scholarly journals Body mass, plasma leptin, glucose, insulin and C-peptide in offspring of diabetic and non-diabetic mothers

2001 ◽  
Vol 145 (1) ◽  
pp. 53-58 ◽  
Author(s):  
L Kostalova ◽  
L Leskova ◽  
A Kapellerova ◽  
V Strbak
Keyword(s):  
Body Mass ◽  
Plasma Insulin ◽  
Tanner Stage ◽  
Strongly Correlated ◽  
C Peptide ◽  
Glucose Levels ◽  
A Prospective Study ◽  
Plasma Leptin ◽  
The Relationship ◽  
Diabetic Mothers

OBJECTIVE: The aim was to investigate the relationship between body mass index (BMI), plasma leptin, glucose, insulin and C-peptide levels in the offspring of diabetic mothers (DM) and non-diabetic healthy mothers (HM). DESIGN: Seventy-two offspring (37 girls and 35 boys, age 4-20 years) of DM were investigated in a prospective study. Those 14-16 years old (Tanner stage II-IV) were compared with age-matched offspring of HM (33 girls and 33 boys). RESULTS: BMI strongly correlated with plasma leptin concentration in the offspring of both DM and HM children. There were higher BMI and plasma leptin and glucose levels in DM than in HM children. There was no difference in plasma insulin or C-peptide levels between HM and age-matched DM children. There was a highly significant positive correlation between plasma leptin and C-peptide in boys of DM. CONCLUSIONS: The higher plasma leptin found in the offspring of DM reflects their higher BMI. A moderately high but still normal glycemia might be a preclinical sign of insulin resistance or other disturbance of glucoregulation.

Relationship between Leptin Concentration in Cord Blood and Foetal Growth and Maternal Anthropometry of GDM Mothers at Delivery

1970 ◽  
Vol 25 (1) ◽  
pp. 9-13
Author(s):  
S Jahan ◽  
TR Das ◽  
KB Biswas
Keyword(s):  
Body Mass Index ◽  
Birth Weight ◽  
Cord Blood ◽  
Body Mass ◽  
Anthropometric Measurements ◽  
Anthropometric Parameters ◽  
Serum Leptin ◽  
C Peptide ◽  
Cord Serum ◽  
The Relationship

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)

scholarly journals Paternal body mass index before conception associated with offspring's birth weight in Chinese population: a prospective study

2021 ◽  
Author(s):  
Renying Xu ◽  
Weixiu Zhao ◽  
Tao Tan ◽  
Haojie Li ◽  
Yanping Wan
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Birth Weight ◽  
Body Mass ◽  
Sensitivity Analyses ◽  
Gestational Weight ◽  
A Prospective Study ◽  
The Relationship ◽  
Multivariable Adjustment ◽  
Chinese Mother

Whether paternal epigenetic information of nutrition might be inherited by their offspring remained unknown. evaluate the relationship between preconception paternal body weight and their offspring's birth weight in 1,810 Chinese mother-father-baby trios. Information on paternal and maternal preconception body weight and height was collected via a self-reported questionnaire. Birth weight was collected from medical records. Paternal preconception body weight was associated with offspring's birth weight (p trend=0.02) after multivariable adjustment. Each standard deviation increment of paternal body mass index was associated with an additional 29.6 g increase of birth weight (95% confident interval: 5.7g, 53.5g). The association was more pronounced in male neonates, and neonates with overweight mothers, and with mothers who gained excessive gestational weight, compared to their counterparts (all p interaction<0.05). Sensitivity analyses showed similar pattern to that of the main analysis. Paternal preconception body weight was associated with birth weight of their offspring.

scholarly journals Teeth complexity, hypsodonty and body mass in Santacrucian (Early Miocene) notoungulates (Mammalia)

2015 ◽  
Vol 106 (4) ◽  
pp. 303-313 ◽  
Author(s):  
Guillermo H. Cassini ◽  
Santiago Hernández Del Pino ◽  
Nahuel A. Muñoz ◽  
M. V. Walter G. Acosta ◽  
Mercedes Fernández ◽  
...  
Keyword(s):  
Surface Area ◽  
Body Mass ◽  
Tooth Enamel ◽  
Tooth Wear ◽  
Occlusal Surface ◽  
South American ◽  
Strongly Correlated ◽  
Size Dependent ◽  
Dental Traits ◽  
The Relationship

ABSTRACTNotoungulates, native South American fossil mammals, have been recently objective of several palaeoecological studies. Ecomorphology and biomechanics of the masticatory apparatus, together with micro and mesowear analyses on tooth enamel, were applied in order to understand their palaeobiology. In particular, the relationship between some dental traits (hypsodonty, occlusal surface area and complexity) and body mass is still poorly understood. These features were measured by means of the hypsodonty index (HI), occlusal surface area (OSA) and tooth area (OTA), enamel crest complexity (ECC) and length (OEL). The relationships between these indices were evaluated in five pan-contemporaneous Santacrucian Notoungulata genera from Patagonia: Adinotherium and Nesodon (Toxodontia), Interatherium, Protypotherium and Hegetotherium (Typotheria). While OSA, OTA and OEL were size dependent and strongly correlated, HI and ECC were size independent. All notoungulates analysed have very hypsodont teeth, indicating high rates of tooth wear in response to an increase of abrasives consumed with the food; their tooth occlusal area and complexity could be related to chewing efforts associated with the toughness of the plants consumed. HI, OSA and ECC were considered useful for palaeoecological reconstructions, but the results presented here show that these three features are integrated as a complex, so should not be evaluated separately.

scholarly journals The Impact of Re-Mating Interval and Genotype on Physiological Response of Rabbits after First Kindling

2021 ◽  
Vol 16 (1) ◽  
pp. 1
Author(s):  
Shereen S. Ghoneim ◽  
Sawsan A. Nasr ◽  
I. El-Wardany ◽  
A. Farid ◽  
A. H. Ahmed ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Plasma Insulin ◽  
Tail Length ◽  
Hormone Concentration ◽  
Plasma Insulin Concentration ◽  
Plasma Urea ◽  
Glucose Levels ◽  
Mating Interval ◽  
Plasma Leptin ◽  
The Impact

This is an experiment aimed to study the effect of re-mating interval on rabbit does after first kindling on hormonal (insulin, leptin, and T3) and metabolites (triglycerides, urea, and glucose) levels. DNA damage in ovary cells of rabbit does during the 2nd parity was also studied. Two varieties were used: APRI (synthetic line) and Baladi Black (BB, Egyptian breed). A total number of 120 mature rabbit does (60 does for each breed) were 6 months of age and were used at the beginning of the breeding season. Does of each breed were divided into three equal groups according to reproductive rhythm. The 1st group was postpartum (PP). The 2nd group was 11 days after parturition (P11). The 3rd group was post-weaning (PW). There were significant (P&ge;0.05) differences in plasma leptin concentration during 1st parity. The highest value of plasma leptin concentration was recorded by the PW group at mating. Also, there were significant differences in plasma insulin and T3 hormones concentrations of doe rabbits. The highest value of plasma insulin concentration was recorded by the PW group at mating in 1st parity and the highest value of plasma T3 hormone concentration was recorded for the PS group at mating. While there were insignificant differences during 2nd parity in T3 hormone concentration in rabbits, the differences of plasma glucose and triglyceride concentrations of doe rabbits during 1st parity and 2nd parity were significant. However, the highest significant value of plasma glucose concentration was recorded by the PW group at mating. On the other hand, there were insignificant differences in plasma urea concentration of doe rabbits during 1st parity and 2nd parity. Finally, no significant effects were observed on comet length, head diameter, tail length, or DNA % tail.

scholarly journals Prognostic Value of the Acute-to-Chronic Glycemic Ratio at Admission in Heart Failure: A Prospective Study

2021 ◽  
Vol 11 (1) ◽  
pp. 6
Author(s):  
Mª José Carrera ◽  
Pedro Moliner ◽  
Gemma Llauradó ◽  
Cristina Enjuanes ◽  
Laura Conangla ◽  
...  
Keyword(s):  
Heart Failure ◽  
Multivariable Analysis ◽  
Acute Hyperglycemia ◽  
Glucose Levels ◽  
Long Term Prognosis ◽  
Shape Curve ◽  
A Prospective Study ◽  
The Impact ◽  
The Relationship

Acute hyperglycemia has been associated with worse prognosis in patients hospitalized for heart failure (HF). Nevertheless, studies evaluating the impact of glycemic control on long-term prognosis have shown conflicting results. Our aim was to assess the relationship between acute-to-chronic (A/C) glycemic ratio and 4-year mortality in a cohort of subjects hospitalized for acute HF. A total of 1062 subjects were consecutively included. We measured glycaemia at admission and estimated average chronic glucose levels and the A/C glycemic ratio were calculated. Subjects were stratified into groups according to the A/C glycemic ratio tertiles. The primary endpoint was 4-year mortality. Subjects with diabetes had higher risk for mortality compared to those without (HR 1.35 [95% CI: 1.10–1.65]; p = 0.004). A U-shape curve association was found between glucose at admission and mortality, with a HR of 1.60 [95% CI: 1.22–2.11]; p = 0.001, and a HR of 1.29 [95% CI: 0.97–1.70]; p = 0.078 for the first and the third tertile, respectively, in subjects with diabetes. Additionally, the A/C glycemic ratio was negatively associated with mortality (HR 0.76 [95% CI: 0.58–0.99]; p = 0.046 and HR 0.68 [95% CI: 0.52–0.89]; p = 0.005 for the second and third tertile, respectively). In multivariable analysis, the A/C glycemic ratio remained an independent predictor. In conclusion, in subjects hospitalized for acute HF, the A/C glycemic ratio is significantly associated with mortality, improving the ability to predict mortality compared with glucose levels at admission or average chronic glucose concentrations, especially in subjects with diabetes.

scholarly journals Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women

2008 ◽  
Vol 52 (4) ◽  
pp. 611-616 ◽  
Author(s):  
Hamilton M. Hinuy ◽  
Mario H. Hirata ◽  
Neusa Forti ◽  
Jayme Diament ◽  
Marcelo F. Sampaio ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Body Mass Index ◽  
Coronary Artery ◽  
Body Mass ◽  
Serum Lipids ◽  
Promoter Polymorphism ◽  
Pcr Rflp ◽  
Artery Disease ◽  
Plasma Leptin ◽  
The Relationship

Variants in leptin gene (LEP) have been implicated in the pathogenesis of obesity. The relationship between LEP G-2548A polymorphism and obesity-related traits was evaluated in a sample of Brazilian women (n = 228) who were randomly selected from two clinical centers in Sao Paulo city. Blood samples were collected for DNA extraction, plasma leptin and serum lipids measurements. LEP G-2548A genotypes were identified by a PCR- RFLP strategy using the endonuclease Alw44I. LEP G-2548A was associated with obesity after adjustment for covariates (age, hypertension, coronary artery disease, smoking and physical activity). Women carrying G allele had a four times higher risk of obesity than the A allele carriers (OR: 4.11, CI95%: 1.06-15.90, p = 0.041). G allele was also related to increased plasma leptin (p = 0.024) and body mass index (p = 0.027). Hypertension, hyperglycemia, dyslipidemia and coronary artery disease were associated with obesity. However LEP G-2548A polymorphism was not related to these variables. All together these data suggest that LEP G-2548A polymorphism has an important role in regulating plasma leptin levels and body mass index in women.

A prospective study of the relationship between body mass index and cataract extraction among US women and men

2002 ◽  
Vol 26 (12) ◽  
pp. 1588-1595 ◽  
Author(s):  
JM Weintraub ◽  
WC Willett ◽  
B Rosner ◽  
GA Colditz ◽  
JM Seddon ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Prospective Study ◽  
Body Mass ◽  
Cataract Extraction ◽  
A Prospective Study ◽  
The Relationship

scholarly journals Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

2012 ◽  
Vol 36 (2) ◽  
pp. 71-75
Author(s):  
Mst Nurun Nahar Begum ◽  
M Quamrul Hassan ◽  
Kishwar Azad
Keyword(s):  
Blood Glucose ◽  
Child Health ◽  
Umbilical Cord ◽  
Clinical Characteristics ◽  
C Peptide ◽  
Infants Of Diabetic Mothers ◽  
Significant Difference ◽  
Peptide Level ◽  
The Relationship ◽  
Diabetic Mothers

Objective: To examine the relationship between umbilical cord C-peptide and risk of hypoglycemia in infants of diabetic mothers. Method: Sixty neonates born to diabetic mothers were studied in BIRDEM hospital. Thirty infants who developed hypoglycemia at any time during the first 24 hours of age were considered as cases. Another 30 infants who did not develop hypoglycemia during the first 24 hours were considered as controls. Umbilical cord C-peptide levels were measured in both groups. All babies were screened for hypoglycemia at 4, 6, 8, 12, 18 and 24 hours of life. Blood glucose value of less than 2.6 mmol/l was considered as hypoglycemia. Results: Clinical characteristics of cases and controls and their mothers did not show any significant difference. In 73.3% of cases hypoglycemia was detected by 6 hours of age. Most babies were asymptomatic (93.3%). It was found that IDMs who developed hypoglycemia had significantly higher cord C-peptide level at birth compared to those who remained normoglycemic (4.57±2.50 vs. 2.81± 2.11 ng/ml, P= 0.005). That means, there is significant association between raised level of cord C-peptide and hypoglycemia in IDMs. Conclusion: Hypoglycemia in infants of diabetic mothers associated with raised cord blood C-peptide levels. DOI: http://dx.doi.org/10.3329/bjch.v36i2.13082 Bangladesh J Child Health 2012; Vol 36 (2): 71-75

scholarly journals Robust Leptin Secretory Responses to Dexamethasone in Obese Subjects*

1997 ◽  
Vol 82 (10) ◽  
pp. 3230-3233 ◽  
Author(s):  
Samuel Dagogo-Jack ◽  
Gregg Selke ◽  
Angela K. Melson ◽  
John W. Newcomer
Keyword(s):  
Body Mass Index ◽  
Sexual Dimorphism ◽  
Total Dose ◽  
Body Mass ◽  
Plasma Insulin ◽  
Dexamethasone Treatment ◽  
Obese Subjects ◽  
Baseline Values ◽  
Plasma Leptin

Abstract Although leptin reverses obesity in rodents, its function and regulation in humans are unknown. Glucocorticoids have been reported to stimulate leptin production in both rodents and humans, but data assessing the effect of obesity on dynamic leptin secretory responses are unavailable. We, therefore, studied 52 lean and obese subjects [20 men and 32 women; aged 19–84 yr; body mass index (BMI) range, 16–47 kg/m2] randomized to treatment with dexamethasone (total dose, 10 mg/4 days) or placebo. Compared with placebo, dexamethasone increased (P = 0.0001) plasma leptin levels by 64–111% above baseline values within 2–4 days. The increases occurred in all ages, showed no sexual dimorphism, and were particularly robust in obese subjects. After dexamethasone treatment, significant interactions were observed between the change in plasma leptin and BMI (P = 0.0001), baseline plasma leptin (P = 0.0006) and plasma dexamethasone levels (P = 0.04), but not age (P = 0.28); an apparent interaction with plasma insulin no longer was significant after controlling for BMI. These results confirm dexamethasone-induced hyperleptinemia in humans and further demonstrate that the response is not defective in obesity.

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