Therapeutic Potential of Alkaloids as Anti-Bacterial Agents: Drugs of Future

2019 ◽  
Vol 15 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Aini Pervaiz ◽  
Haroon Khan ◽  
Surriya Amin
Keyword(s):  
Bacterial Infections ◽  
Therapeutic Potential ◽  
Gram Negative Bacteria ◽  
World Community ◽  
Therapeutic Class ◽  
Global Issue ◽  
The World ◽  
Current Therapies ◽  
Plant Alkaloids

Bacterial infections remain a major threat to the world community in terms of both morbidity and mortality. Indeed, bacterial infections are accountable for millions of fatalities around the globe. Additionally, these bacterial infections represent a notable burden, in particular, for children living in less-developed regions of the world. There are a numbers of classes of antibiotics for the treatment of these complicated and uncomplicated infections. But most of them are struggling with the current challenge of resistance. Obviously, resistance to current antibiotic is a global issue as greatly caused therapeutic outcome and patient compliance. The current researchers are looking towards natural product specially plant-based product for effective and long term solutions. In this regard, alkaloids represent a very important therapeutic class of natural products with clinical significance. The review describes the antibacterial profile of plant based alkaloids. Alkaloid acts as an emerging therapy for bacterial infections by inhibiting a broad range of gram positive and gram negative bacteria that were mostly resistant to current therapies. It was concluded that these alkaloids could be useful and effective therapeutic alternative to existing therapies that are extensively facing challenges of resistance. The current need is to focus on the clinical and safety aspects of these reported preclinical studies. Thus, it could be expected that plant alkaloids will be the popular drugs of future.

scholarly journals An overview of carbapenem, its resistance and therapeutic options for infections caused by carbapenem resistant bacteria

2020 ◽  
Vol 9 (9) ◽  
pp. 1454
Author(s):  
Hari P. Nepal ◽  
Rama Paudel
Keyword(s):  
Bacterial Infections ◽  
Carbapenem Resistance ◽  
Therapeutic Options ◽  
Resistant Bacteria ◽  
Gram Negative Bacteria ◽  
Beta Lactam ◽  
Gram Negative ◽  
Penicillin Binding Proteins ◽  
Carbapenem Resistant ◽  
The World

Carbapenems are beta-lactam drugs that have broadest spectrum of activity. They are commonly used as the drugs of last resort to treat complicated bacterial infections. They bind to penicillin binding proteins (PBPs) and inhibit cell wall synthesis in bacteria. Important members that are in clinical use include doripenem, ertapenem, imipenem, and meropenem. Unlike other members, imipenem is hydrolyzed significantly by renal dehydropeptidase; therefore, it is administered together with an inhibitor of renal dehydropeptidase, cilastatin. Carbapenems are usually administered intravenously due to their low oral bioavailability. Most common side effects of these drugs include nausea, vomiting, diarrhea, skin rashes, and reactions at the infusion sites. Increasing resistance to these antibiotics is being reported throughout the world and is posing a threat to public health.  Primary mechanisms of carbapenem resistance include expulsion of drug and inactivation of the drug by production of carbapenemases which may not only hydrolyze carbapenem, but also cephalosporin, penicillin, and aztreonam. Resistance especially among Gram negative bacteria is of much concern since there are only limited therapeutic options available for infections caused by carbapenem resistant Gram-negative bacterial pathogens. Commonly used drugs to treat such infections include polymyxins, fosfomycin and tigecycline.

scholarly journals ANTIBIOTIC RESISTANCE (ABR) AND COMMUNITY PHARMACIST: A REVIEW

2021 ◽  
pp. 37-39
Author(s):  
DEEPTHI C DENNY ◽  
S KARAN
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Common Factors ◽  
Community Pharmacists ◽  
Primary Source ◽  
Self Medication ◽  
Factors Associated ◽  
Global Issue ◽  
The World ◽  
Information Providers

Antibiotic resistance (ABR) is a major growing global issue. The WHO report points out high proportions of resistance to common bacterial infections in all regions of the world. Common factors associated with resistance include non-adherence to the prescribed course, improper way of disposing the antibiotics (ABs), misuse and abuse, overuse, and underuse of antibiotics. Another complimenting factor for the increase in the antibiotic resistance is self-medication with antibiotics. This all has caused many infectious diseases to be untreatable. Community pharmacists act as primary source of healthcare information providers to whom the patient directly seeks medical advices. Thus, they can play a central role in ensuring the safer use of antibiotics in the community.

scholarly journals Competition Policy as a Strategic Determinant of Economic Development in the Post-pandemic Period: Management and Legal Aspects

2021 ◽  
Vol 39 (7) ◽  
Author(s):  
Nina Avanesova ◽  
Viktoriia Vovk ◽  
Natalia Reshetniak ◽  
Nataliia Volosnikova ◽  
Yuliia Yehorova
Keyword(s):  
Economic Development ◽  
Global Economy ◽  
Legal Aspects ◽  
Economic Situation ◽  
Economic Losses ◽  
Negative Effects ◽  
World Community ◽  
Cultural Life ◽  
The World

The state and tendencies of COVID-19 influence on the economic situation in the world are studied and the socio-economic losses suffered by the world economy during the pandemic are analyzed. The entire world community, starting in mid-December 2019, has come under the enormous influence of the World Coronavirus Epidemic, called COVID-19. The pandemic caused by this virus has already caused thousands of casualties around the world, imposed significant restrictions on the socio-cultural life of the population and radically changed the trends of the global economy. Today, it is difficult to predict what final human casualties and economic losses will be suffered by states in the short, medium and long term. However, it is important to consider individual economic development forecasts and measures selected by the governments of the world's leading countries to overcome the negative effects of the COVID-19 pandemic. This will allow to form a real vision of the possible course of economic processes that will directly affect the level of socio-cultural life of the population.and the real measures taken to stabilize the financial and economic situation at the micro and macro levels.

scholarly journals Factors Responsible for Promoting Religious Extremism in Pakistan: A Case of Khyber Pakhtunkhwa

2019 ◽  
Vol IV (II) ◽  
pp. 50-56
Author(s):  
Surat Khan
Keyword(s):  
Khyber Pakhtunkhwa ◽  
World Community ◽  
Religious Extremism ◽  
Global Issue ◽  
The Social ◽  
The World ◽  
The Future

Religious extremism is related to religion and sensation and has become a global issue, but since long, Pakistan has been considered among those countries that have been the Centre of it. Pakistan has been considered by the world community, as the cause as well as the victim of terrorism and extremism. It is a complicated phenomenon and needs exploring all the social, religious, economic, political and sectarian factors behind it. There are different reasons, causes, sources and factors of extremism and terrorism in the region in general and in Pakistan in particular. Explanation of all these factors is primarily important for understanding this evil in Pakistan and the region. The researcher has tried to find briefly those factors that promoted religious extremism in the society in Pakistan in generally and Pashtun community specifically. The researcher has tried to find out a solution to these factors to combat it in the future.

scholarly journals A New Therapeutic Candidate for Cardiovascular Diseases: Berberine

2021 ◽  
Vol 12 ◽  
Author(s):  
Yun Cai ◽  
Qiqi Xin ◽  
Jinjin Lu ◽  
Yu Miao ◽  
Qian Lin ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Bacterial Infections ◽  
Therapeutic Option ◽  
Research Progress ◽  
Asian Countries ◽  
Protective Mechanisms ◽  
Limited Effectiveness ◽  
The World ◽  
Long Term Prognosis

Cardiovascular diseases (CVD) are the leading cause of death in the world. However, due to the limited effectiveness and potential adverse effects of current treatments, the long-term prognosis of CVD patients is still discouraging. In recent years, several studies have found that berberine (BBR) has broad application prospects in the prevention and treatment of CVD. Due to its effectiveness and safety for gastroenteritis and diarrhea caused by bacterial infections, BBR has been widely used in China and other Asian countries since the middle of the last century. The development of pharmacology also provides evidence for the multi-targets of BBR in treating CVD. Researches on CVD, such as arrhythmia, atherosclerosis, dyslipidemia, hypertension, ischemic heart disease, myocarditis and cardiomyopathy, heart failure, etc., revealed the cardiovascular protective mechanisms of BBR. This review systematically summarizes the pharmacological research progress of BBR in the treatment of CVD in recent years, confirming that BBR is a promising therapeutic option for CVD.

scholarly journals Program for improving the Technical and Tactical training of veteran athletes who specialize in Martial Arts (on the example of SAMBO wrestlers)

2021 ◽  
pp. 121-127
Author(s):  
Oleksandr Khatsaiuk ◽  
Bogdan Kindzer ◽  
Oles Pryshva ◽  
Anastasiya Ivchenko ◽  
Sergii Kulibaba ◽  
...  
Keyword(s):  
Martial Arts ◽  
Theoretical Research ◽  
Successful Performance ◽  
World Community ◽  
Professional Activities ◽  
Training Cycle ◽  
The World ◽  
Tactical Training ◽  
Competitive Actions

Today, there is an increasing interest of the world community in the movement of veteran athletes, including wrestlers who specialize in Sambo (sports). Given the above, the leading and important role is played by scientific and methodological support of key components of the professional activities of veteran athletes who specialize in Sambo. The choice of the optimal technical and tactical arsenal of wrestlers of the studied category, considering their individual and typological features, allows to achieve the main goal – maintaining optimal sports form and winning competitions of various ranks in the selected Martial Arts. As a result of theoretical research, members of the research group developed a Program to improve the Technical and Tactical training of veteran Sambo wrestlers in the System of their annual training cycle. We expect that the introduction into the System of long-term training of veteran Martial Arts who specialize in Sambo wrestling programs to improve their Technical and Tactical training will increase the activity and effectiveness of competitive actions, which will ensure their successful performance in competitions of various ranks. Prospects for further research in the chosen direction of scientific research include testing the Program to improve the Technical and Tactical training of veteran Sambo wrestlers in the System of their annual training cycle, taking into account their individual typological and physiological characteristics.

scholarly journals From Bioorganic Models to Cells

2021 ◽  
Vol 90 (1) ◽  
pp. 57-76
Author(s):  
Stephen J. Benkovic
Keyword(s):  
Dna Replication ◽  
Scientific Research ◽  
Purine Biosynthesis ◽  
World Community ◽  
The World

I endeavor to share how various choices—some deliberate, some unconscious—and the unmistakable influence of many others shaped my scientific pursuits. I am fascinated by how two long-term, major streams of my research, DNA replication and purine biosynthesis, have merged with unexpected interconnections. If I have imparted to many of the talented individuals who have passed through my lab a degree of my passion for uncloaking the mysteries hidden in scientific research and an understanding of the honesty and rigor it demands and its impact on the world community, then my mentorship has been successful.

The Eurasian Idea of Nursultan Nazarbayev

2020 ◽  
pp. 193-208
Author(s):  
Yerzhan Saltybayev ◽  
Lidiya Parkhomchik
Keyword(s):  
World Community ◽  
The World

The First President of Kazakhstan Nursultan Nazarbayev had always emphasized the mutual influences of the culture and religions of people living in the country. Having absorbed both the European and Asian traditions Kazakhstan illustrates the principles of a diverse country that could build bridges among West and East. It became obvious that the newly independent nation led by Nursultan Nazarbayev was confronted with the need to find new forms of cooperation with the world community after the major geopolitical change. As a result, the Leader of the Nation proposed the long-term initiative, namely, the Eurasian idea that was designed to create an atmosphere of mutual confidence and cooperation. In this regard, this chapter will briefly identify the preconditions for the introduction of the Eurasian initiative with special emphasis placed on the transformation of Kazakhstan's vision of the issue. As a result, the conclusions of this chapter focus on the further prospects for integration between the Eurasian states within the frameworks of Nazarbayev's Eurasian concept.

FEATURES OF PASSENGER TRANSPORT DEMAND PLANNING IN THE CONTEXT OF THE COVID-19 PANDEMIC

2021 ◽  
Vol 72 (1) ◽  
pp. 41-46
Author(s):  
O.U. BULATOVA ◽  
Keyword(s):  
Process Modeling ◽  
Social Life ◽  
Transport Systems ◽  
Passenger Transport ◽  
World Community ◽  
Passenger Traffic ◽  
Demand Planning ◽  
The World ◽  
Modeling Transport

Сurrently, we are witnessing the reaction of the world community to the COVID-19 pandemic, and we are also observing how subjects in all areas of the economy respond to current challenges using innovative approaches. Urban passenger transport is one of the most important factors in the development of the economy and social life of the population. Restoring transport infrastruc-ture is a long-term and time-consuming process. Modeling transport systems is key to understand-ing how quickly and effectively the transport system adapts to new realities after the end of the COVID-19 pandemic. If until recently, models were created with an eye to 20 years, at present their relevance is barely enough for 5 years due to the unpredictability of the behavior of transport us-ers. Passenger traffic will decrease, which may increase the popularity of walking and сycling.

scholarly journals Arctic Vector for German Foreign Policy

2021 ◽  
Vol 20 (2) ◽  
pp. 48-54
Author(s):  
Alexander Kotov ◽  
Keyword(s):  
Economic Development ◽  
Natural Resources ◽  
Global Climate ◽  
The Arctic ◽  
German Foreign Policy ◽  
World Community ◽  
Bilateral Relations ◽  
The World ◽  
Ambivalent Relationship

Germany updated its Arctic strategy in 2019. It is determined that in the context of achieving global climate goals this region for Germany to be one of the key ones. It is emphasized that the interests of Germany are in the sustainable supply of natural resources from the Arctic. The long-term Germany`s policy is formed by the informing the world community about the risks of further economic development of the macroregion for global climatic and environmental reasons, which is carried out within the framework of national policies by the Arctic countries. Russia is one of the key Arctic countries with which Germany closely cooperates in the region in the economic and scientific spheres. Based on the assessment of Germany's position on Russia’s Arctic strategy (2020), the paper analyzes the ambivalent relationship between the two countries in the Arctic macro-region with elements of confrontation and cooperation. The author concludes that Russia and Germany can productively cooperate in the Arctic at the level of regions and economic entities, using it at the same time as an implicit field for discussing the current complex agenda of bilateral relations

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