scholarly journals Assessment of Gonadal Function Following Single Dose of Radioiodine Therapy in Differentiated Thyroid Cancer Patients of Reproductive Age

2018 ◽  
Vol 19 (2) ◽  
pp. 92
Author(s):  
Md Sunny Anam Chowdhury ◽  
Sadia Sultana ◽  
Md Abdul Awal ◽  
Suraya Sarmin ◽  
Mohammad Simoon Salekin
Keyword(s):  
Thyroid Cancer ◽  
Single Dose ◽  
Differentiated Thyroid Cancer ◽  
Reproductive Age ◽  
Age Group ◽  
Gonadal Function ◽  
Male Patients ◽  
The Mean ◽  
Reproductive Age Group

<p><strong>Objective</strong>: This interventional study has undertaken to assess the gonadal function of differentiated thyroid cancer (DTC) patients within reproductive age group following single dose of radioactive iodine (131I) therapy/ablation.</p><p><strong>Patients and Methods:<em> </em></strong>A total of 69 patients (25 male and 44 female) of DTC were included in this study, those were referred for 131I ablation after total thyroidectomy. Following RAI, these patients were followed-up three times at three months interval.  The usual I-131 dose was 75 or 100 m Ci for ablation of thyroid residues and 150 mCi for treatment of nodal metastasis. All the patients were interviewed about menstrual (female only) and reproductive history and investigated of the level of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone of male patients and FSH, LH, estradiol (E<sub>2</sub>) of female patients before administration of  131I and three, six and nine months after therapy.</p><p><strong>Result</strong>: In this study all of the 25 (100.0%) male patients showed high FSH level after three months of therapy. The mean± SD FSH level of male patients was found significantly (p-0.001) higher (15.59±7.53 IU/L) after three months of therapy than the pretherapy (4.85±2.57 IU/L) level.  The mean± SD of FSH level was significantly declining in six months and nine months of follow up. The mean± SD of LH hormone level of these patients was found 6.1±3.67 IU/L in pretherapy which was significantly increased to 7.67±4.33 IU/L after three months. The mean LH level was 7.20±3.98 IU/L at six months follow up and 7.3±3.5IU/L after nine months. The differences of LH level between 3 months to 6 months and 6 months to 9 months are not statistically significant. No significant change was observed in testosterone level throughout the study period. In female, five patients developed irregular menstruation (changed duration of cycle or lighter amount), three patients developed amenorrhea associated with hot flashes within six months of 131I administration. Biochemical study of the patients with amenorrhoea showed markedly elevated serum FSH, LH level and declined E<sub>2 </sub>level. The FSH, LH levels of the two patients with amenorrhea became normal within study period and one patient had persistent amenorrhea at 9 months. E<sub>2</sub> level raised slowly.</p><p><strong>Conclusion</strong>: A single dose of radio-iodine (131I) therapy causes impairment of gonadal function of male patients within reproductive age group. In case of female patients the effect is insignificant. The effect is usually reversible and gonadal function of the patients restores within the study period.</p><p>Bangladesh J. Nuclear Med. 19(2): 92-97, July 2016  </p>

A very large leiomyoma of the urethra: A case report

2017 ◽  
Vol 85 (2) ◽  
pp. 79-82 ◽  
Author(s):  
Paolo Fedelini ◽  
Francesco Chiancone ◽  
Maurizio Fedelini ◽  
Marco Fabiano ◽  
Francesco Persico ◽  
...  
Keyword(s):  
Case Report ◽  
Foley Catheter ◽  
Reproductive Age ◽  
Age Group ◽  
Women Of Reproductive Age ◽  
The Mean ◽  
Tract Infections ◽  
Mesenchymal Tumours ◽  
Reproductive Age Group

Introduction: Leiomyomas are benign mesenchymal tumours of smooth muscle origin. They are the most common uterine masses in women of reproductive age group and may be related to the hormonal status. Urethral leiomyomas are very rare. According to the literature, the mean diameter of the urethral leiomyomas is 3.7 cm. Case report: We report a case of a very large leiomyoma of the urethra. A 40-year-old women woman was admitted to our department for a giant vaginal mass. She complained of haematuria, dysuria, recurrent urinary tract infections and dyspareunia. The physical evaluation demonstrated a 6 × 5.5 cm neoformation involving the distal tract of the urethra. The patient underwent an ultrasonography and then a magnetic resonance that suggested the diagnosis of leiomyoma. The neoformation was excised through a suburethral incision. Conclusions: The patient was discharged after 3 days and no intraoperative and postoperative complications occurred. The Foley catheter was removed after a week. The patient was continent to urine, and at 6 months follow-up, the patient was symptom free and no recurrences occurred.

scholarly journals TO STUDY EFFICACY OF AMISULPRIDE IN TREATMENT OF SCHIZOPHRENIA.

2019 ◽  
Vol 3 (12) ◽  
Author(s):  
Om Prakash Raichandani ◽  
Abhijeet Kadam ◽  
Sapna Raichandani
Keyword(s):  
Urban Population ◽  
Extrapyramidal Symptoms ◽  
Reproductive Age ◽  
Age Group ◽  
Female Ratio ◽  
Moderate Severity ◽  
Medical College ◽  
Male Female Ratio ◽  
The Mean ◽  
Reproductive Age Group

The study was performed at the Department of Pharmacology in collaboration with Department of Psychiatry, NSCB Medical College, Jabalpur. The maximum numbers of patients in were in reproductive age group that is in between 20 to 49 years. The mean age in Amisulpride group was 33.26(±10.23) years while in Olanzapine group it was 31.25 (±12.22) years. Schizophrenia was more common (80%) in younger (20-49years) age group. In our study the male /female ratio was 1.7. Our study supports the notion that Schizophrenia is more common in Married and Urban population. Only one patient from Olanzapine  Group suffered  Extrapyramidal  symptoms of  moderate severity requiring  withdrawal from study.2  patients  from Olanzapine group and 1 patient from Amisulpride group  had Tremors and Akathesia  of mild severity. There was no emergence of Extrapyramidal symptoms in rest of the patients (p>.05) Keywords: Efficacy, Amisulpride, Olanzapine & Schizophrenia.

scholarly journals Endometrioma masquerading an ovarian carcinoma

2021 ◽  
Vol 10 (3) ◽  
pp. 1205
Author(s):  
Amanat Sidhu ◽  
Ripan Bala ◽  
Pooja Tandon ◽  
Rajdeep Chhina
Keyword(s):  
Ovarian Carcinoma ◽  
Malignant Tumor ◽  
Chronic Pelvic Pain ◽  
Young Female ◽  
Malignant Potential ◽  
Reproductive Age ◽  
Age Group ◽  
Increased Risk ◽  
Reproductive Age Group

Endometriosis is the presence of endometrial tissue outside the uterus. Endometriosis affects 10-15% of all women in reproductive age group and 70% of the women with chronic pelvic pain. The risk of malignant transformation in an endometrioma has been reported to be low, though there is an increased risk for certain gynecological as well as non-gynecological carcinomas with endometriosis. We present a case diagnosed as having endometrioma transforming into a malignant tumor in a young female. We intend to emphasize that all the clinicians should make their patients aware of the malignant potential of endometriosis and a strict follow up of all cases being treated conservatively should be a must.

scholarly journals Is it safe to perform myomectomy in first trimester of pregnancy? The report of two cases

2021 ◽  
Vol 6 (2) ◽  
pp. 170-174
Author(s):  
Murat Celiloglu ◽  
◽  
Samican Ozmen ◽  
Sefa Kurt ◽  
Orkun Ilgen
Keyword(s):  
Uterine Fibroids ◽  
First Trimester ◽  
Reproductive Age ◽  
Benign Tumors ◽  
Age Group ◽  
Second Trimester ◽  
Review Of The Literature ◽  
First Trimester Of Pregnancy ◽  
Reproductive Age Group

Uterine fibroids are the most common benign tumors in women in the reproductive age group. The incidence of fibroids during pregnancy varies between 1.6 and 10.7%. In 10% of these cases, fibroids lead to complications. The management in symptomatic patients is conservative, and the surgical treatment is delayed until after birth due to its risks. In the last two decades, it has been shown that myomectomy can be an alternative treatment in selected cases, especially in second-trimester pregnancies. However, the data on the success of myomectomies performed earlier in pregnancy are limited. In this case report, we present two cases who were admitted to our clinic during the first trimester of pregnancy and had complicated fibroids. The diagnosis, the follow up and the treatment are presented with the review of the literature.

scholarly journals Radioiodine Treatment of Differentiated Thyroid Cancer at CNMU, Rajshahi

1970 ◽  
Vol 16 (2) ◽  
pp. 54-57
Author(s):  
MM Ahasan ◽  
FU Ahmed ◽  
SM Bodrudozza ◽  
SMK Hasan ◽  
MN Khanam
Keyword(s):  
Thyroid Cancer ◽  
Single Dose ◽  
Retrospective Study ◽  
Differentiated Thyroid Cancer ◽  
Age Group ◽  
Radioiodine Treatment ◽  
Residual Tissue

A retrospective study has been conducted on 19 patients who attended at CNMU, Rajshahi withdifferentiated thyroid cancer, treated with radioiodine for ablation of residual tissue afterthyroidectomy. The patients included in this study were between 06 to 70 years of age, the meanage being about 36 years. The main objective of the study was to evaluate the response of theradioiodine therapy in patient with differentiated thyroid cancer after surgery. The incidence ofpapillary, follicular and mixed variety was found in approximately 69%, 26% and 5% casesrespectively. Result showed that the incidence of thyroid cancer were found more,approximately 58% in the age group 21-40 years. Results also showed that papillary carcinomainvolved approximately 23% in male and 77% in female. It was also found that approximately89% patients were treated successfully by single dose of radioiodine.doi: 10.3329/taj.v16i2.3882TAJ December 2003; Vol.16(2): 54-57

scholarly journals Effectiveness of Structured Counseling and Preventive Strategies in Promoting Awareness and Expressed Habitual Practices Toward Prevention of Urinary Tract Infection Among Women of Reproductive Age Group: A Pilot Study

2022 ◽  
Author(s):  
Sonia Karen Liz Sequera ◽  
Leena Kunnath Chacko
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Reproductive Age ◽  
Age Group ◽  
Preventive Strategies ◽  
The Third ◽  
Post Test ◽  
The Mean ◽  
Experimental Group ◽  
Reproductive Age Group

Abstract Objectives Urinary tract infection (UTI) is the most common infection that affects half of all women in their lifetime and one-fourth have recurrent infections. Health behaviors could prevent the recurrence of UTIs and therefore motivation and increasing awareness are necessary for healthy behavior change. This study was done to evaluate the effectiveness of structured counseling and preventive strategies (SCAPS) in promoting awareness and expressed habitual practices among the women of the reproductive age group to prevent UTI. Materials and Methods Block randomization with multiple interventions and follow-up were conducted among 60 women (30 in each group, randomly assigned using the SNOSE technique) attending the OBG and urology OPDs of a selected medical college hospital. Purposive sampling was used to select the subjects. Women who were positive for urine culture and experiencing typical symptoms of UTI, as assessed using the symptom score checklist, were recruited for the study. Pre-test awareness was assessed using a structured awareness questionnaire and a rating scale for expressed habitual practice. After the pre-test, on the same day, the experimental group received SCAPS intervention followed by a second session during the third month. At the third (before the second session) and the sixth-month post-tests were conducted by delivering the same tool to determine the post-test level of awareness and expressed habitual practice after the administration of SCAPS. Results The study shows there is a significant difference in the awareness and expressed habitual practice values in the experimental group (p < 0.005). The effectiveness of SCAPS showed that the mean ± standard deviation (SD) pre-test score of women (awareness - x̄1 ± SD = 9.47 ± 2.57, hygienic habitual practice - x̄1 ± SD = 20.93 ± 1.91, fluid and dietary practice - x̄1 ± SD = 7.73 ± 2.18 and sexual habits - x̄1 ± SD= 8.00 ± 3.33) was significantly lower than the mean ± SD post-test scores (awareness - x̄2 ± SD =11.37 ± 1.65, awareness - x̄3 ± SD = 12.00 ± 1.05), (hygienic habitual practice - x̄2 ± SD = 22.57 ± 2.16, x̄3 ± SD = 23.90 ± 1.99), (fluid and dietary practice - x̄2 ± SD = 10.07 ± 2.21, x̄3 ± SD =11.97 ± 1.79) and (sexual habits - x̄2 ± SD = 8.81 ± 2.51, x̄3 ± SD =9.81 ± 2.26). Conclusion SCAPS was found to be effective on awareness and preventive habitual practices with regard to UTI. SCAPS can be recommended for vulnerable groups such as females so that UTI could be prevented. Trial Registration CTRI/2018/10/016064 (Registration on 17/10/2018).

scholarly journals Magnitude of menstrual problems among young females of medical and paramedical college

2021 ◽  
Vol 10 (5) ◽  
pp. 2010
Author(s):  
Deepshikha Jaiswal ◽  
Rahul Kumar
Keyword(s):  
Standard Deviation ◽  
Average Duration ◽  
Young Female ◽  
Reproductive Age ◽  
Age Group ◽  
Young Females ◽  
Normal Blood Flow ◽  
The Mean ◽  
Age Of Menarche ◽  
Reproductive Age Group

Background: Menstruation is described as the exclusive sign of femininity. The age of menarche is determined by general health, genetic, socio-economic, nutritional factors, geographic location, exposure to light and psychological state. Objective of current study was to determine the magnitude of menstrual problem among young females of age group17-25 years of medical and paramedical college. Methods: The present study has been conducted on 300 young female students studying in the department of obstetrics and gynaecology in collaboration with paramedical and nursing college, RIMS and R. Saifai, Etawah over a period of 18 months January 2015 to July 2016, with an objective to determine the magnitude of menstrual problem among on young female students of age group 17-25 years.Results: Mean age of the study population was 21.98 years. The mean age of menarche was found to be 13.50 years with standard deviation of 1.315. This was also in accordance with the results of previous studies. The average duration of menstrual blood loss was found to be 4.28 days with standard deviation of 1.092. The average duration of normal blood flow for reproductive age group as estimated is 2-5 days. The mean of menstrual cycle length came out to be 29.79 days with a standard deviation of 4.87. The average amount of blood loss during each menstrual cycle was found to be 65.39 ml with a standard deviation of 11.81. Conclusions: It was concluded that the mean age of menarche was found to be 13.50 years with standard deviation of 1.315. The average duration of normal blood flow for reproductive age group as estimated is 2-5 days.

scholarly journals Disease Free Survival of Well Differentiated Thyroid Cancer: 20 years Experience at a tertiary care center in Lebanon

10.3823/2545 ◽  
2018 ◽  
Vol 11 ◽  
Author(s):  
Rita Hajj Boutros ◽  
Asma Arabi ◽  
Mahmoud Shoucair ◽  
Jaber Abbas ◽  
Ibrahim Salti
Keyword(s):  
Thyroid Cancer ◽  
Vascular Invasion ◽  
Differentiated Thyroid Cancer ◽  
Residual Disease ◽  
Tertiary Care ◽  
Disease Free Survival ◽  
Free Survival ◽  
The Mean ◽  
Disease Free

Background: Thyroid cancer is the most common endocrine malignancy. Although relatively common, to date, there is no study about its prognosis in Lebanon. The objectives of this study were to determine the disease free survival, the recurrence rate and possible predictors of recurrence, as well as the rate of post thyroidectomy complications among patients with differentiated thyroid cancer who received treatment at the American University of Beirut Medical Center. Methods and Findings: retrospective observational study of 480 cases of differentiated thyroid cancer who underwent thyroidectomy between January 1995 and June 2014. The mean age was 42±14 years. 74.4% were females. The mean tumor size was 1.9 cm±1.4. Papillary type was predominant (91%). Males had more extra-glandular extension than females (24.8% versus 10.9% respectively, p=0.001), more lymph node involvement (69.7% versus 52.9% respectively, p=0.017) and more vascular invasion (28.1% versus 14.9%, p=0.007). Around 70% of patients had at least one follow up visit after the surgery; among those, the median follow up duration was 4 years (1month-19years). At last follow-up visit, 78.7% were disease free, 14.9% had residual disease and only 6.3% had recurrent disease. By multivariate analysis, age greater than 45 years was the only independent predictor of persistence or recurrence (p=0.03) whereas both age below 45 years and lack of vascular invasion were significant predictors of disease free survival (p=0.001 and p=0.019 respectively). Conclusion: Differentiated thyroid cancer has an overall good prognosis in this cohort of Lebanese patients. Young age and lack of vascular invasion are the most important predictors of disease free survival.   Key words: Differentiated thyroid cancer: disease free survival, prognostic factors, recurrence

EP.FRI.580 Negative appendectomy rates at a district regional hospital

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Marwa Al-Azzawi
Keyword(s):  
Young Patients ◽  
Regional Hospital ◽  
Reproductive Age ◽  
Negative Appendectomy ◽  
Age Group ◽  
Normal Appendix ◽  
Emergency Procedures ◽  
Initial Investigation ◽  
The Mean ◽  
Reproductive Age Group

Abstract Aim Emergency appendectomy is one of the most common emergency procedures done. Negative appendectomy rates vary and the aim was to identify the rate of it at a DGH.   Method Appendectomy cases at a small regional hospital were during a 2-year period (2017-2018) were included.  Elective and interval appendectomies were excluded.  Histopathology findings were noted.  Results 78 patient had an emergency appendectomy, of which 87% (n = 68) had it done laparoscopically.  Normal appendix on pathology was found in 13.8% (n = 12) of the removed appendices. They were all removed laprascopically. The majority were females (n = 11) compared to males (n = 1).  58% of the normal appendix (n = 7) were identified as a macroscopically normal appendix.  36% of the females were mid-cycle (n = 4).  The mean WBC on admission was 9.5 (4.8-13.6 x109/L) . All of the females had a transabdominal USS as initial investigation but was inconclusive.  Conclusion Negative appendectomy rates are still high in female patients, whether doing further scans such as TVUSS or CTAP might reduce the risks of getting a negative appendectomy, needs to be discussed and tailored to each case, as the majority are young patients in the reproductive age group. 

scholarly journals A comparative interventional study on the efficacy of single and multiple dose combination drug regimen of leucorrhea among women in reproductive age group

2017 ◽  
Vol 4 (4) ◽  
pp. 1230
Author(s):  
Sivakumar K. ◽  
Ajay Raj S. ◽  
Sujatha K.
Keyword(s):  
Single Dose ◽  
Dose Regimen ◽  
Multiple Dose ◽  
Vaginal Discharge ◽  
Drug Regimen ◽  
Reproductive Age ◽  
Age Group ◽  
Cure Rate ◽  
Abnormal Vaginal Discharge ◽  
Reproductive Age Group

Background: Reproductive tract infections (RTIs) in women are becoming major public health problem not only in India but also over the world. Syndromic approach is advocated by World Health Organization (WHO) to manage common RTIs using clinical flow charts based on identifying a syndrome that cause the symptoms reported by patients. The most commonly reported among the women with RTIs is abnormal vaginal discharge or Leucorrhea. Single dose regimen is not preventing the recurrence of infections. A second course of treatment is required followed by standard single dose regimen for achieving better cure rate in chronic vaginal discharge. Objective of the study was to compare the efficacy of single dose drug combination regimen with multiple dose regimens in the treatment of leucorrhoea. Methods: Quasi-experimental study was done in Urban field service area, RMMCH – Chidambaram among Married women in the reproductive age group (15-49 years) with complaints of abnormal vaginal discharge for ≥15 days coupled with any one of the symptoms suggestive of RTI. The study subjects were categorized into two groups – one with single dose regimen and the other with multiple dose regimen. Follow up was done on day 7, 15 and after 6 months of therapy. Results: A total of 113 subjects were recruited with 57 participants in single dose group and 56 in multiple dose groups. The subjects who received single dose had a better cure rate as compared to multiple dose group on day 7(87.7% & 85.7%), day 15 (94.7% & 89.3%) and after six months (84.2% & 76.8%) assessment respectively. Recurrence rate was found to be equal in both the groups. Our study indicates that variables such as age of the study subjects and type of flow had significant association with the outcome. Conclusions: Single-dose therapy is as effective as multiple- dose in the management of vaginal discharge based solely on symptoms. The multiple drug regimens can be given if the symptoms persist after single drug regimen as the chances of developing complications due to chronic vaginal discharge are high. 

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