The Impact of Sequencing Genomes on The Human Longevity Project

Treating old age diseases to achieve human longevity is the greatest challenge. This abstract describes how human longevity is shortened by three old aged deadly diseases namely Cancer, Cardiovascular Diseases and Alzheimer. To prolong human life beyond one hundred years, we focus on the rational drug design to treat one old age disease one at a time. Our work began on Cancers starting in England and completed in America. More research fund is available by both The Royal Cancer Hospital of the University of London, England, and The National Cancer Institute (NCI) of America to develop drugs to treat Cancer than any other diseases. We describe below how novel drugs, like Aziridine Dinitro-benzamide (CB1954) was developed in England to treat Cancer in animals, such as Walker Carcinoma 256, a solid aggressive tumor in Rats and how the animal work is translated in humans, by developing AZQ (US Patent 4,146,622) a rationally designed drug to treat Glioblastoma, a solid aggressive brain tumor in human at the NCI. For the discovery of AZQ, our work was honored with, “The 2004, NIH Scientific Achievement Award” one of America’s highest awards in medicine.” Using the same rational approach, this abstract also describes how novel drugs could be developed on rational basis to treat Breast and Prostate Cancer to achieve human Longevity. Ethical issues achieving longevity are also described.

Download Full-text

The Trouble with Digital Copies

Ethical Issues and Social Dilemmas in Knowledge Management ◽

10.4018/978-1-61520-873-9.ch007 ◽

2011 ◽

pp. 97-112 ◽

Cited By ~ 1

Author(s):

Ugo Pagallo

Keyword(s):

Knowledge Management ◽

Business Models ◽

Ethical Issues ◽

Organizational Innovation ◽

Human Life ◽

File Sharing ◽

Application Systems ◽

Digital Environments ◽

The Right ◽

The Impact

This chapter analyzes some of the most relevant ethical issues and social dilemmas in knowledge management and organizational innovation, by focusing on a paramount feature of digital technology, which is “copying.” The new ways in which information is produced, distributed, and shared in digital environments have in fact changed crucial aspects of human life. Whereas, most of the time, scholars consider such transformations in connection with the impact of digital copies on copyright law, the aim of the chapter is to widen this perspective by examining data protection as well as file sharing application systems. The new economical scenarios and business models proposed by this copy-based technology suggest new ways for balancing property rights and “the right to freely participate in the cultural life of the community.”

Download Full-text

The Trouble with Digital Copies

Digital Rights Management ◽

10.4018/978-1-4666-2136-7.ch069 ◽

2013 ◽

pp. 1379-1394

Author(s):

Ugo Pagallo

Keyword(s):

Knowledge Management ◽

Business Models ◽

Ethical Issues ◽

Organizational Innovation ◽

Human Life ◽

File Sharing ◽

Application Systems ◽

Digital Environments ◽

The Right ◽

The Impact

Download Full-text

The Impact of Third Party Reproduction on Family and Kinship

Journal of Reproduction & Infertility ◽

10.18502/jri.v22i1.4990 ◽

2020 ◽

Author(s):

Zohreh Behjati Ardakani ◽

Mehrdad Navabakhsh ◽

Soraya Tremayne ◽

Mohammad Mehdi Akhondi ◽

Fahimeh Ranjbar ◽

...

Keyword(s):

Ethical Issues ◽

Assisted Reproductive Technologies ◽

Human Life ◽

Reproductive Technologies ◽

Unintended Consequences ◽

Third Party ◽

Human Reproduction ◽

The Family ◽

The Impact

The development of in vitro fertilization (IVF) in the UK, in 1978, proved a major breakthrough in the process of human reproduction, which had remained constant in human history. The impact of IVF and the ensuing assisted reproductive technologies (ARTs) has not been limited in revolutionizing the "natural" practice of biological reproduction, but has reached out to and affected almost every institution in society. Family and kinship, as the social expression of reproduction and the institutions which are the most transparently structured realm of human life are those most profoundly affected by ARTs. Although literature on the implications of ARTs is in general abundant, this article presents new insights on their impact on family and kinship in Iran, which remains a unique case in the Muslim world. It explores the particular way ARTs, especially third-party donation, have been endorsed and practiced in Iran, and their consequences for the family, the infertile individuals, and their position vis-à-vis their kin and social group. The conclusion points to the lack of clarity concerning the initial rulings by the Islamic jurists, who allowed the practice of ARTs, and which has led to a number of unintended consequences regarding the legal, religious, cultural, and ethical issues, affecting the family, its structure and the relationship between the kin group. These consequences range, inter alia, from the question of the anonymity of third-party donor, to the permissibility of gamete donation between blood relatives, and to the absence of enforceable legislation.

Download Full-text

Research Participation Experiences of Informants of Suicide and Control Cases

Crisis ◽

10.1027/0227-5910/a000025 ◽

2010 ◽

Vol 31 (5) ◽

pp. 238-246 ◽

Cited By ~ 9

Author(s):

Paul W. C. Wong ◽

Wincy S. C. Chan ◽

Philip S. L. Beh ◽

Fiona W. S. Yau ◽

Paul S. F. Yip ◽

...

Keyword(s):

Ethical Issues ◽

Research Participation ◽

Self Report ◽

Initial Contact ◽

Psychological Autopsy ◽

Autopsy Study ◽

The People ◽

And Control ◽

The Impact

Background: Ethical issues have been raised about using the psychological autopsy approach in the study of suicide. The impact on informants of control cases who participated in case-control psychological autopsy studies has not been investigated. Aims: (1) To investigate whether informants of suicide cases recruited by two approaches (coroners’ court and public mortuaries) respond differently to the initial contact by the research team. (2) To explore the reactions, reasons for participation, and comments of both the informants of suicide and control cases to psychological autopsy interviews. (3) To investigate the impact of the interviews on informants of suicide cases about a month after the interviews. Methods: A self-report questionnaire was used for the informants of both suicide and control cases. Telephone follow-up interviews were conducted with the informants of suicide cases. Results: The majority of the informants of suicide cases, regardless of the initial route of contact, as well as the control cases were positive about being approached to take part in the study. A minority of informants of suicide and control cases found the experience of talking about their family member to be more upsetting than expected. The telephone follow-up interviews showed that none of the informants of suicide cases reported being distressed by the psychological autopsy interviews. Limitations: The acceptance rate for our original psychological autopsy study was modest. Conclusions: The findings of this study are useful for future participants and researchers in measuring the potential benefits and risks of participating in similar sensitive research. Psychological autopsy interviews may be utilized as an active engagement approach to reach out to the people bereaved by suicide, especially in places where the postvention work is underdeveloped.

Download Full-text

A randomized controlled pilot study examining the impact of exercise on sleep quality (SQ) and sleep modulating cytokines among breast and prostate cancer (BC & PC) patients receiving radiation (RTH)

PsycEXTRA Dataset ◽

10.1037/e548132012-028 ◽

2010 ◽

Author(s):

Karen Mustian ◽

Oxana Palesh ◽

Lisa Sprod ◽

Luke Peppone ◽

Charles Heckler ◽

...

Keyword(s):

Prostate Cancer ◽

Pilot Study ◽

Sleep Quality ◽

Randomized Controlled ◽

Breast And Prostate Cancer ◽

The Impact

Download Full-text

Maintaining the Status Quo: The Impact of Old-Age Interest Groups on the Medicare Catastrophic Coverage Act of 1988

Social Problems ◽

10.1525/sp.1993.40.4.03x0090l ◽

1993 ◽

Vol 40 (4) ◽

pp. 431-444 ◽

Cited By ~ 2

Author(s):

Debra Street

Keyword(s):

Interest Groups ◽

Old Age ◽

Status Quo ◽

The Status ◽

Catastrophic Coverage ◽

The Impact

Download Full-text

Forms of physical activity of the elderly

European Journal of Clinical and Experimental Medicine ◽

10.15584/ejcem.2020.3.10 ◽

2020 ◽

Vol 18 (3) ◽

pp. 221-228

Author(s):

Piotr Czarnecki ◽

◽

Justyna Podgórska-Bednarz ◽

Lidia Perenc ◽

◽

...

Keyword(s):

Physical Activity ◽

Elderly People ◽

Population Aging ◽

Human Life ◽

Good Health ◽

The Elderly ◽

Polish Society ◽

Central Statistical ◽

Key Phrases ◽

The Impact

Introduction. Physical activity is known to be an important factor influencing health throughout human life. This issue has become crucial for public health due to the aging of the population in both developed and developing countries. Aim. is to present a literature review on the forms of physical activity undertaken by the elderly, as well as on issues related to physical activity and the population aging. Material and methods. The study was prepared on the basis of a review of Polish and foreign literature. The following databases and data sources were used: EBSCO, ScienceDirect and Google Scholar. An additional source of data were the websites of the Central Statistical Office. Strictly defined key phrases were used during the collection of literature. The work has been divided into thematic subsections on the aging of the society, the impact of physical activity on health and the main topic, i.e. forms of physical activity selected by the elderly. Analysis of the literature. The number of elderly people in Polish society has increased by almost 3.7 million over three decades. Therefore, an important topic is prophylaxis aimed at increasing the number of days in good health, largely covering the broadly understood activation of the elderly. The available data indicate that only 12% of elderly people undertake physical activity once a week. The most common form of spending free time actively is walking (as many as 73% of people in this population declare this form of physical activity in one of the presented studies). Conclusion. Organized forms of physical activity are undertaken much less frequently by the analyzed age group mainly due to financial limitations and limited availability of sports infrastructure.

Download Full-text

The Status of Mind and Intellect in Digital Environment

Russian Journal of Philosophical Sciences ◽

10.30727/0235-1188-2019-63-2-123-143 ◽

2020 ◽

Vol 63 (2) ◽

pp. 123-143

Author(s):

Elena I. Yaroslavtseva

Keyword(s):

Human Life ◽

Cognitive Activity ◽

Memory Loss ◽

Natural Material ◽

Human Being ◽

Connection To Nature ◽

Digital World ◽

The Status ◽

Natural Foundation ◽

The Impact

The article examines the impact of digitalization on human life and intellectual experience. The development of computer technology demands an understanding of new aspects of human development and requires a capability to overcome not only external conditions but also ourselves. Entering a new level of development cannot imply a complete rejection of previous dispositions, but should be accompanied by reflection on personal experience and by the quest for new forms of interaction in society and with nature. Communicative and cognitive activity of a person has an ontological basis and relies on processes that actually evolve in nature. Therefore, the creation of new objects is always associated with the properties of natural material and gives rise to new points of support in the development of man. The more audacious his projects, the more important it is to preserve this connection to nature. It is always the human being who turns out to be the initiator who knows how to solve problems. The conformity of complex technical systems to nature is not only a goal but also a value of meaningful construction of development perspectives. The key to the nature orientation of the modern digital world is the human being himself, who keeps all the secrets of the culture of his natural development. Therefore, the proposed by the Russian philosopher V.S. Stepin post-non-classical approach, based on the principle of “human-sizedness,” is an important contribution to contemporary research because it draws attention to the “human – machine” communication, to the relationship between a person and technological systems he created. The article concludes that during digital transformation, a cultural conflict arises: in an effort to solve the problems of the future, a person equips his life with devices that are designed to support him, to expand his functionality, but at the same time, the boundaries of humanity become dissolved and the forms of human activity undergo simplification. Transhumanism engages society in the fight against fears of vulnerability and memory loss and ignores the flexibility and sustainability of natural foundation.

Download Full-text