scholarly journals FVC, FEV1 and FEV1/FVC% in Patients with Depressive Illness and their Relationships with the level of Depression

1970 ◽  
Vol 5 (2) ◽  
pp. 94-100
Author(s):  
Shausheen Islam ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Rezina Akter
Keyword(s):  
Pulmonary Function ◽  
Study Groups ◽  
Depressive Illness ◽  
Psychological Disorder ◽  
Personal Contact ◽  
Control Group ◽  
Major Depressive ◽  
Cross Sectional ◽  
Female Patients ◽  
Lung Functions

Background: Depressive illness is a common psychological disorder which affects various organs including lungs. Many studies have reflected decreased lung functions in patients with depressive illness. Objective: The present study was undertaken to measure some pulmonary function parameters in diagnosed female patients with depressive illness to evaluate their lung functions status. Methods: This cross-sectional study was carried out in the Department of Physiology, SSMC, Mitford, Dhaka, from 1st July 2009 to 30th June 2010 on 30 female patients with depressive illness, age ranged from 20- 40 years. Depressed patients (study group) were divided into patients with minor depressive illness (group-B1) and patients with major depressive illness (group- B2). For comparison, 30 age and BMI matched apparently healthy subjects (control group-A) were also studied. The study groups were selected from the Out Patient Department of Psychiatry, SSMC, Mitford, Dhaka and the control group was selected by personal contact. Pulmonary function parameters like FVC, FEV1, FEV1/FVC%, of all subjects were measured by digital spirometer. Statistical analysis was done by using appropriate method as applicable. Results: All the pulmonary function parameters except FEV1/FVC% were significantly (p<0.001) lower in patients with depressive illness in comparison to those of control. Again, pulmonary function parameters like FVC (p<0.01), FEV1 (p<0.05) showed significant negative correlation with the level of depression in patients with major depressive illness. Conclusion: This study reveals that some pulmonary functions may be reduced in patients with depressive illness especially in major depressive patients which is negatively related with level of depression. Key words: FVC; FEV1; depressive illness.DOI: 10.3329/jbsp.v5i2.6784 J Bangladesh Soc Physiol. 2010 December; 5(2): 94-100

scholarly journals A cross-sectional study of lung functions in traffic police personnel at work in Kathmandu Valley, Nepal

2015 ◽  
Vol 1 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Hari Sunder Shrestha ◽  
Ojashwi Nepal ◽  
Kishor Khanal ◽  
Bhoopinder Kumar Kapoor
Keyword(s):  
Cross Sectional Study ◽  
Control Group ◽  
Kathmandu Valley ◽  
Cross Sectional ◽  
Traffic Police ◽  
Police Personnel ◽  
Lung Functions ◽  
Function Test ◽  
Pollution Exposure ◽  
One Way Anova

BACKGROUND: The present study was aimed to assess pulmonary functions in the traffic police personnel (TPP) posted on traffic duty in Kathmandu valley, Nepal. METHODS: The study group consisted of 17 females and 89 males, constituting 16% and 84% of the total police personnel studied, respectively. In the control group of 25 individuals, 16% (n=4) were female and 84% (n=21) were male. Portable desktop spirometer was used for the pulmonary function test (PFT) measurements. RESULTS: It is seen that in females as compared to males, PFT parameters show a significant decrease. One-way ANOVA conducted to compare the effect of duration of air pollution exposure showed that there is a significant variation in PFT parameters among the groups. The exposure duration has significant effect on the PFT parameters. CONCLUSION: Greater the officers are engaged in traffic duty for years, greater is the decrement in their lung functions test. DOI: http://dx.doi.org/10.3126/acclm.v1i1.12315 Ann. Clin. Chem. & Lab. Med. 1(1) 2015: 42-48

Optical Coherence Tomography and Pattern Electroretinography Changes in Egyptian Patients with Major Depressive Disorder

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mostafa S ElShaarawi ◽  
Ayman A Gaafar ◽  
Hisham S. Saad Eldin ◽  
Randa H Ali
Keyword(s):  
Optical Coherence Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Control Group ◽  
Ophthalmological Examination ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Major Depressive ◽  
Cross Sectional ◽  
Pattern Electroretinography

Abstract Background Major depressive disorder (MDD) is a common psychiatric disorder that affects nearly 11.1-14.6 % of the population in their lifetime. Pathophysiology and brain imaging findings show that degenerative and inflammatory processes may play a role. Meta-analysis of voxel-based morphometry studies in MDD demonstrated significant gray matter loss. From anatomical and embryological perspectives, the retina can be considered a unique extension of the brain and is able to reflect axonal histopathology. Being unmyelinated, it can provide insight into the pathophysiological processes of diseases with a neurodegenerative element. Aim to compare retinal optical coherence tomography (OCT) parameters in a group of MDD patients with a healthy control group and to correlate OCT parameters with pattern electroretinography (PERG) parameters. Method a controlled cross sectional study was conducted on 30 MDD patients and 28 age and sex matched controls. Both groups had a full ophthalmological examination, OCT imaging and 7 patients and 11 controls have PERG recorded. Results Thinning of the superior retinal nerve fiber layer, thinning of most of the ganglion cell inner plexiform (GCIP) layer, thinning of most of the macular thickness and thinning of macular volume in both eyes were detected. There was a statistically significant positive correlation between the left GCIP layer and the amplitude of the N95 wave. Also a statistically significant negative correlation existed between MDD duration in years with the left eye's average volume of the outer ring of the macula. Conclusion Significant retinal changes were detected by OCT in MDD patients supporting the theory of neurodegeneration as a pathophysiology of MDD.

scholarly journals IMPACT OF OBESITY ON PULMONARY FUNCTIONS AMONG YOUNG NON-SMOKER HEALTHY FEMALE OF SHAH ALAM, MALAYSIA

2018 ◽  
Vol 11 (10) ◽  
pp. 465
Author(s):  
Aniruddha Bhattacharjee ◽  
Ariitharan A/l Thygoo ◽  
Subramanian Rammohan
Keyword(s):  
Pulmonary Function ◽  
Flow Rate ◽  
Inverse Correlation ◽  
Forced Expiratory Volume ◽  
Female Students ◽  
Control Group ◽  
Contributing Factors ◽  
Cross Sectional ◽  
Pulmonary Functions ◽  
Healthy Female

Objectives: The sedentary lifestyle, physical inactivity, and unhealthy diet of Malaysian female have become important contributing factors to the rise of obesity. Studies on pulmonary function in relation to obesity are very few in Malaysia. Therefore, the study was aimed to evaluate the effect of obesity on pulmonary functions among young adult healthy female students of Shah Alam, Malaysia.Methods: A cross-sectional comparative study was conducted in a total of 100 (50 obese and 50 non-obese) adult non-smoker healthy female students aged 18–25 years. Forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), FEV1 as a percentage of FVC (FEV1/FVC%), maximum midexpiratory flow rate (FEF 25–75%), and peak expiratory flow rate (PEFR) were measured using a computerized spirometer. Body weight, height, waist circumference (WC), and hip circumference (HC) were measured.Results: The mean FVC (L), FEV1 (L), FEV1/FVC ratio, FEF 25–75% (L/s), and PEFR (L/s) of obese group were marginally lower than non-obese control group, but the differences were not statistically significant. WC and waist–hip ratio exhibited significant (p<0.05) inverse correlation with all pulmonary function measurements except FEV1/FVC%. However, body mass index had no significant correlation with any spirometric variables in studied obese females.Conclusion: There was no significant effect of obesity on pulmonary functions in the studied Malaysian females. However, abdominal obesity had more impact on the impairment of pulmonary functions than overall relative obesity.

scholarly journals Differences in Trunk Kinematic between Frail and Nonfrail Elderly Persons during Turn Transition Based on a Smartphone Inertial Sensor

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Alejandro Galán-Mercant ◽  
Antonio I. Cuesta-Vargas
Keyword(s):  
Frail Elderly ◽  
Inertial Sensor ◽  
Angular Displacement ◽  
Population Group ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Control Group ◽  
Elderly Persons ◽  
Cross Sectional ◽  
Physically Active

Objective. Firstly, to, through instrumentation with theiPhone4smartphone, measure and describe variability of tridimensional acceleration, angular velocity, and displacement of the trunk in the turn transition during the ten-meter Extended Timed-Get-up-and-Go test in two groups of frail and physically active elderly persons. Secondly, to analyse the differences and performance of the variance between the study groups during turn transition (frail and healthy).Design. This is a cross-sectional study of 30 subjects over 65 years, 14 frail subjects, and 16 healthy subjects.Results. Significant differences were found between the groups of elderly persons in the accelerometry (P<0.01) and angular displacement variables (P<0.05), obtained in the kinematic readings of the trunk during the turning transitions. The results obtained in this study show a series of deficits in the frail elderly population group.Conclusions. The inertial sensor found in theiPhone4is able to study and analyse the kinematics of the turning transitions in frail and physically active elderly persons. The accelerometry values for the frail elderly are lower than the physically active elderly, whilst variability in the readings for the frail elderly is also lower than the control group.

scholarly journals Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jing-Xu Chen ◽  
Jun-Hui Feng ◽  
Li-Gang Zhang ◽  
Yan Liu ◽  
Fu-De Yang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Uric Acid ◽  
Depressive Disorder ◽  
Suicide Risk ◽  
Serum Levels ◽  
Binary Logistic Regression Analysis ◽  
Healthy Controls ◽  
Major Depressive ◽  
Cross Sectional ◽  
Female Patients

Abstract Background Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients. Methods One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured. Results Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients. Conclusion Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

scholarly journals Skeletal Muscle Response to Deflazacort, Dexamethasone and Methylprednisolone

Cells ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 406 ◽  
Author(s):  
Alan Fappi ◽  
Juliana de Carvalho Neves ◽  
Leandro Nunes Sanches ◽  
Pedro Victor Massaroto e Silva ◽  
Guilherme Yuiti Sikusawa ◽  
...  
Keyword(s):  
Muscle Atrophy ◽  
Saline Solution ◽  
Fiber Type ◽  
Neuromuscular Diseases ◽  
Study Groups ◽  
Control Group ◽  
Cross Sectional ◽  
Genes Expression ◽  
Male Wistar Rats ◽  
Synthetic Glucocorticoids

Glucocorticoids represent some of the most prescribed drugs that are widely used in the treatment of neuromuscular diseases, but their usage leads to side effects such as muscle atrophy. However, different synthetic glucocorticoids can lead to different muscle effects, depending upon its chemical formulation. Here, we intended to demonstrate the muscle histologic and molecular effects of administering different glucocorticoids in equivalency and different dosages. Methods: Seventy male Wistar rats distributed into seven groups received different glucocorticoids in equivalency for ten days or saline solution. The study groups were: Control group (CT) saline solution; dexamethasone (DX) 1.25 or 2.5 mg/kg/day; methylprednisolone (MP) 6.7 or 13.3mg/kg/day; and deflazacort (DC) 10 or 20 mg/kg/day. At the end of the study, the animals were euthanized, and the tibialis anterior and gastrocnemius muscles were collected for metachromatic ATPase (Cross-sectional area (CSA) measurement), Western blotting (protein expression of IGF-1 and Ras/Raf/MEK/ERK pathways) and RT-PCR (MYOSTATIN, MuRF-1, Atrogin-1, REDD-1, REDD-2, MYOD, MYOG and IRS1/2 genes expression) experiments. Results: Muscle atrophy occurred preferentially in type 2B fibers in all glucocorticoid treated groups. DC on 10 mg/kg/day was less harmful to type 2B fibers CSA than other doses and types of synthetic glucocorticoids. In type 1 fibers CSA, lower doses of DC and DX were more harmful than high doses. DX had a greater effect on the IGF-1 pathway than other glucocorticoids. MP more significantly affected P-ERK1/2 expression, muscle fiber switching (fast-to-slow), and expression of REDD1 and MyoD genes than other glucocorticoids. Compared to DX and MP, DC had less of an effect on the expression of atrogenes (MURF-1 and Atrogin-1) despite increased MYOSTATIN and decreased IRS-2 genes expression. Conclusions: Different glucocorticoids appears to cause muscle atrophy affecting secondarily different signaling mechanisms. MP is more likely to affect body/muscles mass, MEK/ERK pathway and fiber type transition, DX the IGF-1 pathway and IRS1/2 expression. DC had the smallest effect on muscle atrophic response possibly due a delayed timing on atrogenes response.

scholarly journals Color Vision in the Gas Station Workers of Isfahan City: A Quantitative Analysis With the Farnsworth D15 Color Test

2021 ◽  
Vol 15 (3) ◽  
pp. 179-184
Author(s):  
Asieh Sadat Sedighi ◽  
◽  
Ali Mirzajani ◽  
Ebrahim Jafarzadehpur ◽  
Jamileh Abolghasemi ◽  
...  
Keyword(s):  
Color Vision ◽  
Vision Loss ◽  
Study Groups ◽  
Control Group ◽  
Color Test ◽  
Cross Sectional ◽  
Color Vision Defects ◽  
Gas Station ◽  
Vision Defects ◽  
Color Vision Loss

Background and Objectives: The color vision evaluation of gas station workers in Isfahan City. Methods: This cross-sectional comparative study was performed on workers at gas stations in Isfahan; all the workers were men. The participants were divided into two 40-people groups of exposure and non-exposure (the members of the fuel sales department). The participants had better vision than 8/10 and no underlying problems or eye disease. Besides, examination, including color vision was performed for all subjects. Color vision was assessed using the D15 test under high to medium light conditions. Also, the color vision test was performed monocularly. Then, the obtained data were analyzed using SPSS V. 22. Results: The two study groups significantly differed in terms of color vision impairment index (P <0.001). Also, more color vision defects were seen in the group exposed to gasoline. The color confusion index (as the indicator of color vision defects) were 1.485 and 1.129 in exposure and non-exposure to gasoline groups, respectively. Thus, color vision defects were significantly higher in the exposure to gasoline group, compared with the control group. Conclusion: The results of this study showed a difference in color vision index between the two groups. Therefore, long-term exposure to organic solvents, such as gasoline in fuel stations may cause color vision loss.

scholarly journals Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

2020 ◽  
Author(s):  
Jing-Xu Chen ◽  
Jun-Hui Feng ◽  
Li-Gang Zhang ◽  
Yan Liu ◽  
Fu-De Yang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Uric Acid ◽  
Depressive Disorder ◽  
Suicide Risk ◽  
Serum Levels ◽  
Binary Logistic Regression Analysis ◽  
Healthy Controls ◽  
Major Depressive ◽  
Cross Sectional ◽  
Female Patients

Abstract Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

scholarly journals Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

2020 ◽  
Author(s):  
Jing-Xu Chen ◽  
Jun-Hui Feng ◽  
Li-Gang Zhang ◽  
Yan Liu ◽  
Fu-De Yang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Uric Acid ◽  
Depressive Disorder ◽  
Suicide Risk ◽  
Serum Levels ◽  
Binary Logistic Regression Analysis ◽  
Healthy Controls ◽  
Major Depressive ◽  
Cross Sectional ◽  
Female Patients

Abstract Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

scholarly journals SERUM MAGNESIUM LEVEL IN DIABETIC RETINOPATHY - A CROSS SECTIONAL STUDY

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. I. Vijayapriya ◽  
Dr. Prakash. S ◽  
Dr. S. Hemadharshini
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Serum Magnesium ◽  
Study Groups ◽  
Control Group ◽  
P Value ◽  
Cross Sectional ◽  
The Difference ◽  
And Control

Background: Among different complications of diabetes, ddiabetic retinopathy is one of the leading causes of blindness in the world. Increase in the frequency of lower serum magnesium levels have been reported among patients with diabetes. Materials and methods: A total of 120 subjects were included in this study and divided into 3 groups. The study groups consisted of 40 patients that are type 2 diabetes with retinopathy and 40 patients with type 2 diabetes without retinopathy and control group consisted of 40 healthy subjects respectively. Both cases and controls were subjected to estimation of biochemical parameters. Results: Among the study population, (80) 66.67% participants were cases and another (40) 33.33% participants were controls. Among the people who had mild NPDR, the median Mg was 1.90 (IQR 1.80, 2.00). It was 1.90 (1.70, 2.00), 1.75 (1.67, 1.92), 1.8 (1.69, 2.0) and 2.10 (1.90, 2.20) among people with DM retinopathy moderate NPDR, severe NPDR, Proliferative retinopathy and no retinopathy respectively. The difference in the Mg across DM retinopathy was statistically significant (P Value 0.008). The difference between the values among both the case and control groups for certain parameters such as SBP, FBG, PPBG, HbA1c, Magnesium, Urea, and Creatinine were found to be statistically significant. Conclusion: Serum magnesium levels were significantly lower in patients with diabetic retinopathy compared to diabetics without complications and control group. Keywords:  Diabetes mellitus, Diabetic retinopathy, Magnesium

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