scholarly journals Combination of Dexmedetomidine and Tramadol in Patient-Controlled Intravenous Analgesia Strengthens Sedative Effect in Pregnancy-Induced Hypertension

2021 ◽  
Vol 12 ◽  
Author(s):  
Shu-Yao Zhang ◽  
Hui Zhao ◽  
Chengcheng Xu ◽  
Qiuzhen Zhang ◽  
Yun Chen ◽  
...  
Keyword(s):  
Serum Level ◽  
P38 Mapk ◽  
Sedative Effect ◽  
Pregnancy Induced Hypertension ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Intravenous Analgesia ◽  
Combinational Treatment ◽  
The Mean ◽  
Different Doses

Objective: The aim of the present study is to explore the combination of dexmedetomidine (DXM) and tramadol (TMD) on sedative effect in patients with pregnancy-induced hypertension (PIH).Methods: A total of 356 patients with pregnancy-induced hypertension (PIH) were randomly divided into three groups: DXM, TMD and DXM + TMD groups. These patients were treated with different doses of DXM, TMD or combination of DXM and TMD by a patient-controlled intravenous injection device. The scores of static pain and dynamic pain, sedation degree, and adverse reaction were recorded. The plasma levels of inflammatory mediators IL-10 and C-reactive protein (CRP), and the serum level of p-p38-MAPK were evaluated.Results: It was found that administration with DXM 1.0 µg/kg/h + TMD 700 mg and DXM 2.0 µg/kg/h + TMD 600 mg result in stronger sedative effect than single administration with DXM or TMD. The mean arterial pressure (MAP) and heart rate (HR) of patients with PIH were decreased with the combinational treatment of DXM and TMD. Interestingly, the PIH patients injected with DXM 1.0 µg/kg/h + TMD 700 mg and DXM 2.0 µg/kg/h + TMD 600 mg showed stronger sedative effect. In addition, the plasma level of level of IL-10 was increased and CRP decreased. The serum level of p-p38/MAPK was decreased.Conclusion: Taken together, our study indicates that combination of DXM and TMD effectively lowers blood pressure and reduces inflammation through increasing the level of IL-10, reducing CRP and inhibiting p-p38/MAPK in patients with PIH. This study suggests that the combination of DXM and TMD could be an anesthetic choice in the management of PIH.

Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

2020 ◽  
Vol 15 (3) ◽  
pp. 227-239 ◽  
Author(s):  
Hader I. Sakr ◽  
Akef A. Khowailed ◽  
Reham S. Al-Fakharany ◽  
Dina S. Abdel-Fattah ◽  
Ahmed A. Taha
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Urate ◽  
Interleukin 1Β ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

scholarly journals Doppler ultrasound of umbilical artery in prediction of fetal outcome in pregnancy induced hypertension Sudanese population

2019 ◽  
Vol 8 (1) ◽  
pp. 96
Author(s):  
Rihab A. Yousif ◽  
Awadia G. Suliman ◽  
Raga A. Aburaida ◽  
Ibrahim M. Daoud ◽  
Naglaa E. Mohammed
Keyword(s):  
Flow Velocity ◽  
Umbilical Artery ◽  
Fetal Outcome ◽  
Fetal Mortality ◽  
Pregnancy Induced Hypertension ◽  
Diastolic Flow ◽  
Induced Hypertension ◽  
The Mean ◽  
Doppler Indices ◽  
In Pregnancy

The pregnancy induced hypertension increase the fetal mortality and morbidity and the using of Doppler umbilical artery indices decrease the fetal mortality and morbidity however, there is few complete data about the most frequently altered Doppler US parameters to predict fetal outcome in pregnancy induced hypertension . Methods This ia cohort prospective study done in two hundred and six women of second and third trimester presenting to antenatal clinic in Soba University Hospital at the department of Obstetrics & Gynecology, in the fetus unit and critical pregnancy in the period From June 2008 to April 2013 to assess the Doppler indices of umbilical artery in pregnancy induced hypertension for prediction of prenatal outcome; 105 pregnancy induced hypertension patients and 101 women with uneventful pregnancies as normal control group included in this study . Baseline investigations and color Doppler of umbilical artery were done. Statistical analysis of data were done using SPSS, Receiver Operating Characteristic (ROC) curve analysis was performed and the area under the curve (AUC) used to determine sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of umbilical artery Doppler indices to predict fetal outcome.Results The study determine that there was significant difference in Doppler indices in PIH and control group ( p<0.01, the mean indices of umbilical artery is higher in PIH group compared with normal pregnancy group , the mean different of S/D ratio was 0.40, mean difference of RI was 0.06 and the mean different of PI index was 0.16, high percentage of adverse fetal outcome had been reported in in Pregnancy Induced Hypertension group than in control , which was more in absent and reversed flow velocity in umbilical artery in Pregnancy Induced Hypertension compared with group of Pregnancy Induced Hypertension with present end diastolic flow velocity. Systolic/Diastolic ratio was most accurate in predicting adverse outcome in pregnancy induced hypertension patients, followed by the Pulastility index then the Resistance index (75%, 66% and 57% respectively).ConclusionThis study concluded that pregnancy induced hypertension leads to worsen placental insufficiently, which appears on the higher Doppler indices of umbilical artery to PIH patients when compared with normal pregnancy. A low diastolic flow and higher indices characterized the pregnancies with abnormal outcomes. Doppler of the umbilical artery was useful to predict fetal well being in PIH patients, high percentage of adverse fetal outcome had been reported in absent and reversed end diastolic flow velocity in umbilical artery compared with group of present flow velocity.

scholarly journals Hematological changes in pregnancy induced hypertension in their third trimester at Jhalawar Medical College, Jhalawar, India

2019 ◽  
Vol 8 (9) ◽  
pp. 3497
Author(s):  
Neelam Jhajharia ◽  
Madhureema Verma
Keyword(s):  
Control Group ◽  
Case Group ◽  
Haematocrit Level ◽  
Haematological Parameter ◽  
Pregnancy Induced Hypertension ◽  
Medical College ◽  
Induced Hypertension ◽  
Life Threatening ◽  
The Mean ◽  
And Control

Background: Pregnancy induced hypertension (PIH) is one of the most common and potential life-threatening complications of pregnancy. This study is aimed to investigate and correlate the hemoglobin, haematocrit, white blood cell count, lymphocytes and platelets in PIH patients in their third trimester.Method: Total 126 subjects were studied out of them 63 patients (case) and 63 healthy pregnant women (control) visiting the Obstetrics and Gynaecology department Jhalawar Medical College, Jhalawar were registered in the study and followed during their pregnancy. Two millilitre of blood sample was drawn aseptically using the 5ml syringe from the median ante cubital vein of all the cases and control participants into EDTA-anticoagulated tubes. Haematological parameter calculated by using Sysmex XN-9100™ Automated Haematology System.Results: The mean hemoglobin level of the case group (8.8206±2.53779) was significantly lower than that of the control group (9.7289±2.47033) (p<0.05). The mean platelet count of the case group (131.4937±62.05999) was significantly lower than that of the control group (324.9683±230.78764) (p<0.05). The mean lymphocytes level of case group (1.2510±0.56369) was significantly lower than that of the control group (1.9295±1.4150) (p<0.05). The mean WBC level of case group (36.3467±119.90635) was significantly high than control group (11.5260±4.83059) (p<0.05). The mean haematocrit level of case group (32.6851±7.29789) was significantly high than control group (30.0424±23.38116) (p<0.05).Conclusion: The mean hemoglobin, mean platelets and mean lymphocytes are lower in PIH patients. The mean WBC and haematocrit are higher in PIH patient. 

scholarly journals What are the maternal risks and pregnancy outcomes after kidney transplantation?

2018 ◽  
Vol 6 (4) ◽  
pp. 111
Author(s):  
Amera Bekhatro Awad Allah Rashed ◽  
Mohamed Magdy Sharaf
Keyword(s):  
Kidney Transplantation ◽  
Pregnancy Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
Assessment Sheet ◽  
Maternal Risks ◽  
The Mean ◽  
Risks Assessment ◽  
Normal Women ◽  
Kidney Functions

Background: Pregnancy after kidney transplantation should be considered as a major concern. Women with transplanted kidney were able to conceive for more than 50 years. Little studies are available highlighting the effects of transplantation on fetal and neonatal health.Purpose: This study was conducted with the purpose of identifying the maternal risks and pregnancy outcomes after kidney transplantation.Methods: Research design: A descriptive (non-experimental) design was used in conducting this study. Tools: Three tools were used during the course of this study, the interviewing questionnaire sheet, maternal risks assessment sheet and pregnancy outcomes sheet.Results: Regarding the maternal risks, there was a significant increase in mean serum creatinine, decrease in estimated glomerular filtration rate, increase in proteinuria, reported abortion rate was 16.3%, pregnancy induced hypertension rate was 20.9%; Among acquired infections, primary herpes simplex was very common with a rate of 18.6% while urinary tract infection rate was 39.5%. Among pregnancy outcomes, the mean gestational age was 35.4 ± 3, mean birth weight was 2,107.8 ± 567.7 and 74.4% of women delivered by C.s. 30.2% of delivered infants experienced incubator admission.Conclusions: The current findings succeeded in answering both study questions.Recommendation: Pregnant women with kidney transplantation should be followed-up more frequent than normal women for early detection of any risks and for obtaining favorable pregnancy outcomes. Women should be monitored frequently for kidney functions, early signs of pregnancy induced hypertension, acquired infections and other maternal risks reported by this study.

scholarly journals Moderate-Severe Endometriosis Shows Higher CA-125 Serum Level Compared to Minimal-Mild Endometriosis

2016 ◽  
Author(s):  
Jhonny Yudho
Keyword(s):  
Serum Level ◽  
Roc Analysis ◽  
Obstet Gynecol ◽  
Test Methods ◽  
Stage I ◽  
Ca 125 ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
The Mean

Objective: To investigate and compare serum profile of CA-125, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in various stages of endometriosis. Methods: Forty endometriosis patients’ blood samples were taken prior to laparoscopic surgery for various indications. Diagnosis of endometriosis was confirmed by laparoscopy. Independent T test methods were used for statistical analysis. ROC analysis was examined for each variable. Results: The mean level of CA-125 serum was 12.0 vs. 36.3 U/ml (p < 0.05); ESR serum was 11 vs. 12.8 mm/hour (p > 0.05); CRP serum was 0.7 vs. 0.3 (p > 0.05) for endometriosis stage I-II and stage III-IV, respectively. The optimal cut off point to discriminate endometriosis stage I-II and III-IV was 16.9 U/ml with sensitivity 83% and specificity 81%. Conclusion: The CA-125 serum level was increased for moderatesevere compare to minimal mild endometriosis patient. [Indones J Obstet Gynecol 2012; 36-3: 121-4] Keyword: CA-125, CRP, endometriosis, ESR, serum

scholarly journals Neonatal and maternal platelet cytosolic calcium in normotensive and hypertensive pregnancies.

1994 ◽  
Vol 71 (1) ◽  
pp. F6-10 ◽  
Author(s):  
M D Kilby ◽  
F Broughton Pipkin ◽  
E M Symonds
Keyword(s):  
Gestational Hypertension ◽  
Venous Blood ◽  
Cytosolic Calcium ◽  
Significant Rise ◽  
Specific Factor ◽  
Pregnancy Induced Hypertension ◽  
Significant Difference ◽  
Induced Hypertension ◽  
The Mean ◽  
In Pregnancy

A prospective study investigated platelet cytosolic calcium in non-pregnant volunteers (n = 30) and samples from the umbilical veins of babies from both normotensive (n = 18) and hypertensive (n = 15) primigravidae, and their mothers. There was no significant difference between the neonatal umbilical venous platelet cytosolic calcium concentration (p[Ca2+]i) in babies born to normotensive primigravidae or to those whose pregnancies were complicated by gestational hypertension (88 x 9 (SE) 2 x 5) in normotensive primagravidae, 80 x 6 (2 x 8) in pregnancy induced hypertension without proteinuria, and 89 x 3 (3 x 2) nmol/l in pre-eclampsia. There was also no significant difference in the p[Ca2+]i from the umbilical veins of the pregnancies studied and those of non-pregnant female volunteers in the follicular phase of their menstrual cycle. This was despite a gradual and significant rise in p[Ca2+]i with increasing severity of disease in the mothers of the babies studied (119 x 9 (4 x 1) in normotensive primagravidae, 130 x 8 (7 x 3) in pregnancy induced hypertension without proteinuria, and 148 x 2 (4 x 5 ) nmol/l in pre-eclampsia). The mean maternal p[Ca2+]i in the three samples returned to concentrations comparable with those in non-pregnant subjects by 12 weeks after birth. These data demonstrate no significant difference between the mean p[Ca2+]i in non-pregnant women and those obtained from the umbilical venous blood of normotensive or hypertensive primigravidae. They suggest that the functional hypoactivity of neonatal platelets is probably not secondary to a decrease in basal p[Ca2+]i. They also suggest that the progressively raised p[Ca2+]i in normal and hypertensive pregnancies might be due to a pregnancy specific factor that does not cross the placenta,

Sign in / Sign up

Export Citation Format

Share Document