scholarly journals Hydrogen Sulfide Plays an Important Role in Diabetic Cardiomyopathy

2021 ◽  
Vol 9 ◽  
Author(s):  
Shizhen Zhao ◽  
Xiaotian Li ◽  
Xinping Li ◽  
Xiaoyun Wei ◽  
Honggang Wang
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Hydrogen Sulfide ◽  
Diabetic Cardiomyopathy ◽  
Lipid Accumulation ◽  
Signal Molecule ◽  
Important Complication ◽  
The Future

Diabetic cardiomyopathy is an important complication of diabetes mellitus and the main cause of diabetes death. Diabetic cardiomyopathy is related with many factors, such as hyperglycemia, lipid accumulation, oxidative stress, myocarditis, and apoptosis. Hydrogen sulfide (H2S) is a newly discovered signal molecule, which plays an important role in many physiological and pathological processes. Recent studies have shown that H2S is involved in improving diabetic cardiomyopathy, but its mechanism has not been fully elucidated. This review summarizes the research on the roles and mechanisms of H2S in diabetic cardiomyopathy in recent years to provide the basis for in-depth research in the future.

scholarly journals Histone Deacetylases in the Pathogenesis of Diabetic Cardiomyopathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiangyu Ke ◽  
Zhirui Lin ◽  
Zebing Ye ◽  
Meifang Leng ◽  
Bo Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Diabetic Cardiomyopathy ◽  
Histone Deacetylases ◽  
Cardiac Fibrosis ◽  
Metabolic Diseases ◽  
Therapeutic Strategies ◽  
Global Burden ◽  
Comprehensive Understanding ◽  
Cellular Processes

The global burden of diabetes mellitus and its complications are currently increasing. Diabetic cardiomyopathy (DCM) is the main cause of diabetes mellitus associated morbidity and mortality; therefore, a comprehensive understanding of DCM development is required for more effective treatment. A disorder of epigenetic posttranscriptional modification of histones in chromatin has been reported to be associated with the pathology of DCM. Recent studies have implicated that histone deacetylases could regulate cardiovascular and metabolic diseases in cellular processes including cardiac fibrosis, hypertrophy, oxidative stress and inflammation. Therefore in this review, we summarized the roles of histone deacetylases in the pathogenesis of DCM, aiming to provide insights into exploring potential preventative and therapeutic strategies of DCM.

scholarly journals Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2411
Author(s):  
Panpan Li ◽  
Hanhan Liu ◽  
Xin Shi ◽  
Verena Prokosch
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Sulfide ◽  
Therapeutic Potential ◽  
Pathological Process ◽  
Degenerative Diseases ◽  
Retinal Neurons ◽  
Signal Molecule ◽  
Physiological Signal ◽  
Retinal Degenerative Diseases ◽  
Significant Injury

Oxidative stress (OS) damage can cause significant injury to cells, which is related to the occurrence and development of many diseases. This pathological process is considered to be the first step to trigger the death of outer retinal neurons, which is related to the pathology of retinal degenerative diseases. Hydrogen sulfide (H2S) has recently received widespread attention as a physiological signal molecule and gas neuromodulator and plays an important role in regulating OS in eyes. In this article, we reviewed the OS responses and regulatory mechanisms of H2S and its donors as endogenous and exogenous regulators in retinal degenerative diseases. Understanding the relevant mechanisms will help to identify the therapeutic potential of H2S in retinal degenerative diseases.

Hydrogen sulfide: an old gas with new cardioprotective effects

2014 ◽  
Vol 128 (5) ◽  
pp. 321-323 ◽  
Author(s):  
Vaibhav B. Patel ◽  
Brent A. McLean ◽  
Xueyi Chen ◽  
Gavin Y. Oudit
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Hydrogen Sulfide ◽  
Diabetic Cardiomyopathy ◽  
Therapeutic Potential ◽  
Cardiovascular Complications ◽  
Signalling Pathways ◽  
Intracellular Signalling Pathways ◽  
Signalling Molecule ◽  
Cardioprotective Effects

Diabetic cardiovascular complications are reaching epidemic proportions and the risk of HF (heart failure) is increased 2–3-fold by diabetes mellitus. H2S (hydrogen sulfide) is emerging as a new gaseous signalling molecule in the cardiovascular system which possesses multifactorial effects on various intracellular signalling pathways. The proven cardioprotective and vasodilator activities of H2S warrant a detailed investigation into its role in diabetic cardiomyopathy. In the present issue of Clinical Science, Zhou et al. demonstrate an important therapeutic potential of the H2S pathway in diabetic cardiomyopathy.

Hydrogen sulfide: a multi-tasking signal molecule in the regulation of oxidative stress responses

2020 ◽  
Vol 71 (10) ◽  
pp. 2862-2869 ◽  
Author(s):  
Tao Chen ◽  
Mimi Tian ◽  
Yi Han
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Sulfide ◽  
Stress Responses ◽  
Stomatal Closure ◽  
Plant Stress ◽  
Signal Molecule ◽  
Environmental Threats ◽  
Enhanced Production ◽  
Response Network ◽  
Plant Stress Responses

Abstract Accumulating evidence suggests that hydrogen sulfide (H2S) is an important signaling molecule in plant environmental interactions. The consensus view amongst plant scientists is that environmental stress leads to enhanced production and accumulation of reactive oxygen species (ROS). H2S interacts with the ROS-mediated oxidative stress response network at multiple levels, including the regulation of ROS-processing systems by transcriptional or post-translational modifications. H2S–ROS crosstalk also involves other interacting factors, including nitric oxide, and can affect key cellular processes like autophagy. While H2S often functions to prevent ROS accumulation, it can also act synergistically with ROS signals in processes such as stomatal closure. In this review, we summarize the mechanisms of H2S action and the multifaceted roles of this molecule in plant stress responses. Emphasis is placed on the interactions between H2S, ROS, and the redox signaling network that is crucial for plant defense against environmental threats.

Hydrogen sulfide attenuates the development of diabetic cardiomyopathy

2014 ◽  
Vol 128 (5) ◽  
pp. 325-335 ◽  
Author(s):  
Xiang Zhou ◽  
Guoyin An ◽  
Xiang Lu
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Sulfide ◽  
P38 Mapk ◽  
Diabetic Cardiomyopathy ◽  
High Glucose ◽  
Mapk Pathways ◽  
Apoptotic Effects

H2S alleviates diabetic cardiomyopathy via attenuation of inflammation, oxidative stress and apoptosis. H2S may reduce high glucose-induced oxidative stress by activating the Nrf2/ARE pathway and exert anti-apoptotic effects by inhibiting JNK and p38 MAPK pathways and activating PI3K/Akt signalling.

Paper of oxidative stress and placenta on the development of gestational diabetes mellitus

2014 ◽  
Author(s):  
Cristina Lopez-Tinoco ◽  
Francisco Vilchez ◽  
Francisco Visiedo ◽  
Isabel Mateo ◽  
Carmen Segundo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus
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