scholarly journals Usefulness of CSF C-Reactive Protein in Differentiating Pyogenic and Aseptic Meningitis

1970 ◽  
Vol 22 (1) ◽  
pp. 78-81 ◽  
Author(s):  
M Belal Uddin ◽  
Manjira Rahman ◽  
AB Siddique
Keyword(s):  
Predictive Value ◽  
Febrile Convulsion ◽  
Cross Sectional Study ◽  
Suspected Case ◽  
C Reactive Protein ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Reactive Protein ◽  
Sensitivity Specificity

A cross sectional study was done about usefulness of CSF- C reactive protein determining the sensitivity, specificity and predictive value of CSF C-reactive protein estimation. The study was conducted in all the Pediatric unit of Rajshahi Medical College Hospital from March 2008 to July 2009. A total of 130 suspected case of meningitis patients were included in the study. Cerebrospinal fluid culture and C-reactive protein were done for all the patients. Among them 102 were diagnosed as meningitis and 28 were other than meningitis. They were diagnosed as febrile convulsion, seizure disorder, IVH, Among these diagnosed as meningitis, CSF culture were positive in 66 patient and CSF C-reactive protein were positive in 59 patients. Sensitivity and specificity of CSF C-reactive protein were 89.39% and 100% respectively. Predictive value of positive and negative test for CSF-CRP was 100% and 83.72%. DOI: 10.3329/taj.v22i1.5021 TAJ 2009; 22(1): 78-81

scholarly journals Association between C - reactive protein and Premature Rupture of Membrane

2016 ◽  
Vol 4 (2) ◽  
pp. 26-31
Author(s):  
Mitheel Ibna Islam ◽  
Monowara Khatun ◽  
Md Shahidul Islam ◽  
Md Nurul Amin ◽  
Shitil Ibna Islam
Keyword(s):  
Amniotic Fluid ◽  
Cross Sectional Study ◽  
C Reactive Protein ◽  
Premature Rupture ◽  
College Hospital ◽  
Cross Sectional ◽  
Predictive Values ◽  
Medical College ◽  
Reactive Protein ◽  
Wbc Count

Background and Objectives: Early diagnosis of clinical chorioamnionitis (ChAm) in patients with premature rupture of membrane (PROM) is essential for its prompt treatment with antibiotics. Amniocentesis may be used to detect subclinical infections in cases of PROM. But the procedure is an invasive one. The present study was undertaken to study the role of plasma C-reactive protein (CRP) in the prediction of clinical chorioamnionitis in case of PROM. Materials & Methods The cross-sectional study was carried out in the of Departments of Obstetrics & Gynaecology, Khulna Medical College Hospital, Khulna over a period 1 year from July 2014 to June 2015. A total of 90 clinically diagnosed cases of PROM (rupture of the membrane with release of the amniotic fluid more than 1 hour prior to the onset of labor) were consecutively included in the study based on predefined enrolment criteria. Clinical ChAm is defined by findings such as leukocytosis [WBC count, >15,000/µL, fetal tachycardia, maternal fever (temperature, >100.4°F), fundal or uterine tenderness, or foul-smelling amniotic fluid]. A CRP value of > 10 mg/L was considered as raised or positive CRP. The risk of developing clinical ChAm in patients with raised CRP was then estimated by computing the Odds ratio. Result: The mean age of the women with PROM was 23.9 years. The patients presented with fundal or uterine tenderness (10%), raised maternal temperature (8.9%), foetal tachycardia (10%), maternal tachycardia (13.3%), foul smelling amniotic fluid (6.7%). Over half (52.2%) of the patients were preterm PROM and the rest were term PROM. Positive CRP was found in 16.7% cases. Raised WBC count and raised ESR were found in 11.1 and 33.3% cases respectively. Over two-thirds (70%) who developed clinical chorioamnionitis had raised CRP as opposed to 10% of those who did not develop the condition. The risk of having raised CRP in patients who developed clinical chorioamnionitis was > 20-fold (4.5 - 97.7) higher than those who did not develop the condition (p < 0.001). The sensitivity and specificity of CRP in diagnosing and ruling out chorioamnionitis respectively in cases of PROM were 70% and 90% respectively. The positive and negative predictive values of the test are 46.7% and 96% respectively. Conclusion: The study concluded that a substantial proportion of the PROM cases with clinical chorioamnionitis is manifested with raised CRP compared to PROM cases without chorioamnionitis. However, CRP is moderately sensitive to diagnose chorioamnionitis and highly specific to rule out the condition in cases with PROM. Ibrahim Cardiac Med J 2014; 4(2): 26-31

Correlation of C-reactive protein with stroke severity in patients with acute ischemic cerebrovascular stroke.

2021 ◽  
Vol 28 (03) ◽  
pp. 306-310
Author(s):  
Mahpara Munir ◽  
Hafiz Bilal Bashir ◽  
Madeeha Qamar
Keyword(s):  
Cross Sectional Study ◽  
Stroke Severity ◽  
Strong Positive Correlation ◽  
C Reactive Protein ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Medical College ◽  
Reactive Protein ◽  
Stroke Study ◽  
Cerebrovascular Stroke

Objective: To determine the correlation of mean serum C - reactive protein with frequency of stroke severity in patients with acute ischemic cerebrovascular stroke. Study Design: Descriptive Cross Sectional study. Setting: Department of Medicine, Allied Hospital Punjab Medical College Faisalabad. Period: March 2016 to September 2016 Material & Methods: Patients fulfilling the selection criteria were enrolled in the study. Besides routine laboratory tests, plasma CRP levels on admission were measured in all patients through hospital pathology laboratory. CRP levels were correlated with the results of NIHSS (National institute of health stroke scale) score based assessment of ischemic stroke severity at admission. Results: In our study, out of 50 cases of acute stroke, 62%(n=31) were male and 38%(n=19) were females, mean±sd for age was calculated as 46.82+8.65 years, mean CRP levels was calculated as 8.04+2.15mg/dL, mean NIHSS levels were calculated as 10.08+3. Correlation of mean serum C-reactive protein with frequency of stroke severity in patients with acute ischemic cerebrovascular stroke was calculated where r value was 0.9183 showing a strong positive correlation, which means that high CRP goes with high NIHSS (and vice versa). Conclusion: We concluded that CRP levels are positively correlated with the frequency of stroke severity in patients with acute ischemic cerebrovascular stroke.

A STUDY TO EVALUATE THE ROLE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN CEREBROVASCULAR ACCIDENT IN THE DARBHANGA MEDICAL COLLEGE AND HOSPITAL

2021 ◽  
pp. 71-73
Author(s):  
Amit Kumar Tiwari ◽  
Umesh Chandra Jha ◽  
Debarshi Jana
Keyword(s):  
Cerebrovascular Accident ◽  
High Sensitivity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Abrupt Onset ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Medical College ◽  
Reactive Protein ◽  
Hs Crp

INTRODUCTION:Cerebrovascular accident (commonly called stroke) is dened as an abrupt onset of a neurologic decit that is attributable to a focal vascular cause. Thus, the diagnosis of stroke is clinical and laboratory studies including brain imaging are used to support the diagnosis AIMS AND OBJECTIVES: To evaluate the serum levels of high sensitivity C-reactive protein (hsCRP) in different types of cerebrovascular accidents on admission. MATERIALS AND METHODS: This study was an institution based cross-sectional study designed to investigate the association of hs-CRP levels with stroke and its types in Indian patients. The study was done in the Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar from march 2019 to March 2020. 50 patients of either sex above 12 years of age admitted in Medicine Department of DMCH, Laheriasarai, Bihar with clinically or radiologically diagnosed stroke. RESULT: The mean level of hsCRP (mean ± s.d.) of the cases in our study was 7.65±7.01 with range 1.4 – 26 and the median was 3.7 and 58% of the cases were having level of hsCRP≥3 (p=0.023).Mean level of hsCRPof cases was signicantly higher than that of control (t98=7.25;p=0.001). CONCLUSION:We concluded that hs-CRPlevel is increased in cases of cerebrovascular accident- ischemic as well as haemorrhagic, suggesting an inammatory response in acute cerebrovascular accident. hs-CRP level is increased in patients with ischemic cerebrovascular accident dramatically but not in haemorrhagic cerebrovascular accident which might be considered as useful adjunct method for determining type of stroke in patients with cerebrovascular problems.

scholarly journals Leukocyte count and C reactive protein as diagnostic factors in febrile convulsion

2017 ◽  
Vol 8 (2) ◽  
pp. 56-58
Author(s):  
Garima Biyani ◽  
Swapan Kumar Ray ◽  
Kripasindhu Chatterjee ◽  
Sukanta Sen ◽  
Pradyut Kumar Mandal ◽  
...  
Keyword(s):  
Leukocyte Count ◽  
Febrile Convulsion ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Medical Sciences ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Time Of Admission

Background: Febrile convulsion (FC) is the most common seizure disorder in childhood. White blood cell (WBC) and C reactive protein (CRP) are commonly measured in FC. Add a paragraph on Aims and Objectives of the study.Aims and Objectives: To compare WBC and CRP in febrile children, aged 6 months to five years, with and without FC, in order to determine whether leukocytosis and elevated CRP can be used as diagnostic tool for febrile seizure.Materials and Methods: In this cross sectional study 214 children (112 with FC), aged 6 months to 5 years, admitted to in the first 48 hours of their febrile disease, either with or without seizure, were evaluated over a 12 months period. Age, sex, temperature; WBC, CRP and hemoglobin were recorded in all children. There was a significant increase of WBC (P<0.001) in children with FC so we can deduct that leukocytosis encountered in children with FC can be due to convulsion in itself.Results: When comparing FC and non-FC children, we encountered a significant increase of WBC (P =0.0005) in children with FC, measured at the time of admission to pediatric medicine ward. There was no significant difference regarding CRP between the two groups. In fact, elevated CRP is a result of underlying pathology.Conclusion: In stable patients, if there’s no reason to suspect a bacterial infection or who don’t have any indication of lumbar puncture, there’s no need to assess WBC as an indicator of underlying infection. Any child with febrile seizure with a high CRP value should be evaluated for infection.Asian Journal of Medical Sciences Vol.8(2) 2017 56-58

scholarly journals Interleukin 21 as a diagnostic marker of rheumatoid arthritis.

2019 ◽  
Vol 26 (08) ◽  
pp. 1229-1232
Author(s):  
Khadija Kiran ◽  
Amtul Huda ◽  
Zuhair Bhatti
Keyword(s):  
Rheumatoid Arthritis ◽  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Diagnostic Marker ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Medical College ◽  
Sensitivity Specificity

To investigate the role of IL-21 as diagnostic marker in diagnosis of rheumatoid arthritis. Study Design: Cross sectional study. Setting: Department of Physiology and Orthopedic Gujranwala Medical College, Gujranwala. Period: October 2017 to October 2018 in one year duration. Materials and Methods: A total of 150 patients were included in the study, main variables assessed in this study were positive predictive value negative predictive value, sensitivity, specificity and accuracy of IL-21 in diagnosis of rheumatoid arthritis. SPSS version 23 was used to analyze the data. P value less than or equal to 0.05 was taken as significant. Study was started after permission from hospital ethical committee and patients were informed in detail about disease and procedure to be done. Non probability consecutive sampling was used. Results: The estimated sensitivity was 93.6%. The estimated specificity was 50%. Positive predictive value was 96.3% and negative predictive value was 35.7%. The overall accuracy was 90.6% for diagnosing rheumatoid arthritis. Conclusion: IL-21 induces MMP3 in rheumatoid arthritis patients, identification of IL-21 from synovium of patients indicates the presence of rheumatoid arthritis. We observed 90.6% diagnostic accuracy of IL-21 for rheumatoid patients taking RA factor as gold standard of diagnostic tool.

scholarly journals Comparing Predictive power of CT-scan Findings among the Malignant Hepatic Mass patients

2015 ◽  
Vol 12 (1) ◽  
pp. 2-6
Author(s):  
Wahida Begum ◽  
Ahmed Hossain ◽  
Waziha A Jahan ◽  
Mahbuba Shirin ◽  
M Abdullah Yusuf ◽  
...  
Keyword(s):  
Ct Scan ◽  
Vena Cava ◽  
Cross Sectional Study ◽  
Medical College Hospital ◽  
College Hospital ◽  
Cross Sectional ◽  
Predictive Values ◽  
Medical College ◽  
Hepatic Mass ◽  
Sensitivity Specificity

Background: CT-scan is useful for the detection of hepatic mass. Objective: The purpose of the present study was to see the predictive values of CT scan in the diagnosis of malignant hepatic mass. Methodology: This cross sectional study was carried out in the Department of Radiology and Imaging at Mymensingh Medical College Hospital (MMCH), Mymensingh, Banghabandhu Sheikh Mujib Medical University (BSMMU), Dhaka and Dhaka Medical College Hospital (DMCH), Dhaka during the period of 1st January 2006 to 31st December 2007. Patients admitted in the Department of Medicine and Department of Hepatobiliary of MMCH, BSMMU, and DMCH with the clinical diagnosis of fever, abdominal pain, anorexia, nausea/vomiting, loss of appetite, jaundice, weight loss and ascites were selected as study population. CT scan and histopathology were performed to all the patients. Result: A total number of 50 patients were recruited for this study.. The sensitivity for multiplicity was 71.4%, specificity was 63.6%, accuracy was 68%, PPV was 71.4% and NPV was 63.6%. The sensitivity for hypodensity as a sign of malignancy was 60.7%, specificity was 18.2%, accuracy was 42.0%, PPV was 48.6% and NPV was 26.7%. The sensitivity, specificity, PPV, NPV and accuracy of contrast enhancement were 100.0%, 22.7%, 62.2%, 100.0% and 66.0% respectively. Again the sensitivity, specificity, PPV, NPV and accuracy of detection of pressure effect on biliary apparatus by CT-scan were 100.0%, 22.7%, 62.2%, 100.0% and 66.0% respectively. Again the sensitivity, specificity, PPV, NPV and accuracy of detection of Lymphadenopathy by CT-scan were 35.7%, 95.5%, 90.9%, 53.8% and 62.0% respectively. The sensitivity, specificity, PPV, NPV and accuracy of detection of Portal vein invasion by CT-scan were 14.3%, 100.0%, 100.0%, 47.8% and 52.0% respectively. The sensitivity, specificity, PPV, NPV and accuracy of detection of hepatic vein invasion by CT-scan were 10.7%, 100.0%, 100.0%, 46.8% and 50.0% respectively. The sensitivity, specificity, PPV, NPV and accuracy of detection of inferior vena cava (IVC) invasion by CT-scan were 7.1%, 100.0%, 100.0%, 45.8% and 48.0% respectively. Conclusion: CT is a useful diagnostic tool for the detection of malignant hepatic masses.Journal of Science Foundation, 2014;12(1):2-6

scholarly journals Clinical Profile of Meningitis in Children

2018 ◽  
Vol 28 (1) ◽  
pp. 6-11
Author(s):  
MB Uddin ◽  
M Rahman ◽  
KI Jahan ◽  
S Yeasmin ◽  
F Rahman
Keyword(s):  
Aseptic Meningitis ◽  
Clinical Problem ◽  
Cross Sectional Study ◽  
Suspected Case ◽  
Pyogenic Meningitis ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Meningitis In Children ◽  
Untreated Individuals

Meningitis is an emergency clinical problem in pediatrics. The mortality from meningitis is close to 100% in untreated individuals and can still be up to 40% in children who received appropriate antibiotic therapy in developing countries. A cross sectional study was done to address the common presentation of meningitis among the children. The study was conducted in the Pediatric unit of Rajshahi Medical College Hospital from March 2008 to July 2009. A total of 130 suspected case of meningitis patients were included in the study. Among them 102 were diagnosed as meningitis of 66 children with pyogenic meningitis, 36 children with aseptic meningitis and 28 children without meningitis were taken as non meningitis group. This study showed that all patients (100%) had fever. 97 (95.10%) had symptom of convulsion. Vomiting was present in 62 (60.78%), excessive cry or irritability present in 50(49%) cases. This study expressed that 75 (73.53%) patients had bulged fontanel. Neck rigidity was present in 67 (65.69%). Only 32.35% had kernig’s sign positive and 17.65% present with Brudginsky’s sign positive. The infancy was the most vulnerable age for pyogenic meningitis. H. influenzae were the leading pathogen (24.24%) in infancy followed by S. pneumoniae (21.21%). The result shows that among 66 pyogenic meningitis, 26 (39.39%) were completely cured and 24 (36.37%) were cured with sequelae. Out of 36 aseptic meningitis 27 (75.00%) were completely cure.TAJ 2015; 28(1): 6-11

scholarly journals Role of ultrasonography in diagnosis of solid space occupying lesion in the liver correlation with FNAC

2016 ◽  
Vol 41 (2) ◽  
pp. 81-88
Author(s):  
Shyamal Kumar Roy ◽  
Sohely Sultana ◽  
Nazir Uddin Mollah ◽  
Tarana Yasmin ◽  
Asish Sarker ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
College Hospital ◽  
Cross Sectional ◽  
Predictive Values ◽  
Transabdominal Ultrasonography ◽  
Medical College ◽  
Diagnostic Usefulness ◽  
Sensitivity Specificity ◽  
Transabdominal Sonography

This cross sectional study was carried enrolling 47 subjects with suspected solid liver mass, in the Department of Radiology and Imaging, Dhaka Medical College Hospital, Dhaka, over a period of twelve months. The aim of this study was to evaluate the diagnostic usefulness of transabdominal ultrasonography in the diagnosis of solid SOL in the liver. Majority of the respondents (42.55%) were found between 41-60 years of age. Five (10.63%) subjects were found below 20 years of age. There were 31 men (65.95%) and 16 women (34.05%). Majority of the metastasis were multiple (85%), hypoechoic (35%) and only 15% had internal calcifications. HCC was single lesion (61.53%) with hyperechoic (38.35%) echogenicity, with a central halo (76.92%) and 15.38% had internal calcifications. Majority of the cholangiocarcinoma were solitary (80%), hypoechoic (60%) and 60% had internal calcifications. Hepatoblastoma were solitary and had calcifications (60%) with mixed echogenicity (60%). Majority of the adenomas were solitary (80%), hypoechoic (60%) and only 20 % had internal calcifications. The validity of transabdominal sonography for the diagnosis of metastasis was confirmed by calculating sensitivity (100%), specificity (96.42%), accuracy (97.87%), positive (95%) and negative predictive (100%) values by using the standard formula given. The sensitivity, specificity, accuracy, positive and negative predictive values for HCC were 92.3%, 97.05%, 95.74%, 92.3% and 97.05% respectively. The sensitivity, specificity, accuracy, positive and negative predictive values for cholangiocarcinoma and hepatoblastoma were 80%, 97.61%, 95.74%, 80% and 97.61% respectively. Sensitivity, specificity, accuracy, positive and negative predictive values were 80%, 100%, 97.87%, 100% and 97.67% respectively for adenoma. From the study result it was concluded that transabdominal ultrasonography could be reliable, non-ionizing and relatively cheap procedure for diagnosis solid hepatic mass lesion.

Rapid detection of Rotavirus antigen in stool sample of acute diarrheic children

2012 ◽  
Vol 6 (1) ◽  
pp. 11-13
Author(s):  
Sushmita Roy ◽  
S.M. Shamsuzzaman ◽  
K.Z. Mamun
Keyword(s):  
Stool Sample ◽  
Rapid Detection ◽  
Cross Sectional Study ◽  
Rapid Diagnosis ◽  
Age Group ◽  
College Hospital ◽  
Cross Sectional ◽  
Rotavirus Infection ◽  
Medical College ◽  
Stool Samples

Rotavirus is one of the leading causes of pediatric diarrhea globally. Accurate and rapid diagnosis of Rotavirus diarrhea should reduce unnecessary use of antibiotics and ultimately reduce drug resistance. Study was designed for rapid diagnosis of Rotavirus antigen in stool sample by ICT (Immunochromatographic test) as well as to observe the seasonal variation of rotavirus infection. This cross sectional study was carried out in the department of Microbiology, Dhaka Medical College from January 2011 to December 2011. Eighty stool samples were collected from Dhaka Shishu Hospital and Dhaka Medical College Hospital. All samples were tested for rotavirus antigen by ICT. Among 80 patients, 42 (52.5%) samples were positive for rotavirus antigen. Among these 42 positive samples, 30 (71.43%) were from 0-12 months of age group, 10 (23.81%) from 13 to 24 months of age group and rest 2 (4.76%) from 25 to 36 months of age group. Rotavirus Ag was detected in stool samples from January to April and another peak episode from October to December. Considering the importance of Rotavirus associated diarrhea, rapid detection of Rotavirus infection in human is substantially needed and should be routinely practiced.DOI: http://dx.doi.org/10.3329/bjmm.v6i1.19354 Bangladesh J Med Microbiol 2012; 06(01): 11-13

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