scholarly journals Calcium Phosphate-Based Bioceramics in the Treatment of Osteosarcoma: Drug Delivery Composites and Magnetic Hyperthermia Agents

2021 ◽  
Vol 3 ◽  
Author(s):  
Tiê Menezes Oliveira ◽  
Fernanda Costa Brandão Berti ◽  
Sidney Carlos Gasoto ◽  
Bertoldo Schneider ◽  
Marco Augusto Stimamiglio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Magnetic Hyperthermia ◽  
Modern Medicine ◽  
Anticancer Drug Delivery ◽  
Human Bones ◽  
Potential Applications ◽  
Inorganic Composition ◽  
Tumor Drugs

The use of biomaterials in medicine is not recent, and in the last few decades, the research and development of biocompatible materials had emerged. Hydroxyapatite (HAp), a calcium phosphate that constitutes a large part of the inorganic composition of human bones and teeth, has been used as an interesting bioceramic material. Among its applications, HAp has been used to carry antitumor drugs, such as doxorubicin, cisplatin, and gemcitabine. Such HAp-based composites have an essential role in anticancer drug delivery systems, including the treatment of osteosarcoma. In addition, the association of this bioceramic with magnetic nanoparticles (MNPs) has also been used as an effective agent of local magnetic hyperthermia. Further, the combined approach of the aforementioned techniques (HAp scaffolds combined with anti-tumor drugs and MNPs) is also an attractive therapeutical alternative. Considering the promising role of the use of bioceramics in modern medicine, we proposed this review, presenting an updated perspective on the use of HAp in the treatment of cancer, especially osteosarcoma. Finally, after giving the current progress in this field, we highlight the urgent need for efforts to provide a better understanding of their potential applications.

Role of Nanoparticles in Cancer Therapy

2022 ◽  
pp. 363-388
Author(s):  
Zeeshan Ahmad Bhutta ◽  
Ayesha Kanwal ◽  
Ambreen Ashar ◽  
Moazam Ali ◽  
Ashar Mahfooz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Genetic Material ◽  
Modern Medicine ◽  
Cancer Treatments ◽  
Delivery Methods ◽  
Anticancer Drug Delivery ◽  
Scientific Fields

The rapid growth of nanotechnology towards the development of nanomedicines has improved cancer treatment. Nanomedicine provides the opportunity to implement complex and targeted multifunctional strategies. Today, nanoparticles (NPs) have many uses in a number of scientific fields. In recent years, it has been repeatedly reported that NPs hold a significant place in the regulation of modern medicine by implementing a varying number of clinical approaches like drug carrying substances, genetic material delivery to tumors, as well as in radiography as a contrast media agent. Various nanomaterials based on organic, inorganic, lipid or glycan compounds, and synthetic polymers have been used to develop and improve new cancer treatments. In this chapter, the authors discussed the role of NPs in cancer treatment among various anticancer drug delivery methods.

scholarly journals Focused ultrasound in neuro-oncology: the role of the Focused Ultrasound Foundation in driving adoption and innovation

2021 ◽  
Author(s):  
Emily C. Whipple ◽  
Camille A. Favero ◽  
Neal F. Kassell
Keyword(s):  
Drug Delivery ◽  
Brain Tumors ◽  
Focused Ultrasound ◽  
Clinical Evidence ◽  
Neurological Injury ◽  
High Concentration ◽  
Potential Applications ◽  
Tumor Agent

Abstract Introduction Intra-arterial (lA) delivery of therapeutic agents across the blood-brain barrier (BBB) is an evolving strategy which enables the distribution of high concentration therapeutics through a targeted vascular territory, while potentially limiting systemic toxicity. Studies have demonstrated lA methods to be safe and efficacious for a variety of therapeutics. However, further characterization of the clinical efficacy of lA therapy for the treatment of brain tumors and refinement of its potential applications are necessary. Methods We have reviewed the preclinical and clinical evidence supporting superselective intraarterial cerebral infusion (SSJACI) with BBB disruption for the treatment of brain tumors. In addition, we review ongoing clinical trials expanding the applicability and investigating the efficacy of lA therapy for the treatment of brain tumors. Results Trends in recent studies have embraced the use of SSIACI and less neurotoxic chemotherapies. The majority of trials continue to use mannitol as the preferred method of hyperosmolar BBB disruption. Recent preclinical and preliminary human investigations into the lA delivery of Bevacizumab have demonstrated its safety and efficacy as an anti-tumor agent both alone and in combination with chemotherapy. Conclusion lA drug delivery may significantly affect the way treatment are delivered to patients with brain tumors, and in particular GBM. With refinement and standardization of the techniques of lA drug delivery, improved drug selection and formulations, and the development of methods to minimize treatment-related neurological injury, lA therapy may offer significant benefits for the treatment of brain tumors.

scholarly journals Biocompatible Nanocarriers for Enhanced Cancer Photodynamic Therapy Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1933
Author(s):  
Sathish Sundar Dhilip Kumar ◽  
Heidi Abrahamse
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Targeting Therapy ◽  
Potential Applications ◽  
Carrier Molecule ◽  
Novel Material ◽  
Potential Benefits ◽  
Targeted Photodynamic Therapy

In recent years, the role of nanotechnology in drug delivery has become increasingly important, and this field of research holds many potential benefits for cancer treatment, particularly, in achieving cancer cell targeting and reducing the side effects of anticancer drugs. Biocompatible and biodegradable properties have been essential for using a novel material as a carrier molecule in drug delivery applications. Biocompatible nanocarriers are easy to synthesize, and their surface chemistry often enables them to load different types of photosensitizers (PS) to use targeted photodynamic therapy (PDT) for cancer treatment. This review article explores recent studies on the use of different biocompatible nanocarriers, their potential applications in PDT, including PS-loaded biocompatible nanocarriers, and the effective targeting therapy of PS-loaded biocompatible nanocarriers in PDT for cancer treatment. Furthermore, the review briefly recaps the global clinical trials of PDT and its applications in cancer treatment.

Oxidized polysaccharides for anticancer-drug delivery: What is the role of structure?

2020 ◽  
pp. 117562
Author(s):  
Lukáš Münster ◽  
Michaela Fojtů ◽  
Zdenka Capáková ◽  
Monika Muchová ◽  
Lenka Musilová ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

scholarly journals Therapeutic efficacy of nanoparticles and routes of administration

2019 ◽  
Vol 23 (1) ◽  
Author(s):  
Dhrisya Chenthamara ◽  
Sadhasivam Subramaniam ◽  
Sankar Ganesh Ramakrishnan ◽  
Swaminathan Krishnaswamy ◽  
Musthafa Mohamed Essa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Transport ◽  
Informed Choice ◽  
Routes Of Administration ◽  
Therapeutic Molecules ◽  
Potential Applications ◽  
Sirna Therapy ◽  
Carbon Based Nanomaterials ◽  
Made In

AbstractIn modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (< 100 nm) and are broadly classified into natural and synthetic nanomaterials. However, “engineered” nanomaterials have received significant attention due to their versatility. Although enormous strides have been made in research and development in the field of nanotechnology, it is often confusing for beginners to make an informed choice regarding the nanocarrier system and its potential applications. Hence, in this review, we have endeavored to briefly explain the most commonly used nanomaterials, their core properties and how surface functionalization would facilitate competent delivery of drugs or therapeutic molecules. Similarly, the suitability of carbon-based nanomaterials like CNT and QD has been discussed for targeted drug delivery and siRNA therapy. One of the biggest challenges in the formulation of drug delivery systems is fulfilling targeted/specific drug delivery, controlling drug release and preventing opsonization. Thus, a different mechanism of drug targeting, the role of suitable drug-laden nanocarrier fabrication and methods to augment drug solubility and bioavailability are discussed. Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the biological and other barriers and their impact on drug transport. The overall aim of this article is to facilitate straightforward perception of nanocarrier design, routes of various nanoparticle administration and the challenges associated with each drug delivery method.

scholarly journals Anticancer drug delivery to cancer cells using alkyl amine-functionalized nanodiamond supraparticles

2019 ◽  
Vol 1 (9) ◽  
pp. 3406-3412 ◽  
Author(s):  
Yue Yu ◽  
Xi Yang ◽  
Ming Liu ◽  
Masahiro Nishikawa ◽  
Takahiro Tei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Alkyl Amine ◽  
Amine Functionalized ◽  
Potential Applications

Nanocarriers have attracted increasing interest due to their potential applications in anticancer drug delivery.

Synthesis and investigating the magnetic properties of magnetite nanocrystallites for drug delivery

2015 ◽  
Vol 29 (22) ◽  
pp. 1550122 ◽  
Author(s):  
Muhammad Zaka Ansar ◽  
Shahid Atiq ◽  
Saira Riaz ◽  
Shahzad Naseem ◽  
Shahid M. Ramay ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Sol Gel ◽  
Magnetic Characteristics ◽  
X Ray Diffraction ◽  
Structural Morphology ◽  
X Ray ◽  
Anticancer Drug Delivery ◽  
Potential Applications ◽  
Very High

In recent years, use of magnetic nanoparticles in biomedical applications has increased tremendously. In particular, magnetite [Formula: see text] nanoparticles being highly biocompatible are rated very high due to their potential applications in biomedicines, for instance in anticancer drug delivery. In this work, the [Formula: see text] nanoparticles have been synthesized using a novel sol–gel based autocombustion technique. The crystal structure of the [Formula: see text] phase was confirmed by the data obtained from X-ray diffraction. Scherrer’s formula was employed to estimate the crystallite size of the [Formula: see text] nanoparticles. The structural morphology, investigated by using a scanning electron microscopy (SEM), revealed well-dispersed and uniform sized grains in the sample prepared using enhanced fuel concentration. A vibrating sample magnetometer (VSM) was employed to investigate the magnetic characteristics of the samples which confirmed the superparamagnetic nature of the [Formula: see text] samples, essentially required for cancer treatment. These nanoparticles could further be modified and functionalized by suitable polymers to achieve better biocompatibility before being injected into the diseased cells.

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