scholarly journals СИСТЕМИ ВІРТУАЛЬНИХ ЛАБОРАТОРНИХ РОБІТ З БІОФІЗИКИ ЯК ЗАСОБИ РЕАЛІЗАЦІЇ ПРИНЦИПУ ПРОФЕСІЙНОЇ СПРЯМОВАНОСТІ НАВЧАННЯ СТУДЕНТІВ

2019 ◽  
Vol 70 (2) ◽  
pp. 141
Author(s):  
Liudmyla P. Sukhovirska ◽  
Olha M. Lunhol ◽  
Oksana V. Zadorozhna
Keyword(s):  
Heart Surgery ◽  
Open Heart Surgery ◽  
Educational Process ◽  
Virtual Learning Environment ◽  
Virtual Laboratory ◽  
Laboratory Work ◽  
Perfusion System ◽  
Software Products ◽  
Biological Physics ◽  
The Creation

The article substantiates expediency and shows the possibility of computer modeling of laboratory works on medical and biological physics for students in the field of training 1201 «Medicine» in the study of the discipline «Medical and Biological Physics». On the example of the laboratory work «Study of the fundamentals of hemodynamics using the apparatus «Perfusion System SORIN C5», the main stages and principles of the creation of virtual laboratory works for institutions of higher medical education were determined. The authors analyze the scientific and methodical literature on the use of specialized software products for reproduction and demonstration of various physical phenomena, the development of virtual laboratories and their implementation in the educational process of higher education institutions. The paper proposes methodical recommendations for the creation of virtual laboratory work in the classes on medical and biological physics for students in the field of training 1201 «Medicine». The article describes the main structural units (menus and submenus), the characteristics and possibilities of using the software developed by the authors in the educational process, which virtually realizes the main stages of the patient's preparation for open heart surgery using the heart-lung machine SORIN C5. The advantages of conducting virtual laboratory works on hemodynamics have been determined, as well as an analysis of educational material with the aim of improving the professional component of medical students' training and their informational and subject competencies. The possibilities of creation a series of laboratory works with their subsequent placement in the virtual learning environment «System of medical and biological physics laboratory works» are considered. Thanks to the leadership of the Municipal Institution «Regional Cardiology Center» (Kropyvnytskyi) for the assistance and provision of information on the work of the apparatus «Perfusion System SORIN C5».

scholarly journals THE EFFECTIVENESS OF IMPLEMENTING "HEART-LUNG MACHINE SORIN C5" SOFTWARE PRODUCT IN THE EDUCATIONAL PROCESS OF MEDICAL UNIVERSITY

2020 ◽  
Vol 76 (2) ◽  
pp. 250-263
Author(s):  
Людмила Павлівна Суховірська ◽  
Ольга Миколаївна Лунгол ◽  
Оксана Володимирівна Задорожна ◽  
Поліна Григорівна Коваленко
Keyword(s):  
Educational Process ◽  
Virtual Laboratory ◽  
Laboratory Work ◽  
Software Product ◽  
Heart Lung Machine ◽  
Biological Physics ◽  
The Difference ◽  
Medical University ◽  
Lung Machine

The article is devoted to the research of the effectiveness of formation of students’ experimental competencies in hydrodynamics and hemodynamics at a medical university using the software "Heart-lung machine SORIN C5" [1]. On the basis of analysis of psychological and pedagogical literature, the professional experimental competencies of medical students are singled out and the role of virtual laboratory works in the development of students’ professional experimental competencies in higher medical education institutions is determined. The authors consider the use of information resources in the educational process on the example of the software product "Laboratory work "Study of the hemodynamics fundamentals using the apparatus "Heart-lung machine SORIN C5", which is an integral part of the discipline "Medical and Biological Physics". The paper describes the main structural elements and implementation of respective scenarios in the virtual laboratory work on hydrodynamics and hemodynamics. The article presents statistical check of the effectiveness of formation of students’ experimental competencies in hydrodynamics and hemodynamics based on the use of Student's t-test. The authors analyze the results of the conducted experiment and show that visualization, the use of web resources in physics and virtual laboratory work contribute to the formation of the logical and epistemological structure of the teaching material and the strengthening of the role of fundamental generalizations of concepts and theories. It is proved that the difference in the knowledge acquisition coefficients in the experimental and control groups is significant and depends not on random samples, but on the difference in the formation of the material structure and teaching methods in medical and biological physics. It has been established that the system of virtual laboratory works contributes to students’ training in general scientific methods of action, forms the proper professional, technological and experimental competence.

scholarly journals Cerebral Effects of Circulatory Arrest at 20° C in the Infant Pig

1974 ◽  
Vol 2 (1) ◽  
pp. 33-42 ◽  
Author(s):  
G. C. Fisk ◽  
J. S. Wright ◽  
B. B. Turner ◽  
W. de C. Baker ◽  
R. G. Hicks ◽  
...  
Keyword(s):  
Brain Damage ◽  
Heart Surgery ◽  
Circulatory Arrest ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Membrane Oxygenator ◽  
Perfusion System ◽  
Experimental Procedure ◽  
Hypothermic Arrest ◽  
Continuous Perfusion

Circulatory arrest at 20° C is used during open heart surgery in infants. It has been stated that significant brain damage does not occur. Piglets between two and six weeks of age were cooled to 20° C using extracorporeal circulation and a membrane oxygenator. After one hour of circulatory arrest the perfusion system was used to rewarm the animals and restore normal circulation. Electroencephalogram was monitored throughout perfusion and surgery, and repeated on surviving animals on the third, fifth, seventh and tenth postoperative days. On the tenth day the animals were killed by injection of pentobarbitone. Other groups were subjected to Continuous perfusion at 20° C, Continuous perfusion at 37° C, Thoracotomy and cannulation, Ischaemia, and Hypoxia. The return of E.E.G. activity was delayed after circulatory arrest compared with those continuously perfused. Lesions were found in the cerebral cortex in all the animals which had circulatory arrest and those subjected to ischaemia and hypoxia. The brains of animals of the other groups were indistinguishable from those killed without any experimental procedure. Despite apparent recovery, brain damage following hypothermic arrest during open heart surgery remains possible.

scholarly journals Measurement Data Collection Device Based on ESP32 for Digital Laboratory

2021 ◽  
Vol 4 (4) ◽  
Author(s):  
Ivan A. Khyzhniak
Keyword(s):  
Data Transfer ◽  
Positive Impact ◽  
Measurement Data ◽  
Educational Process ◽  
Ease Of Use ◽  
Laboratory Work ◽  
Collection Device ◽  
The Creation ◽  
User Friendly ◽  
Digital Training

The potential use of digital laboratories is constantly growing every year, as such a device allows you to conduct research in such fields as biology, physics, chemistry and other natural sciences. It is proved that the use of modern equipment increases the efficiency of laboratory classes in schools. Today, there are a large number of educational digital laboratories, which find many areas of use, from laboratory work at school to laboratories at universities. However, if you analyze these digital labs, you can see that they do not have a user-friendly interface and settings. The purpose of this work is to review existing solutions, as well as find solutions to create an improved version of digital training laboratories. The main disadvantage of existing solutions is the lack of data transfer via Wi-Fi or Bluetooth, as well as connection to a computer or smartphone, which could significantly improve the process of working with such a device. One of the solutions to this problem is the creation of digital training laboratories based on the ESP-32 microcontroller. After analyzing the existing digital laboratories, we can conclude that this area needs improvement, as existing technologies allow to create much better devices in terms of ease of use and opportunities for educational purposes. Bluetooth and Wi-Fi are the main elements, the addition of which will significantly improve digital laboratories. One such solution is the ESP-32 microcontroller, as it includes these modules, and its technical characteristics allow you to create a device that will collect data simultaneously from many connected sensors. The creation of a digital laboratory with such characteristics will significantly improve the process of laboratory work in schools and universities, as well as allow more organized distance learning online, which will have a positive impact on the educational process in schools and universities.

scholarly journals Methodology Of Using A Virtual Laboratory To Determine The Breaking Indication Of The Environment (Glass)

2021 ◽  
Vol 03 (04) ◽  
pp. 584-587
Author(s):  
Kodirova Khamida Nurmuhamadovna ◽  
Keyword(s):  
Refractive Index ◽  
Virtual Laboratory ◽  
Laboratory Work ◽  
Theoretical Knowledge ◽  
Angle Of Incidence ◽  
The Creation

The article describes the creation and use of virtual laboratory work to determine the refractive index of the medium (glass), the ability of students to observe the process in this virtual laboratory work, the angle of incidence of light, the refractive index of the first medium ideas on how to reinforce the theoretical knowledge gained and qualify, along with the construction of error values on the screen.

scholarly journals Detailed analysis of the advantages of virtual laboratory works in physics

2021 ◽  
pp. 32-37
Author(s):  
Alexandr Shamshin
Keyword(s):  
Initial Conditions ◽  
Virtual Laboratory ◽  
Laboratory Work ◽  
Measuring Instruments ◽  
Remote Work ◽  
Laboratory Equipment ◽  
Software Products ◽  
Wolfram Mathematica ◽  
Research Competencies ◽  
Definition Of

Due to the fact, that there is a significant modernization of university laboratory equipment, the widespread transition to computer measurement systems, the widespread introduction of Internet technologies for conducting theoretical and laboratory studies, a number of virtual laboratory works (VLW) have been developed using software resources, such as MATLAB, LabVIEW, LabVIEW Web services, VIPM Browser National Instruments, Wolfram Mathematica, Flash Adobe. The purpose of creating the lab works under consideration was to instill the skills of working with measuring instruments, independent measurements and calculations by each student, the ability to do research on the topic of lab by changing the initial conditions of the system and analyzing their influence on the behavior of the system. It was studied, what in common and what differences have VLW and real laboratory work (RLW) in terms of didactic goals, their content, role in obtaining practical skills, acquiring research competencies. The definition of VLW and RLW, as well as the corresponding remote work, is given. The advantages, possibilities, expediency of the development and application of VLW, created on software products and simulating real physical processes, phenomena and patterns, are discussed. Prospects for further research of VLW with the involvement of actual material of real laboratory work, methods of their software implementation and modeling packages are outlined

Enhanced Effective Fibrinolysis following the Neutralization of Heparin in Open Heart Surgery Increases the Risk of Post-Surgical Bleeding

1990 ◽  
Vol 63 (02) ◽  
pp. 241-245 ◽  
Author(s):  
Jørgen Gram ◽  
Thomas Janetzko ◽  
Jørgen Jespersen ◽  
Hans Dietrich Bruhn
Keyword(s):  
Blood Loss ◽  
Plasminogen Activator ◽  
Heart Surgery ◽  
Degradation Products ◽  
Open Heart Surgery ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Chest Tube Drain ◽  
Median Blood Loss

SummaryThe tissue-type plasminogen activator related fibrinolytic system was studied in 24 patients undergoing cardiopulmonary bypass surgery. The degradation of fibrinogen and fibrin was followed during and after surgery by means of new sensitive and specific assays and the changes were related to the blood loss measured in the chest tube drain during the first 24 postoperative hours. Although tissue-type plasminogen activator was significantly released into the circulation during the period of extracor-poreal circulation (p <0.01), constantly low levels of fibrinogen degradation products indicated that a systemic generation of plasmin could be controlled by the naturally occurring inhibitors. Following extracorporeal circulation heparin was neutralized by protamine chloride, and in relation to the subsequent generation of fibrin, there was a short period with increased concentrations of fibrinogen degradation products (p <0.01) and a prolonged period of degradation of cross-linked fibrin, as detected by increased concentrations of D-Dimer until 24 h after surgery (p <0.01). Patients with a higher than the median blood loss (520 ml) in the chest tube drain had a significantly higher increase of D-Dimer than patients with a lower than the median blood loss (p <0.05).We conclude that the incorporation of tissue-type plasminogen activator into fibrin and the in situ activation of plasminogen enhance local fibrinolysis, thereby increasing the risk of bleeding in patients undergoing open heart surgery

The Hemostatic Mechanism after Open-Heart Surgery

1978 ◽  
Vol 39 (02) ◽  
pp. 474-487 ◽  
Author(s):  
E R Cole ◽  
F Bachmann ◽  
C A Curry ◽  
D Roby
Keyword(s):  
Extracorporeal Circulation ◽  
Heart Surgery ◽  
Polyacrylamide Gel Electrophoresis ◽  
Open Heart Surgery ◽  
Coagulation System ◽  
Open Heart ◽  
Time Activity ◽  
Post Surgery ◽  
Plasma Fractions ◽  
The Mean

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.

Blood Coagulation Studies and Extracorporeal Circulation in Man

1967 ◽  
Vol 18 (03/04) ◽  
pp. 634-646 ◽  
Author(s):  
N Thurnherr
Keyword(s):  
Blood Coagulation ◽  
Extracorporeal Circulation ◽  
Blood Clotting ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Fibrinolytic System ◽  
Open Heart ◽  
Clotting Factors ◽  
Blood Clotting Factors

SummaryBlood clotting investigations have been executed in 25 patients who have undergone open heart surgery with extracorporeal circulation. A description of alterations in the activity of blood clotting factors, the fibrinolytic system, prothrombin consumption and platelets during several phases of the operation is given.

Monitoring of r-Hirudin Anticoagulation during Cardiopulmonary Bypass – Assessment of the Whole Blood Ecarin Clotting Time

1997 ◽  
Vol 77 (05) ◽  
pp. 0920-0925 ◽  
Author(s):  
Bernd Pötzsch ◽  
Katharina Madlener ◽  
Christoph Seelig ◽  
Christian F Riess ◽  
Andreas Greinacher ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Whole Blood ◽  
Heart Surgery ◽  
Ex Vivo ◽  
Open Heart Surgery ◽  
Clotting Time ◽  
Blood Samples ◽  
Alternative Approach ◽  
Ecarin Clotting Time

SummaryThe use of recombinant ® hirudin as an anticoagulant in performing extracorporeal circulation systems including cardiopulmonary bypass (CPB) devices requires a specific and easy to handle monitoring system. The usefulness of the celite-induced activated clotting time (ACT) and the activated partial thromboplastin time (APTT) for r-hirudin monitoring has been tested on ex vivo blood samples obtained from eight patients treated with r-hirudin during open heart surgery. The very poor relationship between the prolongation of the ACT and APTT values and the concentration of r-hirudin as measured using a chromogenic factor Ila assay indicates that both assays are not suitable to monitor r-hirudin anticoagulation. As an alternative approach a whole blood clotting assay based on the prothrombin-activating snake venom ecarin has been tested. In vitro experiments using r-hirudin- spiked whole blood samples showed a linear relationship between the concentration of hirudin added and the prolongation of the clotting times up to a concentration of r-hirudin of 4.0 µg/ml. Interassay coefficients (CV) of variation between 2.1% and 5.4% demonstrate the accuracy of the ecarin clotting time (ECT) assay. Differences in the interindividual responsiveness to r-hirudin were analyzed on r-hirudin- spiked blood samples obtained from 50 healthy blood donors. CV- values between 1.8% and 6% measured at r-hirudin concentrations between 0.5 and 4 µg/ml indicate remarkably slight differences in r-hirudin responsiveness. ECT assay results of the ex vivo blood samples linearily correlate (r = 0.79) to the concentration of r-hirudin. Moreover, assay results were not influenced by treatment with aprotinin or heparin. These findings together with the short measuring time with less than 120 seconds warrant the whole blood ECT to be a suitable assay for monitoring of r-hirudin anticoagulation in cardiac surgery.

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