scholarly journals Serum Copper and Plasma Protein Status in Preterm Delivery

2012 ◽  
Vol 7 (1) ◽  
pp. 41-47
Author(s):  
Masuda Sultana ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Rezina Akter
Keyword(s):  
Birth Weight ◽  
Pregnant Women ◽  
Serum Copper ◽  
Maternal Serum ◽  
Full Term ◽  
Copper Level ◽  
Serum Copper Level ◽  
Medical College ◽  
Protein Status ◽  
Neonatal Blood

Background: Preterm delivery is a major obstetric related problem in Bangladesh. Micronutrient deficiency especially deficiency of copper may affect pregnancy, delivery and outcome of pregnancy. Reduced     serum copper concentration of the pregnant mother may have some role in resulting preterm delivery.Objectives: To observe serum Cu and protein status in preterm mother and their neonates.Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, between January and December 2009. A total number of 136 subjects were included in this study, and were divided into control (n=82) and study (n=54) groups. Of  the control group, 28 were non pregnant women age ranged between 20-30 years, taken for reference value and another 54 were full term group, also treated as control, were sub-divided into normal full term mother (n=27) and their respective neonates ( n=27). Another 54 were preterm group, considered as study group, were sub-divided into preterm mothers (n=27) and their respective neonates (n=27). Age of preterm and full term mothers were between 20-40 years. All the subjects belonged to lower socioeconomic  status. The pregnant women were selected from the labor ward of Sir Salimullah Medical College and Mitford Hospital and non pregnant women were from personal contact. Serum copper level was estimated by spectrophotometric method, to observe its level in these groups of study subjects. Serum total protein, albumin and globulin levels were estimated by usual laboratory technique in order to observe the availability of binding proteins as well as their nutritional status. Again, anthropometric data and blood hemoglobin level of the preterm and full term mother and birth weight of their respective neonates were measured to observe their nutritional status. Correlation of maternal serum copper concentration with that of neonatal blood and also with birth weight of the neonates were done to observe their relationship. Statistical analysis was done by Independent-Samples ‘t” test and Peaeson’s correlation coefficient tests as applicable.Results: Mean serum Cu, total protein and albumin levels were significantly (p<0.001) lower in preterm mother and their neonates in comparison to those of full term mother and their neonates respectively. Whereas, mean serum globulin level showed no statistically significant difference among the groups. Mean birth weight of preterm neonates was significantly lower in comparison to that of full term neonates. Again, maternal serum copper level showed negative correlation with that of neonatal blood but positive correlation with birth weight of their neonates in both full term  and preterm mother, though these relationships were not statistically significant.Conclusions: The present study revealed hypocupremia and hypoproteinemia in pre-term delivery mother and their neonates. This hypocupremia may be due to poor maternal protein status. DOI: http://dx.doi.org/10.3329/jbsp.v7i1.11161 J Bangladesh Soc Physiol. 2012, June; 7(1): 41-47

scholarly journals Serum Copper level in Term women

2012 ◽  
Vol 17 (2) ◽  
pp. 18-20
Author(s):  
Masuda Sultana ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Md Liakat Ali ◽  
Dipok Kumar Sunyal ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Serum Copper ◽  
Full Term ◽  
Copper Level ◽  
Control Group ◽  
Compensatory Mechanism ◽  
Metabolic Demand ◽  
Full Term Delivery ◽  
Group B ◽  
Age Range

Pregnancy is associated with an extraordinary metabolic demand both for the mother and developing fetus. Cu is essential for growth and development of normal human body. To measure serum Cu level in full term mother and non pregnant women. A total number of 55 subjects were included in this study; among them 27 were full term delivery mothers (group B) with age range from 20-40 years, taken as study group and 28 non pregnant women (group A) with age range from 20-30 years were taken as a control group. Statistical analysis was done by using appropriate method as applicable. Mean serum Cu level were significantly higher (p<0.001) in full term pregnant mother in comparison to that of non pregnant women. The present study revealed a higher level of Cu in full term mother than non pregnant women. The increased serum Cu level in full term mother than non pregnant women suggested that compensatory mechanism to counteract anemia this is accompained by increased synthesis of ceruloplasmin. DOI: http://dx.doi.org/10.3329/jdnmch.v17i2.12202 J. Dhaka National Med. Coll. Hos. 2011; 17 (02): 18-20

scholarly journals Evaluation Serum Copper Levels in Preeclampsia and Healthy Pregnant Women

2019 ◽  
Vol 9 (1) ◽  
pp. 18-22
Author(s):  
Nilima Baral ◽  
Rezwana Haque ◽  
Farzana Akonjee Mishu
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Serum Copper ◽  
Copper Level ◽  
Control Group ◽  
Case Group ◽  
Second Trimester ◽  
Serum Copper Level ◽  
Third Trimester

Background: Preeclampsia is a fatal medical disorder of pregnancy. It has been associated with adverse course and outcome of the pregnancy resulting in increased maternal and infant mortality and morbidity. As the pathogenesis of preeclampsia is not completely understood, prevention remains a complex issue. In recent times, there has been an increasing prevalence in the incidence of preeclampsia globally. The aim of this study is to determine the states of the copper in pregnant women with preeclampsia. Methods: This case-control study was carried out in the Department of Biochemistry, Mymensingh Medical College, Mymensingh, from July 2013 to June 2014. The subjects were selected on the basis of inclusion and exclusion criteria by purposive method. This study included 73 patients with preeclampsia as case (Gr.I) classified into two subgroups according to the gestational age: Gr.I(a); preeclampsia in the second trimester (n = 35), and Gr.I(b); preeclampsia in the third trimester (n = 38). Copper levels were analyzed and results were compared with 73 apparently healthy pregnant control (Gr.II), and the corresponding gestational age subgroups [Gr.II(a); normal pregnancy of second trimester (n = 35) and Gr.II(b), normal pregnancy of third trimester (n = 38)]. Results: The mean serum copper level was significantly (p<0.001) lower in case group than that of control group. Similar extent of reduction was observed in serum copper level at different gestational age groups of preeclamptic women when compared with corresponding control groups. Conclusion: Estimation of serum copper level should be incorporated in pre eclamptic patients for prevention of complications. Birdem Med J 2019; 9(1): 18-22

Serum Copper Level and Polycystic Ovarian Syndrome: A Meta-Analysis

2021 ◽  
pp. 1-8
Author(s):  
Qingtao Jiang ◽  
Feng Zhang ◽  
Lei Han ◽  
Baoli Zhu ◽  
Xin Liu
Keyword(s):  
Large Scale ◽  
Polycystic Ovarian Syndrome ◽  
Meta Analysis ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Copper Status ◽  
Plasma Copper ◽  
Mean Differences ◽  
Ovarian Syndrome

<b><i>Introduction:</i></b> The association of serum copper with polycystic ovarian syndrome (PCOS) has been studied for years, but no definite conclusion is drawn. Therefore, we conducted a meta-analysis to investigate serum copper concentrations in PCOS subjects compared with healthy controls. <b><i>Methods:</i></b> Electronic search was performed in PubMed, Google Scholar, and Scopus up to June 30, 2020, without any restriction. Standardized mean differences (SMDs) with corresponding 95% CIs in serum copper levels were employed with random-effects model. <i>I</i><sup>2</sup> was applied to evaluate heterogeneity among studies. <b><i>Results:</i></b> Nine studies, measuring plasma copper levels in 1,168 PCOS patients and 1,106 controls, were included. Pooled effect size suggested serum copper level was significantly higher in women with PCOS (SMD = 0.51 μg/mL, 95% CI = [0.30, 0.72], <i>p</i> &#x3c; 0.0001). The overall heterogeneity was not connected with subgroups of the country, but derived from the opposite result of 1 study. <b><i>Conclusion:</i></b> Our research generally indicated circulating copper level in PCOS sufferers was significantly higher than normal controls. Large-scale studies are still needed to elucidate the clear relation between copper status and etiology of PCOS.

scholarly journals Serum Copper with Coronary Artery Disease in Male and its Relation with Lipid Profile

1970 ◽  
pp. 7-9
Author(s):  
Sifat Jubaira ◽  
Forhadul Haque Mollah ◽  
Tahrim Mehdi ◽  
M Iqbal Arslan
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Artery Disease

The study was designed to explore serum copper as a risk factor for coronary artery disease (CAD). In this case-control study 30 healthy controls and 60 diagnosed cases of acute myocardial infarction (AMI) were enrolled. Serum copper concentration and serum lipid profile were measured in all study subjects. Serum copper level was significantly higher in AMI as compared to controls. The concentrations of serum TC, TG, LDL-C level were found to be significantly higher in cases as compared to controls. The concentration serum HDL-C was found to be significantly lower in cases as compared to controls. CAD leads to raised serum copper level and it has positive correlation with TC, TG and LDL-C but negative correlation with HDL-C in males.Keywords: Coronary artery disease; serum copper; acute myocardial infarction; total cholesterol; triglyceride; low density lipoprotein cholesterol. DOI: 10.3329/bjpp.v24i1.5730Bangladesh J Physiol Pharmacol 2008; 24(1&2) : 7-9

scholarly journals Serum trace metals in Pre-Eclamptic Nigerians

2016 ◽  
Vol 7 (3) ◽  
pp. 78-83 ◽  
Author(s):  
Ikechukwu Chidiebere Ikaraoha ◽  
Nkeiruka Chigaekwu Mbadiwe ◽  
John Ibhagbemien Anetor ◽  
Isreal Agware Ojareva
Keyword(s):  
Trace Metals ◽  
Pregnant Women ◽  
Serum Levels ◽  
Zinc Level ◽  
Serum Copper ◽  
Copper Level ◽  
Medical Sciences ◽  
Lower Serum ◽  
Significant Difference

Background: The role of trace metals in Pathogenesis of Pre-eclampsia has received insufficient attention in Nigeria.Materials and Methods: We examined the effect of serum levels of some trace metals; selenium (Se), zinc (Zn), copper (Cu), cobalt (Co), and manganese (Mn) in the development of pre-eclampsia in Nigeria. Blood samples were collected from 59 pre-eclamptic, 150 normal pregnant and 122 non pregnant women. Serum Se, Zn, Cu, Co and Mn were determined by AAS.Results: Result shows significantly lower serum Se, Zn, Cu, Cu: Zn ratio, Co and Mn in pre-eclamptics compared to normal pregnant women (p<0.001). Comparison of normal pregnant women and controls showed non significant difference in the zinc level (P>0.05), significantly lower levels of serum Se, Co, Mn (p<0.00011, p=0.0022, p<0.0001 respectively) and significantly raised copper level (p<0.001) in normal pregnant women compared to controls.  Serum Se, Zn, Co and Mn were significantly lower (p<0.001) while serum copper and Cu: Zn ratio were significantly higher (p<0.001) in pregnant women compared to controls. ANOVA shows significant progressive decreases in serum Se, Zn Co and Mn, from controls to normal pregnant women and pre-eclamptics (p<0.0001).Conclusion: Decreases in serum level of Se, Zn, Cu, Cu: Zn ratio, Co and Mn may play important role in the pathogenesis of pre-eclampsia.Asian Journal of Medical Sciences Vol. 7(3) 2016 78-83

Low serum copper level and neural tube defect: A case control study

2007 ◽  
Vol 24 (1) ◽  
pp. 68
Author(s):  
Abbas Ali Keshtkar ◽  
Mohammad Jafar Golalipoor ◽  
Azad Reza Mansourian
Keyword(s):  
Neural Tube ◽  
Neural Tube Defect ◽  
Case Control Study ◽  
Case Control ◽  
Serum Copper ◽  
Copper Level ◽  
Serum Copper Level ◽  
Control Study ◽  
Low Serum

Circulating maternal cytokines influence fetal growth in pregnant women with rheumatoid arthritis

2012 ◽  
Vol 72 (12) ◽  
pp. 1995-2001 ◽  
Author(s):  
Florentien D O de Steenwinkel ◽  
Anita C S Hokken-Koelega ◽  
Yaël A de Man ◽  
Y B de Rijke ◽  
Maria A J de Ridder ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Birth Weight ◽  
Disease Activity ◽  
Pregnant Women ◽  
Fetal Growth ◽  
First Trimester ◽  
Maternal Serum ◽  
Time Points ◽  
Lower Birth Weight ◽  
Cytokine Levels

BackgroundHigh rheumatoid arthritis (RA) disease activity during pregnancy is associated with a lower birth weight. Active RA is characterised by high circulating levels of cytokines, which can mediate placental growth and remodelling.ObjectivesTo assess the influence of maternal serum cytokine levels on birth weight in RA pregnancy.MethodsThis study is embedded in the PARA Study, a prospective study on RA and pregnancy. In the present study, 161 pregnant women with RA and 32 healthy pregnant women were studied. The main outcome measures were birth weight SD score (birth weight SDS) in relation to maternal serum levels of interleukin-10 (IL-10), interleukin-6 (IL-6) and tumour necrosis factor-α (TNFα) at three different time points: preconception and during the first and third trimester. Single-nucleotide polymorphisms (SNPs) in the corresponding cytokine genes were also studied.ResultsDuring the first trimester, IL-10 was detectable in 16% of patients with RA, IL-6 in 71%, and TNFα in all patients with RA. Mean birth weight SDS of children born to mothers with RA was higher when IL-10 level was high compared with low (difference=0.75; p=0.04), and lower when IL-6 was high compared with low (difference=0.50; p<0.01) in the first trimester. No correlation was seen at the other time points studied or with TNFα. Cytokine levels were not related to their corresponding SNPs.ConclusionsMaternal IL-10 and IL-6 levels are associated with fetal growth in RA. In the first trimester, high IL-10 levels are associated with higher birth weight SDS, and high IL-6 levels are associated with lower birth weight SDS, even after correction for disease activity.

scholarly journals Estimation of Serum Copper in Post-menopausal Women Attending in a Tertiary Care Hospital, Bangladesh

2019 ◽  
Vol 10 (2) ◽  
pp. 110-113
Author(s):  
N Ferdous ◽  
Farzana Akonjee Mishu ◽  
Shamsunnahar ◽  
Syed Md Tanjilul Haque ◽  
ANM Ashikur Rahman Khan ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Tertiary Care ◽  
Premenopausal Women ◽  
Serum Copper ◽  
Copper Level ◽  
Care Hospital ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Significant Difference

Background: Nutritional needs change throughout the various stages of life. While overall caloric needs tend to decrease with age, the requirements for individual micronutrients do not decrease. In fact, the needs for some micronutrients actually increase with age. The risk of nutritional disturbances mainly trace elements deficiencies is high during postmenopause causing or intensifying serious clinical symptoms. Methods: This cross sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with the Department of Obstetrics and Gynecology, Mymensingh Medical College Hospital during the period from July 2013 to June 2014. A total of 100 subjects were included in this study. Among them 50 apperantly healthy postmenopausal women (Case) aged between 45-60 years were considered as case and another 50 regular menstruating premenopausal women(Control) aged between 30-40 years were selected as control. Results: The mean age of cases and control groups was 50.5±2.3 years and 36.5±4.4 years respectively. In this study we found Serum Copper levels in cases and controls were 115.36±8.836 µg /dl and 90.58 ±6.315 µg/dl respectively had (p< 0.01) significant difference. Conclusion: Serum Copper level was significantly increased in postmenopausal group in comparison to premenopausal women (p< 0.01). Estimation of serum Cu level might be incorporated in every postmenopausal woman for prevention of complications. Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 110-113

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