Combination of the Herbs Radix Rehmanniae and Cornus Officinalis Mitigated Testicular Damage From Diabetes Mellitus by Enhancing Glycolysis via the AGEs/RAGE/HIF-1α Axis

Radix Rehmanniae and Cornus Officinalis (RR-CO) have been widely used as “nourishing Yin and tonifying kidney” herb pairs for the treatment of diabetes mellitus (DM) and its complications in traditional Chinese medicine (TCM). Based on the theory of “kidney governing reproduction” in TCM, the aim of this study was to investigate the therapeutic effects of RR-CO on DM-induced reproduction damage through regulating testicular glycolysis. Moreover, the regulation of AGEs/RAGE/HIF-1α axis on the testicular glycolysis process has also been studied. Spontaneous DM model KK-Ay mice were used to investigate the protective effect of RR, CO, RR-CO on DM-induced reproductive disturbances. RR, CO, RR-CO improved DM-induced renal and testicular morphology damages. Moreover, the impaired spermatogenesis, germ cell apoptosis and motility in testis induced upon DM were also attenuated by RR, CO or RR-CO, accompanied by an increased level of glycolysis metabolomics such as l-lactate, d-Fructose 1,6-bisphosphate, etc. Meanwhile, glucose membrane transporters (GLUT1, GLUT3), monocarboxylate transporter 4 (MCT4) expression, lactate dehydrogenase (LDH) activity, HIF-1α were upregulated by RR, CO and RR-CO treatment compared with the model group, whereas AGE level and RAGE expression were decreased with the drug administration. The RR-CO group was associated with superior protective effects in comparison to RR, CO use only. Aminoguanidine (Ami) and FPS-ZM1, the AGEs and RAGE inhibitors, were used as a tool drug to study the mechanism, showing different degrees of protection against DM-induced reproductive damage. This work preliminarily sheds light on the herb pair RR-CO exhibited favorable effects against DM-induced reproductive disturbances through enhancing testicular glycolysis, which might be mediated by AGEs/RAGE/HIF-1α axis.

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Protective effects of an herbal formulation of Radix Astragali , Radix Codonopsis and Cortex Lycii on streptozotocin-induced apoptosis in pancreatic β -cells: an implication for its treatment of diabetes mellitus

Phytotherapy Research ◽

10.1002/ptr.2285 ◽

2007 ◽

Vol 22 (2) ◽

pp. 190-196 ◽

Cited By ~ 23

Author(s):

Judy Yuet-Wa Chan ◽

Ping-Chung Leung ◽

Chun-Tao Che ◽

Kwok-Pui Fung

Keyword(s):

Diabetes Mellitus ◽

Protective Effects ◽

Radix Astragali ◽

Β Cells ◽

Pancreatic Β Cells ◽

Astragali Radix ◽

Herbal Formulation ◽

Treatment Of Diabetes ◽

Induced Apoptosis ◽

Cortex Lycii

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Antioxidative Property and Molecular Mechanisms Underlying Geniposide-Mediated Therapeutic Effects in Diabetes Mellitus and Cardiovascular Disease

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/7480512 ◽

2019 ◽

Vol 2019 ◽

pp. 1-20 ◽

Cited By ~ 3

Author(s):

Ning Li ◽

Ling Li ◽

Haiming Wu ◽

Heng Zhou

Keyword(s):

Diabetes Mellitus ◽

Cardiovascular Disease ◽

Molecular Mechanisms ◽

Therapeutic Effects ◽

Protective Effects ◽

Iridoid Glucoside ◽

Gardenia Jasminoides ◽

Antioxidative Property

Geniposide, an iridoid glucoside, is a major component in the fruit of Gardenia jasminoides Ellis (Gardenia fruits). Geniposide has been experimentally proved to possess multiple pharmacological actions involving antioxidative stress, anti-inflammatory, antiapoptosis, antiangiogenesis, antiendoplasmic reticulum stress (ERS), etc. In vitro and in vivo studies have further identified the value of geniposide in a spectrum of preclinical models of diabetes mellitus (DM) and cardiovascular disorders. The antioxidative property of geniposide should be attributed to the result of either the inhibition of numerous pathological processes or the activation of various proteins associated with cell survival or a combination of both. In this review, we will summarize the available knowledge on the antioxidative property and protective effects of geniposide in DM and cardiovascular disease in the literature and discuss antioxidant mechanisms as well as its potential applications in clinic.

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Curcumin Protects Against Cognitive Impairments in a Rat Model of Chronic Cerebral Hypoperfusion Combined with Diabetes Mellitus by Suppressing Neuroinflammation, Apoptosis, and Pyroptosis

10.21203/rs.3.rs-111414/v1 ◽

2020 ◽

Author(s):

Yaling Zheng ◽

Jiawei Zhang ◽

Yao Zhao ◽

Yaxuan Zhang ◽

Xiaojie Zhang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cognitive Impairments ◽

Neuronal Cell ◽

Chronic Cerebral Hypoperfusion ◽

Cerebral Hypoperfusion ◽

Receptor Protein ◽

Therapeutic Effects ◽

Protective Effects

Abstract BackgroundChronic cerebral hypoperfusion (CCH) is regarded as a high-risk factor for cognitive decline in vascular dementia (VaD). We have previously shown that diabetes mellitus (DM) synergistically promotes CCH-induced cognitive dysfunction via exacerbating neuroinflammation. Furthermore, curcumin has been shown to exhibit anti-inflammatory and neuroprotective activities. However, the effects of curcumin on CCH-induced cognitive impairments in DM have remained unknown.MethodsRats were fed with a high-fat diet (HFD) and injected with low-dose streptozotocin (STZ), followed by bilateral common carotid artery occlusion (BCCAO), to model DM and CCH in vivo. After BCCAO, curcumin (50 mg/kg) was administered intraperitoneally every two days for eight weeks to evaluate its therapeutic effects. Additionally, mouse BV2 microglial cells were exposed to hypoxia and high glucose to model CCH and DM pathologies in vitro. ResultsCurcumin treatment significantly improved DM/CCH-induced cognitive deficits and attenuated neuronal cell death. Molecular analysis revealed that curcumin exerted protective effects via suppressing neuroinflammation induced by microglial activation, regulating the triggering receptor expressed on myeloid cells 2 (TREM2)/toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) pathway, alleviating apoptosis, and reducing nod-like receptor protein 3 (NLRP3)-dependent pyroptosis.ConclusionsTaken together, our findings suggest that curcumin represents a promising therapy for DM/CCH-induced cognitive impairments.

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Preventive and Protective Properties ofZingiber officinale(Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/516870 ◽

2012 ◽

Vol 2012 ◽

pp. 1-10 ◽

Cited By ~ 38

Author(s):

Yiming Li ◽

Van H. Tran ◽

Colin C. Duke ◽

Basil D. Roufogalis

Keyword(s):

Diabetes Mellitus ◽

Zingiber Officinale ◽

Neural System ◽

Protective Effects ◽

Protective Properties ◽

Safety Issues ◽

Carbohydrate And Lipid Metabolism ◽

Treatment Of Diabetes

Zingiber officinale(ginger) has been used as herbal medicine to treat various ailments worldwide since antiquity. Recent evidence revealed the potential of ginger for treatment of diabetes mellitus. Data fromin vitro, in vivo, and clinical trials has demonstrated the antihyperglycaemic effect of ginger. The mechanisms underlying these actions are associated with insulin release and action, and improved carbohydrate and lipid metabolism. The most active ingredients in ginger are the pungent principles, gingerols, and shogaol. Ginger has shown prominent protective effects on diabetic liver, kidney, eye, and neural system complications. The pharmacokinetics, bioavailability, and the safety issues of ginger are also discussed in this update.

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Researches of the assortment of drugs for the treatment of diabetes II type оn the pharmaceutical market of Ukraine

Farmatsevtychnyi zhurnal ◽

10.32352/0367-3057.2.19.02 ◽

2019 ◽

pp. 13-23

Author(s):

I. V. Kovalevska ◽

O. A. Ruban ◽

O. M. Yevtushenko

Keyword(s):

Diabetes Mellitus ◽

Type Ii Diabetes ◽

Strong Dependence ◽

Pharmaceutical Market ◽

Antidiabetic Drugs ◽

Therapeutic Effects ◽

Minimal Risk ◽

Type Ii ◽

Advantages And Disadvantages ◽

Treatment Of Diabetes

Type II diabetes is a global pandemic, as evidenced by data from a study by the International Diabetes Federation. The disease is a chronic, progressive process with a special metabolic condition that is characterized by hyperglycemia. Therapeutic effects should be aimed at eliminating the main causes of type II diabetes mellitus: insulin secretion dysfunction, a decrease in tissue resistance to insulin, or a combination of these. The aim of the work was to study the range of oral antidiabetic drugs on the pharmaceutical market of Ukraine for the treatment of type II diabetes. The objects of study were drugs used in the treatment of type II diabetes. Studies were conducted using content analysis of official sources of information. In the course of the work, the range of antidiabetic drugs, classification, mechanism of action, cost, main advantages and disadvantages of use were established. It is established that the most common dosage form for the treatment of diabetes are tablets, which occupy more than 90% of the total range of drugs. The lack of modern types of dosage forms in the group A10B is the basis for the creation of new drugs with improved biopharmaceutical and consumer properties. The data obtained indicate a strong dependence of the pharmaceutical market of antidiabetic drugs of Ukraine on imports, with the exception of insulin (А10В). The share of imports in the market in quantitative terms for the period under review amounted to more than 75.86% of the total market volume. It has been established that the use of drugs of the A10B A, A10B F groups with an affordable cost with active therapy contributes to a lower rate of development of diabetes mellitus type II and a high degree of regression to normal glucose, without affecting the fluctuations in body weight. Preparations of the new generation (A10B H, A10B J, A10B X) are highly effective with an insufficient safety profile. The high cost of drugs of these groups makes them inaccessible to the general population. It has been shown that only metformin and voglibosis have a positive effect on body mass fluctuation rates, which will ensure safe and effective glycemic control with minimal risk of hypoglycemia and without weight gain in the treatment of type II diabetes.

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Understanding the Concept of Chronotherapeutics in the Management of Diabetes Mellitus

Current Diabetes Reviews ◽

10.2174/1573399816666201022120825 ◽

2020 ◽

Vol 16 ◽

Author(s):

Shilpi Kashyap ◽

Rajni Bala ◽

Tapan Behl

Keyword(s):

Diabetes Mellitus ◽

Eating Habits ◽

Biological Clock ◽

Therapeutic Effects ◽

Human Beings ◽

Glucose Levels ◽

Obesity And Diabetes ◽

Increased Risk ◽

Treatment Of Diabetes

: The circadian rhythms have been controlled with the aid of a circadian clock in hypothalamus part which is known as suprachiasmatic nucleus. Chronotherapeutics, a branch of pharmacotherapeutics plays a mandate part in the treatment of various disorders, as delivering the drug in correct schedule, correct site, and in correct extent and provides benefit to the patients. The chronopharmacological aspects are very much important in the treatment of diabetes mellitus during daytime as the patients timing of activities of body and medicine treatment has an impact on the increase in the glucose levels in the blood. The fact that increased risk of obesity and diabetes is worse and rates of cardiovascular diseases and death rate is more. A medical savour who works on diabetic problem had been known that the level of glucose in plasma changes independently as regard to eating habits and use of insulin and medicines. People suffering from dawn process is difficult to manage hence the basic aim of a concept is how to detect the function of biological clock of human body, its chronotherapeutic effect on human beings that increases the therapeutic effects and reduces side effects. Keeping these points in mind an attempt has been made in the present review to discuss the role of chronotherapy in the management of diabetes, various techniques used in formulation and design of chronotherapeutic drug delivery systems and regulatory issues related to chronotherapeutics.

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Antihyperglycemic activity of Ophiocordyceps sinensis: A Review

Indian Journal of Agricultural Research ◽

10.18805/ijare.v49i5.5801 ◽

2015 ◽

Vol 49 (5) ◽

Cited By ~ 2

Author(s):

Kanjana Sirisidthi ◽

Piya Kosai ◽

Wannee Jiraungkoorskul

Keyword(s):

Diabetes Mellitus ◽

Antioxidant Activities ◽

Developed Countries ◽

Therapeutic Effects ◽

Medicinal Mushrooms ◽

Antihyperglycemic Activity ◽

Synthetic Drugs ◽

Ophiocordyceps Sinensis ◽

Treatment Of Diabetes ◽

The Developed Countries

Diabetes mellitus, one of the non-communicable diseases, is still the seriously problem due to leading the causes of death in the developed countries. Therefore it is important to identify novel nutraceuticals or drugs for curing or preventing diabetes because the existing synthetic drugs have several limitations. Traditional medicinal plants and medicinal mushrooms are used in the treatment of diabetes mellitus more than century, but only a few of these have proofed their safe and efficacy. Aim of this review article is focused <italic>Ophiocordyceps sinensis</italic> one of the edible and medicinal mushrooms used for therapeutic effects and antioxidant activities. It contains several kinds of polysaccharides, proteins, nitrogen compounds, fatty acids, phenolic acids, and isoflavones. Many researches have evaluated that these phytochemical substances have the major impact on diabetes mellitus. This review focuses on the antihyperglycemic activity of this mushroom and clears that it has the potential to be considered as a candidate for preparing the new treatment of diabetes mellitus.

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Application of Berberine on Treating Type 2 Diabetes Mellitus

International Journal of Endocrinology ◽

10.1155/2015/905749 ◽

2015 ◽

Vol 2015 ◽

pp. 1-12 ◽

Cited By ~ 72

Author(s):

Bing Pang ◽

Lin-Hua Zhao ◽

Qiang Zhou ◽

Tian-Yu Zhao ◽

Han Wang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Side Effects ◽

Scientific Evidence ◽

Good Clinical Practice ◽

Therapeutic Effects ◽

Natural Medicine ◽

Medical Theory ◽

Treatment Of Diabetes ◽

Traditional Chinese Medical

Traditional Chinese medicine (TCM) performs a good clinical practice and is showing a bright future in the treatment of diabetes mellitus (DM). TCM treatment has certain advantages of less toxicity and/or side effects, and herbs could provide multiple therapeutic effects. Berberine (BBR) is a classical natural medicine. In this review, we summarize the application of BBR in the treatment of DM from two aspects. First, modern pharmacological effects of BBR on glucose metabolism are summarized, such as improving insulin resistance, promoting insulin secretion, inhibiting gluconeogenesis in liver, stimulating glycolysis in peripheral tissue cells, modulating gut microbiota, reducing intestinal absorption of glucose, and regulating lipid metabolism. BBR is used to treat diabetic nephropathy (DPN), diabetic neuropathy (DN), and diabetic cardiomyopathy due to its antioxidant and anti-inflammatory activities. Second, the clinical application of BBR is reviewed, such as listing some clinical trials on the effectiveness and safety of BBR, explaining applicable stage and syndrome, the reasonable dose and dose formulation, and the toxicity and/or side effects. This review provides scientific evidence about BBR, as well as introducing some traditional Chinese medical theory and clinical experience, in order to guide clinician to use BBR more suitably and reasonably.

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