scholarly journals Phytoestrogen Bakuchiol Exhibits In Vitro and In Vivo Anti-breast Cancer Effects by Inducing S Phase Arrest and Apoptosis

2016 ◽  
Vol 7 ◽  
Author(s):  
Li Li ◽  
Xueping Chen ◽  
Chi C. Liu ◽  
Lai S. Lee ◽  
Cornelia Man ◽  
...  
2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Yang-Hao Yu ◽  
Han-Peng Kuo ◽  
Hui-Hsia Hsieh ◽  
Jhy-Wei Li ◽  
Wu-Huei Hsu ◽  
...  

Ganoderma tsugae(GT) is a traditional Chinese medicine that exhibits significant antitumor activities against many types of cancer. This study investigated the molecular mechanism by which GT suppresses the growth of doxorubicin-resistant lung adenocarcinoma H23/0.3 cells. Our results reveal that GT inhibits the viability of H23/0.3 cellsin vitroandin vivoand sensitizes the growth suppression effect of doxorubicin on H23/0.3 cells. The data also show that GT induces S phase arrest by interfering with the protein expression of cyclin A, cyclin E, CDK2, and CDC25A. Furthermore, GT induces cellular apoptosis via induction of a mitochondria/caspase pathway. In addition, we also demonstrate that the suppression of cell proliferation by GT is through down-regulation of the PI3K/Akt signaling pathway. In conclusion, this study suggests that GT may be a useful adjuvant therapeutic agent in the treatment of lung cancer.


2018 ◽  
Vol 14 (7) ◽  
pp. 1540 ◽  
Author(s):  
Zhigang Wei ◽  
Ming Zhao ◽  
Yajun Hou ◽  
Xiaoting Fu ◽  
Dawei Li ◽  
...  

2015 ◽  
Vol 44 (25) ◽  
pp. 11408-11419 ◽  
Author(s):  
Jian-Hua Wei ◽  
Zhen-Feng Chen ◽  
Jiao-Lan Qin ◽  
Yan-Cheng Liu ◽  
Zhu-Quan Li ◽  
...  

The complexes exhibited considerable in vitro and in vivo anticancer activity, and higher safety than ciplatin.


PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92853 ◽  
Author(s):  
Tiejun Zhao ◽  
Qiang Sun ◽  
Sonia V. del Rincon ◽  
Amanda Lovato ◽  
Maud Marques ◽  
...  

2019 ◽  
Vol 20 (13) ◽  
pp. 3197 ◽  
Author(s):  
Takanori Matsui ◽  
Taiga Chiyo ◽  
Hideki Kobara ◽  
Shintaro Fujihara ◽  
Koji Fujita ◽  
...  

Esophageal squamous cell carcinoma (ESCC) is the most common primary esophageal malignancy. Telmisartan, an angiotensin II type 1 (AT1) receptor blocker (ARB) and a widely used antihypertensive, has been shown to inhibit proliferation of various cancer types. This study evaluated the effects of telmisartan on human ESCC cell proliferation in vitro and in vivo and sought to identify the microRNAs (miRNAs) involved in these antitumor effects. We examined the effects of telmisartan on three human ESCC cell lines (KYSE150, KYSE180, and KYSE850). Telmisartan inhibited proliferation of these three cell lines by inducing S-phase arrest, which was accompanied by decreased expression of cyclin A2, cyclin-dependent kinase 2, and other cell cycle-related proteins. Additionally, telmisartan reduced levels of phosphorylated ErbB3 and thrombospondin-1 in KYSE180 cells. Furthermore, expression of miRNAs was remarkably altered by telmisartan in vitro. Telmisartan also inhibited tumor growth in vivo in a xenograft mouse model. In conclusion, telmisartan inhibited cell proliferation and tumor growth in ESCC cells by inducing cell-cycle arrest.


RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16973-16990 ◽  
Author(s):  
Dharmasivam Mahendiran ◽  
Sethu Amuthakala ◽  
Nattamai S. P. Bhuvanesh ◽  
Raju Senthil Kumar ◽  
Aziz Kalilur Rahiman

The thiosemicarbazone-based copper(i) complexes causing S phase arrest and apoptosis involving the mitochondrial controlled pathway has been investigated.


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