scholarly journals Trace Elements Have Beneficial, as Well as Detrimental Effects on Bone Homeostasis

2017 ◽  
pp. 391-402 ◽  
Author(s):  
I. ZOFKOVA ◽  
M. DAVIS ◽  
J. BLAHOS
Keyword(s):  
Vitamin D ◽  
Trace Elements ◽  
Protective Role ◽  
Childhood And Adolescence ◽  
Bone Homeostasis ◽  
Duration Of Treatment ◽  
Copper Manganese ◽  
Cobalt Deficiency ◽  
Manganese Magnesium

The protective role of nutrition factors such as calcium, vitamin D and vitamin K for the integrity of the skeleton is well understood. In addition, integrity of the skeleton is positively influenced by certain trace elements (e.g. zinc, copper, manganese, magnesium, iron, selenium, boron and fluoride) and negatively by others (lead, cadmium, cobalt). Deficiency or excess of these elements influence bone mass and bone quality in adulthood as well as in childhood and adolescence. However, some protective elements may become toxic under certain conditions, depending on dosage (serum concentration), duration of treatment and interactions among individual elements. We review the beneficial and toxic effects of key elements on bone homeostasis.

Changes in bone mineral density in men starting androgen deprivation therapy and the protective role of vitamin D

2013 ◽  
Vol 24 (10) ◽  
pp. 2571-2579 ◽  
Author(s):  
S. M. H. Alibhai ◽  
H. Z. Mohamedali ◽  
H. Gulamhusein ◽  
A. H. Panju ◽  
H. Breunis ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Androgen Deprivation Therapy ◽  
Bone Mineral ◽  
Protective Role ◽  
Androgen Deprivation ◽  
Mineral Density

Effect of electromagnetic waves from mobile phone on immune status of male rats: possible protective role of vitamin D

2017 ◽  
Vol 95 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Ola Ahmed El-Gohary ◽  
Mona Abdel-Azeem Said
Keyword(s):  
Vitamin D ◽  
Immune System ◽  
Mobile Phone ◽  
Protective Role ◽  
Vitamin D Supplementation ◽  
Male Rats ◽  
Control Group ◽  
Group I ◽  
Mobile Phone Radiation

There are considerable public concerns about the relationship between mobile phone radiation and human health. The present study assesses the effect of electromagnetic field (EMF) emitted from a mobile phone on the immune system in rats and the possible protective role of vitamin D. Rats were randomly divided into six groups: Group I: control group; Group II: received vitamin D (1000 IU/kg/day) orally; Group III: exposed to EMF 1 h/day; Group IV: exposed to EMF 2 h/day; Group V: exposed to EMF 1 h/day and received vitamin D (1000 IU/kg/day); Group VI: exposed to EMF 2 h/day and received vitamin D (1000 IU/kg/day). After 30 days of exposure time, 1 h/day EMF exposure resulted in significant decrease in immunoglobulin levels (IgA, IgE, IgM, and IgG); total leukocyte, lymphocyte, eosinophil and basophil counts; and a significant increase in neutrophil and monocyte counts. These changes were more increased in the group exposed to 2 h/day EMF. Vitamin D supplementation in EMF-exposed rats reversed these results when compared with EMF-exposed groups. In contrast, 7, 14, and 21 days of EMF exposure produced nonsignificant differences in these parameters among all experimental groups. We concluded that exposure to mobile phone radiation compromises the immune system of rats, and vitamin D appears to have a protective effect.

The Protective Role of Vitamin D 3 in Colitis-Associated Colorectal Cancer in a Mouse Model

2017 ◽  
Vol 152 (5) ◽  
pp. S804
Author(s):  
Li Ma ◽  
Xin Yu ◽  
Hong Lv ◽  
Hongying Wang ◽  
Jiaming QIan
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Mouse Model ◽  
Protective Role ◽  
Vitamin D 3

scholarly journals Evidence of Protective Role of Ultraviolet-B (UVB) Radiation in Reducing COVID-19 Deaths 

2020 ◽  
Author(s):  
Rahul Kalippurayil Moozhipurath ◽  
Lennart Kraft ◽  
Bernd Skiera
Keyword(s):  
Vitamin D ◽  
Growth Rates ◽  
Protective Role ◽  
Negative Association ◽  
Ultraviolet B ◽  
Cumulative Number ◽  
Uvb Radiation ◽  
Daily Growth ◽  
Percentage Points

Abstract Background. Prior studies indicate the protective role of Ultraviolet-B (UVB) radiation in human health, mediated by vitamin D synthesis. In this observational study, we empirically outline a negative association of UVB radiation as measured by ultraviolet index (UVI) with the number of COVID-19 deaths.Methods. We apply a fixed-effect log-linear regression model to a panel dataset of 152 countries over 108 days (n=6524). We use the cumulative number of COVID-19 deaths and case-fatality rate (CFR) as the main dependent variables and isolate UVI effect from potential confounding factors.Findings. After controlling for time-constant and time-varying factors, we find that a permanent unit increase in UVI is associated with a 1.2 percentage points decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01] and a 1.0 percentage points decline in the CFR daily growth rate [p < 0.05]. These results represent a significant percentage reduction in terms of daily growth rates of cumulative COVID-19 deaths (-11.88%) and CFR (-38.46%).Interpretation. We find a significant negative association between UVI and COVID-19 deaths, indicating evidence of the protective role of UVB in mitigating COVID-19 deaths. If confirmed via clinical studies, then the possibility of mitigating COVID-19 deaths via sensible sunlight exposure or vitamin D intervention will be very attractive.

scholarly journals Evidence of protective role of Ultraviolet-B (UVB) radiation in reducing COVID-19 deaths

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Rahul Kalippurayil Moozhipurath ◽  
Lennart Kraft ◽  
Bernd Skiera
Keyword(s):  
Vitamin D ◽  
Growth Rates ◽  
Protective Role ◽  
Negative Association ◽  
Ultraviolet B ◽  
Cumulative Number ◽  
Uvb Radiation ◽  
Daily Growth ◽  
Percentage Points

Abstract Prior studies indicate the protective role of Ultraviolet-B (UVB) radiation in human health, mediated by vitamin D synthesis. In this observational study, we empirically outline a negative association of UVB radiation as measured by ultraviolet index (UVI) with the number of COVID-19 deaths. We apply a fixed-effect log-linear regression model to a panel dataset of 152 countries over 108 days (n = 6524). We use the cumulative number of COVID-19 deaths and case-fatality rate (CFR) as the main dependent variables and isolate the UVI effect from potential confounding factors. After controlling for time-constant and time-varying factors, we find that a permanent unit increase in UVI is associated with a 1.2 percentage points decline in daily growth rates of cumulative COVID-19 deaths [p < 0.01] and a 1.0 percentage points decline in the CFR daily growth rate [p < 0.05]. These results represent a significant percentage reduction in terms of daily growth rates of cumulative COVID-19 deaths (− 12%) and CFR (− 38%). We find a significant negative association between UVI and COVID-19 deaths, indicating evidence of the protective role of UVB in mitigating COVID-19 deaths. If confirmed via clinical studies, then the possibility of mitigating COVID-19 deaths via sensible sunlight exposure or vitamin D intervention would be very attractive.

Role of Vitamin D in Prevention of Metabolic Syndrome and Cardiovascular Diseases

2021 ◽  
Vol 20 (2) ◽  
pp. 431-438
Author(s):  
Raisa Aringazina ◽  
Gulnara Kurmanalina ◽  
Bakhtiyar Kurmanalin ◽  
Tatyana Degtyarevskaya
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Cardiovascular Events ◽  
Medical Science ◽  
Resistance Index ◽  
Duration Of Treatment

Objective: About 90% of cardiovascular diseases can be prevented. In recent years, the role of vitamin D in the prevention of cardiovascular disease and components of metabolic syndrome has been actively discussed. The study aimed to investigate the possible influence of vitamin D3 on the emergence risk of metabolic syndrome and adverse cardiovascular events. Materials and methods: The study enrolled a total of 336 people (170 males and 166 females) aged 50-60 years. For comparative analysis, two groups were formed: Group 1 group involved 150 people treated with placebo, and Group 2 group included 186 people who received vitamin D3 orally in a dose of 2000 IU/day. The duration of treatment and observation was four years. Participants in the study completed a questionnaire developed by the authors of this paper, in which they answered questions about the presence of factors contributing to the development of cardiovascular pathology. Results and Discussion: Daily oral intake of vitamin D3 in a dose of 2000 IU/day for four years did not improve laboratory indicators, which are components of MS, namely, the content in the blood of TC, TG, LDL, HDL, AI, fasting and postprandial glycemia, insulin, and insulin resistance index HOMA2-IR (p>0.05). Prolonged use of vitamin D3 did not reduce the risk of cardiovascular diseases (myocardial infarcts (RR=0.93, 95% CI [0.21-4.09], p=0.92), strokes (RR=1.24, 95% CI [0.18-8.70], p=0.83), stenting (RR=1,23, 95% CI [0.32-4.88], p=0.76), arterial hypertension (RR=1.12, 95% CI [0.47-2.68], p=0.81), as well as cardiovascular death rates (RR=0.83, 95% CI [0.14-4.88], p=0.83) and death from any other causes (RR=0.93, 95% CI [0.21- 4.09], p=0.92). Conclusion: Thus, daily prolonged oral administration of vitamin D3 in a dose of 2000 IU/day does not contribute to the improvement of blood lipid spectrum, glycemia, and insulin resistance in metabolic syndrome and does not reduce the risk of adverse (fatal and non-fatal) cardiovascular events. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.431-438

Abstract P290: The Association of Maternal Pre-pregnancy Weight With Childhood and Adolescent Blood Pressure and the Modifying Role of Vitamin D

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Mingyu Zhang ◽  
Guoying Wang ◽  
Xiaobin Wang ◽  
Noel T Mueller
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Cord Blood ◽  
Medical Center ◽  
Childhood And Adolescence ◽  
Vitamin D Status ◽  
Linear Regression Models ◽  
Child Bmi ◽  
Pregnancy Weight

Introduction: High blood pressure (BP) is the leading modifiable risk factor of cardiovascular diseases. High maternal pre-pregnancy body mass index (BMI) may be one of earliest risk factors for high child BP, but evidence supporting this hypothesis is limited. Vitamin D was recently found to protect against elevated BP in childhood, yet no studies to our knowledge have examined if Vitamin D could be a modifiable target for mitigating the association of pre-pregnancy BMI and child BP. Methods: We analyzed longitudinal data of 719 mother-child pairs in the Boston Birth Cohort enrolled from 1998-2012 at the Boston Medical Center. We calculated child systolic BP (SBP) percentile according to a US reference and defined low Vitamin D as cord blood 25(OH)D concentration <11 ng/mL. We examined the change in child SBP percentile per 5-kg/m 2 increment in pre-pregnancy BMI using linear regression models with GEE estimates. We adjusted for confounders (see Figure footnote) and assessed mediation by further adjusting for child BMI-z score. Results: Our analytic sample included 451 (63%) African American/Haitian mothers, 361 (50%) girls, and 304 (42%) children with low cord blood Vitamin D. A 5-kg/m 2 increment in maternal pre-pregnancy BMI was associated with a 1.99 (95% CI: 1.08, 2.90) percentile increase in child SBP (during childhood [3-12 years]: 1.85, 95% CI: 0.97, 2.73; during adolescence [13-18 years]: 4.22, 95% CI: 1.19, 7.25). Cord blood Vitamin D status modified the associations (P-interaction = 0.023) (Figure, Panel A). Results were attenuated in the mediation analysis, but the interaction remained significant (Figure, Panel B). Conclusion: Higher maternal pre-pregnancy BMI is associated with higher offspring BP in childhood and adolescence, and this association is partially mediated by child weight. The inter-generational association disappeared if mother-newborn cord blood had high Vitamin D. Optimizing maternal Vitamin D status during pregnancy may help prevent the inter-generational cycle of cardiovascular risk.

Sign in / Sign up

Export Citation Format

Share Document