Cancer in Africa: Is It a Genetic or Environmental Health Problem?

Patients of African ancestry have the poorest outcome and the shortest survival rates from cancer globally. This could be attributed to many variables including racial, biological, socioeconomic and sociocultural factors (either single, multiple or combined), which may be responsible for this major health problem. We sought to assess the most common types of cancer that endanger the health of the African people, and tried to investigate the real differences between African and other Non-African patients regarding incidence, prevalence and mortality rates of different cancers. Therefore, identifying the underlying aetiological causes responsible for the increased incidence and mortality rates of African patients will allow for changing the current plans, to make optimized modalities for proper screening, diagnosis and treatment for those African patients, in order to improve their survival and outcomes.

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hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers

BioMed Research International ◽

10.1155/2015/896432 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 15

Author(s):

Elena Lastraioli ◽

Tiziano Lottini ◽

Lapo Bencini ◽

Marco Bernini ◽

Annarosa Arcangeli

Keyword(s):

Potassium Channels ◽

Health Problem ◽

Tumor Therapy ◽

Major Health Problem ◽

Major Health ◽

Incidence And Mortality ◽

Novel Biomarkers ◽

New Biomarkers

Because of their high incidence and mortality solid cancers are a major health problem worldwide. Although several new biomarkers and potential targets for therapy have been identified through biomolecular research in the last years, the effects on patients’ outcome are still unsatisfactory. Increasing evidence indicates that hERG1 potassium channels are overexpressed in human primary cancers of different origin and several associations between hERG1 expression and clinicopathological features and/or outcome are emerging. Aberrant hERG1 expression may be exploited either for early diagnosis (especially in those cancers where it is expressed in the initial steps of tumor progression) or for therapy purposes. Indeed, hERG1 blockage impairs tumor cell growth bothin vitroandin vivoin preclinical mouse model. hERG1-based tumor therapy in humans, however, encounters the major hindrance of the potential cardiotoxicity that many hERG1 blockers exert. In this review we focus on recent advances in translational research in some of the most frequent human solid cancers (breast, endometrium, ovary, pancreas, esophagus, stomach, and colorectum) that have been shown to express hERG1 and that are a major health problem.

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Genetics of impulsivity, anger, and aggression as risk factors for suicidal behavior

Genes, brain, and emotions ◽

10.1093/oso/9780198793014.003.0023 ◽

2019 ◽

pp. 343-365

Author(s):

Dan Rujescu ◽

Ina Giegling

Keyword(s):

Risk Factors ◽

Personality Traits ◽

Suicidal Behavior ◽

Health Problem ◽

Complex Trait ◽

Sociocultural Factors ◽

Psychiatric History ◽

Major Health Problem ◽

Major Health ◽

Intermediate Phenotypes

Suicidal behavior is a major health problem causing more than 1 million deaths worldwide each year. The risk of suicide-related behavior is supposed to be determined by a complex interplay of sociocultural factors, psychiatric history, personality traits, and genetic as well as neurobiological vulnerability. Personality traits like impulsivity, anger or aggression are valuable intermediate phenotypes in the search for the genetics of such a complex trait. This review will summarize genetic factors of phenotypes as risk factors for suicidal behavior. There is hope that simpler, quantifiable measures will be more elementary compared to clinical phenotypes. It is assumed that the number of genes required to produce variations in these traits may be fewer than those involved in producing a diagnostic entity. Further understanding of the genetics and pathophysiology of suicidal behavior is therefore very important.

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Prevention and Treatment of Early Childhood Caries (ECC)

Journal Of Medicine & Health ◽

10.28932/jmh.v1i3.525 ◽

2016 ◽

Vol 1 (3) ◽

Author(s):

Jeffrey .

Keyword(s):

Early Childhood ◽

Health Problem ◽

Early Childhood Caries ◽

Health Providers ◽

Missing Teeth ◽

Optimal Basis ◽

Major Health Problem ◽

Major Health ◽

Childhood Caries

Early Childhood Caries (ECC) is a chronic disease that can be prevented. It commonlyaffects children involving in one or more decayed (with lesions or not) teeth, missing teeth (dueto caries), or teeth with fillings in children aged under 71 months. The disease is sometimesoverlooked, but this condition usually affects the general health of children. Early detection ofEarly Childhood Caries (ECC) can prevent problems which are harmful to children. Therefore,the ECC must be prevented and for teeth that have had dental caries they should be givenproper treatment so as not to worsen and affect the quality of life in children. Prevention of thisdisease is a significant component in any health program to prepare for the optimal basis forthe oral health of children. This condition will become a serious health problem if not handledproperly, and it is a major health problem for health providers throughout the world.Primarypreventive must be initiated since a woman getting pregnant.Keywords: Early Childhood Caries (ECC), prevention, treatment

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Acute Cholecystitis Caused by Ceftriaxone Stones in an Adult

Case Reports in Medicine ◽

10.1155/2009/132452 ◽

2009 ◽

Vol 2009 ◽

pp. 1-2 ◽

Cited By ~ 6

Author(s):

Christian D. Becker ◽

Robert A. Fischer

Keyword(s):

Adult Patient ◽

Acute Cholecystitis ◽

Health Problem ◽

Medical Literature ◽

Early Recognition ◽

Gallstone Formation ◽

Sludge Formation ◽

Major Health Problem ◽

Major Health ◽

First Case

Acute cholecystitis is a major health problem. There are multiple etiologies to be considered and early recognition of the condition is important to optimize management and outcome. We report the first case in the medical literature of symptomatic acute cholecystitis triggered by ceftriaxone-associated gallbladder sludge formation and, importantly, solid ceftriaxone gallstone formation in an adult patient with underlying mineral and pigment cholecystolithiasis, necessitating cholecystectomy. This case serves as a reminder for physicians to keep this uncommon cause of cholecystolithiasis and cholecystitis in mind in patients who receive prolonged ceftriaxone therapy. These patients should be cautioned to promptly report to their physicians any signs or symptoms of cholecystitis in order to ensure timely and appropriate evaluation.

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New Drugs for Acute Heart Failure

University Heart Journal ◽

10.3329/uhj.v7i1.10208 ◽

2012 ◽

Vol 7 (1) ◽

pp. 35-38

Author(s):

Mohammad Salman ◽

Syed Allahsan ◽

Manzoor Mahmood ◽

Md Khairul Anam ◽

Shahed Mohammad Anwar ◽

...

Keyword(s):

Heart Failure ◽

Renal Failure ◽

Acute Heart Failure ◽

Health Problem ◽

Standard Therapy ◽

New Drugs ◽

European Medicines Agency ◽

Major Health Problem ◽

Major Health ◽

Long Time

Acute heart failure is a major health problem responsible for several million hospitalizations worldwide each year. Standard therapy has not changed for long time and includes diuretics and variable use of vasodilators or inotropes. Recently Nesiritide and Levosimendan are two drugs for the treatment of acute heart failure which have been approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMEA), respectively. There was little concern that Nesiritide can worsen the renal failure but recent trials had abolished this concern. DOI: http://dx.doi.org/10.3329/uhj.v7i1.10208 UHJ 2011; 7(1): 35-38

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A Review on Lepa Kalpana in Dadru W.R.T. to Brihatrayi and Laghutrayi

International Journal of Health Sciences and Research ◽

10.52403/ijhsr.20210413 ◽

2021 ◽

Vol 11 (4) ◽

pp. 102-105

Author(s):

Lalita Sharma ◽

Sudama Singh Yadav

Keyword(s):

Fungal Infection ◽

Health Problem ◽

Skin Diseases ◽

Modern Science ◽

Treatment Modalities ◽

Major Health Problem ◽

Psychological Burden ◽

Major Health ◽

Almost All ◽

Topical Absorption

Skin is the outermost covering of body and the largest organ of the integumentary system. Skin diseases are major health problem with emotional and psychological burden on patients. In Ayurvedic classics, almost all the skin diseases come under the broad heading of Kushtha. Dadru is a type of Kushtha which can be correlated with Tinea infection (fungal infection) in modern science. Three genera of dermatophytes infect skin i.e. Trichophyton spp, Epidermophyton spp and Microsporum spp. Ayurveda describes a multitude of treatment modalities for skin diseases in relation with various types of kushtha. One of them is the topical use of medicaments over the skin for topical absorption which allows faster absorption and better management of skin diseases. Lepa kalpana is a herbal or herbo-mineral drug for topical use. Although lepa is an important therapy in various diseases but it is highly useful specifically in dermatological diseases. This review describes different lepas which are especially mentioned for Dadru in doctrines of Ayurveda. Key words: Dadru, Kushtha, Lepa kalpana , Skin diseases.

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Recent trends in incidence and mortality rates for leukemias, and in survival rates for childhood acute lymphocytic leukemia, in upstate New York

Cancer ◽

10.1002/1097-0142(19860501)57:9<1850::aid-cncr2820570926>3.0.co;2-h ◽

1986 ◽

Vol 57 (9) ◽

pp. 1850-1858 ◽

Cited By ~ 3

Author(s):

Anthony P. Polednak

Keyword(s):

New York ◽

Acute Lymphocytic Leukemia ◽

Survival Rates ◽

Mortality Rates ◽

Lymphocytic Leukemia ◽

Upstate New York ◽

Incidence And Mortality ◽

Recent Trends

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Protein S Deficiency - An Uncommon Cause with Common Presentation

Journal of Nepal Paediatric Society ◽

10.3126/jnps.v35i2.13616 ◽

2016 ◽

Vol 35 (2) ◽

pp. 192-194

Author(s):

Nabanita Kora ◽

Rajib Das ◽

Sabyasachi Som ◽

Sumanta Laha ◽

Nayan Bannerji ◽

...

Keyword(s):

Health Problem ◽

Rare Case ◽

Protein S ◽

Protein S Deficiency ◽

Major Health Problem ◽

Major Health ◽

Young Stroke ◽

Common Presentation ◽

S Deficiency

Correction: The correct PDF for this article was loaded on 9th March 2017. We offer our sincere apologies for having the wrong PDF loaded for this article.Stroke in child poses a major health problem. Thrombophilic factors have been implicated in 4-8% of young stroke worldwide. Protein S deficiency is a very rare cause of stroke. A few cases have been reported in literature. We are reporting a rare case of protein S deficiency causing stroke in a two year old child.J Nepal Paediatr Soc 2015;35(2):192-194

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Sociocultural aspects of schistosomiasis mansoni in an endemic area in Minas Gerais, Brazil

Cadernos de Saúde Pública ◽

10.1590/s0102-311x1998000400026 ◽

1998 ◽

Vol 14 (4) ◽

pp. 841-849 ◽

Cited By ~ 17

Author(s):

Andréa Gazzinelli ◽

Maria Flávia Gazzinelli ◽

Matilde Miranda Cadete ◽

Samuel Pena Filho ◽

Ilcéia Ribeiro Sá ◽

...

Keyword(s):

Endemic Area ◽

Minas Gerais ◽

Sociocultural Factors ◽

Small Community ◽

Major Health Problem ◽

Major Health ◽

Attitudes And Practices ◽

School Aged Children ◽

Qualitative Approaches ◽

Knowledge Attitudes And Practices

A study to determine the sociocultural factors influencing knowledge, attitudes, and practices of individuals from a small community toward Schistosoma mansoni infection was carried out in an endemic area in the State of Minas Gerais, Brazil. The study used qualitative approaches to collect data from school-aged children and teachers. Specific findings were that the individuals interviewed were aware of the disease, but also held inaccurate popular beliefs about transmission. Misconceptions coexisted with accurate knowledge both in children and teachers. The disease was not seen as a major health problem and did not affect their activities since it did not cause severe symptoms in most of the individuals. Although the majority of the participants related transmission to water and lack of sanitation, they did not take any preventive measures since their subsistence is highly dependent on irrigation, farming, fishing, and other essential work that is directly related to water activities. The authors discuss the development of a health education program based on the knowledge and perception of individuals about the disease and its determinants as being important for the context and behavioral change.

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