scholarly journals Study of Efficacy and Safety of Triple Combination Agent (4% Hydroquinone, 0.05% Tretinoin and 0.05% Clobetasone Butyrate) in the Treatment of Melasma

2013 ◽  
Vol 8 (1) ◽  
pp. 22-25 ◽  
Author(s):  
Md Mesbah Uddin Khan ◽  
Abu Reza Sayem Ahamed
Keyword(s):  
Sun Exposure ◽  
Skin Type ◽  
Base Line ◽  
Efficacy And Safety ◽  
Triple Combination ◽  
College Hospital ◽  
Medical College ◽  
Type Iv ◽  
Remarkable Reduction ◽  
Association Medical

Melasma is a very common disorder of hypermelanosis affecting face. The pigmented patches usually affect darker complexioned individual especially Asian. An interventional study was carried out to detect the efficacy and safety of triple combination agent (4% Hydroquinone, 0.05% Tretinoin and 0.05% Clobetasone butyrate) in the treatment of melasma. Total 50 clinically diagnosed cases of melasma attending in outpatient department of Dermatology and Venereology, Diabetic Association Medical College Hospital (DAMCH), Faridpur were evaluated. Maximum patients (40%) were between 31-35 years of age and 80% were female. Sun exposure (60%) and contraceptive pill (36%) were common precipitating factors. Of them 54% patients have skin type IV, 24% patients have skin type III. Centrofacial melasma (64%) was the commonest pattern of melasma. MASI score at base line was 9.45, and after 12th week were 4.62. After completion of therapy there was remarkable reduction (51.11%) of severity of melasma. The triple combination agent were well tolerated and commonly observed side effects were erythema (34%) and burning (22%). This study demonstrates that every night application of triple combination agents has significant lightening effect in the treatment of melasma.a DOI: http://dx.doi.org/10.3329/fmcj.v8i1.16893 Faridpur Med. Coll. J. 2013;8(1): 22-25

scholarly journals Evaluation of Efficacy and Safety Profile of Intense Pulsed Light Treatment in Melasma in Darker Skin Type

2020 ◽  
Vol 12 (1) ◽  
pp. 3-8
Author(s):  
Nishant Choudhary ◽  
Abhishek De ◽  
Amrita Sil ◽  
Gobinda Chatterjee
Keyword(s):  
Safety Profile ◽  
Severity Index ◽  
Skin Type ◽  
Intense Pulsed Light ◽  
P Value ◽  
Efficacy And Safety ◽  
Pulsed Light ◽  
First Line Therapy ◽  
Type Iv ◽  
Before And After

AbstractIntroduction. We undertook a prospective, interventional study to evaluate the efficacy and safety profile of Intense Pulsed light (IPL) treatment of melasma in dark skin phenotypes.Material and Methods. The study was conducted in 32 patients of skin type IV and V. IPL with 640 nm and 690 nm filters was used. The patients were called once a month to undergo 6 sessions. Melasma area and severity index (MASI) and Clinician Global Impression Scores were used for evaluation. We followed “per protocol” analysis.Results. Out of 26 patients who completed the treatment, 12 patients showed improvement, MASI remained unchanged in 10 patients and 4 patients showed deterioration. MASI scores before and after treatment were 6.70 ± 3.53 and 6.32 ± 3.90 (p value=0.6891). Erythema and pain were the common side effects noted. Seventeen out of 32 patients had thyroid disorders.Conclusion. IPL should be avoided as a first line therapy in darker skin type. However, it can be used as an adjuvant therapy in some cases after careful deliberations.

Chemical and Laser Resurfacing of the Eyelids and Face

2011 ◽  
Author(s):  
John B. Holds
Keyword(s):  
Sun Exposure ◽  
Skin Lesions ◽  
Healing Time ◽  
Skin Type ◽  
Skin Resurfacing ◽  
Skin Preparation ◽  
Type Iv ◽  
Malignant Skin ◽  
Chemical Peels ◽  
History Of

Chemical peels, mechanical abrasion, and more recently laser and electrosurgical devices are used to resurface eyelid and facial skin. The common feature in these techniques is the denaturation or removal of the skin surface. These techniques typically help to hide skin changes related to sun exposure and aging by evening the skin tone, decreasing dyschromia, and diminishing wrinkles. These techniques all require careful case selection and patient preparation with appropriate treatment and postoperative care. Recent interest has focused on less invasive therapy with techniques that leave the epithelium largely intact, shortening healing time and reducing the risk of complications. Aging and sun damage induce a number of changes in skin, including wrinkling, the development of muscle- or gravity-related folds, irregular pigment or dyschromia, and the growth of benign and malignant skin lesions. Scars from acne, trauma, or surgery can also be indications for skin resurfacing. Potential benefit in all of these techniques must be balanced against risks and expected healing time. A medical history must be obtained, looking for a history of immune dysfunction, prior acne, or a history of herpes simplex outbreaks. Prior treatment with radiation or isotretinoin (Accutane) may diminish the pilosebaceous units required for healing. Acne rosacea and cutaneous telangiectasia may be aggravated by skin resurfacing. Cutaneous history must focus on scarring tendencies such as keloid formation, skin type, and ancestry. In particular, one must determine the patient’s skin type, most commonly by assigning a Fitzpatrick’s skin type. Patients with skin type III require careful topical preparation for skin resurfacing treatment in most cases, and patients with skin type IV or higher are more prone to scarring and pigment issues and are not treated with medium depth to deep skin resurfacing techniques by most clinicians. Wrinkles may be graded by the Glogau classification scheme. This scale from “fine wrinkles” (type 1) to “only wrinkles” (type IV) will help to define the amount and type of treatment needed. These loose recommendations will generally hold true in determining effective therapy. The deeper and more invasive the treatment, the more important the role of skin preparation and prophylaxis.

scholarly journals Gestational Diabetes Mellitus and Associated Risk Factors in Patients Attending Diabetic Association Medical College Hospital in Faridpur

2017 ◽  
Vol 7 (3) ◽  
pp. 126-133
Author(s):  
Poly Begum ◽  
Dipti Rani Shaha ◽  
Khalifa Mahmud Walid
Keyword(s):  
Risk Factors ◽  
Past History ◽  
Economic Status ◽  
College Hospital ◽  
Family History Of Diabetes ◽  
Medical College ◽  
Socio Economic Status ◽  
History Of ◽  
Associated Risk Factors ◽  
Association Medical

Background: The prevalence of gestational diabetes mellitus (GDM) is increasing all over the world and varies widely depending on the region of the country, dietary habits and socio-economic status. The prevalence of GDM with its associated risk factors has important health complications for both mother and child.Objectives: The aim of this study was to evaluate the prevalence of GDM and risk factors associated with it in women attending Diabetic Association Medical College Hospital in Faridpur for ante-natal care.Materials and Methods: In this cross-sectional study, screening for GDM was performed in 303 pregnant women. Women who consented to participate underwent a standardized 2-hour 75 gm oral glucose tolerance test (OGTT). A proforma containing general information on demographic characteristics, socio-economic status, education level, parity, family history of diabetes and past history of GDM etc. was filled in. American Diabetes Association (ADA) criteria for 75 gm 2-hour OGTT was used for diagnosing GDM.Results: A total of 303 women participated in the study and GDM was diagnosed in 22 (7.3%) women. A single abnormal value was observed in additional 33 (10.89%) women. On bivariate analysis risk factors found to be significantly associated with GDM were age, household income, parity, educational level, socio-economic status, hypertension, BMI, weight gain, acanthosis nigricans, family history of diabetes and past history of GDM; but on multivariate analysis only upper middle class and presence of acanthosis nigricans were found to be significantly associated with GDM.Conclusion: This study demonstrates a high prevalence of GDM in Bangladesh. These estimates for GDM may help for new suggestions to prevent and manage gestational diabetes.J Enam Med Col 2017; 7(3): 126-133

scholarly journals Study on drug profile used in diabetic foot ulcer

2020 ◽  
Vol 9 (7) ◽  
pp. 1095
Author(s):  
Rajalakshmi Ramesh ◽  
Kowsalya Moorthi ◽  
Saravanan Kunchithapatham ◽  
Prema Mariappan
Keyword(s):  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Base Line ◽  
Age Group ◽  
College Hospital ◽  
Medical College ◽  
The Common ◽  
Using Data ◽  
Collection Form

Background: The objective was to study about the drugs used in management of diabetic foot ulcer (DFU) and to grade the wounds using Wagner’s scale.Methods: An observational study was conducted at Department of Pharmacy, Rajah Muthiah Medical College Hospital over a period of six months from November 2018 to April 2019. The data was collected from 85 patients using data collection form. The patients were selected based on inclusion and exclusion criteria.Results: Overall 85 patients were enrolled in this study. The prevalence of DFU found to be 36% more in males 58 (68%) than in females 27 (32%). Considering the age group, higher prevalence was reported in patients among the age group of 60-70. This study shows, patients were found commonly to have habits of alcohol 18 (21%), smoking 11 (13%) and both 22 (26%). Overall, 23 classes of drugs were used in this study. Among these, mostly were antibiotics 12 (52%) then hypoglycemic drugs 5 (21%) and others are analgesics (9%), anti-ulcerant and vitamins. This study shows that the common antibiotics prescribed are metronidazole 39 (24%), cefotaxime 36 (22.7%), ciprofloxacin 25 (15.8%) and piperacillin 21 (13.2%). The common hypoglycemic drug used were of insulin 63 (74%), metformin 43 (77%), glimepiride 12 (14%) and metformin and glimepiride 12 (14%). By using Wagner’s scale, out of 85 patients, most of the ulcer were predominantly between grade IV and V.Conclusions: Targeting range of glycaemic levels and proper antibiotics is the best way of treating DFU. This study has provided the base line data regarding management of DFU which helps to improve therapeutic outcome.

Efficacy and safety of oral simvastatin in the treatment of patients with vitiligo

2020 ◽  
pp. jim-2020-001390
Author(s):  
Shiyu Zhang ◽  
Tanja Prunk Zdravković ◽  
Tao Wang ◽  
Yuehua Liu ◽  
Hongzhong Jin
Keyword(s):  
Side Effects ◽  
Autoimmune Disease ◽  
Clinical Efficacy ◽  
Skin Disorder ◽  
Task Force ◽  
The Other ◽  
Efficacy And Safety ◽  
College Hospital ◽  
Medical College ◽  
European Task

Vitiligo, an autoimmune disease, is a depigmentation skin disorder characterized by hypopigmentation spots and patches that are difficult to treat. The purpose of this study is to analyze the clinical efficacy of simvastatin in the treatment of vitiligo. From December 2016 to October 2019, five vitiligo patients from Peking Union Medical College Hospital were treated with simvastatin and tacrolimus. For simvastatin, the first three patients (patient 1, patient 2, and patient 3) began to take 40 mg/day, and the latter two patients began to take 20 mg/day. From week 5, patients 1 and 2 received 20 mg simvastatin once a day. And the 0.1% tacrolimus ointment was used topically. The response was measured using the Vitiligo European Task Force (VETF) scoring system at baseline and at the fourth and eighth weeks of treatment. The results of the VETF score showed that three of the patients achieved significant clinical efficacy. There was no significant improvement in the other two cases. No serious acute or chronic side effects were observed. In conclusion, our results suggest that conventional oral simvastatin is safe, although it may not be effective in the treatment of vitiligo.

scholarly journals Study of Efficacy and Safety of Acitretin as Monotherapy in the Treatment of Moderate to Severe Plaque Type Psoriasis

2020 ◽  
Vol 14 (1) ◽  
pp. 16-19
Author(s):  
Sumitendra Kumar Sarkar ◽  
Krishna Gopal Sen ◽  
Md Kamal Mostofa ◽  
Md Habibur Rahman
Keyword(s):  
Symptomatic Relief ◽  
Treatment Options ◽  
Response Rates ◽  
Efficacy And Safety ◽  
College Hospital ◽  
Female Ratio ◽  
Medical College ◽  
Plaque Type ◽  
Male Female Ratio ◽  
Aromatic Retinoid

Psoriasis is a chronic papulosquamous disorder with remissions and exacerbations. Varied estimates of the population prevalence of the disease in different parts of the world range from 0.1 - 3%. It is not uncommon in our country. Although there are no treatment options offering a complete cure, a number of options exist for providing symptomatic relief, inducing as well as prolonging remission. Various systemic therapies such as methotrexate, acitretin, cyclosporine, and biologic agents can be used. A review of pharmacokinetics, safety and a discussion of relapse rate establish acitretin, an aromatic retinoid as an efficacious, convenient, oral monotherapy for initial and maintenance of severe psoriasis. A prospective clinical trial was conducted to find out the efficacy and safety of acitretin as monotherapy in the treatment of moderate to severe plaque type psoriasis (PASI range 10-42). Thirty two clinically diagnosed cases of moderate to severe plaque type psoriasis attending the Skin and VD out patient department of Faridpur Medical College Hospital, Faridpur were selected randomly. Majority (46.9%) were between 61 to 80 years of age and only 3.1% patients were in the <20 years age group. The average age was 57.3 years and range was 19-90 years. Majority (68.8%) of the patients were male and 31.2% patients were female. The male female ratio was 2.2:1. After 8 weeks of treatment with acitretin PASI 50 and PASI 75 response rates were 55% and 24% respectively and after 12 weeks of treatment, PASI 50 and PASI 75 response rates were 75% and 50% respectively. As side effects of the treatment, 4(12.5%) patients developed alopecia, each of xerophthalmia and cheilitis was seen in 3(9.37%) patients, each of fatigue and pruritus was seen in 2(6.25%) patients and only 1(3.12%) patient developed myalgia. This study demonstrates that acitretin as monotherapy is effective and safe in the treatment of moderate to severe plaque type psoriasis. Faridpur Med. Coll. J. Jan 2019;14(1): 16-19

scholarly journals Efficacy of Betamethasone Oral Mini-Pulse Therapy in the Treatment of Lichen Planus

2016 ◽  
Vol 10 (2) ◽  
pp. 47-49
Author(s):  
Krishna Gopal Sen ◽  
Md Kamal Mostofa ◽  
Ahammed Ali ◽  
Sumitendra Kumar Sarkar ◽  
Chandona Sorcar ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Histopathological Examination ◽  
Pulse Therapy ◽  
Inflammatory Disorder ◽  
Efficacy And Safety ◽  
Inclusion Criteria ◽  
College Hospital ◽  
Male And Female ◽  
Medical College ◽  
Mucous Membranes

Lichen planus (LP) is a common inflammatory disorder that affects the skin, mucous membranes, nails and hair. There are various modalities of treatment but none is curative. Betamethasone oral mini-pulse (OMP) therapy has been used effectively and safely in vitiligo, alopecia areata and lichen planus. We sought to evaluate the efficacy and safety of Betamethasone OMP in patients with lichen planus. This prospective study was carried out among patients with lichen planus fulfilling the inclusion criteria, attending the skin and VD outpatient department of Dhaka Medical College Hospital, Dhaka Bangladesh over a period of 6 months from January 2005 to June 2005. A total of 20 patients with lichen planus diagnosed clinically and confirmed by histopathological examination were selected randomly for this study. Among them both male and female were in equal number. The study subjects were treated with 5 mg of Betamethasone orally on 2 consecutive days per week, for 3 months. Treatment response and side effects were monitored 4 weekly. The response was good in 60% and fair in 40% and there was no excellent response. This study indicates that further prospective placebo controlled studies are needed to clarify the efficacy of oral Betamethasone in lichen planus.Faridpur Med. Coll. J. Jul 2015;10(2): 47-49

scholarly journals STUDY OF 24 CASES OF NECROTISING FASCIITIS FOR PREDISPOSING FACTOR AND THEIR MANAGEMENT

2021 ◽  
Vol 5 (10) ◽  
Author(s):  
Prabhat Kumar Sinha ◽  
Neha Thawait ◽  
Atul Vyas
Keyword(s):  
Complete Blood Count ◽  
Age Groups ◽  
Base Line ◽  
Predisposing Factor ◽  
College Hospital ◽  
E Coli ◽  
Medical College ◽  
Function Test ◽  
Necrotizing Fascitis ◽  
Systemic Examination

Background & Method: Whole study was done in our Institute with patient attending outdoor and emergency department of INDEX MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTER. Collection of data –From each patient thorough history was taken, clinically examination was done, vitals where recorded, systemic examination was done and local examination of the lesion was done. Every patient base line investigation of complete blood count, renal function test liver function test serum electrolyte blood grouping serology of of HIV and Hbs antigen were done. Result: Most of the Patient was in the age group of 40years to 60 years. Conclusion: A total of 24 cases of necrotizing fascitis were studied over 1st June 2019 to 25 march 2020. Greater number of cases was reported among middle aged group of 40years to 60 years. Rarity of disease among pediatric age groups affected person were mostly male -21, female-3 most common precipitating factors was trauma. Most common predisposing factors were advanced age, anemia, diabetes and alcoholism. Microbiological profile of patients reveals most polymicrobial organisms involved,most common organisms were streptococcus>E. coli,> staphylococci>pseudomonas/. Keywords: necrotizing, fasciitis, predisposing & management.

scholarly journals Study on Association between BMI and Vitamin D Levels in South Indian Rural Population

2021 ◽  
Vol 9 (4) ◽  
pp. 213-218
Author(s):  
Dr. A Ponnambalam ◽  
◽  
Dr. M Arun ◽  
Dr. G Prabhu ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Age Groups ◽  
Sun Exposure ◽  
Research Centre ◽  
Vitamin D Status ◽  
College Hospital ◽  
Hydroxyvitamin D ◽  
Medical College ◽  
South Indian ◽  
Vitamin D Levels

Introduction: Vitamin D deficiency is a global health problem worldwide and is considered to be apandemic with implications for compromised bone health and other chronic diseases. A few studieshave examined the association between vitamin D status and body mass index (BMI). However,prospective data using the biomarker serum 25-hydroxyvitamin D 25(OH) D3 are limited andtherefore examined in the present study. Methods: Participants were selected from subjectsattending to Medicine Outpatient Department (OPD) in Sri Venkateshwara Medical College Hospital &Research Centre (SVMCH & RC) willing to participate in the present study between Jan 2020 to Dec2020. Anthropometric measurements, personal, medical history questionnaire, food frequencyquestionnaire (FFQ) for vitamin D, and sun exposure questionnaire were collected from all theparticipants in the present study, blood samples for serum 25(OH)D3 were collected from allsubjects. Results: Our study showed that the majority of healthy individual cases of the study i.e.,68.0% have a deficiency in vitamin D status, while 68.0% have ≤20 ng/dl in vitamin D, and 32.0%in >20 ng/dl. Moreover, the study showed a negative association between the level of circulating25(OH) D3 and BMI. Conclusion: This study demonstrated that the association between BMI and25(OH)D concentrations in populations from south India can be seen across different age groups andin both men and women. The study also exemplified that higher BMI leads to lower vitamin D status,providing evidence for the role of obesity as a causal risk factor for the development of vitamin Ddeficiency.

scholarly journals Evaluation of efficacy and adverse effects of paroxetine in the treatment of major depressive disorder patients.

2020 ◽  
Vol 27 (07) ◽  
pp. 1459-1464
Author(s):  
Ali Gul Tunio ◽  
Kausar Aamir ◽  
Ghulam Serwar Shaikh ◽  
Muhammad Tariq Rajput ◽  
Rehmat Ali Wagan ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Adverse Effects ◽  
Depressive Disorder ◽  
Base Line ◽  
Major Depressive ◽  
College Hospital ◽  
Medical College ◽  
Symptoms Of Depression ◽  
Psychiatric Department

Major depressive disorder is a serious and disabling disease in world; it is a most common chronic and recurrent disorder with fourth cause of loss in disability in the worldwide. Objectives: To evaluate the efficacy and adverse effects of Paroxetine in major depressive disorder patients. Study Design: Open Labeled study. Setting: Department of Psychiatry, Chandka Medical College Hospital Larkano. Period: Three months (August to October 2019). Material & Methods: Total 40 patients of either sex were enrolled from OPD of Psychiatric department with age of 18 to 65 years. Follow-up visits were carried out fortnightly after making evaluation on symptoms at base line visit (day 0) continued till 90 days, and then results were compiled. The SPSS-16 version was used for the analysis of data. Results: Paroxetine is highly significant (p=0.001) to decrease the symptoms of depression during treatment of 90 days. Conclusion: In this study, Paroxetine is more effective drug to decrease the symptoms like, weight loss, sexual disturbance, insomnia and with less adverse effects in patients of major depressive disorder.

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