scholarly journals Incidence of Congenital Hypothyroidism in the Newborn of A Tertiary Hospital in Southern Bangladesh

1970 ◽  
Vol 29 (3) ◽  
pp. 82-87
Author(s):  
CH Rasul ◽  
SN Lucky ◽  
SR Miah ◽  
F Moslem

Background: Congenital hypothyroidism is the commonest preventable cause of mental retardation. It is more prevalent in endemic goiter regions like Bangladesh. But magnitude of the problem has not been studied at national level.Objective: To detect the incidence of congenital hypothyroidism among the newborn delivered in Khulna Medical College Hospital in southern part of Bangladesh and to rationalize the development of neonatal screening program.Methodology: All the living newborns delivered between Oct '01 to June ‘05 in Khulna Medical College Hospital were included in the study. After taking the relevant information from mother, cord blood sample were collected from the newborn within 24 hours of birth and kept in freezer. At the end of collection of each two month, the lot of blood sample was sent to the laboratory of Institute of Nuclear Medicine, Dhaka for radioimmunoassay of TSH. Potential cases with TSH value above 10 MIU/L were recalled for thyroid function test for confirmation of diagnosis.Results: After discarding unsatisfactory samples, 1353 samples were assayed for TSH. Among the study population 88.2% hailed from Khulna district and the rest of the cases came from neighboring districts. Male to female ratio was 1.2:1. Regarding the birth weight 33.4% babies were of low birth weight. TSH above 10 MIU/L were found in 35 babies among whom one baby was hypothyroid and the other member of the twin was also hypothyroid although the TSH level was below 10 MIU/L. Thus incidence of congenital hypothyroidism was 1.5 per thousand living newborn among the studied cases.Conclusion: The incidence of congenital hypothyroidism in southern part of the country is quite high in relation to global incidence. Although this is not the national picture but the high figure is alarming. So, neonatal screening program should be implemented as soon as possible to find out the real case burden in the community and thereby to take care of them and reduce the number of mentally retarded children in our country. Key words: Congenital hypothyroidism; neonatal screening; mental retardation. DOI: 10.3329/bjch.v29i3.6186 Bangladesh J Child Health 2005; Vol 29 (3): 88-92

1970 ◽  
Vol 21 (1) ◽  
pp. 18-22 ◽  
Author(s):  
C Habibur Rasul ◽  
S Nahar Lucky ◽  
S Rahman Miah ◽  
F Moslem

Congenital hypothyroidism is the commonest preventable cause of mental retardation. It is more prevalent in endemic goiter regions like Bangladesh. But magnitude of the problem has not been studied at national level. This study was done to detect the frequency of congenital hypothyroidism in southem part of Bangladesh & to develop neonatal screening program. All the living newborns delivered between Oct 01 to June 05 Khulna Medical College Hospital were included in the study, After taking the relevant information from mother, cord blood sample were collected from the newborn within 120 hours of birth and kept in freezer. At the end of collection of each two months, the lot was sent to the laboratory of Institute of Nuclear Medicine, Dhaka for radioimmunoassay of TSH. Potential cases with TSH above 10 MIU were recalled for thyroid function test for confirmation of diagnosis. Fifteen hundred samples were collected in total during 45 months of study. One forty seven unsatisfactory samples were discarded; thereby 1353 samples were eventually assayed for TSH. Among the study population 88.2% hailed from Khulna district and the rest of the cases came from neighboring districts. Male to female baby ratio was 1.2:1. Regarding the birth weight 33.4% babies were low birth weight. TSH above 10 was found in 35 babies among whom one baby was hypothyroid and the other member of the twin was also hypothyroid although the TSH level was below 10. None of newborn had TSH level above 20. Thus frequency of congenital hypothyroidism was 1.5 per thousand living newborn. Congenital hypothyroidism in southern part of the country is quite high in relation to global incidence. Although this is not the national picture but the high figure is alarming. Therefore neonatal screening program should be implemented as soon as possible to reduce the number of mentally retarded child.   doi: 10.3329/taj.v21i1.3212 TAJ 2008; 21(1): 18-22


1970 ◽  
Vol 9 (2) ◽  
pp. 82-86
Author(s):  
Afzalur Rahman Mahmood ◽  
Zannatun Nur

This cross sectional type of descriptive study was carried out among the patients attending the Skin and Venereal Disease (VD) Out Patient Department (OPD) of Dhaka Medical College Hospital (DMCH) from August 2006 to November 2006 with a view to explore the current situation of scabies and its predisposing factors. In this regard 213 clinically diagnosed scabies contracted patients were interviewed randomly by using pre-tested questionnaire. Risk factors were assessed considering their dwelling places, types of families, number of family members, persons living in each room, using fomites of infected persons, socioeconomic condition, occupation, level of education, regular bathing and cloth washing habit along with age, sex distribution and clinical presentation of scabies. The mean age of the respondents was 13.16 years with a standard deviation (SD) of ±5.38 years and majority (36.15%) was in the age group of 1-5 years. Male, female ratio was 1.15:1. Major level of education was in the group of class I to V (38%). 50.73% had family members comprised of 4 to 6. Majority (38.50%) belonged to lower middle class (income 3001-6000 taka/month). Among the respondents maximum (54.93%) were infected by family members. 77.94% respondents used fomites of affected persons and 66% respondents shared beds of infected persons. Mean duration of illness was 42 days with standard deviation of ±4.47 days. Among the male, majority (82.63%) had lesion on lower abdomen and buttock. In contrary, 80.28% female had lesion on hand. 58.68% presented with papule. The study recommends that emphasis should be given on personal hygiene and life style of people as well as educating them about scabies. Key words: Scabies, Predisposing factors, Skin and VD outdoor DOI = 10.3329/jom.v9i2.1436    J MEDICINE 2008; 9 : 82-86


1970 ◽  
Vol 19 (1) ◽  
pp. 7-10
Author(s):  
CM Ali ◽  
TK Sikdar ◽  
N Sultana ◽  
N Ahmed ◽  
AKMR Haque ◽  
...  

The study was conducted among 568 patients of STDs out of 58560 male and female patients in the OPD of Dermatology Department of Dhaka Medical College Hospital (DMCH) during the period of March 2009 to February 2010 irrespective of sex and age >15 years with a view to assess the prevalence of sexually transmitted diseases. In this study prevalence of STDs such as gonorrhea, syphilis, non gonococcal urethritis, chancroid, genital herpes and genital warts were 29.58%, 12.68%, 41.58%,4.93%,8.45% and 2.82% respectively; male and female ratio were 3.73:1. The highest prevalence rate was found in age group of 25-34 years (42.25%). According to educational status of the respondents, 33.80% were up to secondary level and only 2.82% were master degree holder. Among occupation 36.62% were in service, and 15.49% were students. According to socioeconomic status 40.14% were poor and only 9.86% were from upper middle class. Key words: Sexually transmitted diseases; prevalence. DOI: 10.3329/jdmc.v19i1.6243 J Dhaka Med. Coll. 2010; 19(1) : 7-10.


2020 ◽  
Vol 32 (2) ◽  
pp. 36-42
Author(s):  
Md Shofiqul Islam ◽  
Md Belal Hossain ◽  
Md Rustam Ali ◽  
Md Sanaul Haque Mia ◽  
Md Belal Uddin ◽  
...  

Congenital hypothyroidism is the commonest preventable cause of mental retardation. It is more prevalent in endemic goiter regions like Bangladesh. This study was done to assess the congenital hypothyroidism in neonates (age 4 to 28 days) admitted in Rajshahi Medical College Hospital. It was a cross sectional descriptive study conducted at pediatric department of Rajshahi Medical College Hospital from July 2016 to June 2018. After taking written consent from each mother/guardian, 3 ml venous blood was collected and sent to the laboratory of Institute of Nuclear Medicine and Allied Sciences, Rajshahi to estimate serum TSH/ serum TSH and T4 level. Total 500 samples were collected in two years of study period. All information was put in the data collection sheet and was analyzed through standard statistical method by using SPSS version 16.0. Serum level of TSH ≥ 20 μIU/ml was considered as congenital hypothyroidism. Serum level increased but bellow 20μIU/ml were recalled to repeat serum TSH level within 2 to 6 weeks of age. Among 500,321(64.2%) male and 179 (35.8%) female, Among 500 study population, 199 and 135 came from Rajshahi and Chapai Nawabganj district respectively. Total 7 mothers were hypothyroid and on thyroid replacement therapy. TSH level above 20 μIU/ml was found in 5 neonates, 11 to 20 μIU/ml in 7 neonates. After repeat TSH testing one infant had serum TSH level above 20 μIU/ml. Finally total 6 infants were diagnosed as having congenital hypothyroidism. Thus frequency of congenital hypothyroidism was 1.2%. Congenital hypothyroidism in Rajshahi region is very high in relation to global incidence. Although this is not the actual picture of our country but this figure is alarming. Therefore neonatal screening program should be started as soon as possible to reduce the number of mentally retarded child. Maternal obesity and thyroidal status have significant association with neonatal TSH level. TAJ 2019; 32(2): 36-42


2021 ◽  
Vol 7 (1) ◽  
pp. 56-59
Author(s):  
Sumiya Bent Kalam ◽  
Sadia Islam ◽  
Mohammad Abdullah Az Zubayer Khan ◽  
Tanjina Akhter

Background: Elderly people are posing a significant health burden in our country for their multi morbidity as economic growth has increased our life expectancy. Pattern of multi morbidity of this older people varies according to geography, ethnicity, culture and life style. Aim: The aim of this study was to identify the prevalence and pattern of multi morbidity of elderly patients admitted in a tertiary care hospital. Method: 50 random cases of elderly patients aged more than 60 years admitted in medicine and allied wards of Dhaka medical college hospital were observed at this cross-sectional study from January 2017 to June 2017(total 6 months period). Data were reviewed and analyzed using simple frequency and percentage. Protocol was reviewed by institutional ethical board (IRB) of Dhaka medical college hospital. Result: A total number of 50 elderly patients with age ranging from 60 to 95 years were observed with male and female ratio 1.3:1 having multi morbidity among 92.0% patients and female is more affected than male. Hypertension, ischemic heart disease, diabetes mellitus and stroke were found most common diseases as individual. Hypertension and diabetes mellitus was found as the most common multi morbidity pattern followed by hypertension and IHD, stroke & diabetes mellitus. Conclusion: This study sheds light on priority needs of elderly patients in terms of medical facility in tertiary care hospital of Bangladesh. Journal of National Institute of Neurosciences Bangladesh, January 2021, Vol. 7, No. 1, pp. 56-59


2020 ◽  
Vol 23 (2) ◽  
pp. 171-179
Author(s):  
Md Zahidul Islam ◽  
Md Abdur Rahman ◽  
Md Sirajul Islam Mahfuz

Purpose: To analyse the prevalence, distribution and presentation of different congenital head-neck lesions with their age, sex, site and side predilection. Methods: 50 patients of head-neck congenital swelling was selected from january/2013 upto december/2013 in the OPD of otorhino-laryngology, head and neck deptt. of Dhaka medical college hospital under a specific prospective study protocol. Results: The most frequent swelling was thyroglossal cyst(42%), followed by branchial arch anomalies (18%),dermoid cyst(14%),pre-auricular sinus(14%),lymphangioma(8%) and haemangioma(4%).Amongst the cervical swellings the sequential preponderence was thyroglossal cyst(52%),branchial arch anomalies(23%),dermoid cyst(13%), lymphangioma(10%) and haemangioma (2%).The majority of branchial arch anomalies(100%) were of second arch. The majority of patients were of first(52%) and second(30%) decade and the male to female ratio for thyroglossal cysts was 1:1.1.The majority of lesions were painless swelling and all were surgically excised. Conclusion: The overall frequency and age-sex distribution of congenital head-neck swellings as well as site, nature and type specific predominance of some of them in OPD of Dhaka medical college hospital are almost similar to international findings. Bangladesh J Otorhinolaryngol; October 2017; 23(2): 171-179


1970 ◽  
Vol 4 (1) ◽  
pp. 53-57 ◽  
Author(s):  
PK Das ◽  
S Ghafur ◽  
B Bhattarcharjee ◽  
A Dey ◽  
AL Mollah ◽  
...  

Background: Coronary artery disease (CAD) is now an emerging epidemic in developing countries including Bangladesh. Younger people are being affected here more and more. Young individuals with acute myocardial infarction (AMI) may have unique presentation, risk factor, angiographic profile and outcome which may have an influence on the preventive strategies. This study is an attempt to investigate the same. Methods: Young patients (aged d” 40 yrs) with AMI admitted to the coronary care unit of Chittagong Medical College Hospital over a period of one year were included in the study. Assessments of the patients were done with clinical history, physical examination and systemic evaluation. Location and types (STEMI, NSTEMI) of myocardial infarction were determined by ECG and serum troponin- 1 assay. Blood for glucose and lipid profile was drawn within 24 hours of admission. High sensitivity testing for C-reactive protein (hs CRP) was done in all patients. Coronary angiography was done within 6 weeks of hospital discharge. Results: A total of 83 Patients with age d” 40 years were included .Age range were 21-40 years (34.21 ± 5.07 yrs). There were 71 male (85.5%). Male: female ratio was 5.9:1. Most of the young AMI patients presented lately to the hospital. Majority of these patients were thinly built, came from urban or semiurban areas, engaged in heavy physical activities and belonged to lower socioeconomic group. A positive family history of CAD was present in 18 patients (28.68 %). Smoking was the most prevalent risk factor followed by a raised serum triglyceride or low high density lipoprotein (HDL). A raised hs CRP was present in 47 patients (49.39%). The overall in hospital mortality was only 3.61 %. Coronary angiography done in 38 patients revealed single vessel disease in the majority. Conclusion: The study focuses our attention to the rising incidence of AMI in young individuals who are less prone to CAD. Early detection of AMI and timely intervention needs high index of suspicion in this age group. These young patients have got low BMI High TG, Low HDG High hs CRP & habit of smoking. Avoidance of smoking, controlling high TG and/or low HDL may reduce incidence of AMI among young patients. Use of high dose of statin at an early age in young persons with raised CRP may be considered. Keywords: Myocardial infarction; Young. DOI: http://dx.doi.org/10.3329/cardio.v4i1.9390 Cardiovasc. J. 2011; 4(1): 53-57


2014 ◽  
Vol 13 (2) ◽  
pp. 21-27
Author(s):  
Sunam Kumar Barua ◽  
Sohely Rahman ◽  
Prashanta Kumar Chakrabarti ◽  
Zahangir Alam

This prospective study was performed in the department of Physical Medicine, Dhaka Medical College Hospital (DMCH), Dhaka for a period of 6 months to see the effect of phonophoresis (Ultrasound therapy with Naproxen gel) on adhesive capsulitis. During this period 240 (4% of total patients) patients were diagnosed as adhesive capsulitis of shoulder in outpatient department, Physical Medicine, Dhaka Medical College Hospital. Sixty patients were selected for the study and divided them into two groups. In group A, patients were treated with phonophoresis and exercises in contrast with group B patients who were treated with same exercises without phonophoresis for same duration. Patients in both groups were followed up weekly for consecutive six weeks. The mean age of the patients in this study was 51.73 ± 10.01 year, with a range of 35 to 70 years. Out of sixty patients 31 (51.7%) were male and 29 (48.3%) were female. The male: female ratio was 1.07: 1. Among 60 patients, 27 (45%) were housewives, 20 (33.3%) service holders (official job), 4 (6.7%) businessmen, 1 (1.7%) teacher and 8 (13.3%) retired persons. In this study 53.3% patients had right shoulder involvement and rest of them (46.7%) had left sided involvement. Pain was improved just after initiation of treatment and it was completely alleviated in group A patients after 6th week, on the contrary although pain was increased after 1st week of treatment thereafter it was gradually decreased but it was not completely alleviated in group B patients at the end of the study. All sorts of range of motions (abduction, internal rotation on abduction, external rotation on abduction) of affected shoulder were improved more rapidly in group A compared to group B patients. Shoulder pain and disability index (SPADI) were significantly reduced in group A compared to group B patients.DOI: http://dx.doi.org/10.3329/cmoshmcj.v13i2.21057


1970 ◽  
Vol 26 (3) ◽  
pp. 128-134
Author(s):  
ASM Nawshad Uddin Ahmed ◽  
MA Rob ◽  
Ferdous Rahman ◽  
Redwanur Rahman ◽  
Nazmul Huda

y, mainly due to infections and complications of prematurity. The present article is a descriptive analysis of the most common reasons for hospital admission of VLBW infants, morbidity during hospital stay, and their immediate outcome at a community level medical college hospital in Bangladesh. Sixty VLBW neonates (< 1,500 grams weight), 37 males and 23 females, < 72 hours of age were enrolled prospectively from March 2005 to February 2007; 4 babies were excluded. Thirty-four babies were hospital born and 26 home delivered cases admitted postnatally. The mean birth weight and gestational age of the newborns were 1270 ± 169 grams and 30.9 ± 2.9 weeks respectively. Forty-one of 60 cases (68.3%) mothers received at least one antenatal care visit. Common clinical presentations were prematurity alone (36.7%) and its complications like delayed crying (25.0%), feeding problem (23.3%), lethargy (16.7%), hypothermia (10.0%) and respiratory problem (8.3%). The commonest morbidity during hospital stay was neonatal hyperbilirubinemia requiring phototherapy (26.7%), apnoea of prematurity (15.0%), and septicaemia (11.7%). The overall survival rate was 56.7%; most of the deceased cases were those < 1250 grams (15/28, 53.6%) and < 30 weeks of gestation (17/30, 56.7%). No infant with a birth weight < 850 grams or a gestational age < 28 weeks survived. The most common cause of death was birth asphyxia (38.5%), followed by extreme prematurity (26.9%), and septicaemia (19.2%). Very low birth weight infants had relatively higher survival rates probably due to low infection rate. DOI: 10.3329/jbcps.v26i3.4196 J Bangladesh Coll Phys Surg 2008; 26: 128-134


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