scholarly journals Metformin, the Rise of a New Medical Therapy for Endometriosis? A Systematic Review of the Literature

2021 ◽  
Vol 8 ◽  
Author(s):  
Emanuela Stochino-Loi ◽  
Attila L. Major ◽  
Tessa E. R. Gillon ◽  
Jean-Marc Ayoubi ◽  
Anis Feki ◽  
...  
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Adverse Effects ◽  
Therapeutic Potential ◽  
Review Of The Literature ◽  
Medical Treatments ◽  
Contraceptive Effect ◽  
Antiproliferative Agent ◽  
Pain Symptoms ◽  
Control Pain

Medical treatments for endometriosis aim to control pain symptoms and stop progression of endometriotic lesions. However, their adverse effects and their contraceptive effect in women who desire pregnancy, limit their long terms use. Although there is only one study investigating the effects of metformin on women with endometriosis, metformin seems to have a unique therapeutic potential. It may be a helpful anti-inflammatory and antiproliferative agent in the treatment of endometriosis. As such metformin may be more beneficial thanks to the lack of serious side effects.

scholarly journals Can Enhanced Peroxides Decrease the Side Effects of Tooth Bleaching? A Systematic Review of the Literature

2014 ◽  
Vol 3 (2) ◽  
pp. 84-91
Author(s):  
Boniek Borges ◽  
Mariana Vale ◽  
Felipe Afonso ◽  
Isauremi Assunção
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Calcium Phosphate ◽  
Adverse Effects ◽  
Amorphous Calcium Phosphate ◽  
Morphological Changes ◽  
Potassium Nitrate ◽  
Tooth Bleaching ◽  
Review Of The Literature ◽  
Bleaching Gels

ABSTRACT Adverse effects of tooth bleaching on dental structures remain a topic of discussion in the literature, and the search for protocols that reduce such reported adverse effects is ongoing. The goal of this systematic literature review was to determine whether the use of tooth bleaching gels with added minerals, such as fluoride, calcium, hydroxyapatite, potassium nitrate, amorphous calcium phosphate, and casein phosphopeptide-amorphous calcium phosphate, reduced the occurrence of the main adverse effects of tooth bleaching. The electronic database search identified 16 studies that evaluated the effects of bleaching gels with added minerals on enamel hardness and/or roughness, mineral loss, post-treatment sensitivity, morphological changes, and/or cohesive enamel strength. The findings of this review suggest that the addition of minerals to bleaching gels can contribute to the reduction of most adverse effects, mainly sensitivity, without affecting treatment efficiency. How to cite this article Borges B, Vale M, Afonso F, Assunção I. Can Enhanced Peroxides Decrease the Side Effects of Tooth Bleaching? A Systematic Review of the Literature. Int J Experiment Dent Sci 2014;3(2):84-91.

scholarly journals Post-treatment physiological effects, adverse effects and complications after the selected aesthetic treatments. Review of the literature

2021 ◽  
Vol 10 (5) ◽  
pp. 211-216
Author(s):  
Weronika S. Kononowicz ◽  
◽  
Beata Malara ◽  
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Physical Attractiveness ◽  
Treatment Effects ◽  
Well Being ◽  
Post Treatment ◽  
Physiological Effects ◽  
Review Of The Literature ◽  
Skin Defects

Aesthetic treatments are performed in order to improve physical attractiveness, well-being, and to eliminate skin defects. These procedures are also associated with physiological post-treatment effects, side effects and complications. The aim of the article was to discuss selected aesthetic treatments with their typical complications and to present the types of natural post-treatment effects and dangerous side effects. Knowledge of the causes and occurrence of undesirable effects after various aesthetic treatments allows to increase awareness of the risks associated with the performance of such procedures.

scholarly journals Efficacy and safety of Botulinum toxin A for improving esthetics in facial complex: A systematic review

2021 ◽  
Vol 32 (4) ◽  
pp. 31-44
Author(s):  
Ritu Gangigatti ◽  
Vincent Bennani ◽  
John Aarts ◽  
Joanne Choi ◽  
Paul Brunton
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Adverse Effects ◽  
Botulinum Toxin A ◽  
Meta Analysis ◽  
Common Adverse Effect ◽  
Efficacy And Safety ◽  
Improvement Rate ◽  
Graphical Comparison ◽  
Average Improvement

Abstract Aim: To evaluate efficacy and safety of Botulinum toxinA for improving esthetics in the facial complex and correlating them to the dosage and side effects through a systematic review. Methods: A literature search was performed using PubMed, Medline, Web of Sciences, and Scopus databases. Quality of studies was appraised through the GRADE system. This review follows the ‘Preferred reporting items for systematic review and meta-analysis protocols’ (PRISMA-P) 2015 statement. Efficacy was analyzed through improvement rate and effect sizes. Graphical comparison of efficacy and ocular adverse effects (adverse effects around the eye) at various anatomical locations was made by calculating the average improvement rate and adverse events. Results: Twenty-five studies were included in this systematic review after application of the inclusion criteria. Moderate to severe cases in glabellar, lateral canthal, and forehead regions showed higher improvement rates between 20U to 50U, with an effect lasting up to 120 days. Gender and age seemed to have a direct effect on efficacy. Headaches were the most common adverse effect, followed by injection site bruising; all adverse effects resolved within 3-4 days. Conclusions: Treatment with Botulinum toxinA to enhance esthetics of facial complex is efficient and safe at all recommended dosages. Presence of complexing proteins influenced the efficacy of BoNT-A. undesirable muscular adverse effects around the eyes were more predominant when treating the glabellar region. There was no correlation found between the BoNT-A dosage and side effects, however, an increase in dosage did not always lead to an increase in efficacy.

scholarly journals Nandrolone Decanoate: Use, Abuse and Side Effects

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 606
Author(s):  
Federico Giuseppe Patanè ◽  
Aldo Liberto ◽  
Andreana Nicoletta Maria Maglitto ◽  
Pasquale Malandrino ◽  
Massimiliano Esposito ◽  
...  
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Adverse Effects ◽  
English Language ◽  
Scientific Literature ◽  
Reproductive Organs ◽  
Nandrolone Decanoate ◽  
Inclusion Criteria ◽  
Pubmed Database ◽  
Study Results

Background and Objectives: Androgens play a significant role in the development of male reproductive organs. The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones. Class II anabolic androgenic steroids (AAS), including nandrolone, are rapidly becoming a widespread group of drugs used both clinically and illicitly. The illicit use of AAS is diffused among adolescent and bodybuilders because of their anabolic proprieties and their capacity to increase tolerance to exercise. This systematic review aims to focus on side effects related to illicit AAS abuse, evaluating the scientific literature in order to underline the most frequent side effects on AAS abusers’ bodies. Materials and Methods: A systematic review of the scientific literature was performed using the PubMed database and the keywords “nandrolone decanoate”. The inclusion criteria for articles or abstracts were English language and the presence of the following words: “abuse” or “adverse effects”. After applying the exclusion and inclusion criteria, from a total of 766 articles, only 148 were considered eligible for the study. Results: The most reported adverse effects (found in more than 5% of the studies) were endocrine effects (18 studies, 42%), such as virilization, gynecomastia, hormonal disorders, dyslipidemia, genital alterations, and infertility; cardiovascular dysfunctions (six studies, 14%) such as vascular damage, coagulation disorders, and arteriosus hypertension; skin disorders (five studies, 12%) such as pricking, acne, and skin spots; psychiatric and mood disorders (four studies, 9%) such as aggressiveness, sleep disorders and anxiety; musculoskeletal disorders (two studies, 5%), excretory disorders (two studies, 5%), and gastrointestinal disorders (two studies, 5%). Conclusions: Based on the result of our study, the most common adverse effects secondary to the abuse of nandrolone decanoate (ND) involve the endocrine, cardiovascular, skin, and psychiatric systems. These data could prove useful to healthcare professionals in both sports and clinical settings.

Risk of infectious, hematological, and gastrointestinal side effects in patients treatedwith ibrutinib: A systematic review and meta-analysis of randomized controlled trials.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e18265-e18265
Author(s):  
Myo Zaw ◽  
Kyaw Zin Thein ◽  
Aung Tun ◽  
Lukman Tijani ◽  
Elizabeth Guevara
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Adverse Effects ◽  
Randomized Controlled Trials ◽  
Chemokine Receptors ◽  
Meta Analysis ◽  
Controlled Trials ◽  
High Grade ◽  
Randomized Controlled ◽  
Gastrointestinal Side Effects

e18265 Background: Bruton’s tyrosine kinase (BTK) is essential for signaling of B-cell and chemokine receptors. Ibrutinib targets BTK and has become frontier in many hematologic malignancies. We undertook systematic review and pooled analysis of randomized controlled trials (RCTs) to determine infectious, hematological and gastrointestinal risks associated with ibrutinib. Methods: We performed a comprehensive literature search using MEDLINE, EMBASE databases and meeting abstracts through December 31, 2016. The RCTs that mention infectious, hematological and gastrointestinal side effects as adverse effects were incorporated in the analysis. Mantel-Haenszel method was used to calculate the estimated pooled risk ratio with 95% confidence interval (CI). Results: Four RCTs with a total of 1505 patients were eligible for the analysis. Studies compared Ibrutinib (I) vs ofatumumab, I vs chlorambucil, I+ bendamustine (B)+ rituximab (R) vs placebo + B+ R and I vs temsirolimus were included in the analysis. The relative risks (RR) of all-grade side effects were as follows: infection, 1.34 (95% CI: 1.04 – 1.74; p = 0.02); pneumonia, 1.16 (95% CI: 0.82–1.66; p = 0.38); anemia, 0.77 (95% CI: 0.64 – 0.93; p = 0.007); neutropenia, 0.99 (95% CI: 0.87 – 1.14; p = 0.98); thrombocytopenia, 0.86 (95% CI: 0.71 – 1.04; p = 0.12); diarrhea, 1.74 (95% CI: 1.48 – 2.05; p < 0.0001); nausea, 0.94 (95% CI: 0.80 – 1.10; p = 0.45); and vomiting, 0.98 (95% CI 0.74 – 1.30; p = 0.93). The RR of high-grade adverse effects were as follows: febrile neutropenia, 1.32 (95% CI: 0.84 – 2.08; p = 0.21); infection, 1.20 (95% CI: 0.73 – 1.98; p = 0.45); pneumonia, 1.22 (95% CI: 0.76–1.95; p = 0.39); anemia, 0.48 (95% CI: 0.33 – 0.71; p < 0.0001); neutropenia, 0.99 (95% CI: 0.86 – 1.15; p = 0.94); thrombocytopenia, 0.61 (95% CI: 0.47 – 0.81; p = 0.001); diarrhea, 1.72 (95% CI: 0.88 – 3.34;p = 0.10); nausea, 2.56 (95% CI: 0.59 – 10.99; p = 0.20); and vomiting, 0.42 (95% CI 0.11 – 1.63; p = 0.21). Conclusions: Ibrutinib increased the risk of all-grade diarrhea and infection whereas the risks of all-grade anemia, high-grade anemia and thrombocytopenia were significantly lower in the study arm, favoring ibrutinib.

Interferon-beta injection in multiple sclerosis patients is related to the induction of headache and flu-like pain symptoms: a systematic review and meta-analysis of randomised controlled trials

2021 ◽  
Vol 19 ◽  
Author(s):  
Leonardo Gomes Pereira ◽  
Gabriela Trevisan ◽  
Patrícia Rodrigues ◽  
Fernanda Tibolla Viero ◽  
Julia Maria Frare ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Adverse Effects ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
First Choice ◽  
Pain Symptoms ◽  
Randomised Controlled ◽  
Multiple Sclerosis Patients

: Multiple sclerosis (MS) is a chronic neurodegenerative, inflammatory and autoimmune disease characterised by the demyelination of the central nervous system. One of the main approaches to treating MS is the use of disease-modifying therapies (DMTs). Among the DMTs are interferons (IFNs), which are cytokines responsible for controlling the activity of the immune system, exerting immunomodulatory, antiviral, and antiproliferative activities. IFN-beta (IFN-β) is the first-choice drug used to treat relapsing-remitting MS. However, the administration of IFN-β causes numerous painful adverse effects, resulting in lower adherence to the treatment. Therefore, this study aimed to investigate the headache and flu-like pain symptoms observed after IFNβ injection in MS patients using a systematic review and meta-analysis of randomised controlled trials. The search of research databases identified 2370 articles. Nine articles were included (three involving IFNβ-1b and six involving IFNβ-1a). All studies included in the meta-analysis had a low risk of bias. Headache and flu-like pain symptoms frequency increased in MS patients treated with IFN-β. Thus, the adverse effects of headache and flu-like pain symptoms appear to be linked to IFN-β treatment in MS. The protocol of the study was registered in the Prospective International Registry of Systematic Reviews.

scholarly journals A Review of Clinical Applications and Side Effects of Methotrexate in Ophthalmology

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Ge Wang ◽  
Xiaoyan Peng
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Side Effects ◽  
Adverse Effects ◽  
Clinical Application ◽  
Clinical Applications ◽  
The Other ◽  
Price Ratio ◽  
Clinical Use ◽  
High Effectiveness

Methotrexate (MTX) is a folate analog widely used against a range of diseases including malignancies and autoimmune disorders. Its high effectiveness-price ratio also won extensive application in ophthalmology. On the other hand, although MTX has an excellent pharmacological efficacy, MTX associated side effects in clinical use, which vary from patient to patient, are nonnegligible. There is no comparatively systematic review on MTX associated side effects and its risk factors. This review aimed to reveal novel clinical approaches of MTX and its adverse effects in order to provide a reference for ophthalmic scholars in clinical application of MTX.

scholarly journals Cannabinoid Effects on Experimental Colorectal Cancer Models Reduce Aberrant Crypt Foci (ACF) and Tumor Volume: A Systematic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Eduardo Orrego-González ◽  
Luisa Londoño-Tobón ◽  
José Ardila-González ◽  
Diego Polania-Tovar ◽  
Ana Valencia-Cárdenas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Side Effects ◽  
Tumor Volume ◽  
Therapeutic Potential ◽  
Colonic Neoplasms ◽  
Experimental Studies ◽  
Aberrant Crypt Foci ◽  
Mesh Terms ◽  
Cancer Models

Objective. Colorectal cancer represents a heavy burden for health systems worldwide, being the third most common cancer worldwide. Despite the breakthroughs in medicine, current chemotherapeutic options continue to have important side effects and may not be effective in preventing disease progression. Cannabinoids might be substances with possible therapeutic potential for cancer because they can attenuate the side effects of chemotherapy and have antiproliferative and antimetastatic effects. We aim to determine, through a systematic review of experimental studies performed on animal CRC models, if cannabinoids can reduce the formation of preneoplastic lesions (aberrant crypt foci), number, and volume of neoplastic lesions. Materials and Methods. A systematic, qualitative review of the literature was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Embase, and Scopus databases were searched. We use the following Medical Subject Headings (MESH) terms in PubMed: “colorectal neoplasms,” “colonic neoplasms,” “colorectal cancer,” “polyps,” “rimonabant,” “cannabidiol,” “cannabinoids,” “azoxymethane,” “xenograft,” and “mice.” Only studies that met the eligibility criteria were included. Results. Eight in vivo experimental studies were included in the analysis after the full-text evaluation. Seven studies were azoxymethane (AOM) colorectal cancer models, and four studies were xenograft models. Cannabidiol botanical substance (CBD BS) and rimonabant achieved high aberrant crypt foci (ACF) reduction (86% and 75.4%, respectively). Cannabigerol, O-1602, and URB-602 demonstrated a high capacity for tumor volume reduction. Induction of apoptosis, interaction with cell survival, growth pathways, and angiogenesis inhibition were the mechanisms extracted from the studies that explain cannabinoids’ actions on CRC. Conclusions. Cannabinoids have incredible potential as antineoplastic agents as experimental models demonstrate that they can reduce tumor volume and ACF formation. It is crucial to conduct more experimental studies to understand the pharmacology of cannabinoids in CRC better.

From Me to You

2016 ◽  
Vol 25 (6) ◽  
pp. 438-443 ◽  
Author(s):  
Kate Faasse ◽  
Keith J. Petrie
Keyword(s):  
Social Context ◽  
Side Effects ◽  
Adverse Effects ◽  
Drug Response ◽  
Effective Management ◽  
Social Modeling ◽  
Medical Treatments ◽  
The Social ◽  
The Media

The social context in which people take medicines can strongly influence the drug response in both positive and negative ways. We first examine the role of social modeling in influencing treatment outcomes through modifying placebo and nocebo responses, and then explore possible mechanisms for these effects. Viewing another person show improvement after taking a drug can increase the placebo component of the medicine and thus the overall potency of the treatment. Likewise, seeing another person who has taken the same medicine report side effects can substantially increase adverse effects. Such effects can also occur on a wider scale following changes in medicine formulations or from vaccinations programs, when the media transmit adverse effects from these treatments to a wider audience. Females seem to be more susceptible than males to the social modeling of adverse effects of treatments. A greater awareness of the effects of social modeling has potential to improve the effectiveness of medical treatments, minimize side-effect burden, and also lead to more effective management of health scares.

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