scholarly journals A 32-year-old obese Male with Prolonged Increased Transaminase Level Associated with NASH after HBV Hepatitis

1970 ◽  
Vol 11 (1) ◽  
pp. 90-93
Author(s):  
Ahmedul Kabir ◽  
Jayanta Banik ◽  
Robed Amin ◽  
Faizul Islam Chowdhury
Keyword(s):  
Chronic Hepatitis ◽  
Liver Enzymes ◽  
Transaminase Level ◽  
Elevated Serum ◽  
Hbv Dna ◽  
Alanine Transaminase ◽  
Aspartate Transaminase ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Steatohepatitis ◽  
Obese Male

Nonalcoholic steatohepatitis (NASH) is an underdiagnosed liver disease and is the main cause of persistent elevated serum liver enzymes among the general population. Here, we report the case of a 32-year-old obese man who was diagnosed as a case of chronic hepatitis caused by HBV infection. He was treated with Lamivudine for two years. Though his HBV DNA load became negative, he had persistently elevated ALT and AST for two years. Then a liver biopsy was planned for greater diagnostic and prognostic certainty, as the patient was obese, and aspartate transaminase to alanine transaminase ratio was greater than one. The histopathology showed steatosis, ballooning degeneration, microinflammation and fibrosis compatible with non-alcoholic steatohepatitis. We present the case as we think that clinicians should be aware of the possibility, that hepatitis B viral hepatitis with prolonged elevated serum liver enzymes might be associated with non-alcoholic steatohepatitis. Keywords: Non-alcoholic fatty liver, steatohepatitis DOI:10.3329/jom.v11i1.4283 J Medicine 2010: 11: 90-93

scholarly journals Characteristics of chronic hepatitis B: Lower alanine transaminase level to start treatment in HBEAG Negatives

Gut ◽  
2011 ◽  
Vol 60 (Suppl 1) ◽  
pp. A59-A60
Author(s):  
M. S. Alam ◽  
G. Azam ◽  
G. Mustafa ◽  
N. Ahmad ◽  
M. Khan
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Transaminase Level ◽  
Alanine Transaminase

scholarly journals Influence of GSTM1, GSTT1 and GSTP1 xenobiotic metabolism genes polymorphisms on treatment efficiency in patients with chronic hepatitis C

2014 ◽  
Vol 95 (2) ◽  
pp. 202-208
Author(s):  
E V Ostapchuk ◽  
V V Godovan
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Transaminase Level ◽  
Virologic Response ◽  
Alanine Transaminase ◽  
Early Virologic Response ◽  
Gstp1 Gene ◽  
Peginterferon Alfa ◽  
Gstm1 Genotype

Aim. To analyze the influence of GSTT1, GSTM1 and GSTP1 genes polymorphism on treatment effectiveness in patients with chronic hepatitis C in Odessa Region using different treatment protocols. Methods. Three groups of patients with chronic hepatitis C were included. Patients of the first group (n=33) were treated with peginterferon alfa-2a and ribavirin, of the second group (n=18) - with tilorone and ribavirin, of the third group (n=26) - with silybi mariani fructuum extract. GSTT1, GSTM1 genes polymorphisms, as well as A313G polymorphism of GSTP1 gene were determined. The treatment effect was assessed by changes of biochemical parameters and viral load. Results. Patients of the first group with AG + GG genotypes had higher rate of rapid and early virologic response (73.7 and 27.3% respectively, р=0.013). Level of alanine transaminase also normalized earlier, and was significantly lower after 12 weeks of treatment in patients with AG + GG genotypes (0.57±0.28 mmol/l×h) compared to patients with АА genotype (0.99±±0.77 mmol/l×h, р=0.033). There was no influence of GSTT1 and GSTM1 genes polymorphisms on the chance of rapid and early virologic response and alanine transaminase levels. No response was found only in 4 patients with GSTT1+/GSTM1+ genotype. Conclusion. GSTT1 and GSTM1 deletion genes polymorphisms did not influence the speed of virologic response in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirin. No virologic response in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirin was only found in patients with GSTT1+/GSTM1+ genotype. AG + GG GSTP1 genotype was associated with more rapid alanine transaminase level normalization and rapid virologic response in patients treated with peginterferon alfa-2a and ribavirin. GSTT1+, GSTM1+ genotypes and АА genotype of GSTP1 gene are associated with better treatments results in patients treated with silybi mariani fructuum extract.

Clinical Implications of Alanine Transaminase Level in the Diagnostic Accuracy of Alpha-Fetoprotein for Predicting Hepatocellular Carcinoma in Patients with Hepatis B Infection

2020 ◽  
Author(s):  
Bo Hu ◽  
Jiahao Chen ◽  
Manli Wu ◽  
Jiao Gong ◽  
Zhihuan Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Hepatitis ◽  
Transaminase Level ◽  
Alanine Transaminase ◽  
Alpha Fetoprotein ◽  
Clinical Implications ◽  
Gamma Glutamyl Transferase ◽  
Upper Limit ◽  
Glutamyl Transferase ◽  
Better Than

Abstract Background Abnormally elevated AFP level is often observed in patients with chronic hepatitis infections without evident of (hepatocellular carcinoma) HCC. Our study aimed to investigate the influence of alanine transaminase (ALT) on the accuracy of alpha-fetoprotein (AFP) for detecting HCC. Methods This retrospective study recruited 799 patients with HCC, cirrhosis and chronic hepatitis due to hepatitis B infection and healthy adults between July 2017 and January 2019. Comparisons of the area under the receiver-operating curves (AUCs) for detecting HCC in different ALT levels were calculated. Results Serum ALT and gamma-glutamyl transferase level were significantly associated with elevated AFP in patients without HCC. The AUC of AFP was higher in patients with ALT ≤ 2 upper limit of normal (ULN) than in patients with ALT > 2ULN (0.806 vs 0.611, P <0.001). Nevertheless, there was not significant differences in the AUCs of AFP/(ALT×Aspartate aminotransferase(AST) in patients with ALT ≤ 2 ULN and with ALT > 2ULN (0.769 vs 0.769, P = 0.68). AFP/(ALT×AST) was better than AFP in patients with ALT > 2ULN for detecting HCC (P <0.001). Conclusions Higher ALT level might impair the accuracy of AFP for diagnosing HCC. AFP tests showed better accuracy in patients with ALT ≤ 2 ULN whereas AFP/(ALT×AST) ratio was recommended in patients with elevated ALT level.

Elevated Serum Alanine Transaminase (ALT) in Patients of Type 2 Diabetes Mellitus

2021 ◽  
Vol 15 (11) ◽  
pp. 3096-3097
Author(s):  
Nasir Shah ◽  
Saqib Jahangir ◽  
Naeem Ahmed ◽  
Muhammad Saleem Hasan ◽  
Yasir Abbas Zaidi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Type Ii Diabetes ◽  
Transaminase Level ◽  
Elevated Serum ◽  
Alanine Transaminase ◽  
Type Ii

Objective: The objective of this study was to determine the prevalence of raised serum alanine transaminase level in patients of type 2 diabetes mellitus. Design: cross-sectional study Study Settings: This study was conducted at Department of Internal Medicine Abbas Institute of Medical Sciences Muzaffarabad from November 2020 to April 2021. Material and Methods: Total 144 patients were included in the study having age from 18 to 60 of both genders with Type 2 DM. It was labeled as elevated if it was ≥50 IU/L. A written informed consent was taken from each patient. Results: Patient’s age ranged from 36 to 70 years having mean value of 44.4±8.3 y. BMI ranged from 21.2 Kg/m2 to 34.7 Kg/m2 with a mean of 27.2±3.7 Kg/m2. Disease duration was from 2 to 14 years with a mean of 7.1±3.8 years. Elevated serum ALT was noted in 38 (26.4%) patients with type-II diabetes. Conclusion: Elevated serum ALT was noted in a substantial proportion of patients with type-II diabetes and was significantly more frequent in patients with poor glycemic control which warrants good glycemic control to prevent and routine screening of such patients in future practice to timely identify and manage this complication to improve the outcome. Keywords: Type 2 Diabetes Mellitus, Serum Alanine Transaminase, Prevalence

scholarly journals Non-alcoholic steatohepatitis associated with Netherton syndrome

2018 ◽  
Vol 11 (1) ◽  
pp. e224191
Author(s):  
Stephanie Tanner ◽  
Atharina Julai ◽  
David Angelo Gorard
Keyword(s):  
Body Mass Index ◽  
Vitamin E ◽  
Elevated Serum ◽  
Alanine Transaminase ◽  
Ultrasound Guided ◽  
Histological Features ◽  
Netherton Syndrome ◽  
Alcoholic Steatohepatitis ◽  
Routine Monitoring ◽  
Vitamin E Supplementation

A 21-year-old man with Netherton syndrome underwent investigation of a persistently elevated serum alanine transaminase, detected on routine monitoring. He drank no alcohol, was not diabetic or overweight (body mass index 23 kg/m2) and had no clinical features of liver dysfunction. A FibroScan yielded an elevated result of 9.3 kPa. An ultrasound guided liver biopsy showed histological features consistent with non-alcoholic steatohepatitis, with activity score of 4 and fibrosis stage of 3. The patient was started on vitamin E supplementation and remains under surveillance.

scholarly journals Melatonin Levels in Patients with Nonalcoholic Fatty Liver Disease Compared with Healthy Individuals according to Fibrosis Level

2021 ◽  
Vol 13 (2) ◽  
pp. 109-114
Author(s):  
Masoudreza Sohrabi ◽  
Ali Gholami ◽  
Mahsa Taheri ◽  
Sina Fekri ◽  
Bahare Amirkalali ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Liver Enzymes ◽  
Venous Blood ◽  
Elevated Serum ◽  
Control Group ◽  
Melatonin Level ◽  
Healthy Individuals ◽  
Alcoholic Fatty Liver

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases worldwide. Studies have shown that melatonin, as a regulatory hormone, is effective in different cell protective pathways. We aimed to compare serum melatonin levels of patients with NAFLD with different stages of fibrosis with that of healthy individuals. METHODS In this cross-sectional study patients, aged >20 years with elevated serum liver enzymes and trance abdominal sonographic diagnosis of fatty liver who met the exclusion criteria for NAFLD were included. The participants were categorized into three groups as follows: 1) severe fibrosis (fibrosis > 9.1 kPa and steatosis > 285 dbm), 2) mild-moderate fibrosis (fibrosis: 6-9.0 kPa and steatosis 240-285), and 3) normal group with fibrosis < 5.8 kPa and steatosis < 240 dbm based on Fibroscan evaluation. Five ml of fasting venous blood was taken from each patient and the control group for laboratory assessment. A questionnaire including demographic, anthropometric, laboratories (serum ALT, AST, triglyceride, total cholesterol and melatonin level), and clinical data was completed for all participants. RESULTS 97 people with a mean±SD age of 42.21 ± 11 years were enrolled. 59 (60.0%) patients were women. we observed that the melatonin levels were increased by advancing fibrosis. Based on control- attenuated parameter results the melatonin levels significantly differed between the healthy individuals and patients with severe steatosis. There was a direct association between increased melatonin levels and liver enzymes. CONCLUSION As a regulatory hormone, melatonin may directly be associated with liver cell injuries. Therefore, considered regulatory substances such as melatonin either diagnostic or therapeutic can improve the patients’ outcome.

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