scholarly journals A Bibliometric Analysis of Pyroptosis From 2001 to 2021

2021 ◽  
Vol 12 ◽  
Author(s):  
Dan Ma ◽  
Bin Yang ◽  
Baoyi Guan ◽  
Luxia Song ◽  
Qiyu Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Bibliometric Analysis ◽  
Future Research ◽  
Pyrin Domain ◽  
The Future ◽  
The Usa ◽  
The Relationship ◽  
Related Pathway ◽  
Receptor Family

BackgroundPyroptosis is a new programmed cell death discovered in recent years. Pyroptosis plays an important role in various diseases. Nevertheless, there are few bibliometric analysis systematically studies this field. We aimed to visualize the research hotspots and trends of pyroptosis using a bibliometric analysis to help understand the future development of basic and clinical research.MethodsThe articles and reviews regarding pyroptosis were culled from Web of Science Core Collection. Countries, institutions, authors, references and keywords in this field were visually analyzed by using CtieSpace and VOSviewer software.ResultsA total of 2845 articles and reviews were included. The number of articles regarding pyroptosis significantly increased yearly. These publications mainly come from 70 countries led by China and the USA and 418 institutions. We identified 605 authors, among which Thirumaladevi Kanneganti had the most significant number of articles, and Shi JJ was co-cited most often. Frontiers in immunology was the journal with the most studies, and Nature was the most commonly cited journal. After analysis, the most common keywords are nod like receptor family pyrin domain containing 3 inflammasome, apoptosis, cell death, gasdermin D, mechanism, caspase-1, and others are current and developing areas of study.ConclusionResearch on the pyroptosis is flourishing. Cooperation and exchanges between countries and institutions must be strengthened in the future. The related pathway mechanism of pyroptosis, the relationship between pyroptosis and other types of programmed cell deaths as well as the role of pyroptosis in various diseases have been the focus of current research and developmental trends in the future research.

scholarly journals Relationships between Interpersonal Trust and Knowledge Sharing in Workplace: The Mediational Role of Prosocial Motives

2018 ◽  
Vol 11 (8) ◽  
pp. 163 ◽  
Author(s):  
Weixu Ding ◽  
Eugene Choi ◽  
Atsushi Aoyama
Keyword(s):  
Knowledge Sharing ◽  
Interpersonal Trust ◽  
Future Research ◽  
Empirical Methods ◽  
Emotional Factors ◽  
Prosocial Motives ◽  
The Future ◽  
Mediational Role ◽  
The Relationship

This study is different from the usual cases that testing the intuitive factor as rewarding that affects the employees’ knowledge sharing. In this study, the focus shifts to concentrating on the emotional factors such as interpersonal trust and the prosocial motives. Empirical methods are used to test the hypotheses, and the results show that interpersonal trust affects employees’ knowledge sharing significantly. Moreover, the prosocial motives have been evidenced that it moderately mediates the relationship between interpersonal trust and knowledge sharing. This study has well evidenced all the hypotheses and gives suggestions for the future research at the end.

scholarly journals The Potential Role of Lithium as an Antiviral Agent against SARS-CoV-2 via Membrane Depolarization: Review and Hypothesis

2021 ◽  
Vol 89 (1) ◽  
pp. 11
Author(s):  
Abdallah Barjas Qaswal ◽  
Aiman Suleiman ◽  
Hasan Guzu ◽  
Taima’a Harb ◽  
Bashir Atiyat
Keyword(s):  
Cell Death ◽  
Immune System ◽  
Antiviral Agent ◽  
Membrane Depolarization ◽  
The Body ◽  
Pyrin Domain ◽  
The Face ◽  
Preclinical And Clinical Studies ◽  
Receptor Family

Studies on potential treatments of Coronavirus Disease 2019 (COVID-19) are important to improve the global situation in the face of the pandemic. This review proposes lithium as a potential drug to treat COVID-19. Our hypothesis states that lithium can suppress NOD-like receptor family pyrin domain containing-3 (NLRP3) inflammasome activity, inhibit cell death, and exhibit immunomodulation via membrane depolarization. Our hypothesis was formulated after finding consistent correlations between these actions and membrane depolarization induced by lithium. Eventually, lithium could serve to mitigate the NLRP3-mediated cytokine storm, which is allegedly reported to be the inciting event of a series of retrogressive events associated with mortality from COVID-19. It could also inhibit cell death and modulate the immune system to attenuate its release, clear the virus from the body, and interrupt the cycle of immune-system dysregulation. Therefore, these effects are presumed to improve the morbidity and mortality of COVID-19 patients. As the numbers of COVID-19 cases and deaths continue to rise exponentially without a clear consensus on potential therapeutic agents, urgent conduction of preclinical and clinical studies to prove the efficacy and safety of lithium is reasonable.

scholarly journals The Role of Ferroptosis in Cardiovascular Disease and Its Therapeutic Significance

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhenzhen Chen ◽  
Youyou Yan ◽  
Chao Qi ◽  
Jia Liu ◽  
Longbo Li ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Damage ◽  
Regulated Cell Death ◽  
Cardiac Pathophysiology ◽  
Cause Of Deaths ◽  
New Type ◽  
The Relationship ◽  
Infarction Heart ◽  
Related Pathway

Cardiovascular diseases (CVDs) are the leading cause of deaths worldwide with regulated cell death playing an important role in cardiac pathophysiology. However, the classical mode of cell death cannot fully explain the occurrence and development of heart disease. In recent years, much research has been performed on ferroptosis, a new type of cell death that causes cell damage and contributes to the development of atherosclerosis, myocardial infarction, heart failure, and other diseases. In this review, we discuss the role of different organelles in ferroptosis and also focus on the relationship between autophagy and ferroptosis. Additionally, we describe the specific mechanism by which ferroptosis contributes to the development of CVD. Finally, we summarize the current research on ferroptosis-related pathway inhibitors and the applications of clinically beneficial cardiovascular drugs.

scholarly journals Hard Feelings: Predicting Attitudes Toward Former Romantic Partners

2021 ◽  
Author(s):  
David Joachim Grüning ◽  
Anna-Lena Loose ◽  
Joachim Israel Krueger
Keyword(s):  
Perceived Social Support ◽  
Positive Association ◽  
Romantic Partners ◽  
Negative Association ◽  
Future Research ◽  
Negative Attitudes ◽  
The Usa ◽  
The Relationship ◽  
Practical Implications

Most research on relationship quality addresses ongoing involvements. Research on past relationships is rare. As a first step, Athenstaedt and colleagues (2020) explored attitudes toward former romantic partners in an Austrian sample of heterosexual respondents. They found that men held less negative attitudes than women. In two studies conducted in Germany and the USA, we replicate this gender difference and explore the role of three psychological predictors. Like Athenstaedt et al., we find that the degree of perceived social support before the breakup and continued friendly relations after the breakup have a positive association with ex-partner attitude. Critically, we introduce and corroborate the hypothesis that regret over having started the relationship has a negative association. However, regret also fails to mediate the association between gender and ex-partner attitude. We discuss the practical implications of these findings and note directions for future research.

Coping Humor as a Mediator Between Emotional Intelligence and Job Satisfaction

2017 ◽  
Vol 16 (3) ◽  
pp. 155-159 ◽  
Author(s):  
Peizhen Sun ◽  
Jennifer J. Chen ◽  
Hongyan Jiang
Keyword(s):  
Job Satisfaction ◽  
Emotional Intelligence ◽  
Future Research ◽  
Satisfaction Scale ◽  
Primary School Teachers ◽  
Mediating Role ◽  
Regulation Of Emotion ◽  
The Relationship ◽  
Overall Job Satisfaction

Abstract. This study investigated the mediating role of coping humor in the relationship between emotional intelligence (EI) and job satisfaction. Participants were 398 primary school teachers in China, who completed the Wong Law Emotional Intelligence Scale, Coping Humor Scale, and Overall Job Satisfaction Scale. Results showed that coping humor was a significant mediator between EI and job satisfaction. A further examination revealed, however, that coping humor only mediated two sub-dimensions of EI (use of emotion and regulation of emotion) and job satisfaction. Implications for future research and limitations of the study are discussed.

Moderating Role of Gender in the Relationship between Cognitive Errors and Anxiety among Adolescents

2020 ◽  
Vol 4 (1) ◽  
pp. 86-102
Author(s):  
Tasnim Rehna ◽  
Rubina Hanif ◽  
Muhammad Aqeel
Keyword(s):  
Mental Health Problems ◽  
Adolescent Psychopathology ◽  
Future Research ◽  
Cognitive Errors ◽  
Adolescent Anxiety ◽  
Study Results ◽  
The Status ◽  
Manifest Anxiety ◽  
The Relationship

Background: Widespread social paradigms on which the status variances are grounded in any society, gender plays pivotal role in manifestation of mental health problems (Rutter, 2007). A hefty volume of research has addressed the issue in adults nonetheless, little is vividly known about the role of gender in adolescent psychopathology. Sample: A sample of 240 adolescents (125 boys, 115 girls) aging 12-18 years was amassed from various secondary schools of Islamabad with the approval of the Federal Directorate of Education (FDE), relevant authorities of the schools and the adolescents themselves. Instruments: Taylor Manifest Anxiety Scale (Taylor & Spence, 1953) and Children’s Negative Cognitive Errors Questionnaire (CNCEQ) by Leitenberg et al., (1986) were applied in present study. Results: Multiple regression analysis revealed that cognitive errors jointly accounted for 78% of variance in predicting anxiety among adolescents. Findings also exhibited that gender significantly moderated the relationship between cognitive errors and adolescent anxiety. Implications of the findings are discoursed for future research and clinical practice.

Religion and the Military

2018 ◽  
pp. 535-552
Author(s):  
Leana A. Bouffard ◽  
Haerim Jin
Keyword(s):  
Criminal Justice ◽  
Military Service ◽  
Criminal Justice Policy ◽  
Future Research ◽  
Period Effects ◽  
Offending Patterns ◽  
Role Of Religion ◽  
The Military ◽  
The Relationship

This chapter provides an overview of the literature examining the role of religion and military service in the desistance process. It also identifies outstanding issues and directions for future research. It first presents an overview of research examining the role of religion in desistance and highlights measurement issues, potential intervening mechanisms, and a consideration of faith-based programs as criminal justice policy. Next, this chapter covers the relationship between military service and offending patterns, including period effects that explain variation in the relationship, selection effects, and the incorporation of military factors in criminal justice policy and programming. The chapter concludes by highlighting general conclusions from these two bodies of research and questions to be considered in future research.

Institutions and the Embedded Entrepreneur

2019 ◽  
pp. 115-134
Author(s):  
Maryann Feldman ◽  
Paige Clayton
Keyword(s):  
Current Evidence ◽  
Future Research ◽  
Institutional Logic ◽  
The Relationship ◽  
Regional Resources

This chapter examines the relationship between entrepreneurs and the communities in which they are embedded. It argues that the actions of entrepreneurs and their firms are contextually situated in specific geographies that make their actions endogenous in the development of place and define a place-specific institutional logic. This argument is at odds with the view that industry clustering is due to the role of incumbent firms. This chapter reconciles these views by adopting a temporal view, allowing both incumbents and geography to co-occur and influence clustering. It then considers the current evidence of entrepreneurs’ effects on regional resources and capacity, and concludes with suggestions for future research.

The Role of Normative Information in Judgments of Others

2019 ◽  
Author(s):  
Katherine H. Rogers
Keyword(s):  
Social Desirability ◽  
Interpersonal Perception ◽  
Future Research ◽  
Average Person ◽  
The Individual ◽  
The Relationship ◽  
Source Of Information

When forming impressions of an other’s personality, people often rely on information not directly related to the individual at hand. One source of information that can influence people’s impressions of others is the personality of the average person (i.e., normative profile). This relationship between the normative profile and an impression is called normative accuracy or normativity. In this chapter, you will learn about the average personality, why it is important, the relationship to social desirability and what it means to have a normative impression, as well as correlates and moderators of normativity. More broadly, you will learn about current research and views regarding the normative profile and normative impressions as well as concrete steps for incorporating this approach into your future research on interpersonal perception.

scholarly journals Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?

2021 ◽  
Vol 22 (12) ◽  
pp. 6222
Author(s):  
Kacper Szewczyk ◽  
Aleksandra Chojnacka ◽  
Magdalena Górnicka
Keyword(s):  
Vitamin E ◽  
Metabolic Disorders ◽  
Tissue Concentration ◽  
Biological Properties ◽  
Biological Role ◽  
Future Research ◽  
The Past ◽  
The Subject ◽  
The Relationship

Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature. They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds, and nuts. The main forms in the diet are α- and γ-tocopherol, due to the highest content in food products. Nevertheless, α-tocopherol is the main form of vitamin E with the highest tissue concentration. The α- forms of both tocopherols and tocotrienols are considered as the most metabolically active. Currently, research results indicate also a greater antioxidant potential of tocotrienols than tocopherols. Moreover, the biological role of vitamin E metabolites have received increasing interest. The aim of this review is to update the knowledge of tocopherol and tocotrienol bioactivity, with a particular focus on their bioavailability, distribution, and metabolism determinants in humans. Almost one hundred years after the start of research on α-tocopherol, its biological properties are still under investigation. For several decades, researchers’ interest in the biological importance of other forms of vitamin E has also been growing. Some of the functions, for instance the antioxidant functions of α- and γ-tocopherols, have been confirmed in humans, while others, such as the relationship with metabolic disorders, are still under investigation. Some studies, which analyzed the biological role and mechanisms of tocopherols and tocotrienols over the past few years described new and even unexpected cellular and molecular properties that will be the subject of future research.

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