scholarly journals Comparative Study of the Lipid Lowering Effect of Leaf Extract of Catharanthus roseus & Atorvastatin

2017 ◽  
Vol 1 (2) ◽  
pp. 53-56 ◽  
Author(s):  
Sabina Jesmin ◽  
Anisur Rahman Khan ◽  
Waseka Akther Jahan ◽  
Md. Abdullah Yusuf ◽  
Wahida Begum ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Catharanthus Roseus ◽  
Serum Lipid ◽  
Leaf Extract ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Long Evans ◽  
Lipid Lowering Effect ◽  
Different Doses

Background: Leaf extract of Catharanthus roseus has medicinal effect.Objective: The purpose of the present study was to compare the effect of leaf extract of Catharanthus roseus (Nayantara) with atorvastatin on serum lipid profile in fat-fed rats.Methodology: This was an experimental animal study carried out in the Department of Pharmacology and Therapeutics at Dhaka Medical College, Dhaka from July 2005 to June 2006 for a period of one year. Adult Long Evans rats of both sexes were used for the study. The rats were divided into seven groups designed as A, B, C, D, E, F and G. Each group was comprised of 8 rats which were treated for 10 days and were sacrificed on 11th day. The experiment were designed to demonstrate the effect of C. roseus on serum lipid profile in hyperlipidaemic rats and the hypolipidaemic effects were compared to a standard oral lipid lowering drug, atorvastatin.Result: A total number of 56 adult Long Evans rats of both sexes were used for the study. Here the effect of leaf extract of C. roseus at different doses on lipid level of fat-fed rats was observed which were compared with the hyperlipidaemic control group. In the same time the effect of Atorvastatin on serum lipid level were observed. The observed lipid lowering effect of leaf extract of C. roseus was evaluated biochemically by significant (p<0.001) decrease of serum total cholesterol (TCL), triglyceride (TG) and low density lipoprotein (LDL) levels. The leaf extract of C. roseus was given at three different doses daily in oral route for 10 days along with fatty diet and statistically significant (p<0.05) decrease was observed in all serum lipid parameter (TCL,TG, LDL) except high density lipoprotein (HDL). Which was more evident in higher doses treated group (1 ml/kg and 1.5 ml/kg). Atorvastatin reduced all three parameter (TCL, TG, &LDL) significantly (p<0.001). It increased HDL significantly high (p<0.001).Conclusion: The leaf extract of C. roseus is responsible for lipid lowering effect.Journal of National Institute of Neurosciences Bangladesh, 2015;1(2): 53-56

scholarly journals Effect of Red Raspberry (Rubus idaeus L.) Consumption With or Without Fructo-Oligosaccharide on Metabolic Indices: A Single-Blinded Randomized, Crossover Clinical Trial (OR29-03-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Xuhuiqun Zhang ◽  
Anqi Zhao ◽  
Indika Edirisinghe ◽  
Amandeep Sandhu ◽  
Britt Burton-Freeman
Keyword(s):  
Clinical Trial ◽  
Lipid Profile ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Rubus Idaeus ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Lowering Effect ◽  
Insulin Responses ◽  
Lipid Lowering Effect

Abstract Objectives Red raspberries (RRB) contain a unique polyphenol profile associated with cardio-metabolic benefits. Fructo-oligosaccharides (FOS), as prebiotics, present an approach to augment the cardio-metabolic benefits of RRB through their known effects in modifying the gut microbiota composition. The objective of this study is to determine the effect of RRB intake with or without FOS on glucose and insulin responses and fasting lipid profile in insulin-resistant (IR) (n = 20) and metabolically healthy reference (R) adults (n = 11) in a single-blinded, randomized, 12-week crossover clinical trial. Methods In this crossover study, after one-week run-in, subjects consumed RRB (1 cup RRB equivalence) or RRB + FOS (1 cup RRB equivalence with 8 g FOS) for 4 weeks in random order separated by 4-week washout between supplementation periods. Before and after each supplementation period, glucose and insulin responses were assessed by 2-h postprandial glycemic challenge with RRB (75 g glucose equivalence) and the plasma lipid profile characterized (total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL) and triglycerides (TG)). Results IR group had significantly elevated fasting and postprandial glucose and insulin, and higher fasting TG and lower HDL compared to R at baseline (0-week) (P ≤ 0.05); no differences in TC and LDL between groups (P > 0.05). After 4-week intervention, RRB decreased TC and LDL of IR group from baseline by 7% (P = 0.024) and 9% (P = 0.007), respectively, whereas adding FOS significantly attenuated the lipid-lowering effect of RRB. Alternatively, addingFOS to RRB augmented RRB effect on glycemic variables: 4-week intake of RRB + FOS significantly decreased 30 min incremental areas under curve (iAUC 0–30) of IR group for glucose and insulin from baseline by 20% (P = 0.014) and 18% (P = 0.012), respectively. Conclusions 4-week RRB intervention improves glycemic and lipid profiles in people with IR. Adding FOS to RRB supplement enhanced the glycemic benefits, but attenuated the lipid-lowering effect of RRB. Funding Sources This work was supported by the National Processed Raspberry Council.

scholarly journals Relationship between serum lipid level and meibomian gland dysfunction subtype in Korea : A propensity score analysis

2021 ◽  
Author(s):  
Minji Ha ◽  
Jiyun Song ◽  
Sunkyoung Park ◽  
Kyungdo Han ◽  
Ho Sik Hwang ◽  
...  
Keyword(s):  
General Population ◽  
Propensity Score ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
Serum Lipid Level ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
The Mean

Abstract Purpose: To analyze the correlation between systemic lipid profile levels and each meibomian gland dysfunction (MGD) subtype in Korea.Methods: The ophthalmic data of 95 eyes and the serum lipid profiles of 95 patients were reviewed. These factors were compared with those of the general population using data from the Korean National Health and Nutrition Examination Survey (KNHANES), which evaluated 2,924 subjects. Of these, 475 propensity score-matched normal controls were selected for comparison with the 95 MGD patients based on a 1:5 ratio. In addition, we analyzed the correlations between serum lipid profile levels and MGD subtypes in MGD patients.Results: The mean high-density lipoprotein (HDL) value of the MGD patients was significantly higher than that of the general population (P < 0.0001). However, the mean total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels of the MGD patients were not significantly different from those of the general population (TC: P = 0.3950, TG: P = 0.6331, LDL: P = 0.2079). In addition, no serum lipid levels statistically differed among the MGD subtypes (TC: P = 0.7650, HDL: P = 0.2480, LDL: P = 0.3430, TG: P = 0.7030).Conclusion: A statistically significant, but marginal, increase in HDL concentration was observed in the MGD group, although there was no difference in any serum lipid level among the MGD subtypes.

scholarly journals Effect of the combination of Leptadenia hastata (pers) decne and Momordica balsamina linn leaf extracts on lipid profile of streptozotocin-induced diabetic rats

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Nafisatu Kabir ◽  
Umar Ismail Alhaji ◽  
Dorcas Bolanle James ◽  
Hajia Mairo Inuwa ◽  
Muhammad Kano Atiku
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Lipid Level ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Diabetic Rats ◽  
Lipid Lowering ◽  
Low Density ◽  
Leaf Extracts

Abstract Background Changes in blood lipid level (dyslipidemia) play a central role in the onset and pathogenesis of macrovascular complications of diabetes mellitus. Traditional herbal healers commonly use anti-diabetic polyherbal formulations to provide a multi-therapeutic approach for the treatment of diabetes mellitus and its associated complications. The effect of the aqueous leaf extracts of Leptadenia hastata (pers) Decne, Momordica balsamina Linn and their combination on lipid profile of streptozotocin (STZ)-induced diabetic rats was therefore evaluated in the present study. Results We evaluated the serum lipid profile and blood glucose level of STZ-induced diabetic rats (60 mg/kg body weight) treated with the aqueous leaf extracts of L. hastata (400 mg/kg) and M. balsamina (200 mg/kg) alone and in combination (400 + 200 mg/kg) after a period of 4 weeks. A significantly decreased (p < 0.05) level of total cholesterol (TC), triglyceride (TG), very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) cholesterol levels and increased (p < 0.05) level of high-density lipoprotein (HDL) cholesterol was observed in all the treated groups when compared to the untreated diabetic rats. Furthermore, the combination treatment was potentially a more effective blood lipid-lowering (p < 0.05) agent when compared to the single treatments. Conclusion Results from this study demonstrated the blood lipid-lowering potential of the aqueous leaf extracts of L. hastata, M. balsamina, and their combination. However, the polyherbal combination could be more potent in controlling diabetes mellitus, associated dyslipidemia, and its complications.

scholarly journals Acute Toxicity Study and Comparative effect of Kigelia Pinnata (Cucumber Tree) Ethanolic leaf extract on Serum Lipid profile of Albino Wistarrats treated fat diet.

2019 ◽  
Vol 1 ◽  
pp. 144-152
Author(s):  
C I Tarnande ◽  
F Uboh
Keyword(s):  
Acute Toxicity ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Leaf Extract ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Ethanol Solution ◽  
Serum Lipid Profile ◽  
Kigelia Pinnata ◽  
Ethanolic Leaf Extract

The aim of this study was designed to evaluate the activity of the Kigelia Pinnata ethanolic leaf extract on the serum lipid profile of male albino Wistar rats exposed to a fat diet. Kigelia Pinnata leaves were obtained, air dried, powdered and extracted in a Soxhlet apparatusin 400ml ethanol solution. Hypolipidaemic activity studies on rat models fed with palm oil and coconut milk was conducted. The acute toxicity test of the extract was carried out by the lorke's method. Results showed that Kigelia Pinnata ethanolic leaf extract significantly lowered (P<0.05) plasma Total Cholesterol (TC), Low Density Lipoprotein (LDL)-Cholesterol and Triacylglycerol (TG) and significantly (P<0.05) increased plasma High Density Lipoprotein (HDL)-Cholesterol. Toxicity studies suggested that, the extract was safe at the doze 2000mg/kg. Overall findings from this study showed that the ethanolic extract exhibited hypolipidaemic activity and may possess cardio-protective properties.

scholarly journals Cardioprotective Potential of Methanol Extract of Costus Afer Leaf on Carbon Tetrachloride-Induced Cardiotoxicity in Albino Rats

2017 ◽  
Vol 9 (2) ◽  
pp. 51 ◽  
Author(s):  
U. O. Njoku ◽  
O. F. C. Nwodo ◽  
M. O. Ogugofor
Keyword(s):  
Lipid Peroxidation ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Leaf Extract ◽  
Methanol Extract ◽  
Antioxidant Activities ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
Cardiac Biomarker ◽  
Costus Afer

<em>Costus afer</em> leaf extract is one of the native heritages of folklore medicine in Nigeria, used for the treatment of various disease conditions. Therefore this study was undertaken to evaluate the cardioprotective potential of the methanol extract of <em>Costus afer</em> leaves on CCl<sub>4</sub>- induced cardiotoxicity in albino rats. Twenty-eight (28) albino rats were divided into four main groups: normal control (normal saline only), CCl<sub>4</sub> control (saline and CCl<sub>4</sub>), aspirin treated (1.2 mg/kg b.w aspirin and CCl<sub>4</sub>) and <em>Costus afer</em> extract treated (extract and CCl<sub>4</sub>) groups. <em>Costus afer</em> extract was administered in four doses; 100, 200, 300, and 400 mg/kg b.w. p.o for 7 days. On day 7, CCl<sub>4</sub> (2.5 ml) cardiotoxicity was induced in animals of CCl<sub>4</sub> control, aspirin treated and extract pre-treatment groups. The parameters studied in this respect were cardiac biomarker enzymes; Creatine Kinase (CK), Aspartate Transaminases (AST) and Lactate Dehydrogenase (LDH), serum lipid profile; Triacylglycerol (TAG), Total Cholesterol (TC), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and artherogenic index (AR), lipid peroxidation; malondialdehyde (MDA) level and enzymatic antioxidant levels of cardiac tissue homogenate; Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Reductase (GR). CCl<sub>4</sub> intoxication produced significant (p &lt; 0.05) increases in cardiac biomarker enzymes, serum lipid profile (TAG, TC, and LDL) along with enhanced lipid peroxidation in heart, while significant (p &lt; 0.05) decreases in enzymatic antioxidant activities and HDL contents were also observed when compared to normal control. <em>Costus afer</em> leaf extract protected against  CCl&lt; cardiotoxic effect by restoring the cardiac functions alterations, augmenting antioxidant activities, reducing lipid peroxidation and improving lipid profile levels near normal. From the results, <em>Costus afer</em> leaves expressed cardioprotective potential and could be helpful in the management of cardiac dysfunction.

scholarly journals Study of serum lipid profile in type 2 diabetes mellitus patients and its association with diabetic nephropathy

2017 ◽  
Vol 4 (6) ◽  
pp. 1513 ◽  
Author(s):  
Ullasini Kolhar ◽  
Priyanka P.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Lipid Lowering

Background: Dyslipidaemia is highly prevalent in type 2 Diabetes mellitus patients. The role of dyslipidaemia in macrovascular complications of Diabetes have been extensively studied but its role in microvascular complications namely nephropathy is still unclear. The present study was undertaken to study the prevalence and pattern of dyslipidaemia and its association with Diabetic nephropathy (DN) in patients with type 2 DM.Methods: 100 patients with type 2 DM attending OPD or admitted, over a period of 1 year were studied. Detailed history was taken and clinical examination was done. Serum lipid profile was studied in all patients and its association with DN was assessed.Results: The prevalence of dyslipidaemia in DM patients in our study was 90% and there was no statistically significant difference in the prevalence among males and females. Poorly controlled diabetics had high prevalence of dyslipidaemia as compared to well controlled diabetics. The prevalence of Diabetic nephropathy in our study was 41%. There was significant association of DN with high Total Cholesterol, high Low-density lipoprotein (LDL-C) and high Triglycerides. There was no significant association of DN with High density lipoprotein (HDL-C).Conclusions: Present study highlights the magnitude of dyslipidaemia in type2 DM patients and that there is a significant association of DN with lipid parameters. Hence patients should be managed with life style modifications with or without lipid lowering agents to achieve target lipid values along with adequate glycemic control to prevent or delay the appearance and progression of DN.

scholarly journals Comparison of Lipid Lowering Effect of Aqueous Extract of Cinnamon (Cinnamomum Cassiae) with that of Rosuvastatin on Experimentally Induced Hypercholesterolaemic Rats

2019 ◽  
Vol 31 (1) ◽  
pp. 52-61
Author(s):  
Sagia Afrose ◽  
Md Ismail Khan ◽  
Elisa Omar Eva ◽  
Mohammad Imtiaj Mahbub
Keyword(s):  
Serum Lipid ◽  
Lipid Level ◽  
Serum Lipid Level ◽  
Lipid Lowering ◽  
High Cholesterol Diet ◽  
P Value ◽  
High Cholesterol ◽  
Lowering Effect ◽  
Lipid Lowering Effect ◽  
Experimentally Induced

Background: Hypercholesterolemia is a condition characterized by very high level of cholesterol in the blood. Too much cholesterol increases risk of developing heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the coronary arteries that supply blood to the heart. A phenolic compound of the cinnamon extract lowers serum lipid level by inhibiting HMG COA reductase & by activation of nuclear receptor peroxisome proliferator activated receptor alpha (PPAR-α). We are trying to evaluate the lipid lowering effect of cinnamon (Cinnamomum cassiae) in comparison with rosuvastatin in hypercholesterolaemic rats. Aim: To find out the lipid lowering effect of aqueous extract of cinnamon (Cinnamomum cassiae) and compare it with a established lipid lowering drug (rosuvastatin) on hypercholesterolaemic rats. Method: This was a experimental study conducted in the department of Pharmacology, Dhaka medical college & Hospital from July 2015 to June 2016. Sample size was 30.The study was designed as 2 parts: Experiment-1 & Experiment -2. Result: Cinnamon produces no statistically significant effect on serum lipid level of healthy rats (P- value >0.05; which is not significant). Cinnamon significantly reduced serum lipid level of high cholesterol diet induced hypercholesterolaemic rats. But, there is statistically significant difference between cinnamon and rosuvastatin lipid lowering effect in high cholesterol diet induced hypercholesterolaemic rats (p value <0.05; which is significant). Conclusion: The study was conducted to find out lipid lowering effect of cinnamon on experimentally induced hypercholesterolaemic rats. The present study found that cinnamon (Cinnamomum cassaiae) significantly lowers serum lipid level in experimentally induced hypercholesterolaemic rats. So cinnamon can be used as alternative lipid lowering agent for its easy availability, cost effectiveness and as well as lack of significant side effects. TAJ 2018; 31(1): 52-61

scholarly journals Pulverized Mangifera indica (Mango) Seed-kernel Modulated Serum Lipid Profile in Monosodium Glutamate-challenged Rats

2017 ◽  
Vol 5 (2) ◽  
pp. 72 ◽  
Author(s):  
Anthony Cemaluk C. Egbuonu ◽  
Gladys A. Ekwuribe
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Mangifera Indica ◽  
Monosodium Glutamate ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Oral Exposure ◽  
Seed Kernel ◽  
Sample Extract

Mangifera indica seed kernel was assessed for antinutirent content and effects on serum lipid profile of monosodium glutamate-challenged rats. Group A rats received 8000 mg/kg body weight, b.w of monosodium glutamate (MSG). Group B rats received the sample extract (300 mg/kg b.w). Group C rats were sham-administered distilled water. Groups D and E rats received 8000 mg/kg b.w of MSG in addition to 200 and 400 mg/kg b.w, respectively of sample extract. Tannin (29.21±5.39 mg/100 g) was highest (p<0.05) while phytate (0.38±0.02 mg/100g) was least. After fourteen days daily oral exposure, MSG-exposed rats had higher (p<0.05) total cholesterol (CHOL), triacylglycerol (TAG) and low density lipoprotein (LDL) but lower (p<0.05) high density lipoprotein (HDL) concentration compared to rats in the other groups. MSG-intoxicated rats co-treated respectively with 200 and 400 mg/kg b.w of the extract had dose dependent reduction (p<0.05) compared to the corresponding effects in non-extract-co-treated MSG-intoxicated rats. Compared to others, rats in the Extract group had higher (p<0.05) CHOL: TAG but lower (p<0.05) TAG:CHOL ratios while rats in the MSG-group had higher (p<0.05) HDL:LDL but lower (p<0.05) LDL:HDL ratios. Results demonstrated the preponderance of tannin in, and significant serum lipid lowering potential in normal and MSG-challenged rats of, the sample. Studies using antinutrient-process-reduced sample in hyperlipidemia-related health-challenged models and collaborating the suggested implication of lipid-profile-component-ratios are warranted and recommended.

scholarly journals Night sleep duration and risk of each lipid profile abnormality in a Chinese population: a prospective cohort study

2020 ◽  
Author(s):  
Qiaofeng Song ◽  
Xiaoxue Liu ◽  
Wenhua Zhou ◽  
Shouling Wu ◽  
xizhu wang
Keyword(s):  
Lipid Profile ◽  
Sleep Duration ◽  
Chinese Population ◽  
Serum Lipid ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
Serum Lipid Level ◽  
Cox Proportional Hazards Model ◽  
Lipoprotein Cholesterol ◽  
Low Hdl

Abstract Background To explore the associations between sleep duration and abnormalities in each serum lipid level in a Chinese population. Methods A prospective study was conducted with 33,817 participants from the general Chinese population. Sleep duration was categorized as ≤5, 6, 7, 8 or ≥9 h. Each lipid profile abnormality was defined according to the Chinese Guidelines for the Prevention and Treatment of Dyslipidemia in Adults. The Cox proportional hazards model was used to assess these associations. Results Compared with a seven-hour sleep duration, longer sleep duration was significantly associated with high low-density lipoprotein cholesterol (LDL-C) (HR: 1.18; 95% CI: 1.10–1.17) in fully adjusted models. And a longer sleep duration was significantly associated with low high-density lipoprotein cholesterol (HDL-C) levels (HR: 1.22; 95% CI: 1.19–1.35). In subgroup analyses, the positive association between long sleep duration and high LDL-C and low HDL-C levels in men and in the different age groups were more pronounced than the association in women. No significant interactions were observed in the association between sleep duration and each abnormal serum lipid level by sex/age in the study population(p- interaction>0.05). Conclusions These findings suggest that longer sleep duration is associated with high LDL-C and low HDL-C levels among the Chinese population.

scholarly journals Relationship between serum lipid level and meibomian gland dysfunction subtype in Korea using propensity score matching

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Minji Ha ◽  
Jiyun Song ◽  
Sunkyoung Park ◽  
Kyungdo Han ◽  
Ho Sik Hwang ◽  
...  
Keyword(s):  
General Population ◽  
Propensity Score ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Lipid Level ◽  
Density Lipoprotein ◽  
Serum Lipid Level ◽  
Meibomian Gland ◽  
The Mean ◽  
The Relationship

AbstractTo analyze the relationship between systemic lipid profile levels and meibomian gland dysfunction (MGD) subtype in Korea. The ophthalmic data of 95 eyes and the serum lipid profiles of 95 patients were reviewed. These factors were compared with those of the general population using data from the Korean National Health and Nutrition Examination Survey (KNHANES), which evaluated 2,917 subjects. Of these, the comparison group (1:5 ratio; n = 475) was selected using propensity score matching according to age and sex. In addition, we analyzed the relationship between serum lipid profile levels and MGD subtypes in MGD patients. The mean high-density lipoprotein (HDL) value of the MGD patients was significantly higher than that of the general population (P < 0.0001). Moreover, the mean low-density lipoprotein (LDL) levels of the MGD patients was significantly lower than that of the general population (P = 0.0002). However, the mean total cholesterol (TC), and triglyceride (TG) levels of the MGD patients were not significantly different from those of the general population (TC: P = 0.4282, TG: P = 0.5613). In addition, no serum lipid levels statistically differed among the MGD subtypes (TC: P = 0.7650, HDL: P = 0.2480, LDL: P = 0.3430, TG: P = 0.7030). A statistically significant increase in HDL and decrease in LDL concentration were observed in the MGD group, although there was no difference in any serum lipid level among the MGD subtypes.

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