months, compared with 6% and 8%, respectively for all GRASP patients.ConclusionsWe found no evidence of an association between previous treatment for CT/NGU or NG in GUM services and subsequent presentation with an azithromycin-resistant strain. As many CT diagnoses occur in non-GUM settings, further research is needed to determine whether azithromycin-resistant NG is associated with azithromycin exposure in other settings and for other conditions.

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