scholarly journals A New Therapeutic Candidate for Cardiovascular Diseases: Berberine

2021 ◽  
Vol 12 ◽  
Author(s):  
Yun Cai ◽  
Qiqi Xin ◽  
Jinjin Lu ◽  
Yu Miao ◽  
Qian Lin ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Bacterial Infections ◽  
Therapeutic Option ◽  
Research Progress ◽  
Asian Countries ◽  
Protective Mechanisms ◽  
Limited Effectiveness ◽  
The World ◽  
Long Term Prognosis

Cardiovascular diseases (CVD) are the leading cause of death in the world. However, due to the limited effectiveness and potential adverse effects of current treatments, the long-term prognosis of CVD patients is still discouraging. In recent years, several studies have found that berberine (BBR) has broad application prospects in the prevention and treatment of CVD. Due to its effectiveness and safety for gastroenteritis and diarrhea caused by bacterial infections, BBR has been widely used in China and other Asian countries since the middle of the last century. The development of pharmacology also provides evidence for the multi-targets of BBR in treating CVD. Researches on CVD, such as arrhythmia, atherosclerosis, dyslipidemia, hypertension, ischemic heart disease, myocarditis and cardiomyopathy, heart failure, etc., revealed the cardiovascular protective mechanisms of BBR. This review systematically summarizes the pharmacological research progress of BBR in the treatment of CVD in recent years, confirming that BBR is a promising therapeutic option for CVD.

scholarly journals Helicobacter pyloriAntibiotic Resistance: Trends Over Time

2000 ◽  
Vol 14 (10) ◽  
pp. 895-899 ◽  
Author(s):  
Raymond G Lahaie ◽  
Christiane Gaudreau
Keyword(s):  
Bacterial Infections ◽  
Bacterial Resistance ◽  
Reliable Data ◽  
Asian Countries ◽  
Resistance To Antibiotics ◽  
Treatment Regimens ◽  
The World ◽  
Trends Over Time ◽  
H Pylori ◽  
Resistance Rates

Resistance to antibiotics can be a major problem in the treatment of bacterial infections. As the use of antibiotics increases, bacterial resistance to these agents is rising and in many cases is responsible for the failure of treatment regimens. Although the treatment ofHelicobacter pyloriinfection requires the use of more than one antibiotic to obtain adequate eradication rates, the efficacy of the currently used antibiotic combinations has been shown to be decreased by resistance to one of the antibiotics. The use of antibiotics in regimens for the treatment ofH pyloriis increasing in many countries, including Canada. This increase is both in the use of these antibiotics alone for the treatment of nongastrointestinal infections and in their use in association with proton pump inhibitors for the treatment ofH pyloriinfection. In several European and Asian countries, where resistance to antibiotics is being monitored, it has been demonstrated thatH pyloriresistance to metronidazole and to clarithromycin increased throughout the 1990s. Thus far, the data available in Canada do not show increased resistance to either of these antibiotics. As for other antibiotics used in the treatment ofH pyloriinfection, such as tetracycline and amoxicillin, the rate of resistance to these agents is still very low and does not constitute a significant problem. Because the efficacy of the regimens used in the treatment ofH pyloriinfection is compromised by resistance to the antibiotics used, it is important thatH pyloriresistance rates in Canada and throughout the world continue to be monitored. Only with such reliable data can the most optimal regimens be recommended.

Therapeutic Potential of Alkaloids as Anti-Bacterial Agents: Drugs of Future

2019 ◽  
Vol 15 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Aini Pervaiz ◽  
Haroon Khan ◽  
Surriya Amin
Keyword(s):  
Bacterial Infections ◽  
Therapeutic Potential ◽  
Gram Negative Bacteria ◽  
World Community ◽  
Therapeutic Class ◽  
Global Issue ◽  
The World ◽  
Current Therapies ◽  
Plant Alkaloids

Bacterial infections remain a major threat to the world community in terms of both morbidity and mortality. Indeed, bacterial infections are accountable for millions of fatalities around the globe. Additionally, these bacterial infections represent a notable burden, in particular, for children living in less-developed regions of the world. There are a numbers of classes of antibiotics for the treatment of these complicated and uncomplicated infections. But most of them are struggling with the current challenge of resistance. Obviously, resistance to current antibiotic is a global issue as greatly caused therapeutic outcome and patient compliance. The current researchers are looking towards natural product specially plant-based product for effective and long term solutions. In this regard, alkaloids represent a very important therapeutic class of natural products with clinical significance. The review describes the antibacterial profile of plant based alkaloids. Alkaloid acts as an emerging therapy for bacterial infections by inhibiting a broad range of gram positive and gram negative bacteria that were mostly resistant to current therapies. It was concluded that these alkaloids could be useful and effective therapeutic alternative to existing therapies that are extensively facing challenges of resistance. The current need is to focus on the clinical and safety aspects of these reported preclinical studies. Thus, it could be expected that plant alkaloids will be the popular drugs of future.

scholarly journals Adenosquamous Carcinoma of the Lateral Oropharyngeal Wall

2010 ◽  
Vol 89 (11) ◽  
pp. E18-E21 ◽  
Author(s):  
Daniel P. Nadeau ◽  
Paul C. Shick ◽  
Robin Lindsay
Keyword(s):  
World Literature ◽  
Adenosquamous Carcinoma ◽  
Current Treatment ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
The World ◽  
Aggressive Tumor ◽  
Long Term Prognosis

Adenosquamous carcinoma of the head and neck is a rare and aggressive tumor, with fewer than 100 cases reported in the world literature to date. We report a case of adenosquamous carcinoma of the oral pharynx arising as a second primary malignancy in a patient being treated for primary gastric MALT (mucosa-associated lymphoid tissue) lymphoma. We also review the literature to assess current treatment and long-term prognosis of this rare tumor.

scholarly journals Research Progress of the Influence of Acromegaly on Cardiovascular Diseases

2021 ◽  
Vol 5 (5) ◽  
pp. 147-151
Author(s):  
Yalan Wang ◽  
Jiahe Xie
Keyword(s):  
Growth Hormone ◽  
Cardiovascular Diseases ◽  
Growth Factor ◽  
Mortality Rate ◽  
Cardiovascular System ◽  
Pituitary Adenomas ◽  
Progressive Disease ◽  
The Body ◽  
Research Progress

Acromegaly is a progressive disease caused by an increased in the levels of growth hormone (GH), followed by an increased in the levels of insulin-like growth factor-1 (IGF-1). Most cases are caused by GH-secreting pituitary adenomas. Long-term exposure to excessive GH would affect all systems of the body, of which the cardiovascular system has the highest incidence rate and mortality rate. This review discusses the influence of acromegaly on cardiovascular diseases and its treatment.

ON THE IRRIGATION REGIME OF AGRICULTURAL CROPS

2018 ◽  
pp. 13-17 ◽  
Author(s):  
A Ramazanov ◽  
S Buriev
Keyword(s):  
Water Demand ◽  
Agricultural Crops ◽  
Irrigation Regime ◽  
Asian Countries ◽  
Total Water ◽  
Total Water Consumption ◽  
Central Asian ◽  
The World ◽  
Central Asian Countries

The article presents a comparative analysis of the results of long-term fundamental and applied researches to establish the total water consumption and irrigation regime of cotton crops in the irrigated zone of Zakavkazye (Azerbaijan) and Central Asian countries. It is marked their adequacy in determining the water demand of plants and suggested the necessity of transition to methods widely used in the world.

scholarly journals Cardiovascular diseases in combination with SARS-CoV-2 viral infection: cours and forecast

2021 ◽  
Vol 17 (3) ◽  
pp. 97-105
Author(s):  
O. I. Gushchina ◽  
N. G. Lozhkina
Keyword(s):  
Cardiovascular Diseases ◽  
Myocardial Damage ◽  
Special Group ◽  
Cardiovascular Pathology ◽  
Treatment Information ◽  
Increased Risk ◽  
Long Term Prognosis ◽  
The Relationship ◽  
Research Grant

In a pandemic, a special group is made up of patients with cardiovascular pathology. Cardiovascular diseases are largely associated with an increase in mortality and an increased risk of complications in patients infected with the SARS-CoV-2 virus. This determines the importance of risk stratification, the choice of optimal personalized therapy and the study of the long-term prognosis of myocardial infarction against the background of infection caused by SARS-CoV-2. Despite the rapidly growing attention to this issue, the mechanisms of the relationship between cardiovascular disease and COVID-19 are not completely clear. We conducted a systematic review to summarize important aspects of COVID-19 for cardiologists. The authors discuss both well-studied factors of the infectious process leading to acute myocardial damage and decompensation of existing chronic cardiac diseases, and new, fundamental, determining prognosis and treatment. Information on the topic was used from publications based on the PubMed, Google Scholar and eLibrary.ru databases. This work was carried out within the framework of a research grant № 67573613 of Pfizer.

Hepatic comorbidity in psychiatry. A case report

2017 ◽  
Vol 41 (S1) ◽  
pp. S483-S483
Author(s):  
G. Pardo de Santayana ◽  
R. Landera ◽  
M. Juncal ◽  
O. Porta ◽  
L. Sánchez ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Antipsychotic Drugs ◽  
Therapeutic Option ◽  
Blood Levels ◽  
Good Tolerance ◽  
Iatrogenic Complications ◽  
Competing Interest ◽  
Long Term Prognosis ◽  
Long Acting

IntroductionComorbidity between mental and physical illnesses is very common and their possible interactions must always be taken into account. Hepatic disorders in particular, can affect the blood levels of antipsychotic drugs altering their effects on patients. Therefore, it is very important to assess in each case which treatment might be the most beneficial for the patient to avoid iatrogenic complications.AimTo review articles in Pub-Med and UpToDate about the possible iatrogenic complications that can arise using antipsychotic drugs in patients with hepatic disorders.MethodsWe describe the case of a 52-year-old male with Schizophrenia who was diagnosed of HCV infection ten years ago, for which he rejected any kind of treatment due to delirious ideation. In the past he was treated with oral Paliperidone with good tolerance, which he discontinued because of pour insight and stopped attending Psychiatric consultation. In April 2016 the patient was hospitalised suspecting a hepatocellular carcinoma.ResultsDuring hospitalization he began treatment with long-acting injectable formulation of Paliperidone Palmitate that improved his insight. The patient agreed to perform the necessary tests to verify the suspected diagnosis, which was sadly confirmed. He achieved psychopathological stability, but unfortunately the patient died 6 months later because of his hepatocellular carcinoma.ConclusionsPaliperidone is a good therapeutic option in patients with hepatic disorders because it is not metabolised by the liver. It also has a depot formulation that improves adherence in patients with low insight, reducing the danger of future psychotic decompensation and improving the long-term prognosis.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals A Normalized Mortality Rate Showed the Diverse Severity of COVID-19 and Its Association With Other Chronic Diseases

2020 ◽  
Author(s):  
Santosh Kumar ◽  
P.R. Renjith ◽  
C. Priscilla ◽  
Selva Kumar Ganesan
Keyword(s):  
Cardiovascular Diseases ◽  
Mortality Rate ◽  
Chronic Diseases ◽  
Respiratory Diseases ◽  
The United States ◽  
World Health ◽  
Asian Countries ◽  
The World ◽  
The Usa ◽  
Health Organization

Covid-19 has given a halt to all the activities in the world. Europe was most affected followed by the United States of America. It has taken more than 200,000 lives till now. In this study, we have assessed the severity of Covid-19 by analyzing the mortality rate in Covid-19 and other diseases to see the severity of Covid-19 and other chronic diseases. The Covid-19 data and “death rate” data caused by other diseases were downloaded from the world health organization (WHO) website. A normalized period based method was used to see the mortality rate of Covid-19 in comparison to other diseases. The deaths occurred by cardiovascular diseases, cancer, and respiratory diseases were more in number than the Covid-19 caused deaths in the 45 days period where most of the Covid-19 deaths had taken place. The severity of Covid-19 in the USA was moderate. The severity of Covid-19 in Asian countries was found to be at a low. Europe showed the highest diversity in the mortality rate of Covid-19. Cardiovascular diseases, cancer, and non-communicable diseases were still more lethal and caused more deaths than Covid-19.

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