scholarly journals Exacerbation of Psoriasis Following COVID-19 Vaccination: Report From a Single Center

2021 ◽  
Vol 8 ◽  
Author(s):  
Yi-Wei Huang ◽  
Tsen-Fang Tsai
Keyword(s):  
Human Leukocyte ◽  
Temporal Association ◽  
Control Group ◽  
Morphologic Change ◽  
Post Vaccination ◽  
Leukocyte Antigen ◽  
Plaque Type ◽  
History Of ◽  
Guttate Psoriasis ◽  
Dermatologic Disease

The temporal association had been reported between vaccination and exacerbation of psoriasis, and episodes of psoriasis flare-up have recently been attributed to COVID-19 vaccines. We recruited 32 unimmunized controls and 51 vaccinated psoriasis patients, 49 of whom were under biological therapy, with regular clinic visits receiving a total of 63 shots of vaccines, including 30 doses of Moderna mRNA-1273 and 33 doses of AstraZeneca-Oxford AZD1222. Fifteen episodes of exacerbation attacked within 9.3 ± 4.3 days, which is higher than two episodes in the control group (p = 0.047). The mean post-vaccination severity of the worsening episodes increased from PASI 3.1 to 8.0 (p < 0.001). Three patients showed morphologic change from chronic plaque-type to guttate psoriasis. Deterioration of psoriasis following COVID-19 vaccination was not associated with age, sex, disease duration, psoriatic arthritis, family history of psoriasis, history of erythroderma, current biologics use, comorbidities, vaccine types, human leukocyte antigen (HLA)-C genotypes, baseline PASI nor pre-vaccination PASI. For those who received two doses of vaccination, all but one patient aggravated after the first shot but not the second. The mechanism of psoriasis exacerbation in immunized individuals is unclear, but Th17 cells induced by COVID-19 vaccines may play a role. In the pandemic era, psoriasis patients and physicians should acknowledge the possibility of fluctuation of disease activity when vaccinated against COVID-19. Nevertheless, compared to a treatable dermatologic disease with rapid resolution of exacerbation, psoriasis patients who do not have contraindications to vaccination should benefit from COVID-19 vaccines in the prevention of severe COVID-19 infection and fatality.

scholarly journals Human Leukocyte Antigen HLA-DRB1 Determinants Susceptibility to Gastroesophageal Reflux Disease

2017 ◽  
Vol 19 (1) ◽  
pp. 3-9
Author(s):  
Batool Mutar Mahdi ◽  
Riyadh Mohamad Hasan ◽  
Wafaa Hazim
Keyword(s):  
Reflux Disease ◽  
Familial Aggregation ◽  
Human Leukocyte ◽  
Oesophageal Reflux ◽  
Control Group ◽  
Leukocyte Antigen ◽  
Oesophageal Reflux Disease ◽  
History Of ◽  
H Pylori ◽  
And Control

Background: Gastro oesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to Gastro oesophageal reflux disease as supported by familial aggregation of this disease. Aim of the study was to investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with (GERD).Methods: Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January 2014 and July 2016. Sixty Iraqi Arab Muslim patients with a history of heartburn and dyspepsia were compared with 100 Iraqi Arab Muslims controls. All study patients and control groups underwent upper gastrointestinal endoscopic examinations and their serums were analyzed for CagA antibodies Immunoglobulin G (IgG) for H. pylori. HLA-DRB1 genotyping were done to both groups.Results: A total of 60 patients with erosive gastritis; GERD (Grade II and III) were evaluated, together with 100 controls. There is a significant increase of H. pylori infection (p=0.0001) in GERD patients than control group. HLA-DRB1* 15: 01was significantly increased in GERD patients in comparison with control group and an increased frequency of HLADRB1*11: 01 in control group compared with patients group.Conclusions: There is an association between HLA-DRB1 *15: 01 in GERD patients with H pylori positive patients.J MEDICINE Jan 2018; 19 (1) : 3-9

scholarly journals Human leukocyte antigen HLADRB1 determinants susceptibility to gastroesophageal reflux disease

2017 ◽  
Vol 54 (1) ◽  
pp. 41-45
Author(s):  
Batool Mutar MAHDI ◽  
Riyadh Mohamad HASAN ◽  
Wafaa Hazim SALIH
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Familial Aggregation ◽  
Human Leukocyte ◽  
Control Group ◽  
Leukocyte Antigen ◽  
History Of ◽  
H Pylori ◽  
And Control

ABSTRACT BACKGROUND Gastroesophageal reflux disease (GERD) is characterized by diverse symptoms. There is an evidence for a genetic component to GERD as supported by familial aggregation of this disease. OBJECTIVE To investigate whether certain human leucocyte antigen genes HLA-DRB1 are associated with GERD. METHODS Patients and controls were prospectively recruited from GIT center at Al-Kindy Teaching Hospital (Baghdad-Iraq) between January 2014 and July 2016. Sixty Iraqi Arab Muslims patients with a history of heartburn and dyspepsia compared with 100 Iraqi Arab Muslims controls. All study patients and control groups underwent upper gastrointestinal endoscopic examinations and their serums were analyzed for CagA antibodies Immunoglobulin G (IgG) for H. pylori. HLA-DRB1 genotyping were done to both groups. RESULTS A total of 60 patients with erosive gastritis; GERD (Grade II and III) were evaluated, together with 100 controls. There is a significant increase of H. pylori infection (P=0.0001) in GERD patients than control group. HLA-DRB1* 15:01 was significantly increased in GERD patients in comparison with control group and an increased frequency of HLADRB1*11:01 in control group compared with patients group. CONCLUSION There is an association between HLA-DRB1 *15:01 in GERD patients with H. pylori positive patients.

scholarly journals Genetic diversity among volunteer donors of bone marrow in southeastern Brazil, according to the HLA system

2014 ◽  
Vol 132 (3) ◽  
pp. 158-162
Author(s):  
Letícia Sarni Roque ◽  
Rodolpho Telarolli-Junior ◽  
Leonor Castro Monteiro Loffredo
Keyword(s):  
Bone Marrow ◽  
Human Leukocyte ◽  
Mixed Race ◽  
University Hospital ◽  
Southeastern Brazil ◽  
Leukocyte Antigen ◽  
Hla System ◽  
History Of ◽  
Allelic Group ◽  
Southeastern Region

CONTEXT AND OBJECTIVE: Checking the histocompatibility of the molecules of the human leukocyte antigen (HLA) system is vital for performing bone marrow transplantation with allogeneic material. The objective of this study was to characterize bone marrow donors according to gender, age, ethnicity and HLA groups at a regional hemotherapy center in Brazil.DESIGN AND SETTING:Descriptive study on registered donors at a regional hemotherapy center in a public university hospital in the southeastern region of Brazil.METHODS: The records of 66,780 donors who were registered between 2005 and June 2011 were consulted, and the variables studied were tabulated.RESULTS:There were equal numbers of male and female donors and 82.8% of them were under 45 years of age. In terms of ethnicity, 77.3% declared themselves to be white, 15.0% mixed race, 5.7% black and 2% others. In terms of immunogenetic characterization, the most frequent HLA-A allelic group was HLA-A*02, with 39.20% of the donors; in the HLA-B allelic group, the most common was HLA-B*35, with 14.18%; while in the HLA-DRB1 allelic group, the most frequent was HLA-DRB1*03, with 17.03%. Comparison between these results and data from the Brazilian Bone Marrow Donor Registry (REDOME) showed that there were demographic and immunogenetic differences due to the history of immigration in the region of Ribeirão Preto, in southeastern Brazil.CONCLUSIONS: The results reinforce the importance of understanding the demographic and immunogenic profile of regions of Brazil, in order to reduce the waiting time for a histocompatible donor.

scholarly journals Polymorphisms of the Human Leukocyte Antigen DRB1 and DQB1 Genes and the Natural History of Human Papillomavirus Infection

2002 ◽  
Vol 186 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Paulo C. Maciag ◽  
Nicolas F. Schlecht ◽  
Patricia S. A. Souza ◽  
Thomas E. Rohan ◽  
Eduardo L. Franco ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Natural History ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
History Of

scholarly journals Galectin-3 as a Novel Multifaceted and Not Only Cardiovascular Biomarker in Patients with Psoriasis with Regard to Systemic Treatment—Preliminary Data

Biology ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 88
Author(s):  
Anna Baran ◽  
Paulina Kiluk ◽  
Julia Nowowiejska ◽  
Tomasz W. Kaminski ◽  
Magdalena Maciaszek ◽  
...  
Keyword(s):  
Protective Role ◽  
Control Group ◽  
Plaque Type ◽  
Before And After ◽  
Diagnostic Role ◽  
Galectin 3 ◽  
Healthy Control ◽  
History Of ◽  
Cardiovascular Biomarker ◽  
Positive Correlations

Galectin-3 (gal-3) is a multifunctional regulator of various biological processes and diseases, which are common comorbidities in psoriasis. Data regarding potential diagnostic role of gal-3 in psoriasis are insufficient. Serum gal-3 levels were evaluated before and after twelve weeks of treatment with acitretin or methotrexate in 31 patients with plaque-type psoriasis and compared to 11 healthy control group. The mean serum galectin-3 level in patients with psoriasis was significantly higher compared to the control group (p < 0.01). In patients with obesity and long-lasting psoriasis (>20 years) positive relations of gal-3 and PASI were noted. In psoriatics with low gal-3 levels, positive correlations between the gal-3 and BMI, glucose level, and with the latter in short-lasting psoriasis (<20 years) were noted. In the long history of psoriasis, gal-3 was negatively correlated with lipids levels. The Gal-3 level might be a multifaceted modulator of the course of psoriasis and predictive factor of cardiometabolic comorbidities’ development, especially in patients with a long history of the disease or obesity. Patients with low serum gal-3 and short history of psoriasis are presumably at greater risk of diabetes. In patients with long-lasting psoriasis and concomitant obesity, gal-3 may exert a protective role against dyslipidemia or perhaps further CMD development.

scholarly journals Treatment of Anti-HLA Donor-Specific Antibodies Results in Increased Infectious Complications and Impairs Survival after Liver Transplantation

2020 ◽  
Vol 9 (12) ◽  
pp. 3986
Author(s):  
Sinem Ünlü ◽  
Nils Lachmann ◽  
Maximilian Jara ◽  
Paul Viktor Ritschl ◽  
Leke Wiering ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Causes Of Death ◽  
Human Leukocyte ◽  
Infectious Complications ◽  
Control Group ◽  
Leukocyte Antigen ◽  
High Urgency ◽  
Donor Specific Antibodies ◽  
One Year ◽  
The Relationship

Donor-specific anti-human leukocyte antigen antibodies (DSA) are controversially discussed in the context of liver transplantation (LT). We investigated the relationship between the presence of DSA and the outcome after LT. All the LTs performed at our center between 1 January 2008 and 31 December 2015 were examined. Recipients < 18 years, living donor-, combined, high-urgency-, and re-transplantations were excluded. Out of 510 LTs, 113 DSA-positive cases were propensity score-matched with DSA-negative cases based on the components of the Balance of Risk score. One-, three-, and five-year survival after LT were 74.3% in DSA-positive vs. 84.8% (p = 0.053) in DSA-negative recipients, 71.8% vs. 71.5% (p = 0.821), and 69.3% vs. 64.9% (p = 0.818), respectively. Rejection therapy was more often applied to DSA-positive recipients (n = 77 (68.1%) vs. 37 (32.7%) in the control group, p < 0.001). At one year after LT, 9.7% of DSA-positive patients died due to sepsis compared to 1.8% in the DSA-negative group (p = 0.046). The remaining causes of death were comparable in both groups (cardiovascular 6.2% vs. 8.0%; p = 0.692; hepatic 3.5% vs. 2.7%, p = 0.788; malignancy 3.5% vs. 2.7%, p = 0.788). DSA seem to have an indirect effect on the outcome of adult LTs, impacting decision-making in post-transplant immunosuppression and rejection therapies and ultimately increasing mortality due to infectious complications.

scholarly journals HLA-B27 antigen frequency among suspected Spondyloarthropathy patients attaining a tertiary level hospital of Bangladesh

2015 ◽  
Vol 40 (3) ◽  
pp. 102-106 ◽  
Author(s):  
A Nessa ◽  
S Tabassum ◽  
S Sultana
Keyword(s):  
Healthy Subjects ◽  
Age Groups ◽  
Human Leukocyte ◽  
Disease Association ◽  
Control Group ◽  
Hla B27 ◽  
Leukocyte Antigen ◽  
Male Preponderance ◽  
Antigen Frequency ◽  
Medical University

Human leukocyte antigen B27 (HLA-B27), a class I molecules of the major histocompatibility complex has a strong disease association with different types of spondarthropathies (SpA). The strength of this disease association varies markedly among racial and ethnic populations. The present study aimed to identify the HLA-B27 antigen frequencies among suspected SpA patients as well as healthy Bangladeshi individuals. The frequency of HLA-B27 was determined in 1500 patients and 1000 healthy subjects attending the Bangabandhu Sheikh Mujib Medical University (BSMMU). HLAB 27 typing was done by microlymphocytotoxicity test using commercial kit. A total of 738 (49.2%) suspected SpA patients and 107 (10.7%) healthy subjects tested positive for HLA-B27 antigen with higher frequency among younger age groups (54.9%, 52.4% and 56.2% in 0-14 years, 15-24 years and 25–34 years of age respectively). The male female positivity was almost same (11.4% and 9.6%) among control group, but in patient group it was 53.0% and 41.2% respectively. The findings of this hospital based study showed a high frequency of HLA-B27 among suspected SpA patients with male preponderance which is comparable with neighboring countries.Bangladesh Med Res Counc Bull 2014; 40 (3): 102-106

Immune Recovery Uveitis and Human Leukocyte Antigen Typing: A Report on Four Patients

2005 ◽  
Vol 15 (5) ◽  
pp. 607-609 ◽  
Author(s):  
G. Modorati ◽  
E. Miserocchi ◽  
R. Brancato
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Hla Typing ◽  
University Hospital ◽  
Immune Recovery ◽  
Human Leukocyte Antigen Typing ◽  
Immune Recovery Uveitis ◽  
Leukocyte Antigen ◽  
Immunodeficiency Virus ◽  
History Of

Purpose To report the typing of human leukocyte antigen (HLA) in four human immunodeficiency virus-positive (HIV) patients with immune recovery uveitis (IRU). Methods The medical history of four consecutive patients who presented at the Ocular Immunology and Uveitis Service (University Hospital San Raffaele, Milan, Italy) with definite diagnosis of IRU is reported. The HLA typing was tested in all patients. Results All patients presented the clinical and ophthalmological characteristics of IRU. The HLA typing analysis showed the presence of HLA B 8–18 in all patients. Conclusions The data obtained from these patients indicate the presence of the same HLA typing (B 8–18). The clinical relevance of such association needs to be further evaluated.

scholarly journals Clinical Update on Spondyloarthritis

2016 ◽  
Vol 8 ◽  
Author(s):  
Isabelle Hebert MD FRCPC ◽  
Isabelle Fortin MD
Keyword(s):  
Clinical Manifestations ◽  
Human Leukocyte ◽  
Seronegative Arthritis ◽  
Resonance Imaging ◽  
Peripheral Arthritis ◽  
Buttock Pain ◽  
Leukocyte Antigen ◽  
History Of ◽  
Inflammatory Bowel ◽  
Magnetic Resonance Imaging Mri

The spondyloarthritides encompass various clinical manifestations. The hallmark of the spondyloarthropathies is inflammatory axial and sacroiliac (buttock) pain. Associated findings include peripheral arthritis, uveitis, conjunctivitis, enthesitis, and psoriasis. Human leukocyte antigen (HLA) B27 is positive in a majority of patients. Radiographic abnormalities appear first on vertebral column/sacroiliac magnetic resonance imaging (MRI) and many years later on radiography, which makes the diagnosis challenging. Of course, rheumatoid factor is negative – hence the term seronegative arthritis. Other clinical clues that help identify this disease’s spectrum are a family history of ankylosing spondylitis (AS), psoriasis, or inflammatory bowel disease (IBD); intestinal or genitourinary symptoms; or the presence of psoriasis. All this heterogeneity makes an early diagnosis difficult.

scholarly journals Glanzmann thrombasthenia and its perioperative management in head trauma: A rare and challenging situation

2016 ◽  
Vol 03 (01) ◽  
pp. 052-055
Author(s):  
Neeraj Kumar ◽  
Abdul Khan ◽  
Nilesh Kumar ◽  
Ashish Bindra ◽  
Charu Mahajan ◽  
...  
Keyword(s):  
Platelet Transfusion ◽  
Perioperative Management ◽  
Factor Viia ◽  
Human Leukocyte ◽  
Coagulation Disorder ◽  
Glanzmann Thrombasthenia ◽  
Leukocyte Antigen ◽  
Emergency Situations ◽  
History Of ◽  
Challenging Situation

AbstractGlanzmann thrombasthenia is a rare inherited coagulation disorder, manifesting itself in early childhood as bleeding episodes. The patients with this disease may present with uncontrollable bleeding following trauma. We report a patient of Glanzmann syndrome with head injury, who presented to us following fall from stairs. Platelet transfusion is the mainstay of treatment in emergency situations. As patients generally have a history of platelet transfusion they may be refractory to the same. Leuko reduced or human leukocyte antigen matched platelets should be used. Recombinant factor VIIa can be used to control bleeding in refractory cases and in patients with antibodies against platelets. Anti-fibrinolytics can also be used as adjuvants. There is need of advanced perioperative coagulation screening spot tests in emergency trauma settings as routine coagulation tests may not be able to pick up the abnormality. Thromboelastography/thromboelastometry can be a great tool for perioperative management of such coagulation disorders.

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