scholarly journals Fibromyalgia and Associated Disorders: From Pain to Chronic Suffering, From Subjective Hypersensitivity to Hypersensitivity Syndrome

2021 ◽  
Vol 8 ◽  
Author(s):  
Yves Maugars ◽  
Jean-Marie Berthelot ◽  
Benoit Le Goff ◽  
Christelle Darrieutort-Laffite
Keyword(s):  
Hypersensitivity Syndrome ◽  
Chronic Fatigue ◽  
Cognitive Disorder ◽  
Imaging Data ◽  
Fatigue Syndrome ◽  
Wide Range ◽  
Associated Symptoms ◽  
Post Traumatic ◽  
The Many ◽  
Definition Of

The concept of fibromyalgia has progressed to achieve a certain consensus regarding the definition of the condition. We summarize what is known in 2020, be it in terms of diagnosis, with the criteria that have changed over the years, or at the level of the psychological profile, via the notions of “catastrophizing” and “coping” and post-traumatic syndrome. The importance of fatigue and sleep disorders is underlined, with the chronological sequence of post-traumatic syndrome, chronic fatigue, and then amplification of the pain and the onset of multiple associated symptoms. The etiopathogenic debate has been enriched thanks to neuro-imaging data to discover the start of the central neurological signature. The many associated symptoms are reanalyzed in the context of so-called sister conditions which form sometimes more or less separate entities, such as chronic fatigue syndrome or restless legs syndrome for example. What these conditions have in common is hypersensitivity, not just to pain, but also to all exteroceptive stimuli, from deep sensitivity in the neuro-vegetative system, the sense organs and certain functions of the central nervous system, to the psychological aspects and sleep control. In summary, it is possible to define fibromyalgia as a cognitive disorder of cortical integration of chronic pain, with amplification of painful and sensory nociception, decrease in the threshold for the perception of pain, and persistence of a stimulus that maintains the process in chronicity. Fibromyalgia is part of a group of chronic hypersensitivity syndromes of central origin, with a very wide range of means of expression.

Dampness and mold hypersensitivity syndrome and vaccination as risk factors for chronic fatigue syndrome

2019 ◽  
Vol 18 (1) ◽  
pp. 107-108 ◽  
Author(s):  
Tamara Tuuminen ◽  
Tiina Jääskeläinen ◽  
Kirsi Vaali ◽  
Olli Polo
Keyword(s):  
Risk Factors ◽  
Chronic Fatigue Syndrome ◽  
Hypersensitivity Syndrome ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

scholarly journals Myalgic Encephalomyelitis (ME) or What? An Operational Definition

Diagnostics ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 64 ◽  
Author(s):  
Frank Twisk
Keyword(s):  
Muscle Weakness ◽  
Neuromuscular Disease ◽  
Chronic Fatigue ◽  
Operational Definition ◽  
Sudden Onset ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Definition Of ◽  
Neurological Disturbance ◽  
Sensory Functions

Myalgic encephalomyelitis (ME), identified as a new clinical entity with distinctive features in 1956, was originally considered as a neuromuscular disease. In 1988 the Centers for Disease Control and Prevention introduced the ill-defined concept of chronic fatigue syndrome (CFS). As predicted, CFS, unjustly considered to be a synonym for ME, pushed ME to the background. To develop effective therapies for of ME and CFS, it is essential to investigate patients with ME specifically. For that reason, an operational definition of ME is indispensable. This article proposes an operational definition based on the most recent formal definitions and symptoms observed in ME. ME is a multi-systemic illness, which (1) often has a sudden onset, in most cases a respiratory and/or gastro-intestinal infection, but a gradual or more dramatic onset is also possible; (2) has an epidemic and an endemic form; (3) has an unique clinical pattern deviating from other post-viral states; (4) is distinguished by muscle fatigability/prolonged muscle weakness after trivial exertion; (5) is accompanied by symptoms relating to neurological disturbance, especially of cognitive, autonomic, and sensory functions; (6) can be accompanied by symptoms associated with cardiac and other systems; (7) is characterized by fluctuation of symptoms (within and between “episodes”); (8) has a prolonged relapsing course; and (9) has a tendency to become chronic. In conclusion, a discriminative definition for ME contains four mandatory elements: (1) muscle fatigability/post-exertional muscle weakness lasting for days; (2) operational criteria for “neurological disturbance, especially of cognitive, autonomic and sensory functions”; (3) fluctuation of symptoms; and (4) a prolonged relapsing course. This tentative definition of ME justifies the qualification “neuromuscular disease”.

scholarly journals A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS

2021 ◽  
Vol 12 ◽  
Author(s):  
Angus Mackay
Keyword(s):  
Critical Evaluation ◽  
Significant Proportion ◽  
Chronic Fatigue ◽  
Neural Pathways ◽  
Fatigue Syndrome ◽  
Chronic Neuroinflammation ◽  
Stress Threshold ◽  
Wide Range ◽  
Stress Signals ◽  
The Brain

A significant proportion of COVID-19 patients are suffering from prolonged Post-COVID-19 Fatigue Syndrome, with characteristics typically found in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). However, no clear pathophysiological explanation, as yet, has been provided. A novel paradigm for a Post-COVID-19 Fatigue Syndrome is developed here from a recent unifying model for ME/CFS. Central to its rationale, SARS-CoV-2, in common with the triggers (viral and non-viral) of ME/CFS, is proposed to be a physiologically severe stressor, which could be targeting a stress-integrator, within the brain: the hypothalamic paraventricular nucleus (PVN). It is proposed that inflammatory mediators, released at the site of COVID-19 infection, would be transmitted as stress-signals, via humoral and neural pathways, which overwhelm this stress-center. In genetically susceptible people, an intrinsic stress-threshold is suggested to be exceeded causing ongoing dysfunction to the hypothalamic PVN's complex neurological circuitry. In this compromised state, the hypothalamic PVN might then be hyper-sensitive to a wide range of life's ongoing physiological stressors. This could result in the reported post-exertional malaise episodes and more severe relapses, in common with ME/CFS, that perpetuate an ongoing disease state. When a certain stress-tolerance-level is exceeded, the hypothalamic PVN can become an epicenter for microglia-induced activation and neuroinflammation, affecting the hypothalamus and its proximal limbic system, which would account for the range of reported ME/CFS-like symptoms. A model for Post-COVID-19 Fatigue Syndrome is provided to stimulate discussion and critical evaluation. Brain-scanning studies, incorporating increasingly sophisticated imaging technology should enable chronic neuroinflammation to be detected, even at a low level, in the finite detail required, thus helping to test this model, while advancing our understanding of Post-COVID-19 Fatigue Syndrome pathophysiology.

scholarly journals Addressing the Long COVID Crisis: Integrative Health and Long COVID

2021 ◽  
Vol 10 ◽  
pp. 216495612110565
Author(s):  
Alan Roth ◽  
Pan San Chan ◽  
Wayne Jonas
Keyword(s):  
Well Being ◽  
Chronic Fatigue ◽  
Lifestyle Changes ◽  
Integrative Health ◽  
Fatigue Syndrome ◽  
Cerebrovascular Events ◽  
Wide Range ◽  
Health Related ◽  
And Behavior ◽  
Patients Experience

While COVID-19 has killed millions of people globally, its lasting effects on the health and well-being of entire populations are just becoming clear. As many as 30% of those diagnosed with COVID-19 report continuing health-related problems, regardless of the severity of the initial infection. Given the infection rate in the world, that translates to between 5.4 and 17.9 million globally; about 700 000 in the US. The syndrome goes by many names; here we call it “long COVID.” Patients experience a wide range of symptoms, including serious organ system effects such as pulmonary fibrosis, myocarditis, new diabetes diagnoses, stroke, and other cerebrovascular events. They also experience ongoing pain, fatigue, and cognitive dysfunction. We suggest here that these patients require an integrative health approach, one that combines traditional medical management, non-pharmacological approaches, and behavior and lifestyle changes. Such an approach has been shown to be beneficial in other chronic illnesses such as fibromyalgia, chronic fatigue syndrome, and post-Lyme disease.

scholarly journals Article Commentary: Kynurenine Pathway Pathologies: Do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)

2013 ◽  
Vol 6s1 ◽  
pp. IJTR.S11193 ◽  
Author(s):  
Adele Blankfield
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Neuropsychiatric Symptoms ◽  
Protein Energy Malnutrition ◽  
Chronic Fatigue ◽  
Kynurenine Pathway ◽  
Metabolic Dysfunction ◽  
Fatigue Syndrome ◽  
Inflammatory Conditions ◽  
Protein Energy ◽  
Definition Of

Chronic fatigue syndrome (CFS) and fibromyalgia (FM) appear to meet the criteria of a tryptophan-kynurenine pathway disorder with potential neuroimmunological sequelae. Aspects of some of the putative precipitating factors have been previously outlined. 2 , 3 An analysis of the areas of metabolic dysfunction will focus on future directions for research and management. The definition of dual tryptophan pathways has increased the understanding of the mind-body, body-mind dichotomy. The serotonergic pathway highlights the primary (endogenous) psychiatric disorders. The up-regulation of the kynurenine pathway by physical illnesses can cause neuropathic and immunological disorders 1 associated with secondary neuropsychiatric symptoms. Tryptophan and nicotinamide deficiencies fall within the protein energy malnutrition (PEM) spectrum. They can arise if the kynurenine pathway is stressed by primary or secondary inflammatory conditions and the consequent imbalance of available catabolic/anabolic substrates may adversely influence convalescent phase efficiency. The replacement of depleted or reduced NAD+ levels and other cofactors can perhaps improve the clinical management of these disorders.

Chronic Fatigue Immune Dysfunction Syndrome: An Epidemic?

PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 804-804
Author(s):  
MUDR ALEŠ KMINEK ◽  
MUDR IVO SIMUNEK
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Children And Adolescents ◽  
Immune Dysfunction ◽  
Chronic Fatigue ◽  
Case Definition ◽  
Fatigue Syndrome ◽  
Definition Of ◽  
Mild Fever

To the Editor.— We read with great interest the article "Chronic Fatigue in Adolescents" by Smith et al in the August 1991 issue.1 We appreciate the statement by the authors that "the CDC-recommended criteria for case definition of the chronic fatigue syndrome (CFS) were developed mainly from adult populations and may not be appropriate for children and adolescents." We have studied children suffering from unexplained fatigue, mild fever, nonexudative pharyngitis, lymphadenopathia, etc, since 1987, ie, prior to publication of CDC-recommended criteria of CFS.2

Immunological anomalies and thrombocytopenia in 117 dogs and cats diagnosed with Chronic Fatigue Syndrome (cfs)

2003 ◽  
Vol 51 (1) ◽  
pp. 61-72 ◽  
Author(s):  
W. Tarello
Keyword(s):  
Inclusion Bodies ◽  
Central Italy ◽  
Clinical Signs ◽  
Chronic Fatigue ◽  
Granulocytic Ehrlichiosis ◽  
Protein Levels ◽  
Fatigue Syndrome ◽  
Imidocarb Dipropionate ◽  
Canine Population ◽  
Associated Symptoms

Medical records of thirty-five consecutive cases of canine granulocytic ehrlichiosis (CGE) diagnosed cytologically in Central Italy in 1995-2000 were analysed retrospectively. Tick exposure was reported in 16 dogs (45.7%) and concurrent babesiosis in 19 dogs (54.3%). Ehrlichia-like inclusion bodies were found in neutrophils in a percentage varying from 0.5% to 11%. Frequently recorded clinical signs included anorexia (71.4%), lethargy (45.7%), conjunctivitis (31.4%), fever (25.7%), lameness (20%) and ataxia (20%). Among the 16 representative dogs in which protein electrophoresis was performed, 10 (62.5%) showed high globulin levels and 6 (37.5%) had concurrent high total protein levels. During treatment with doxycycline, all associated symptoms, including those unusually described, such as pyoderma intertrigo, erythema, apparent blindness and oral papillomatosis, progressively disappeared in 31 (89%) out of 35 dogs. The efficacy of treatment was marked in dogs simultaneously treated twice with imidocarb dipropionate: among the 14 dogs in which a fast recovery was noted, 11 (80%) were concurrently affected by babesiosis and consequently treated with the specific medicament leading to excellent outcomes. The main conclusion is that CGE is present among dogs from Central Italy and should be included in the differential diagnosis of possible zoonotic agents affecting the canine population.

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