Role of Nanoparticles in Cancer Therapy

2022 ◽  
pp. 363-388
Author(s):  
Zeeshan Ahmad Bhutta ◽  
Ayesha Kanwal ◽  
Ambreen Ashar ◽  
Moazam Ali ◽  
Ashar Mahfooz ◽  
...  

The rapid growth of nanotechnology towards the development of nanomedicines has improved cancer treatment. Nanomedicine provides the opportunity to implement complex and targeted multifunctional strategies. Today, nanoparticles (NPs) have many uses in a number of scientific fields. In recent years, it has been repeatedly reported that NPs hold a significant place in the regulation of modern medicine by implementing a varying number of clinical approaches like drug carrying substances, genetic material delivery to tumors, as well as in radiography as a contrast media agent. Various nanomaterials based on organic, inorganic, lipid or glycan compounds, and synthetic polymers have been used to develop and improve new cancer treatments. In this chapter, the authors discussed the role of NPs in cancer treatment among various anticancer drug delivery methods.

2021 ◽  
Vol 3 ◽  
Author(s):  
Tiê Menezes Oliveira ◽  
Fernanda Costa Brandão Berti ◽  
Sidney Carlos Gasoto ◽  
Bertoldo Schneider ◽  
Marco Augusto Stimamiglio ◽  
...  

The use of biomaterials in medicine is not recent, and in the last few decades, the research and development of biocompatible materials had emerged. Hydroxyapatite (HAp), a calcium phosphate that constitutes a large part of the inorganic composition of human bones and teeth, has been used as an interesting bioceramic material. Among its applications, HAp has been used to carry antitumor drugs, such as doxorubicin, cisplatin, and gemcitabine. Such HAp-based composites have an essential role in anticancer drug delivery systems, including the treatment of osteosarcoma. In addition, the association of this bioceramic with magnetic nanoparticles (MNPs) has also been used as an effective agent of local magnetic hyperthermia. Further, the combined approach of the aforementioned techniques (HAp scaffolds combined with anti-tumor drugs and MNPs) is also an attractive therapeutical alternative. Considering the promising role of the use of bioceramics in modern medicine, we proposed this review, presenting an updated perspective on the use of HAp in the treatment of cancer, especially osteosarcoma. Finally, after giving the current progress in this field, we highlight the urgent need for efforts to provide a better understanding of their potential applications.


2018 ◽  
Vol 19 (12) ◽  
pp. 3950 ◽  
Author(s):  
Marilina García-Aranda ◽  
Elisabet Pérez-Ruiz ◽  
Maximino Redondo

Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.


Liposomes are spherical shaped vesicles comprising of at least one phospholipid bilayer that serve as a novel drug delivery framework. They are microscopic structures in which a fluid system is totally encased by a film made out of lipid bilayers. It varies in size, conformation, charge and drug transporter stacked with assortment of particles, for example, small molecules of drug, plasmids, nucleotides or proteins and so on. Ongoing advances in nanotherapeutics have brought about engineered liposomes rising in nanomedicine, giving better restorative control of diseased states. This has made ready for the improvement of second-stage liposomes for increased efficiency and could at last lead to a change in perspective from the regular drug delivery methods.


Author(s):  
Muddukrishnaiah K.

Due to drug resistance, lack of cancer cell selectivity, and solubility, conventional cancer treatments lose their therapeutic uses, and as such, new therapeutic agents need to be developed. Nanomaterials and peptides are increasingly being used in the fields of cancer diagnosis, biomarker discovery due to their therapeutic values and novel way of targeting and curing the disease. Synergism among the peptide-conjugated nanoparticles is an exhilarating group of materials, not only sharing the benefits of conventional nanomedicine, but also possessing the unique properties of excellent biocompatibility, biodegradability, versatile sensitivity, specific biological purpose, and synthetic feasibility. These virtues inspired by the scientists and have taken advantage in the peptide-conjugated nano drugs for the accurate delivery of drugs reliably to the site of the lesion. This chapter offers a summary of emerging technologies that have recently been developed in the broad field of peptide-conjugated nanoparticles and offers guidance for targeted drug delivery and cancer therapy.


Nanoscale ◽  
2019 ◽  
Vol 11 (14) ◽  
pp. 6519-6532 ◽  
Author(s):  
Lucie Reinišová ◽  
Soňa Hermanová ◽  
Martin Pumera

A biomedical perspective is used to assess micro/nanomotor-based anticancer drug delivery systems with recommendations for their effective future development.


2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Jachmann ◽  
K Klingberg ◽  
M C Zapata-Garcia ◽  
D S Srivastava ◽  
A Exadaktylos ◽  
...  

Abstract Background Within NCD`s, Cancer accounts for the 2nd most frequent cause after Cardiovascular diseases and in some European countries it´s the leading cause of premature deaths. One of the challenges within cancer therapy can be found in inequity in access to cancer treatment, because this causes worse health outcomes, which are attributable to the accessibility of health care and thus avoidable. The objective of the systematic review was to identify barriers in access to cancer treatment in Europe (inter-country) and within 6 European countries (intra-country): Spain, Germany, Switzerland, Finland, Bulgaria, UK. Methods To obtain data scientific (PubMed, CINAHL, Embase) and grey literature were searched using keywords relating to inequity in access to cancer therapy in Europe. Collected Abstracts of published articles in English between 01/2013 and 05/2018 were reviewed independently. Identified barriers in access to cancer therapy were grouped into 2 categories: patient and health system/provider factors, followed by thematic analysis for each category. Results Out of 786 unique articles, 14 were included in the systematic review. The most frequent cited barriers within Europe were patient socioeconomic status (n = 7, 50%), age (n = 4, 28.6%) and reimbursement and availability of cancer medicine (n = 4, 28.6%). Conclusions This review showed that different barriers in access to cancer therapy still exist in Europe and therefore demonstrated an urgent need for actions to reduce these disparities across all Europe. Additional to the known equity stratifiers the role of health system factors concerning different reimbursement processes and shortages in widely used cancer drugs was emphasized. The amount of available studies with main focus on barriers in access to cancer therapy in Europe varies by equity stratifier, cancer site and type of treatment and seems to be very limited, showing a need for future investigations upon this topic with possibly uniform scales. Key messages This review showed that different barriers in access to cancer therapy still exist in Europe and therefore demonstrated an urgent need for actions to reduce these disparities across all Europe. Additional to the known equity stratifiers the role of health system factors concerning different reimbursement processes and shortages in widely used cancer drugs was emphasized.


2019 ◽  
Vol 20 (24) ◽  
pp. 6358 ◽  
Author(s):  
Giuseppina Emanuela Grieco ◽  
Noemi Brusco ◽  
Giada Licata ◽  
Laura Nigi ◽  
Caterina Formichi ◽  
...  

Diabetes mellitus is a group of heterogeneous metabolic disorders characterized by chronic hyperglycaemia as a consequence of pancreatic β cell loss and/or dysfunction, also caused by oxidative stress. The molecular mechanisms involved inβ cell dysfunction and in response to oxidative stress are also regulated by microRNAs (miRNAs). miRNAs are a class of negative gene regulators, which modulate pathologic mechanisms occurring in diabetes and its complications. Although several pharmacological therapies specifically targeting miRNAs have already been developed and brought to the clinic, most previous miRNA-based drug delivery methods were unable to target a specific miRNA in a single cell type or tissue, leading to important off-target effects. In order to overcome these issues, aptamers and nanoparticles have been described as non-cytotoxic vehicles for miRNA-based drug delivery. These approaches could represent an innovative way to specifically target and modulate miRNAs involved in oxidative stress in diabetes and its complications. Therefore, the aims of this review are: (i) to report the role of miRNAs involved in oxidative stress in diabetes as promising therapeutic targets; (ii) to shed light onto the new delivery strategies developed to modulate the expression of miRNAs in diseases.


2019 ◽  
Vol 9 (7) ◽  
pp. 757-763 ◽  
Author(s):  
Xiao Duan ◽  
Xue Yang ◽  
Chunlei Dai ◽  
Tong Tong ◽  
Congxiu Miao ◽  
...  

PEGlyation nanogels have shown potential in cancer therapy due to their outstanding biodegradability and biocompatibility. In this study, glutathione (GSH)-responsive PEGlyation nanogels were loaded with camptothecin (CPT) (CPT@A2B5-PEG) by one-pot synthesis based on the monomers of disulfide-based diacrylate (A2) and N-(2-aminoethyl) ethane-1,2-diamine (B5). The nanogels with responsive cross-linked networks were degraded into small molecules according to their GSH-sensitivity. The nanogels were of the correct size as measured by TEM and DLS, and uptake into A549 cells was observed within 6 h. Cell viability assays showed that CPT@A2B5-PEG produced similar anticancer efficacy to free CPT. The GSH-responsive CPT-loaded PEGlyation nanogels produced by one-pot synthesis are therefore promising platforms for anticancer drug delivery.


RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36910-36922 ◽  
Author(s):  
Min Li ◽  
Fangrong Zhang ◽  
Kerong Chen ◽  
Cheng Wang ◽  
Yujie Su ◽  
...  

Schematic illustration of the combination of NPs and MSCs drug delivery systems for cancer therapy.


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