scholarly journals Stress Hyperglycaemia During Acute Coronary Syndrome of Non-Diabetic Patients

2018 ◽  
Vol 25 ◽  
pp. 30-34
Author(s):  
Z Rahman ◽  
ASMM Rahman ◽  
ARMS Ekram ◽  
R Uddin ◽  
MK Rahman ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Asian Population ◽  
Diabetic Patients ◽  
South Asian Population ◽  
College Hospital ◽  
Cross Sectional ◽  
Acute Hyperglycemia ◽  
Coronary Syndrome ◽  
Study Population ◽  
Glucose Abnormalities

The risk of diabetes mellitus and coronary heart disease is high among South-Asian population. In this study, our objective was to measure blood glucose level during acute coronary syndrome of previously known non-diabetic patients that will give the information about the frequency of acute hyperglycemia in acute coronary syndrome (ACS) among Bangladeshi population. It is an observational cross sectional study performed in Rajshahi Medical College Hospital. A total of 248 non-diabetic subjects with ACS got admitted into hospital. FBS and standard OGTT within 3 days of ACS were done. This study was done to find out glucose abnormalities among ACS patients. Out of 248 study population, 135(54.44%) had glucose abnormalities. Male was 87.10% (216). Among male, IGT (prediabetic) was 31.94% (69) and diabetic 24.54% (53). Mean age (±SD) of our study population was 51.71±11.84 years. Normal glucose tolerance (NGT) was found in 45.6% (113) cases, IGT (prediabetic) and diabetic were detected among 30.6% (76) and 23.8% (59) cases respectively. Non-diabetic Bangladeshi patients showed a high prevalence of hyperglycemia in acute coronary syndrome (ACS). We should create awareness about a new risk factor- acute hyperglycemia during acute coronary syndrome and take appropriate and effective measures to reduce morbidity as well as mortality as a consequence of acute hyperglycemia during ACS with or without diabetes.TAJ 2012; 25: 30-34

scholarly journals Glycemic Status During Acute Coronary Syndrome of Non-Diabetic Patients

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 697-699
Author(s):  
Md Zillur Rahman ◽  
Nazmun Nahar ◽  
Md Azizul Hoque ◽  
Md Moksedur Rahman ◽  
Md Daharul Islam ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Fasting Blood Glucose ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Acute Hyperglycemia ◽  
Coronary Syndrome ◽  
Study Population ◽  
Glucose Abnormalities

The risk of diabetes mellitus and coronary heart disease is high among South-Asian population. In this study, our objective was to measure blood glucose level during acute coronary syndrome of previously known nondiabetic patients that will give the information about the frequency of acute hyperglycemia in acute coronary syndrome (ACS) among Bangladeshi population. It is an observational cross sectional study performed in Rajshahi Medical College Hospital (RMCH). A total of 248 non-diabetic subjects with ACS got admitted into hospital. Fasting blood glucose (FBS) and standard oral glucose tolerance test (OGTT ) within 3 days of ACS were done. This study was done to find out glucose abnormalities among ACS patients. Out of 248 study population, 135 (54.44%) had glucose abnormalities. Male was 87.10% (216). Among male, IGT (prediabetic) was 31.94% (69) and diabetic 24.54% (53). Mean age (±SD) of our study population was 51.71±11.84 years. Normal glucose tolerance (NGT) was found in 45.6% (113) cases, IGT (prediabetic) and diabetic were detected among 30.6% (76) and 23.8% (59) cases respectively. Non-diabetic Bangladeshi patients showed a high prevalence of hyperglycemia in acute coronary syndrome (ACS). We should create awareness about a new risk factor- acute hyperglycemia during acute coronary syndrome and take appropriate and effective measures to reduce morbidity as well as mortality as a consequence of acute hyperglycemia during ACS with or without diabetes.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 697-699

scholarly journals Clinical Characteristics and Angiographic Profile of Acute Coronary Syndrome Patients in a Tertiary Hospital of Bangladesh

2018 ◽  
Vol 33 (1) ◽  
pp. 10-15
Author(s):  
Mohsin Ahmed ◽  
Khandaker Abu Rubaiyat ◽  
Mohammed Abaye Deen Saleh ◽  
Abdul Wadud Chowdhury ◽  
CM Khudrate E Khuda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Healthy Person ◽  
Diabetic Patients ◽  
College Hospital ◽  
Coronary Syndrome ◽  
Triple Vessel Disease ◽  
Artery Disease

Aims: Coronary artery disease is a devastating disease precisely because an otherwise healthy person in the prime of life may die or become disabled without warning. The objectives were to study the clinical profile, risk factors prevalence, angiographic distribution and severity of coronary artery stenosis in acute coronary syndrome (ACS) patients admitted in Cardiology Department of Dhaka Medical College Hospital, Dhaka.Materials and Methods: A total of 800 patients of ACS were analyzed for various risk factors, angiographic patterns and severity of coronary artery disease at DMCH, Dhaka, Bangladesh.Results: Mean age of presentation was 51.27±8.80 years. Majority were male 628 (78.5%) and rest were females (21.5%). Most patients had ST elevated myocardial infarction (STEMI) 509 (63.6%) followed by non-STEMI (NSTEMI) 207 (25.9%) and Unstable Angina (UA) 84 (10.5%). Risk factors: smoking was present in 388 (48.5%), hypertension in 289 (36.13%), diabetes in 235 (29.38%), dyslipidaemia in 169 (21.13%) and obesity in 356 (44.5%) patients. Singlevessel disease was present in 30.32% patients, Doublevessel disease was present in 23.23% patients and Triple vessel disease was present in 27.15% patients.Conclusion: STEMI was the most common presentation. ACS occurred earlier in comparison to Western population. Smoking was most prevalent risk factor. Diabetic patients had more multivessel disease.Bangladesh Heart Journal 2018; 33(1) : 10-15

scholarly journals Frequency of CYP2C19*2 Allele in Patients with Acute Coronary Syndrome: A Cross-sectional Study from Central Kerala, India

2021 ◽  
Author(s):  
Christina Ann George ◽  
Shibu Thadathil Sreedharan ◽  
Smitha Kalarikkal Satheesan ◽  
Sindhu Panakkaparambil Surendranath
Keyword(s):  
Acute Coronary Syndrome ◽  
Cross Sectional Study ◽  
Government Medical College ◽  
Sectional Study ◽  
Therapy Failure ◽  
Cross Sectional ◽  
Medical College ◽  
Coronary Syndrome ◽  
Variant Genotype ◽  
Study Population

Introduction: Ischaemic Heart Diseases (IHD) are increasing at an alarming rate globally. Pharmacotherapy, the mainstay of management of IHD, has Dual Antiplatelet Therapy (DAPT) at its crux. DAPT, comprising of clopidogrel and aspirin, is used often for 12 months in medically managed Acute Coronary Syndrome (ACS). Clopidogrel being a prodrug, needs to be activated after ingestion, mainly by Cytochrome family of enzymes, for the desired pharmacological effects. Abnormal enzymes that convert clopidogrel to its active form can reduce the effectiveness of the drug. Therefore, Single Nucleotide Polymorphisms (SNPs) of the enzymes involved, would predispose the patient to therapy failure and recurrence of the illness. This study aims at identifying the presence of a genetic variant associated with clopidogrel responsiveness in patients with ACS. Aim: To estimate the frequency of CYP2C19*2 allele in patients with ACS presenting to Government Medical College, Thrissur, Kerala, India. Materials and Methods: Present study was a cross-sectional study done among 60 patients who presented to Government Medical College, Thrissur with ACS, between June 2018 to June 2019. Having obtained informed consent from the participants blood samples were collected in Ethylene diamine tetra-acetic Acid (EDTA) tubes. Samples were used to look for presence of CYP2C19*2 allele by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Out of 60 patients 38 were males and 22 were females. Most common age group was 61-65 years. The frequency of CYP2C19*2 allele was 41% in the study population and the variant genotype (AA/AG) was present in 62%. Conclusion: The variant genotype was found to be present in a high frequency in the study population implying the high risk for therapy failure in the study population. This asserts the need to probe the matter further, as the gene is also implicated in the metabolism of several other drugs. The introduction of pharmacogenomic testing prior to initiation of therapy may be therefore recommended for better treatment outcome. However, to validate the same, further studies with larger sample size may be necessary.

scholarly journals Prevalence of fatty liver in type 2 Diabetic patients: Experience from northern Bangladesh

2018 ◽  
Vol 27 (2) ◽  
pp. 11-13
Author(s):  
M Akhtarul Islam ◽  
PM Basak ◽  
BC Sarkar ◽  
MMR Khan ◽  
MM Khanam ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Diabetic Patients ◽  
Fatty Change ◽  
Type 2 Diabetic Patients ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Study Population ◽  
Patients Experience

This study was done to find out the prevalence of fatty liver in type2 Diabetic patients. This was a descriptive cross-sectional comparative study carried out in Department of Medicine, Rajshahi Medical College Hospital and Rajshahi Diabetic Association Hospital from July 2008 to June 2010. 100 (one hundred) diagnosed type2 diabetic patients were included. All of those study population were free from taking any hepatoxic drugs and free from any preexisting liver disease. This exclusion was done by history, through clinical examination and relevant investigations. Among 100 type2 diabetic patients, 66 (66%) had normal, 25 (25%) had mild fatty change, 6 (6%) had moderate fatty change in liver; 2 (2%) had mild hepatomegally and 1 (1%) had congested liver. Non had cirrhosis or hepatocellular carcinoma.TAJ 2014; 27(2): 11-13

scholarly journals Diabetic Cardiovascular Autonomic Neuropathy

2021 ◽  
Author(s):  
Amira Siddig ◽  
Abbasher Hussien Mohamed Ahmed ◽  
Khabab Abbasher Hussien Mohamed Ahmed ◽  
Mohammed Eltahier Abdalla Omer
Keyword(s):  
Autonomic Neuropathy ◽  
Diabetic Neuropathies ◽  
Cardiovascular Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Study Population

Abstract Introduction: Diabetic neuropathies are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves. Cardiac autonomic neuropathy (CAN) represents a serious complication associated with Diabetic neuropathies. Objectives: The aim of the study is to investigate the presence of cardiovascular diabetic autonomic neuropathy in a group of adult diabetic Sudanese patients with ischemic heart disease. Methodology: This is a descriptive prospective cross sectional hospital based study. The study population included type 1 and type 2 diabetic patients admitted to the cardiac care unit in ELshaab Teaching Hospital with acute coronary syndrome over a period of two years, from April 2017to April 2019. Results: A total of 49 males (65.33%) and 26 females (34.67%) were included in the study. CAN was detected in 94.67% of the studied group Conclusion: An incidence of 94.67% cardiovascular autonomic neuropathy in our sample indicates a high occurrence of this syndrome among our diabetic patients. Poor glycemic control is a common feature among our studied group. Sub-clinical autonomic neuropathy can be detected early using autonomic function tests.

Abstract 573: Relation between Admission Plasma Glucose and In-Hospital Mortality is Different between Diabetic and Non-Diabetic Patients with Acute Myocardial Infarction

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Masaharu Ishihara ◽  
Sunao Kojima ◽  
Masami Kosuge ◽  
Kazuo Kimura ◽  
Hisao Ogawa
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Hospital Mortality ◽  
Hospital Admission ◽  
Plasma Glucose ◽  
Linear Relation ◽  
Diabetic Patients ◽  
Acute Hyperglycemia ◽  
Coronary Syndrome

It has been well demonstrated that acute hyperglycemia is associated with high mortality after acute myocardial infarction (AMI). However, optimal plasma glucose (PG) level is not known. The relation between PG and mortality may be different between diabetic and non-diabetic patients. This study consisted of 3,750 patients who were admitted to the 35 hospitals participating to the Japanese Acute Coronary Syndrome Study (JACSS) group within 48 hours after the onset of AMI. PG was measured at the time of hospital admission. In non-diabetic patients, there was a linear relation between PG and in-hospital mortality. Non-diabetic patients with PG <6 mmol/L had the lowest mortality (2.5%). As PG increased by 1 mmol/L, mortality increased by 17% (13%–21%, p<0.001). However, in diabetic patients, there was a U-shape relation between PG and mortality (Figure ). Diabetic patients with PG 9–10 mmol/L had the lowest mortality (1.9%); both diabetic patients with PG <7 mmol/L (9.4%, p=0.009) and those with PG ≥11 mmol/L (9.1%, p<0.001) had significantly higher mortality than those with PG 7–11 mmol/L (3.2%). Diabetic patients with PG 9–10 mmol/L had the lowest mortality, whereas lower PG was better in non-diabetic patients. Optimal PG level may be different between diabetic and non-diabetic patients with AMI.

scholarly journals ACUTE CORONARY SYNDROME;

2017 ◽  
Vol 24 (12) ◽  
pp. 1818-1822
Author(s):  
Huma Muzaffar ◽  
Shakeel Ahmad ◽  
Naeem Asghar
Keyword(s):  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional ◽  
Coronary Syndrome ◽  
Study Population ◽  
Artery Disease ◽  
Medical Wards

Objectives: To determine the frequency of raised low density lipoprotein (LDL)cholesterol in patients with acute coronary syndrome. Study Design: Cross sectional study.Setting: Coronary care unit (CCU) and medical wards at Allied Hospital Faisalabad. Durationand Dates: Six months from 01-01-2010 to 30-06-2010. Methods: This was a cross sectionalstudy that included 215 patients fulfilling the criteria of acute coronary syndrome admittingin CCU and medical wards. The demographic details, history and clinical examination of thepatients were recorded and blood samples were collected for the estimation of LDL cholesterol.Statistical Test: Descriptive statistics like mean and standard deviation (S.D) was appliedon age and LDL cholesterol. Gender and type of coronary artery event will be presented aspercentages. Frequency of raised LDL cholesterol was calculated in patients with ACS. Results:In this study population, out 215 patients, 183 (85.1) were found to have raised LDL cholesterollevels. There were 117 (54.4) males and 98 (45.6) females. Mean age was 56.29+- 13.01. Thefrequency of raised level of LDL cholesterol was slightly high in among males. STEMI was mostcommon type of ACS followed by unstable angina and NSTEMI. Conclusions: Frequency ofraised LDL cholesterol was high among the patients with acute coronary syndrome. It supportsthe potential for preventive efforts in persons with high risk of coronary artery disease.

scholarly journals Evaluation of Liver Function Tests in Type2 Diabetic patients

2018 ◽  
Vol 29 (1) ◽  
pp. 21-23
Author(s):  
M Akhtarul Islam ◽  
MMR Khan ◽  
PM Basak ◽  
MM Khanam ◽  
PM Bhattacharyya
Keyword(s):  
Liver Function Tests ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Normal People ◽  
Study Population ◽  
Moderate Elevation

This was a descriptive cross-sectional comparative study carried out in Department of Medicine, Rajshahi Medical College Hospital and Rajshahi Diabetic Association Hospital from July 2008 to June 2010. 100 (one hundred) diagnosed type2 diabetic patients and 30 apparently healthy people were included. All of those study population were free from taking any hepatoxic drugs and free from any preexisting liver disease. This exclusion was done by history, through clinical examination and relevant investigations. The prevalence of abnormal serum bilirubin, ALT, AST, Alkaline phosphatase, prothrombin time and S. albumin were 6%, 30%, 7%, 6%, 54% and 12% respectively in type2 diabetic patients and 00%, 3.3%, 00%, 6.7%, 10% and 3.3% respectively in normal people. All the LFTs of type 2 diabetic patients were mildly abnormal except 2 patients (2%) had moderate elevation of ALT, 7 patient (7%) had markedly prolonged PT, and 1 patient (1%) had moderately decreased s. albumin. In normal people all LFTs abnormalities were mild.TAJ 2016; 29(1): 21-23

scholarly journals Gender based differences in clinical and Angiographic characteristics and outcomes of Acute Coronary Syndrome (ACS) in Asian population

2019 ◽  
Vol 35 (5) ◽  
Author(s):  
Afrasyab Altaf ◽  
Hammad Shah ◽  
Momin Salahuddin
Keyword(s):  
Acute Coronary Syndrome ◽  
Rural Population ◽  
Asian Population ◽  
Anterior Wall ◽  
Limited Data ◽  
Cross Sectional ◽  
Creative Commons ◽  
Coronary Syndrome ◽  
Gender Based ◽  
Open Access Article

Objective: There is very limited data about gender based differences in Acute Coronary Syndrome (ACS) in Asian population. This study was therefore aimed to ascertain gender based differences in clinical and angiographic characteristics and clinical outcomes in patient admitted with ACS. Methods: This was a cross sectional, observational study including patients admitted with diagnosis of ACS. Patients were divided into two groups (Males and Females) and their clinical characteristics were noted. Gender based assessment was done following coronary angiography. Results: A total of 386 patients were included, with 210 males and 176 females. Anterior wall myocardial infarction (AWMI) was present in 177(45.86%) patients. Mean age was 72.8±12.9 years in females and 66.8±11.2 years in males. Diabetes was present in 38.1% females and 31% males. Patients from rural population were 225(58.3%), while from urban 161(41.7%). Mean ejection fraction was 43.9±7.9% in women and 38.2±8.68% in males. Conclusion: ACS was more common in males, rural population and AWMI was most common cause. Women were more elderly and had more adverse events as compared to males. Impaired renal dynamics were more commonly observed in males. Women were less aggressively treated with coronary interventions and radial approach was better tolerated regardless of gender. doi: https://doi.org/10.12669/pjms.35.5.743 How to cite this:Altaf A, Shah H, Salahuddin M. Gender based differences in clinical and Angiographic characteristics and outcomes of Acute Coronary Syndrome (ACS) in Asian population. Pak J Med Sci. 2019;35(5):---------. doi: https://doi.org/10.12669/pjms.35.5.743 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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